Hypolipidemic Effects Of Aqueous Extract Research Articles

HYPOLIPIDEMIC ACTIVITY OF HIPTAGE BENGHLENSIS LEAF EXTRACTS ON HIGH FAT DIET INDUCED HYPERLIPIDAEMIC RATS

The present study was designed to evaluate the hypolipidemic effects of aqueous extract (HBAE) and ethanolic extract (HBEE) of Hiptage benghalensis leaves using a high-fat-diet induced hyperlipidemic animal model. Albino male wistar rats (120–150 g) were split into various groups, each of which had six individuals. Normal rats (group I) were received 0.3% carboxy methyl cellulose (CMC) with a standard laboratory diet, while hyperlipidemic rats (group II, III, IV, V, VI and VII) were fed high-fat diet for induction of hyperlipidemia. Hyperlipidaemic control group (group II) received 0.3% CMC (10 mL/kg/day), standard group (group III) received gemfibrozil (50 mg/kg/day, p.o.), HBAE groups (group IV and V) received aqueous extract of H. benghalensis (100 and 200 mg/kg/day, p.o.), and HBEE groups (group VI and VII) received an ethanolic extract of H. benghalensis (100 and 200 mg/kg/day, p.o.), concurrent with high fat diet for consecutive four weeks. The HBAE and HBEE treatments led to a significant (p < 0.05) reduction in serum lipids (TC, TG, LDL and VLDL) and elevation in cardioprotective HDL, when compared to hyperlipidaemic rats (group II). Phytochemical screening revealed the presence of phytoconstituents such as alkaloids, flavonoids, saponins, tannins, phenolic compounds and steroids, which may be attributed to observed hypolipidemic effects. The present study’s findings concluded that HBEE (200 mg/kg, p.o.) had potent hypolipidemic effects.

Comparative Analysis of the Hypoglycaemic and Hypolipidemic Effects of Aqueous Extract of some Ethno medicinal Plants in Alloxan Induced Diabetic Rats

Diabetes mellitus is a complex metabolic disorder associated with the development of metabolic complications. This research evaluated the hypoglycemic and hypolipidaemic effects of Moringa oleifera (MO), Treculia africana (TA) and Albizzia chevalieri (AC) plant extracts on diabetes. Albino rats were randomly divided into six (six) main groups; MC, MO, TA, AC, Normal Control (NC) and Diabetic Control (DC) groups. Group MO, TA and AC were further subdivide into three sub groups. Diabetes mellitus was induced by a single dose intraperitoneal injection of alloxan 150 mg/kg body weight. Fasting blood glucose level and lipid profile were assayed using standard methods. Intraperitoneal injection of 150 mg/kg of Alloxan in the albino rats resulted in significant (p<0.05) elevation of serum glucose, total cholesterol (TC), triglyceride (TG), very low density lipoprotein (VLDL-C), and low density lipoprotein (LDL-C). Also, there was significant decrease (p<0.05) in HDL-C and body weight of the albino rats compared with that of the NC group. Oral administration of MO, TA and AC to diabetic albino rats for 21 days significantly (p<0.05) reduced fasting blood glucose level, normalized lipid profile and restore body weight of the albino rats in treated groups compared to diabetic control groups. All the plant extracts studied in this research significantly (p<0.05) increase the regeneration of damaged pancreatic β cells. Treatment with MO (800 mg/kg) confirmed highly significant (p<0.05) effect compared to TA and AC.

Hypoglycemic and hypolipidemic effects of aqueous extract of phaseolus vulgaris pods in streptozotocin-diabetic rats

The present investigation was carried out to evaluate the reduction potential of aqueous extract of casing of pods of phaseolus vulgaris in blood glucose and lipids levels among hyperglycemic streptozotocin (STZ)-induced rats. Oral administration of 150mg/kg of aqueous oral administration of aqueous pod extract of phaseolus vulgaris to diabetic rats for 40days resulted in a significant decrease in blood glucose (p<001), cholesterol (P<0.01) and triglycerides (P<0.01). In addition, glibenclamide reduced blood glucose, cholesterol and triglycerides. It is concluded that both aqueous extract of casing of pods of phaseolus vulgaris and glibenclamide reduced the blood levels of glucose and lipids. In addition, aqueous extract of phaseolus vulgaris pods was more effective than glibenclamide in reducing blood glucose.

