Objective To analyze the risk factors of intrauterine adhesion (IUA) after hysteroscopic resection of endometrial polyps. Methods Totally 359 patients undergoing hysteroscopic resection of endometrial polyps from January 2013 to December 2016 were enrolled in this study. The clinical data of IUA group and non-IUA group were compared. Univariate analysis was performed to identify the risk factors of IUA,and multivariate Logistic regression analysis was further performed to get the independent risk factors. Results Of these 359 patients,IUA occured after operation in 56 patients (15.60%). Univariate analysis showed underlying diseases (χ2=7.381,P=0.004),multiple polyps (χ2=3.376,P=0.040),uterus with uterine fibroids or endometrial hyperplasia (χ2=6.495,P=0.009),history of curettage(χ2=31.576,P=0.000),pelvic infection (χ2=8.582,P=0.001),intrauterine device (χ2=7.161,P=0.006),history of cesarean section (χ2=5.493,P=0.014),and multigravida were (χ2=16.886,P=0.000) the risk factors of IUA. Logistic regression analysis showed other diseases of uterus(χ2=19.542,P=0.026),history of curettage (χ2=29.614,P=0.000),pelvic infection (χ2=5.627,P=0.002),intrauterine device (χ2=11.342,P=0.08),history of cesarean section(χ2=8.549,P=0.035),and multigravida (χ2=15.493,P=0.000) were the independent risk factors of IUA after hysteroscopic resection of endometrial polyps. Conclusion Other diseases of uterus,history of curettage,pelvic infection,intrauterine device,history of cesarean section,and/or multigravida can increase the risk of IUA after hysteroscopic resection of endometrial polyps.