Hyperthyroid Group Research Articles

Subclinical hypothyroidism as an independent predictor of cardiovascular prognosis in left ventricular thrombus patients.

Left ventricular thrombus (LVT) is associated with an increased risk of adverse cardiovascular events, and thyroid hormones are known to affect the cardiovascular system in various ways. However, subclinical thyroid dysfunction still deserves to be emphasized, and its impact on the prognosis of patients with LVT is rare but needs to be investigated. We used retrospective data from patients diagnosed with LVT at Fuwai Hospital over the past 10 years to assess the relationship between thyroid functional status and prognosis of LVT using multivariate Cox proportional hazards models, and validated the improved predictive effect of including thyroid function in the prognostic assessment of LVT using receiver operating characteristic (ROC) curves. Subclinical hypothyroidism was significantly associated with a higher incidence of major adverse cardiovascular and cerebrovascular events (MACCEs) (HR 1.774, 95% CI: 1.053-2.989; p = 0.031) and cardiovascular death (HR 1.986, 95%CI: 1.110-3.553; p = 0.021) in LVT patients, whereas no significant correlation was observed in the subclinical hyperthyroidism group. In addition, including thyroid function in the prognostic consideration of LVT patients would contribute to the predictive effect of MACCEs (AUC for 1 year: 0.715; AUC for 2 years: 0.745; AUC for 3 years: 0.684). Subclinical hypothyroidism can be used as an independent predictor of MACCEs in patients with LVT, and there is a clinical value in using subclinical hypothyroidism as an important factor suggesting a poor prognosis in patients with LVT.

Role of Zinc Alpha2-Glycoprotein and Retinol-Binding Protein-4 in Iraqi Women with Thyroid Dysfunctions

Thyroid dysfunction (TD) and diabetes mellitus (DM) are two of the most frequent chronic endocrine disorders. This study included 60 women with thyroid disorders: 30 with hypothyroidism and 30 with hyperthyroidism, aged between 20 and 40 years. This study used 30 healthy women aged 20-40 years as a control group. Anthropometric measurements of Body Mass Index (BMI), hematological analysis of glycated hemoglobin (HbA1c), biochemical parameters (Thyroid-stimulating hormone TSH, Free triiodothyronine FT3, Free thyroxine FT4, Fasting Blood Sugar FBS), and adipokine concentrations zinc-α2-glycoprotein (AZGP-1) and retinol-binding protein-4 (RBP-4) were performed for all participants. The results revealed that the serum levels of zinc-α2-glycoprotein and retinol-binding protein-4 are significantly higher in hyperthyroidism (P<0.0001) compared to both healthy and hypothyroid women. Besides that, zinc-α2-glycoprotein has a negative correlation with TSH in the hyperthyroidism group. In the hypothyroidism group, it correlates positively with retinol-binding protein-4. In addition to that, retinol-binding protein-4 is positively correlated with FT3 and FT4 and negatively correlated with BMI in the hyperthyroidism group. For this reason, we conclude that these adipokines can aid in the diagnosis and monitoring of thyroid disorders, thereby preventing the onset of disease complications associated with type 2 diabetes mellitus. It is important to highlight that women with hypothyroidism are more likely than those with hyperthyroidism to develop diabetes.

Therapeutic Potential of the Algerian Ground Nut (Bunium bulbocastanum) Dietary Supplement in the Treatment of Thyroid-induced Dysfunction and Associated Growth Performance and Meat Quality in Rabbits (Oryctolagus cuniculus)

