Abstract Objectives: The objectives of the present study were to (a) estimate the prevalence of hypodontia in permanent dentition of the North Indian Orthodontic subjects and to compare the results of the present study with specific findings of other populations; (b) evaluate occurrence of hypodontia in relation to gender, tooth type, location and pattern of distribution in maxillary and mandibular dental arches. Materials and Methods: Initial Pretreatment Orthodontic records of 1063 patients in the age range of 12–30 years collected from the archives of the department and the subjects who reported to the routine outpatient department of the department for orthodontic treatment and gave their consent for collecting pre–treatment orthodontic records. The initial pretreatment records to diagnose hypodontia and other dental anomalies included (a) orthodontic study models, (b) orthopantomograms, and (c) relevant findings from patient history sheets. Results: Thirty-two subjects fulfilled the selection criteria thus, giving the prevalence rate of hypodontia in the North Indian Orthodontic population of 3.01% out of which 21 were females and 11 were males with most common age group of 12–15 years. Maximum number of subjects were found to have only 1 CMT more commonly in the anterior region than the posterior region of the jaw and more in mandibular arch with mandibular central incisor to be the most common type of congenitally missing permanent tooth. In majority of hypodontia subjects, the most common associated dental anomaly was retained primary tooth. Conclusion: The prevalence of hypodontia of this study was within the range of that reported in the literature. Prompt diagnosis of hypodontia and other anomalies at an early age can help in planning various treatment modalities with a multidisciplinary team approach to establish a functional and esthetic dentition.