Requiring both stress and energy conditions to be met simultaneously proved key to modeling brittle crack formation at singular and nonsingular stress concentrations in linear elastic materials. The present work extends this so-called coupled stress and energy criterion to brittle crack nucleation in hyperelastic media using the example of silicone adhesives. For this purpose, we provide a comprehensive constitutive as well as fracture mechanical characterization of the structural silicone adhesive DOWSIL™ 993 using a large set of experiments and propose a mixed-mode failure model for crack initiation in nonlinear elastic materials. Characterized in independent experiments, the model is used to determine critical loads of hyperelastic adhesive bonds in both shear and tension dominated configurations. For any of the examined adhesive joint configurations the model predicts and explains size effects and agrees well with experimental findings. We study stable and unstable crack propagation observed in video recordings of our experiments. It is shown that crack initiation, crack growth and crack arrest are caused by nonmonotonic energy release rates and can be predicted. Effects of excess energy available after crack nucleation and initial unstable crack growth are discussed.