Background: Both traditional usage and initial scientific findings suggest that Bunium bulbocastanum, commonly known as Talghouda tuber nut, may offer health benefits, particularly for thyroid dysfunction. This study aims to investigate the therapeutic potential of dietary supplementation in managing pharmacologically thyroid-induced dysfunction and its effects on growth performance and meat quality in rabbits. Methods: Thirty 45-day-old male Lionhead rabbits were divided into three groups, each with two subgroups. The Control groups received either a standard diet (C) or a diet supplemented with 35% dried Talghouda (Csup). The Hypothyroid group included rabbits induced with hypothyroidism using carbimazole at a dose of 5 mg/kg BW/day (HytCar) and those subsequently treated with dried Talghouda (HytTal). Similarly, hyperthyroid group comprised rabbits induced with hyperthyroidism using levothyroxine (HyrLevo) and those treated with dried Talghouda (HyrTal). Thyroid function was assessed by measuring serum levels of T3, T4 and TSH. Additionally, growth performance and meat quality parameters were evaluated. Result: Talghouda supplementation significantly influenced thyroid hormone levels in rabbits, elevating T3 and T4 in the hyperthyroid groups (HyrLevo and HyrTal) compared to controls, while suppressing TSH in hyperthyroid groups and elevating it in hypothyroid groups. Talghouda treatment improved growth performance, evidenced by increased weight gain and higher eviscerated carcass weights in the hyperthyroid-treated groups. Meat quality also improved, with favourable pH, dry matter percentage and mineral content observed in the Talghouda-treated hypothyroid group. These findings suggest that Bunium bulbocastanum is a viable natural intervention for managing thyroid dysfunction while maintaining or enhancing growth and meat quality in rabbits, offering promising pharmacological and economic benefits.

Clinical Significance of Thyroid Autoantibodies in Differential Diagnosis and Predicting the Course of Programmed Cell Death Protein-1 Inhibitor-Induced Thyroid Dysfunction

ObjectiveThyroid immune-related thyrotoxicosis is one of the most common adverse effects in patients treated with programmed cell death protein-1 (PD-1) inhibitors. We investigated the significance of levels of serum anti-thyroglobulin antibodies (TgAbs), anti-thyroid peroxidase antibodies (TPOAbs), and thyroid-stimulating hormone receptor antibodies (TRAbs) in the identification of anti-PD-1-induced thyroid thyrotoxicosis. MethodsWe divided 161 patients with thyroid dysfunction who received PD-1 inhibitors at our hospital between January 2022 and June 2024 into 3 groups: primary hypothyroidism group, primary hyperthyroidism group, and destructive thyroiditis group. The characteristics of the 3 groups were determined, and the positivity rates of serum TgAbs, TPOAbs, and TRAbs were assessed. An additional 42 patients diagnosed with Hashimoto’s thyroiditis were selected as the control group for PD-1 inhibition-induced destructive thyroiditis. Age, sex, and time of transition from thyrotoxicosis to hypothyroidism in the 2 groups were compared. ResultsIn the primary hypothyroidism group, only 1 case was TPOAbs-positive (1/1%). In the destructive thyroiditis group, the positivity rate for TPOAbs or TgAbs was 92.9%, and TPOAbs and TgAbs were negative in the primary hyperthyroidism group. TRAbs were undetectable in all 3 groups. There were statistically significant differences in age, sex, and time from thyrotoxicosis to hypothyroidism in the PD-1 induced destructive thyroiditis and Hashimoto’s thyroiditis groups. ConclusionsIn patients with thyrotoxicosis caused by PD-1 inhibitors, serum TgAb, and TPOAb levels can be used to distinguish between primary hyperthyroidism and destructive thyroiditis. This study provides insights into novel treatment targets and effective management strategies for PD-1-induced thyrotoxicosis.

Detection of TPO antibody and TFT among Thyroiditis patients in Thi-Qar Governorate, Iraq

Thyroiditis is a general term that refers to thyroid gland inflammation. The present research was conducted to identify the role of thyroid peroxidase antibodies (TPO-Ab) in Thyroiditis patients and assaying the levels of thyroid function tests (TFT), which include levels of serum triiodothyronine hormone (T3), thyroxin hormone (T4), and thyroid stimulating hormone (TSH). A total of 86 serum samples (76 thyroiditis patients and 10 controls) from August 2023 to November 2023, at Al-Haboby Teaching Hospital and some private clinics in Thi-Qar Governorate were enrolled in the present study. The sandwich-ELISA technique assayed the levels of TPO-Ab, and the levels of (TFT) T3,T4, and TSH by using a competitive binding assay. Thyroiditis patients were divided into hypothyroidism and hyperthyroidism type with 47(61.84%) and 29(38.16%) patients, respectively (P≤0.05). Hypothyroidism and hyperthyroidism groups showed elevated mean serum levels of TPO-Ab (29.78%) and (20.68%) for members of each group separately, with a mean of (478.8) and (1070), respectively. While the mean of TPO-Ab in the control group was (319.5). The means of TFT in hypothyroidism group for T3,T4 and TSH were (0.9215), (5.402), and (22.86), respectively. The means of TFT in hyperthyroidism group for T3,T4 and TSH were (1.003), (7.409) and (0.3893), respectively, compared to the control. The mean of TFT for T3,T4 and TSH was (0.781), (7.374), and (1.603), respectively.

