Hypertensive Brainstem Encephalopathy Research Articles

Hypertensive Brainstem Encephalopathy Combined with Acute Ischemic Stroke

Posterior reversible encephalopathy syndrome is a clinicoradiological syndrome characterized by a unique reversible pattern on imaging and total regression of clinical symptoms and signs. Hypertensive brainstem encephalopathy (HBE), a brainstem variant of posterior reversible encephalopathy syndrome, is rare. In addition, a concomitant occurrence of acute ischemic stroke and HBE is even more rare. We here report three patients with HBE accompanied by acute cerebral infarction detected by brain magnetic resonance imaging and the importance of initial blood pressure control.

Reversible Obstructive Hydrocephalus Associated with Hypertensive Brainstem Encephalopathy

Reversible Obstructive Hydrocephalus Associated with Hypertensive Brainstem Encephalopathy

Hypertensive Brainstem Encephalopathy Mimicking Peritumoral Edema after Gamma Knife Radiosurgery for Cerebellopontine Angle Meningioma: A Case Report

An 83-year-old man presented with hypertensive brainstem encephalopathy manifesting as general weakness, dysarthria, gait disturbance, urinary incontinence, and decreased cognitive function. The patient had a history of gamma knife radiosurgery (GKR) for cerebellopontine angle (CPA) meningioma 10 years prior. Compared with previous magnetic resonance (MR) imaging results, a recent MR image revealed massive brainstem hyperintensity in T2-weighted images, not in the parieto-occipital lobes. The lesions were nearly completely resolved several days after normalization of the blood pressure. Isolated hypertensive brainstem encephalopathy without concomitant typical parieto-occipital abnormalities are unusual and the diagnosis is challenging especially after gamma knife radiosurgery for cerebellopontine angle meningioma. We describe a patient with hypertensive brainstem encephalopathy that was initially confused with peritumoral edema.

Hypertensive Brainstem Encephalopathy in a Patient with Acute Lacunar Infarction

Hypertensive Brainstem Encephalopathy in a Patient with Acute Lacunar Infarction

Predominant Hypertensive Brainstem Encephalopathy with Supratentorial Involvement: Case Report and Literature Review

Hypertensive encephalopathy is an acute disorder characterized by severe hypertension, headache, vomiting, altered mental status, visual changes, and seizures. Syndromes of hypertensive encephalopathy are usually reversible if quickly diagnosed and treated. The most common finding of hypertensive encephalopathy is bilateral edema in the supratentorial white matter, especially in the parieto-occipital area. However, atypical feature of hypertensive encephalopathy involving the frontal lobes, brainstem, cerebellum, cortical watershed zones, and basal ganglia has been sporadically reported. Brainstem and/or cerebellar lesions may be presented as the only abnormalities in unusual cases (1). Here we report three cases of hypertensive encephalopathy involving brainstem showing characteristic alternating linear bright and low signals in the pons on T2-weighted magnetic resonance imaging (MRI), although many brainstem lesions showed no peripheral sparing compared to those of osmotic demyelination (2). This retrospective study has been approved by our Institutional Review Board. The requirement for obtaining informed consent from patients was waived.

Brainstem swelling and noncommunicating hydrocephalus caused by hypertensive brainstem encephalopathy

Hypertensive encephalopathy is a life-threatening medical condition manifested by headache, confusion, seizures, and visual disturbance, and, if treatment is delayed, it may progress to coma and death [1, 2] (Chester et al., Neurology 28:928-939, 1978; Vaughan and Delanty, Lancet 356:411-417, 2000). Involvement of the brainstem with or without supratentorial lesions has been reported and is termed hypertensive brainstem encephalopathy (HBE). Cases of HBE involving supratentorial deep gray and white matter are rare and extensive hyperintensity was predominantly seen in brainstem regions on fluid-attenuated inversion recovery and T2-weighted magnetic resonance images. We present radiologic findings of a patient with HBE involving deep supratentorial gray and white matter, causing tonsillar herniation and noncommunicating hydrocephalus by mass effect.

Hypertensive brain stem encephalopathy with pontine hemorrhage: A case report

Hypertensive brain stem encephalopathy with pontine hemorrhage: A case report

Hypertensive Encephalopathy with Reversible Brainstem Edema

Presented here is a 36-year-old male with arterial hypertension who developed brainstem edema and intracranial hemorrhage. Magnetic resonance scan revealed diffuse brainstem hyperintensity in T2-weighted and fluid-attenuated inversion-recovery images, with an increase in apparent diffusion coefficient values. After a reduction in blood pressure, rapid resolution of the brainstem edema was observed on follow-up. The patient's condition was thus interpreted as hypertensive brainstem encephalopathy. While many consider this a vasogenic phenomenon, induced by sudden, severe hypertension, the precise mechanism remains unclear. Prompt recognition and aggressive antihypertensive treatment in such patients are essential to prevent permanent or life-threatening neurologic injury.

