The aim of this study is to investigate the effects of thermal radiation and chemical reactions on magnetohydrodynamic hyperbolic tangent liquid, which includes nanoparticles on a stretched surface while taking into account Brownian motion and thermophoresis. The nonlinear partial differential equations governing the system are converted into nonlinear ordinary differential equations through suitable similarity transformations. The focus of the study is to elucidate important engineering concepts such as skin friction, Sherwood number, and heat transfer, as well as to understand the effects of various expressions on the different profiles. The Keller-box approach, a sophisticated numerical tool, is used to get the numerical answers to the current enquiry. The generated findings are extensively tested for correctness and dependability. The findings of this study might have far-reaching ramifications for a variety of technical applications, including heat exchangers, chemical reactors, and thermal management systems.The results show that the rate of mass transfer rises with the increment in the factors of chemical reaction, thermal radiation, nanoparticles volume, and Brownian motion.