Changes in apoptosis and adipokine biomarkers in the heart tissue of rats with experimental hyperthyroidism

Background and purpose: This study aimed to investigate the effects of hyperthyroidism on heart tissue through adipokines and apoptotic signalling pathways. Materials and Methods: A total of 14 Sprague-Dawley male rats were assigned to 2 groups, a control and a hyperthyroid group. The control group received 0.9% NaCl, while the hyperthyroid group received 1 mg/kg levothyroxine dissolved in 0.9% NaCl throughout the study. Thyroid-stimulating hormone (TSH) and free thyroxine (FT4) levels in serum samples, whereas fibronectin type III domain-containing protein 5 (FNDC5), adiponectin, B-cell lymphoma-2 (Bcl-2) and tumour protein 53 (p53) levels in heart tissue were determined by ELISA method. Results: Serum TSH level decreased (p<0.01) while the level of FT4 significantly (p<0.01) increased in the hyperthyroid group compared to the control group. The level of adiponectin in the cardiac tissue of levothyroxinetreated rats was found to be significantly higher than in the control group (p<0.01). Additionally, compared to the control group, the antiapoptotic Bcl-2 level increased (p<0.05) while the proapoptotic p53 level decreased in the hyperthyroid group (p<0.01). Conclusions: In this study, the effects of hyperthyroidism on hormone levels, which are important regulators of energy and metabolic homeostasis, and changes in apoptosis markers were revealed in heart tissue. We consider that apoptosis was potentially prevented by activating mechanisms in order to protect cardiac functions in the beginning, but this scene may be reversed in progressive hyperthyroidism cases. Therefore, their pathways need to be supported by more detailed and time-compared studies.

Ten-year incidence of keratoconus in relation to sex, age, and thyroid gland dysfunction: a nationwide population-based cohort study (2009-2018).

Keratoconus is a corneal ectatic disorder that often leads to visual impairment and may require corneal transplantation. However, its age and gender-based incidence and potential association with thyroid gland dysfunction (TGD) remain poorly understood. This study aims to clarify these aspects and investigate the possible connection between keratoconus and TGD. We conducted a nationwide population-based cohort study using data from the Korean National Health Insurance Service database. A retrospective chart review was conducted on 4,059,021 patients aged over 20 without underlying corneal diseases in 2009. The end of the review period was at ten years, or until the onset of keratoconus. To evaluate the association with TGD, multivariate Cox regression analysis was used with adjustment of confounding variables such as sex and age. During the review period, 2,334 patients developed keratoconus before the 10-year mark. Females exhibited a higher keratoconus incidence (7.101 per 100,000 person-years) compared to males (5.559) (P<0.001). After adjusting for age, the hazard ratio (HR) for keratoconus was 1.295 times higher [95% confidence interval (CI): 1.193-1.406] in females compared to males. Age groups were stratified in 10-year intervals. The highest incidence of keratoconus was observed in the 20 to 29-year age group (10.695 per 100,000 person-years). All other age groups had significantly lower HR values, with the lowest at 50-59 years (0.508, 95% CI: 0.447-0.577). Keratoconus incidence per 100,000 person-years was 6.227 in subjects without TGD, 6.019 in the hypothyroidism group and 8.287 in the hyperthyroidism group, respectively. Although not statistically significant, individuals with hyperthyroidism showed a higher HR (1.290, 95% CI: 0.939-1.771) for keratoconus when compared to those without TGD, after adjusting for age and sex. This study emphasizes a female predominance in keratoconus incidence and suggests a possible connection between hyperthyroidism and keratoconus. Furthermore, it affirms a higher incidence of keratoconus among young individuals.

