Ibuprofen In Tablets Research Articles

Determination of Ibuprofen in Tablets and Human Blood Samples: Effect of Clay in Minimizing Overvoltage of Ibuprofen Oxidation

AbstractIn the current research, clay particles modified graphite electrode (Clay−CPE) was used for the electrocatalytic oxidation of ibuprofen (IBU). This clay was utilized to reduce the distortions of ibuprofen oxidation peak shape and for a better signal to noise ratio. The surface characterization of the clay and their activity toward IBU oxidation were studied by electrochemical methods in particular: cyclic voltammetry, Tafel plots and electrochemical impedance spectroscopy. The number of the electrons, rate constant and kinetic parameters related to ibuprofen oxidation were calculated. The ibuprofen peak gets more symmetrical in the presence of clay giving a detection limit (LOD) of 8.35×10−7 mol L−1 (3Sb/M) using differential pulse voltammetry. The main practical applicability of the modified electrode was explored by determining ibuprofen in tablets and human blood samples.

STABILITY INDICATING RP-HPLC ASSAY OF HYDROCODONE AND IBUPROFEN IN TABLETS

Objective: The combination of hydrocodone and ibuprofen is prescribed to temporarily relieve severe pain. A new selective, precise and accurate stability indicating reverse phase high performance liquid chromatography (RP-HPLC) technique was developed for identification and estimation of hydrocodone and ibuprofen in tablets.
 Methods: The analysis of hydrocodone and ibuprofen was executed on phase Zodiac C18 (250 × 4.6 mm, 5 μm) column with sodium dihydrogen phosphate (0.1M, pH5.0) and methanol (60:40, v: v) as a mobile phase with a flow rate of 1.0 ml/min. The detection and measurement was done at 234 nm. The stability of hydrocodone and ibuprofen was examined under different conditions recommended by ICH, including alkaline, acidic, neutral, oxidative, photolytic and thermal.
 Results: Hydrocodone and ibuprofen are eluted at 4.019 min and 4.999 min, respectively. The assay method was linear (range: 3.75-11.25 µg/ml and 100-300 μg/ml) with R2values of 0.9996 and 0.9999 for hydrocodone and ibuprofen, respectively. Method was accurate (recovery: 99.65% and 99.37% for hydrocodone and ibuprofen, respectively), precise (RSD: 0.262% and 0.261% for hydrocodone and ibuprofen, respectively), selective and robust. In degradation studies, peaks of degradants did not interfere with the peaks of hydrocodone and ibuprofen. This validated method was applied to assay the content of hydrocodone and ibuprofen in tablets.
 Conclusion: This method can be opted in the routine quality control test of fixed dose tablet combination comprising of hydrocodone and ibuprofen.

Determination of ibuprofen and paraben in pharmaceutical formulations using flow-injection and derivative spectrophotometry

A flow-injection UV spectrophotometric method for the determination of ibuprofen in tablets was developed. The proposed method was achieved by using a flow cell which was located in a UV spectrophotometer and a peristaltic pump helped maintaining the carrier solvent, 0.1 M NaOH. During the study, flow rate, loop volume and the number of injections per hour were 15 mL/min, 193 μL and 100, respectively. The analytical signal of ibuprofen was linear in the concentration range of 400–1200 μg/mL. The detection limit and limit of quantification were determined as 27 and 91 μg/mL, respectively. Results for the determination of ibuprofen in tablets, 600 ± 2 mg/tablet (mean ± SD), were in good agreement with the labeled quantities, 600 mg/tablet. A relatively high recovery value, 100.4 ± 0.6%, proves the accuracy of the proposed method. The spectro-photometric method and reference HPLC method were shown to be comparable when Student’s t-test and Fisher test were applied to both methods. In addition, a fourth order derivative UV spectrophotometric method (at 268.8 nm and n = 9) for the determination of ibuprofen and a first order (at 271 nm and n = 1) derivative UV spectrophotometric method for the determination of paraben in pediatric syrups were developed. Recovery values for the determination of ibuprofen and paraben were 102.4 ± 1.1% and 100.2 ± 2.3%, respectively.