Hypertensive Brainstem Encephalopathy with Atypical Supratentorial Involvement

Hypertensive Brainstem Encephalopathy with Atypical Supratentorial Involvement

Hypertensive brainstem encephalopathy involving deep supratentorial regions: does only blood pressure matter?

We report on a 42-year-old female patient who presented with high arterial blood pressure of 245/150 mmHg and hypertensive brainstem encephalopathy that involved the brainstem and extensive supratentorial deep gray and white matter. The lesions were nearly completely resolved several days after stabilization of the arterial blood pressure. Normal diffusion-weighted imaging findings and high apparent diffusion coefficient values suggested that the main pathomechanism was vasogenic edema owing to severe hypertension. On the basis of a literature review, the absolute value of blood pressure or whether the patient can control his/her blood pressure seems not to be associated with the degree of the lesions evident on magnetic resonance imaging. It remains to be determined if the acceleration rate and the duration of elevated arterial blood pressure might play a key role in the development of the hypertensive encephalopathy pattern.

A case of hypertensive encephalopathy with extensive spinal lesions on MRI

A 14-year-old female had repeated vomiting, headache, abdominal pain, visual field deficit and lethargy at the onset of hypertensive encephalopathy. Cerebrospinal fluid (CSF) test revealed a high level of IgG and protein. MRI demonstrated no supratentorial cerebral lesions but hyperintense lesions were observed from the lower pons to the Th8 level of spinal cord and cerebellar cortex on T2 weighted and FLAIR images without contrast enhancement. The two antihypertensive drugs stabilized to control her blood pressure and improved her clinical symptoms. Reexamination of MRI and cerebrospinal fluid test also revealed clear improvement of the above abnormalities. The abnormal findings on abdominal CT and renography led us to suspect renal infarction. Abdominal angiography demonstrated multifocal stenoses of renal interlobar arteries, which were supposed to supply the renal infarcted regions. These suggested that the renal infarctions due to fibromuscular dysplasia caused systemic hypertension. There have been only two reports that demonstrated spinal cord lesions in reversible posterior leukoencephalopathy syndrome (RPLES). We report extensive spinal lesions on MRI and a high level of IgG in CSF at the subacute phase in a young female with RPLES associated with hypertensive (brainstem) encephalopathy.

Blurred Vision With Acute Hypertension Indicating Hypertensive Brainstem Encephalopathy -Case Report-

A 49-year-old woman presented with hypertensive brainstem encephalopathy (HBE) manifesting as visual disturbance and papilledema but no other neurological abnormal findings. Magnetic resonance (MR) imaging showed extensive lesions in the brainstem and bilateral thalami but not in the occipital lobes. The patient also had renal failure and underwent hemodialysis. Her visual disturbance and MR lesions resolved rapidly after antihypertensive treatment. This case of HBE only caused visual disturbance despite the presence of massive brainstem edema. The presence of fetal-type posterior cerebral artery may have spared the occipital lobe. Clinicians should consider HBE in hypertensive patients with blurred vision. HBE is reversible if immediate antihypertensive treatment is initiated, but neurological sequelae may develop if treatment is delayed.

Hypertensive Brainstem Encephalopathy

A 34-year-old man, previously in good health with no past history of hypertension, presented with a 2-day history of bitemporal headaches and a sudden onset of left-sided weakness 4 days after ingesting traditional Chinese medications for nonspecific abdominal pain. He was afebrile, drowsy, disoriented, and dysarthric, with a blood pressure of 270/170 mm Hg. Clinical examination revealed mild left facial weakness and strength of Medical Research Council grade 4/5 in the left upper and lower limbs. Deep tendon reflexes were brisk, and he demonstrated bilateral extensor plantar responses. Fundoscopy revealed grade 4 hypertensive retinopathy changes (Figure 1). ECG was consistent with left ventricular hypertrophy. Treatment with intravenous glyceryl trinitrate was commenced to achieve normotension. …

Two Cases of Hypertensive Encephalopathy Involving the Brainstem

Hypertensive encephalopathy is a medical emergency whose clinical manifestations are usually associated with bilateral parieto-occipital lesions. Predominant brainstem edema without accompanying occipital lesions is rare in hypertensive encephalopathy and usually occurs in patients with secondary hypertension. We describe the clinical and radiological features of two patients with reversible hypertensive brainstem encephalopathy. Both patients had chronic renal failure, but the extensive neuroimaging abnormalities revealed few clinical features of brainstem involvement. The clinical findings and neuroimaging abnormalities resolved once the hypertension was treated.