DYNAMIC CHANGES ININFLAMMATORY PROFILES OF THYROID DYSFUNCTION: A COMPARATIVE ANALYSIS OF HYPERTHYROIDISM AND HYPOTHYROIDISM

Introduction and Aim:The thyroid gland, an endocrine organ, produces vital hormones (T3 and T4) regulating metabolism. Thyroid-stimulating hormone (TSH) controls their release, impacting body tissues. C-reactive protein (CRP), an acute-phase protein, serves as a biomarker, crucial in diagnosing and managing various health conditions, particularly thyroid disorders. Elevated CRP levels often accompany thyroid dysfunction, highlighting the link between inflammation and thyroid disease pathogenesis, essential for diagnosis and management strategies. Methods: The research was conducted at the College of Paramedical Sciences, Teerthanker Mahaveer University &amp;Teerthanker Mahaveer Hospital &amp; Research Center, Moradabad in India, using random sampling. Blood sample was collected in the vacutainer and serum was separated for the clinical examination of CRP by turbidimetric immunoassay method. Clinical examinations were estimated in the biochemistry lab at the College of Paramedical Sciences by using a Semiautoanalyser. Results:The CRP levels in both hypothyroid and hyperthyroid groups were found higher as compared to euthyroid individuals, with mean CRP levels of 8.42 mg/dl, 5.67 mg/dl, and 5.05 mg/dl, respectively. A positive correlation between CRP and TSH is observed in hypothyroidism (r = 0.220). While hyperthyroidism exhibits slightly elevated CRP levels compared to healthy controls (5.67 mg/dl vs. 5.05 mg/dl), this difference lacks statistical significance (p&gt;0.05). Notable variances in serum Hs-CRP levels are observed among individuals with hypothyroidism compared to euthyroidism (p&lt;0.05), hyperthyroidism compared to euthyroidism (p&gt;0.05), and hyperthyroidism compared to hypothyroidism (p&lt;0.05), as determined by statistical analysis. Conclusion:A notable elevation in CRP levels among individuals with hypothyroidism and hyperthyroidism compared to those with euthyroidism. Additionally, a positive correlation is observed between CRP and TSH levels, particularly in the hypothyroid group. The disparities in Hs-CRP levels among different thyroid conditions underscore the link between thyroid function and inflammatory status.

CROSS-SECTIONAL STUDY OF BLOOD PRESSURE AND TSH VALUES IN A POPULATION WITH CASSAVA AS STAPLE FOOD

Background: Tapioca is one of the staple foods of the people of Kerala. If it is not prepared properly during cooking the cyanide present in it will interfere with body functions. The cyanide is metabolized into thiocyanate by the liver. Thiocyanate has been shown to interact with the blood pressure and thyroid function. Objectives: The objectives of the study are to observe the variation in physiology of the human body due to the effect of low dose cyanide in diet on the blood pressure and thyroid function. Materials and methods: A descriptive cross-sectional study design was conducted in the department of General Medicine out-patient department of a tertiary care hospital of central Kerala. This research was conducted after obtaining ethical clearance from the institutional ethical committee. The blood pressure of each subject was recorded. The fasting TSH values of each subject were determined. Results: There were no significant changes in the systolic blood pressure in hypothyroid group (p=0.288) and hyperthyroid group (p=0.915). There were no significant changes in diastolic blood pressure in hypothyroid group (p=0.270) and in hyperthyroid group (p=0.813). There was significant difference in TSH values in the hypothyroid group (p=0.001) and in the hyperthyroid group (p=0.001) compared to the matched controls. Conclusions: The above study did not show significant changes in the systolic and diastolic blood pressure compared to matched controls. These findings are unusual since thyroid dysfunction is known to cause increase in blood pressure as seen in various other studies. This means low dose cyanide in diet in a population with cassava as staple food might be protective from hypertension and is good for the cardiovascular system. There was significant increase in TSH values in the hypothyroid group. There was significant decrease in TSH values in hyperthyroid group. These findings are comparable with the values obtained in other studies.

Impact of carbimazole combined with vitamin E on testicular injury induced by experimental hyperthyroidism in adult albino rats: oxidative/inflammatory/apoptotic pathways.