Ibuprofen-selective electrode on the basis of a neutral carrier, N-trifluoroacetylbenzoic acid heptyl ester

An ibuprofen-selective electrode on the basis of a composition of an anion exchanger, 2,3,4-tris(dodecyloxy)benzyltrimethylammonium with a neutral carrier, N-trifluoroacetylbenzoic acid heptyl ester, is proposed. It exhibits good selectivity, a wide pH-range, and a low limit of detection. A procedure for the determination of ibuprofen in tablets is developed.

Properties of ibuprofen ion-selective electrodes based on the ion pair complex of tetraoctylammonium cation

Abstract Ibuprofen membrane electrodes based on different plasticizers: diisobutyl phthalate (DIBP), o-nitrophenyloctyl ether (o-NPOE), dioctyl sebacate (DOS) and tetraoctylammonium 2-(4-isobutylphenyl)propionate were prepared. All electrodes show: a near Nernstian slope of characteristic (58.3–60.9 mV decade−1) in the measurement range (10−4–10−1 mol L−1), limit of detection (5.0×10−5 mol L−1), really long lifetime (12 months), dependence of the electrode potential on pH (5.5–9.0), reproducibility of potential (0.6–1.2 mV) and selectivity coefficients in relation to some organic and inorganic anions. The electrodes were applied for the determination of ibuprofen in tablets by the calibration curve method and the standard addition method.

Accelerated degradation of ibuprofen in tablets

The forced degradation of 11 ibuprofen tablet brands was carried out according to current industry best practices. The results indicated an incompatibility between ibuprofen and two common tablet excipients (polyethylene glycol and polysorbate 80) that were observed to accelerate the degradation of ibuprofen in tablets stored for three weeks at 70°C/75% RH. Studies of binary drug/excipient samples supported the conclusion. One degradant that was observed at increased levels was 4-isobutylacetophenone (4-IBAP), which is a known toxin.

Europium(III)-Sensitized Chemiluminescence Determination of Ibuprofen in Pharmaceutical Preparations and Biological Fluids

Chemiluminescence reaction of the system containing europium(III) ion, KMnO4, Na2SO3, and ibuprofen was investigated for the determination of ibuprofen. The introduction of Eu(III) ion into the system of KMnO4-Na2SO3-ibuprofen caused a significant increase in the chemiluminescence signal. The increment of the chemiluminescence signal is proportional to ibuprofen concentration in the range of 5.0 × 10−8–5.0 × 10−6 g/ml with a detection limit of 1 × 10−8 g/ml. The relative standard deviation for 1.0 × 10−7 g/ml ibuprofen solution was 1.7% (n = 11). The proposed method was successfully applied to determine ibuprofen in tablets and human plasma.

Determinação espectrofotométrica simultânea de paracetamol e ibuprofeno em formulações farmacêuticas usando calibração multivariada

A simple method was proposed for determination of paracetamol and ibuprofen in tablets, based on UV measurements and partial least squares. The procedure was performed at pH 10.5, in the concentration ranges 3.00-15.00 µg ml-1 (paracetamol) and 2.40-12.00 µg ml-1 (ibuprofen). The model was able to predict paracetamol and ibuprofen in synthetic mixtures with root mean squares errors of prediction of 0.12 and 0.17 µg ml-1, respectively. Figures of merit (sensitivity, limit of detection and precision) were also estimated. The results achieved for the determination of these drugs in pharmaceutical formulations were in agreement with label claims and verified by HPLC.

A new potentiometric ibuprofenate ion sensor immobilized in a graphite matrix for determination of ibuprofen in tablets

The characteristics, performance, and application of an electrode, namely, Pt|Hg|Hg 2(IBP) 2|Graphite, where IBP stands for ibuprofenate ion, are described. This electrode responds to IBP with sensitivity of (58.6 ± 0.9) mV decade − 1 over the range 5.0 × 10 − 5–1.0 × 10 − 1 mol L − 1 at pH 6.0–9.0 and a detection limit of 3.8 × 10 − 5 mol L − 1. The electrode is easily constructed at a relatively low cost with fast response time (within 15–30 s) and can be used for a period of 5 months without any considerable divergence in potentials. The proposed sensor displayed good selectivity for ibuprofen in the presence of several substances, especially concerning carboxylate and inorganic anions. It was used for the direct assay of ibuprofen in commercial tablets by means of the standard additions method. The analytical results obtained by using this electrode are in good agreement with those given by the United States Pharmacopeia procedure.