Haemato-Protective and Hypolipidemic Effects of Aqueous Extract of Libyan Propolis Against Sodium Nitrite Induced Haematotoxicity and Hyperlipidemia in Guinea Pigs

Flavonoids and various phenolics are the most important pharmacologically active constituents in propolis capable of scavenging free radicals. The present work aimed to evaluate the effectiveness of aqueous extract of Libyan propolis as a natural source of antioxidants to minimize the harmful effects of sodium nitrite induced haematotoxicity and hyperlipidemia in Guinea pigs. In this study, Twenty four adult male Guinea pigs were used for this study and divided into four groups. The first group was control group, the 2nd was the propolis group orally received propolis (200 mg/kg body wt), the 3rd was the experimental and received sodium nitrite orally at a dose of 80 mg/kg body weight, the 4th one co-administered sodium nitrite orally at a dose of 80 mg/kg body weight with propolis (200 mg/kg body wt) daily for 35 days. Blood samples were obtained for assessment of haematological parameters and serum lipids profile. In sodium nitrite treated animals, there were severe haematological changes and dyslipidemia. Haematologically, Guinea pigs that received sodium nitrite orally at a dose of 80 mg/kg body weight daily for 35days had significantly (p<0.05) lower red blood cell count, hemoglobin content, haematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, white blood cell count, and platelets count than those in the control animals. On the other hand, mean corpuscular volume of sodium nitrite treated animals was significantly (p<0.05) elevated as compared to the control animals. The serum cholesterol, triglycerides, low density lipids cholesterol, very low density lipids cholesterol concentrations, and the atherogenic ratios based on lipid profile parameters (Castelli’s risk index I, Castelli’s risk index II, atherogenic coefficient and atherogenic index of plasma) were increased and serum high density lipids cholesterol concentration was decreased in sodium nitrite treated group. Co-administration of propolis significantly improved of all haematological and lipid profile parameters, and atherogenic ratios parameters. It can be concluded that, sodium nitrite had adverse effects on haematological, lipid profile parameters, and the atherogenic ratios parameters. Propolis supplementation showed a remarkable amelioration of these abnormalities in sodium nitrite treated male Guinea pigs. It is recommended that the use of sodium nitrite must be limited and use of propolis as antioxidant to prevent the toxic effect. Further studies are necessary to elucidate exact mechanism of protection of haematotoxicity, hyperlipidemia, atherogenic and potential usefulness of aqueous extract of Libyan propolis as a protective agent against sodium nitrite induced haematotoxicity, dyslipidemia and atherogenic in clinical trials.

Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats

BackgroundHericium erinaceus, as a commonly used medicine or food, has attracted much attention due to its health effects when used as a home remedy for some diseases. The aim of this work was to investigate the hypoglycemic and hypolipidemic effects of aqueous extract of Hericium erinaceus (AEHE) in streptozotocin (STZ)-induced diabetic rats.MethodsDiabetes was induced in Wistar rats by the administration of STZ (55 mg/kg BW.) intraperitoneally. AEHE (100 and 200 mg/kg BW.) was administered for a period of 28 days. The effects of AEHE on glucose, insulin, and lipid files in blood, and oxidative stress parameters in the liver were evaluated. The body weights of rats were recorded at day 0, 14 and 28th days.ResultsThe administration of AEHE for 28 days in STZ diabetic rats resulted in a significant decrease in serum glucose level and a significant rise in serum insulin level. AEHE treatment attenuated lipid disorders. In addition, AEHE administration increased the activities of CAT, SOD, and GSH-Px, and GSH level, and reduced MDA level in the liver tissue significantly.ConclusionOur results suggest that AEHE possesses hypoglycemic, hypolipidemic, and antioxidant properties in STZ-induced diabetes rats.

Hypolipidemic effects of aqueous extract of Acalypha capitata leaves in rats fed on high cholesterol diet

Objective To evaluate the hypolipidemic effects of aqueous extract of Acalypha capitata ( A. capitata ) leaves in rats fed on high cholesterol diet. Methods Cholesterol diet was administered to Wistar rats at a dose of 40 mg per 0.2 mL 3 times daily for 14 days while the control received distilled water. These animals were treated with extract of A. capitata at doses of 100 and 200 mg/kg. Lipid profiles were observed and compared. Results Administration of A. capitata caused significant decrease in cholesterol, triglyceride and low density lipoprotein-cholesterol when compared with the control ( P Conclusions This observation suggests that the leaf extract of A. capitata could probably serve as a potential natural product for treatment of hyperlipidaemia.