Thyroid hormones play essential roles in spermatogenesis, but their effects on infertile males remain poorly understood. This study aimed to evaluate the impact of combining carbimazole (CBZ) with vitamin E (VE) on testicular injury induced by experimental hyperthyroidism in adult albino rats, focusing on oxidative, inflammatory, and apoptotic pathways. In this experimental study, 64 adult male albino Wistar rats were divided into eight groups: Group I (control-untreated), Group II (CBZ-control), Group III (VE-control), Group IV (CBZ + VE-control), Group V (levothyroxine-induced testicular injury), Group VI (levothyroxine + CBZ-treated), Group VII (levothyroxine + VE-treated), and Group VIII (levothyroxine + CBZ + VE-treated). The study was conducted in the Faculty of Medicine, Suez Canal University (Ismailia, Egypt). After cervical decapitation, both testes and epididymis were examined histopathologically and immunohistochemically. Significant differences were observed among groups concerning malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT; all P < 0.001). Polymerase chain reaction analysis showed significant differences in tumor necrosis factor-α (TNF- α ), interleukin-10 (IL-10), Bcl-2-associated X protein (BAX), B-cell lymphoma 2 protein (Bcl2), p53, Caspase-3, Caspase-8, Caspase-9, and nuclear factor-kappa B (NF- κ B) mRNA levels (all P < 0.001). Hyperthyroid group treated with CBZ alone (Group VI) exhibited testicular side effects, affecting seminiferous tubules and spermatogenesis. However, the Group VIII showed improved spermatogenesis and a decrease in testicular side effects. The addition of VE to the treatment of hyperthyroid rats with CBZ reduced testicular side effects and seminiferous tubular affection when potentially improving spermatogenesis. Further research is needed to elucidate the underlying mechanisms fully.

Does Radioactive Iodine Treatment Damage the Lacrimal System?

In this prospective study, we aimed to make a quantitative assessment of the lacrimal glands before and after radioactive iodine (RAI) treatment in patients with hyperthyroidism and thyroid cancer. The study included 80 eyes of 40 patients. There were 25 patients in group 1 (hyperthyroid group) and 15 patients in group 2 (thyroid cancer group). Group 1 has received low dose ( 131 I) and group 2 high dose ( 131 I). Before, and at the first and sixth month after RAI treatment, all patients underwent ophthalmological examinations, Schirmer tests, TBUT tests, tear osmolarity (TO), and ocular surface examinations. The age and sex characteristics of both groups were similar. Although no significant change was observed in tear film tests before and after treatment in group 1, a significant decrease in Schirmer and TBUT values and a significant increase in TO were observed in group 2 in the first month after treatment. These values returned to normal in the sixth month. Although no Schirmer test was observed lower than 10 mm in any patient before RAI treatment, the Schirmer test was measured 5 to 10 mm in 4 (10%) patients in group 2 in the first month after treatment. Again, in these patients, TBUT was below 10 seconds and TO was greater than 308 mOsm/L. In this study, although no change was observed in tear function tests in patients receiving low doses of RAI, a decrease in tear secretion and an increase in TO were detected in patients receiving high doses in the early period.

The effect of thyroid disorders on obstetric and perinatal outcomes: an observational retrospective study in a tertiary care center of north India

Background: The incidence of hypothyroidism in pregnancy is between 0.5-3.5%, hyperthyroidism occurs in about 0.2-0.4%. They are associated with various maternal-fetal complications. Methods: This retrospective observational cohort study was conducted in SMGS Hospital, Jammu, India after ethical clearance. Admitted patients were included over a period of 1 year from January to December 2021. Inclusion criteria was women belonging to any period of gestation admitted to the labour room and woman with established thyroid disorder. Exclusion criteria was women on drugs influencing thyroid functions. Results: 1641 (10.43%) of 15722 women had thyroid disorders. Hypothyroidism in 10.37% (8.99% subclinical and 1.37% overt) and hyperthyroidism in 0.06%. PPROM was seen in 5.9% subclinical, 2.7% overt hypothyroid, none of hyperthyroid group. 7% subclinical, 8.5% overt hypothyroid and 1/10 women in hyperthyroid group had GDM. Abruption seen in 2.5% subclinical, 1.7% overt hypothyroid and none in hyperthyroid. In subclinical group 3.2% had gestational hypertension, 5.2% had preeclampsia and 0.6% had eclampsia. In overt hypothyroid, 2.8% had gestational hypertension, 7.9% preeclampsia and 1.7% eclampsia. In hyperthyroid group, 1/10 had gestational hypertension, 1/10 had preeclampsia. 18.2% subclinical, 14.7% overt hypothyroid, 2/10 in hyperthyroid group had history of abortion. 7% subclinical, 9.6% overt hypothyroid and 0/10 hyperthyroid group had infertility. 25.8% babies born were abnormal in terms of less gestational age at birth, low birth weight, IUGR, low apgar and IUD. 16.5% babies that had low birth weight &lt;2.5 kg. Conclusions: The impact of thyroid disorders warrants routine screening for thyroid dysfunctions in all women in prenatal and antenatal period to predict and prevent adverse maternal-neonatal outcomes.