Retinopathy and Choroidopathy as the Initial Signs of Hypertensive Brainstem Encephalopathy

Retinopathy and Choroidopathy as the Initial Signs of Hypertensive Brainstem Encephalopathy

Hypertensive brain stem encephalopathy in a patient with chronic renal failure

Hypertensive brain stem encephalopathy is a rare disorder that can be seen in severe hypertensive encephalopathy. Patients with chronic renal failure are more prone to develop this disorder because a mild elevation of the blood pressure can already induce brain changes. It is important to diagnose this entity as soon as possible because the symptoms and brain stem lesions are reversible following treatment and because it is important to exclude brain stem ischemia in the diagnostic work-up. Brain MRI and particularly diffusion weighted images are crucial for this purpose.

Hypertensive Brainstem Encephalopathy Without Parieto-occipital Lesion-Two Case Reports-

Two patients presented with malignant hypertension associated with encephalopathy predominantly manifesting as brainstem lesion. T(2)-weighted and fluid-attenuated inversion recovery magnetic resonance (MR) imaging revealed diffuse hyperintense areas in the pons and scattered lesions in the cerebellum, basal ganglia, and cerebral subcortex without parieto-occipital lesions. Diffusion-weighted MR imaging demonstrated these lesions as normal intensity, indicating vasogenic edema. These lesions resolved rapidly once hypertension was controlled. Review of clinical findings for 14 other patients with hypertensive brainstem encephalopathy without parieto-occipital lesions suggested that anterior circulation structures supplied by the carotid artery are frequently involved in such patients.

A brainstem variant of reversible posterior leukoencephalopathy syndrome

Reversible posterior leukoencephalopathy syndrome (RPLS) is caused by various heterogeneous factors, the commonest being hypertension, followed by nonhypertensive causes such as eclampsia, renal diseases and immunosuppressive therapy. Patients with RPLS exhibit bilateral white and gray matter abnormalities in the posterior aspects of the cerebral hemispheres. However, this syndrome may affect the brainstem predominantly, and these cases are designated as hypertensive brainstem encephalopathy. We present here two patients with reversible brainstem encephalopathy: one with hypertension and the other without hypertension. These patients presented with swelling and diffuse hyperintensities of the brainstem in fluid-attenuated inversion-recovery (FLAIR) and T2-weighted MRI, but with relatively mild clinical symptoms. They recovered without major neurological deficits, but had residual lacunar lesions in the pons. Reversible brainstem encephalopathy with characteristic MRI features was found in both hypertensive and nonhypertensive patients. These patients were diagnosed with a brainstem variant of RPLS, which is potentially fully reversible after an adequate treatment, and therefore should be carefully differentiated from other brainstem disease conditions.

Localized Lesions on MRI in a Case of Hypertensive Brainstem Encephalopathy

We report a case of hypertensive brainstem encephalopathy (HBE) with unusual magnetic resonance imaging (MRI) findings. A 67-year-old woman presented with high blood pressure and stupor as the only symptoms. MRI revealed lesions localized in the area from the upper medulla oblongata to the lower pons with high fluid-attenuated inversion recovery (FLAIR) and T2-weighted signal intensity, but these were not seen in the whole brainstem and there were no accompanying occipital lobe changes. To our knowledge, no similar case has been reported. The lesions and symptoms dramatically improved after normalization of blood pressure. Severe hypertension that exceeded the range of autoregulation may have resulted in segmental vasodilatation and the increased vascular permeability may have lead to vasogenic edema in the localized areas of the brainstem.

Hypertensive brainstem encephalopathy: clinical and radiographic features

Reversible posterior leukoencephalopathy syndrome associated with hypertension rarely presents with predominant involvement of the brainstem and relative sparing of the supratentorial regions. We describe the clinical and neuroimaging features of three patients with reversible hypertensive brainstem encephalopathy. Headache and confusion in the setting of severe hypertension, with a relative paucity of brainstem signs and symptoms, despite extensive neuroimaging abnormalities in the brainstem support the diagnosis. The clinical findings and neuroimaging abnormalities resolve with treatment of the hypertension, further distinguishing this syndrome from brainstem infarction.