ANTIOXIDANT ACTIVITIES AND HYPOLIPIDEMIC EFFECTS OF AN AQUEOUS EXTRACT FROM FLOWER BUDS OF CLEISTOCALYX OPERCULATUS (ROXB.) MERR. AND PERRY

ABSTRACT The antioxidant activities and hypolipidemic effects of aqueous extract from Cleistocalyx operculatus flower buds (COB) (Roxb.) Merr. and Perry, a commonly used material for drink preparation in Vietnam, were investigated in vitro and in diabetic rats. In vitro, the aqueous extract of COB which has highest phenolic and flavonoid contents showed a strong antioxidant effect and highest pancreatic lipase inhibitory activity when compared with green tea and guava leaf extracts. Oral administration of aqueous extract from COB (500 mg/kg body weight/day) on streptozotocin-induced diabetic rats for 8 weeks resulted in significant reduction in the levels of glucose, total cholesterol and triglyceride in plasma as well as the concentration of glucose and sorbitol in the lens. In addition, COB showed significant recovery in the activities of antioxidant enzymes (superoxide dismutase, glutathione S-transferase) and glutathione level in liver with markedly decrease in the lipid peroxide level in liver and lens of the COB-treated diabetic rats. These results indicated that COB showed antioxidant activities, prevention of sorbitol accumulation in lens and hypolipidemic effects in addition to its antidiabetic effects and may be considered as a promising material for the prevention of diabetic complications and metabolic syndrome. PRACTICAL APPLICATIONS In recent years, research on traditional medicinal plants for the management of diabetes has attracted the interest of medical scientists. A suitable plant material for antidiabetes and prevention of diabetic complications should possess various biological components, such as antihyperglycemia, antioxidant activities and antihyperlipidemia, without side effects. In this study, the aqueous extract from Cleistocalyx operculatus flower buds (COB) with high polyphenolic and flavonoid content has shown beneficial biological functions in vitro and in diabetic rats, including antioxidant activity, hypolipidemic and hypoglycemic effects. The results of our study suggest that COB might have a potential role in the management of the prediabetic state and the prevention of diabetic complications. Therefore, there is the possibility for the development of C. operculatus as a beverage for the prevention of diabetes, as well as the prevention of the metabolic syndrome.

Anti-hyperglycaemic and Hypolipidemic Effects of Ocimum basilicum Aqueous Extract in Diabetic Rats

The hypoglycaemic and hypolipidemic effects of the aqueous extract of Ocimum basilicum (OB) whole plant were investigated in normal and streptozotocin (STZ) diabetic rats. After a single oral administration, OB significantly reduced blood glucose levels in normal (p<0.01) and diabetic rats (p<0.001). After 15 days of repeated oral administration, OB produced a potent reduction on blood glucose levels (p<0.001) in diabetic rats and a less reduction in normal rats (p<0.05). Total plasma cholesterol and triglycerides levels were significantly reduced after repeated oral administration in diabetic rats (p<0.001) and (p<0.05) respectively. However, no change was observed in total plasma cholesterol and triglycerides levels in normal rats after both single and repeated oral administration. In addition, plasma insulin levels and body weight remained unchanged over 15 days of oral administration in normal and diabetic rats. We conclude that the aqueous extract of OB exhibits potent anti-hyperglycaemic and hypolipidemic activities in diabetic rats without affecting basal plasma insulin concentrations.

Anti-diabetic and Hypolipidemic Effects of Aqueous-Extract from the Flower of &lt;i&gt;Inula japonica&lt;/i&gt; in Alloxan-Induced Diabetic Mice

The anti-diabetic and hypolipidemic effects of aqueous-extract from the flower of Inula japonica (IJ) and its two fractions (IJR and IJP) were investigated in alloxan-induced diabetic mice. An oral glucose tolerance test (OGTT) of IJ was also performed in normal and diabetic mice. The results showed that IJ (1000 mg/kg), IJR (500 mg/kg) and IJP (250 mg/kg) significantly reduced blood glucose levels in diabetic mice by oral administration (p<0.01). IJ and IJP markedly decreased serum triglyceride concentrations (p<0.05) in diabetic mice. Their hypoglycemic activities were better than gliclazide (40 mg/kg) and compared with metformin (250 mg/kg). IJ raised plasma insulin levels in alloxan-induced diabetic mice. IJ, IJR and IJP significantly decreased the consumption of water and food in diabetic mice. OGTT showed that IJ slightly lowered blood glucose levels in normal mice, but significantly decreased blood glucose in diabetic mice between 60-150 min after a glucose load (p<0.05). The data indicated that IJ has both anti-diabetic and hypolipidemic effects.

Hypoglycemic and hypolipidemic effects of aqueous extract of Arachis hypogaea in normal and alloxan-induced diabetic rats.

The hypoglycemic and hypolipidemic effect of aqueous extract of Arachis hypogaea was investigated in normal and alloxan-induced diabetic rats. The extract caused a significant (P < 0.05) decrease of fasting blood glucose of both normal and alloxan-induced diabetic rats from 102.60 +/- 1.65 mg/dl to 88.79 +/- 0.94 mg/dl for normal and 189.0 +/- 30.79 mg/dl to 107.55 +/- 1.54 mg/dl for alloxan-induced diabetic rats. The extract also caused a significant (P < 0.05) decrease in serum triglyceride, total cholesterol, HDL-cholesterol and LDL-cholesterol in both normal and alloxan-induced diabetic rats.