Does thyroid diseases contribute to the natural history of idiopathic adult-onset dystonia? Data from the Italian Dystonia Registry.

A few earlier observations and recent controlled studies pointed to the possible contribution of thyroid diseases in idiopathic adult-onset dystonia (IAOD). The aim of this study was to investigate the association between thyroid status and clinical characteristics of IAOD, focusing on dystonia localization, spread, and associated features such as tremors and sensory tricks. Patients were identified from those included in the Italian Dystonia Registry, a multicentre dataset of patients with adult-onset dystonia. The study population included 1518 IAOD patients. Patients with hypothyroidism and hyperthyroidism were compared with those without any thyroid disease. In the 1518 IAOD patients, 167 patients (11%; 95% CI 9.5-12.6%) were diagnosed with hypothyroidism and 42 (2.8%; 95% CI 1.99-3.74) with hyperthyroidism. The three groups were comparable in age at dystonia onset, but there were more women than men in the groups with thyroid disease. Analysing the anatomical distribution of dystonia, more patients with blepharospasm were present in the hyperthyroidism group, but the difference did not reach statistical significance after the Bonferroni correction. The remaining dystonia-affected body sites were similarly distributed in the three groups, as did dystonia-associated features and spread. Our findings provided novel information indicating that the high rate of thyroid diseases is not specific for any specific dystonia subpopulation and does not appear to influence the natural history of the disease.

The Effect of Inflammatory Markers in the Hemogram Parameters of Pregnant Women with Thyroid Disease on Obstetric and Neonatal Outcomes

Aim: This study aimed to determine the differences in hemogram parameters, especially in inflammatory markers and perinatal and neonatal outcomes of pregnant women with thyroid disease, and to examine the effects of these differences on pregnancy outcomes. Material and Methods: The data of 80 pregnant women diagnosed with thyroid disease according to the American Thyroid Association (ATA) criteria at the first admission between 2016 and 2019 and 100 pregnant women whose thyroid hormone levels were within the normal reference range were retrospectively analyzed. Obstetric outcomes such as type and time of delivery, and the presence of additional disease during pregnancy, and neonatal outcomes such as weight, gender, and Apgar score at birth were compared. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), white blood cell (WBC) count, and hemoglobin (Hb) and mean platelet volume (MPV) values, which are accepted as inflammation markers, were also compared between groups. Results: There was no significant difference between hypothyroid and hyperthyroid pregnant women in terms of Hb (p=0.319) and PLR (p=0.341) values. Third-trimester WBC (p=0.015) values were higher and MPV (p=0.007) values were lower in the hypothyroid pregnant women compared to the control group. The highest NLR (p=0.005) value was observed in the hypothyroid group. Comorbidities were found to be 27.4% (n=20) in the hypothyroid group, 14.3% (n=1) in the hyperthyroid group, and 1.0% (n=1) in the control group (p&amp;lt;0.001). Conclusion: Pregnant women with thyroid disease may have differences in hemogram parameters, especially in inflammatory markers, and these differences may affect pregnancy outcomes.

Thyroid dysfunction and autoantibodies among patients infected with Covid 19 in Erbil city /IRAQ

Background and objectives: Autoimmune thyroid diseases or specifically Anti-thyroid peroxidase antibodies increasing after corona virus infection pandemic. This study investigating Anti-thyroperoxidase, anti-thyroid stimulating receptor antibodies in conjunction with traditional thyroid markers after corona virus infection hoping that this would aid in reduction of enduring morbidity and associated health concerns. Methods: This cross-sectional study was conducted in Rizgary Teaching Hospital and Erbil Teaching Hospital in Erbil, Iraq, within the period of February to September 2022. The study comprised hundred patients; 80 females and 20 males, these patients had clinical symptoms suspecting thyroid abnormalities and were suspected for having a sort of thyroid disease. They had abnormal thyroid function tests, with investigating thyroid autoantibodies and corona virus infection. Investigations include thyroid function test and antithyroid antibodies. Results: The level of Anti-thyroid peroxidase antibodies was positive among 75 hypothyroidism patients than among hyperthyroidism cases 2, p-value 0.012. Positive Anti-thyroperoxidase antibodies and hypothyroidism were significantly more common among corona virus infected cases, p-value 0.012 and 0.0109 respectively. However; anti-thyroid stimulating hormone receptor antibody was positive only among hyperthyroidism group (18%); p-value was significant 0.019. Conclusions: This study confirmed the correlation between thyroid function test, Anti-thyroperoxidase antibodies values and corona virus infection. Autoimmune thyroid diseases are more common among female cases, in addition; antithyroid antibodies especially Anti-thyroperoxidase antibodies were more common among female patients. There was high prevalence of both hypothyroidism and positive anti-TPO Ab in COVID-19 cases.

How Radioactive Iodine Treatment Affects the Retina.

Objective The aim of this study was to quantitatively assess the macular and retinal nerve fiber layer thicknesses in patients with hyperthyroidism and thyroid cancer undergoing radioactive iodine (RAI) therapy. Study Design This prospective study was conducted in accordance with the principles of the Declaration of Helsinki and approved by the Bagcilar Training and Research Hospital Clinical Research Ethics Committee. Written informed consent was obtained from the patients following a detailed explanation of the study objectives and protocol. Patient selection was randomized. Patients scheduled for RAI treatment in the Nuclear Medicine Clinic were referred to the ophthalmology clinic, respectively. Patients without additional ocular pathology were included in the study. Methods All patients had received RAI therapy using Iodine-131 for hyperthyroidism or thyroid cancer. A complete ophthalmological examination and measurement of macular and retinal nerve fiber layer thickness using optical coherence tomography were performed on all patients before and at the first and sixth months and in first year after RAI treatment. The results were prospectively evaluated. Results The study included 80 eyes of 40 patients. The hyperthyroid group was group 1, and the thyroid cancer group was group 2. There were 25 patients in group 1 and 15 patients in group 2. The mean age was 43.76 ± 11.85 years (range: 22-65 years) in group 1 and 39.87 ± 9.13 years (range: 30-58 years) in group 2. There was no significant difference between the two groups regarding age and sex ( p > 0.05). In both groups, no significant difference was found in the macular thickness and retinal nerve fiber layer thicknesses values obtained in both eyes before and after the RAI treatment. Conclusion As a result of our study, we observed that RAI intake did not harm the retinal layer.

Evaluation of Bone Mineral Changes in Panoramic Radiographs of Hypothyroid and Hyperthyroid Patients Using Fractal Dimension Analysis

Objective Hyperthyroidism and hypothyroidism are endocrinopathies that cause a decrease in bone mineral density. The aim of this study is to investigate possible bone changes in the mandible caused by hyperthyroidism and hypothyroidism using fractal analysis (FA) on panoramic radiographs.Material and Methods Panoramic radiographs of a total of 180 patients, including 120 patient groups (60 hyperthyroid, 60 hypothyroid) and 60 healthy control groups, were used. Five regions of interests (ROI) were determined from panoramic radiographs and FA was performed. ROI1: geometric midpoint of mandibular notch and mandibular foramen, ROI2: geometric midpoint of mandibular angle, ROI3: anterior of mental foramen, ROI4: basal cortical area from distal mental foramen to distal root of first molar, ROI5: geometric center of mandibular foramen and mandibular ramus.Results While a significant difference was observed between the patient and control groups regarding ROI1 and ROI2 (p < 0.05); there was no significant difference between the groups in relation to ROI3, ROI4, and ROI5. All FA values were lower in the hyperthyroid group than in the hypothyroid group.Conclusion Fractal analysis proves to be an effective method for early detection of bone mass changes. In the present study, it was concluded that while the mandibular cortical bone was intact, trabecular rich regions were affected by osteoporosis caused by thyroid hormones. Necessary precautions should be taken against the risk of osteoporosis in patients with thyroid hormone disorders.

The relation between oral health and body mass index among women with hyperthyroidism

Background: Hyperthyroidism is a medical condition in which excessive synthesis and secretion of thyroid hormones into the blood. According to multiple research, hyperthyroidism is linked to weight loss and increased metabolism.&#x0D; Objective: To assess how hyperthyroidism affects oral health in relation to body mass index.&#x0D; Patients and Methods: The sample was composed of 90 female patients aged 25-45 years include hyperthyroid group and healthy group, the hyperthyroid patients were diagnosed by specialist and under treatment with carbimazole.Clinical evaluation of caries was done according to World Health Organization(2013). The body mass index was measured from the patient’s weight and height, according to the formula World Health Organization(2000). Plaque Index of Silness and Löe was used to evaluate dental plaque (1964),Using the gingival index of Loe and Silness the gingival inflammation was evaluated (1963).&#x0D; Results: Found the Body mass index in the hyperthyroid group was higher than the healthy group with significant difference. The most correlations between caries and body mass index in the hyperthyroid group were weak negative not significant while in the healthy group most correlations were weak positive not significant, the correlations of Gingival index and body mass index were weak positive not significant in both groups.The plaque index had weak negative in hyperthyroid while in control positive correlation and all correlation were not significant.&#x0D; Conclusion: In the present study,the Body mass index higher among women with hyperthyroidism under treatment with carbimazole and the correlation between caries experience and body mass index was negative and not significant.

EVALUATION OF THYROID PROFILE AND ITS PROGNOSTIC VALUE IN PATIENTS OF ACUTE CORONARY SYNDROME

Objective: The objective of the study is to study the association of thyroid dysfunction with acute coronary syndrome (ACS), its complications and duration of hospital stay. Methods: This prospective comparative study was done on 100 patients divided equally into ACS patients with control (normal thyroid function) and ACS patients with thyroid dysfunction admitted in a tertiary care center, Udaipur, Rajasthan with ACS during the period of February 2021–July 2022. We studied the prevalence, prognostic factor of thyroid hormone in these patients. Results: The mean ejection fraction of the control group was 51.16±11.72%, of hypothyroid group was 49.00±13.55% and of hyperthyroid group was 51.12±13.78%. 29 cases of cardiac failures, 38 cases of arrhythmias, and 32 cases of major adverse cardiac events were observed. 56% of patients required thrombolysis, out of which 67.86% were from the subclinical hypothyroid group. The mean hospital stay in control group was 4.53±1.55, in hypothyroid group was 5.27±1.84 and in hyperthyroid group was 7.00±1.92.18% mortality. Conclusion: Patients with acute myocardial infarction, initially develop alteration in thyroid hormone levels, which is possibly a compensatory mechanism to reduce the metabolic demand of the heart, by reducing myocardium contraction and cardiac output but may cause cardiac failure and higher rates of cardiovascular complications like arrhythmias and death in some of the patients. Thyroid dysfunctions in patients with ACS may also need a longer duration of intensive care and close monitoring during follow-up.

Effect of H. pylori infection on incidence of hyperthyroidism and hypothyroidism in men and women

There are some controversial studies that associate Helicobacter pylori infection with autoimmune thyroid disease (AITD). The study aimed to evaluate the effect of H. pylori infection on the development of thyroid diseases, so the study was carried out on 90 patients (male and female) with thyroid disorders, and 50 healthy individuals as a control group. Venous blood samples were drawn from all participants, and serum was obtained after centrifugation and kept in labeled Eppendorf tubes then stored at -20°C till used in biochemical and immunological assays including estimation of anti-H. pylori IgG and Anti-cag-A IgG titer by ELISA method, while assessment of Tri-iodothyronine (T3), tetra iodothyroixine (T4), and thyroid Stimulating Hormone (TSH) by (e601 Cobas) automated immunoassay analyzer. The result recorded a significant decrease in TSH concentration (P &lt; 0.05) in the hyperthyroidism group and a significant increase in TSH concentration (P &lt; 0.05) in hypothyroidism patients whereas the concentration of T4 and T3 recorded a significant increase (P &lt; 0.05) in hyperthyroidism group while a significant decrease in T4 and T3 concentrations (P &lt; 0.05) occur in hypothyroidism patients when compared with control (Euthyroidism) group. On the other hand, there is a significant increase (p &lt;0.05)in the titer of H.pylori IgG and the titer of anti-cag IgG in both females and males of hyperthyroidism and hypothyroidism groups in comparison to control Euthyroidism group. The highest prevalence of H.pylori IgG positive ( 74.5%) occurs hypothyroidism group followed by (71.4%) for hyperthyroidism patients while (56%) occurs in the control group (Euthyroidism). In conclusion, our findings indicated that H.pylori infection is more susceptible in thyroid disorder patients, and anti –Helicobacter pylori IgG antibodies distribution among hypothyroidism is greater than in other groups.