Symptoms Of Hyperactivity Research Articles

Clinical Study of Limosilactobacillus reuteri for the Treatment of Children with Chronic Tic Disorders/Tourette Syndrome: A Mid-Term Efficacy Evaluation.

Gut microbiota plays an important role in tic disorders (TDs); however, clinical research on probiotics for chronic TDs treatment is lacking. We aimed to investigate the effectiveness of probiotics, hypothesizing that their clinical efficacy is comparable to that of clonidine in treating chronic TDs. Patients were randomly assigned to receive either Limosilactobacillus reuteri or clonidine transdermal patch treatment for 8weeks while maintaining their existing treatment. The Yale Global Tic Severity Scale (YGTSS); Swanson, Nolan, and Pelham-IV Scale (SNAP-IV); and Child Behavior Check List (CBCL) scores were assessed before and after treatment. We matched the patients in both groups for age, sex, age at onset, and tic type. A significant improvement in YGTSS scores was observed in both groups (p = 0.024). The improvement in attention deficits on the SNAP-IV scale was similar between the two groups, with no significant difference (p = 0.465). For hyperactivity disorder, after matching patients in both groups for age, sex, age at onset, tic type, and Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) scores, a significant difference in improvement was observed between the groups (p = 0.010), with the probiotics group showing greater improvement (0.3 ± 0.58 vs. 0.1 ± 0.50). At 9weeks, social ability on the CBCL scale increased by 3.2 ± 6.26 from baseline in the probiotics group and by 0.6 ± 4.07 in the clonidine group, with a significant difference between the two (p = 0.049). Although there was no significant difference in behavioral problems between the two groups (p = 0.347), the trend of improvement was more pronounced in the probiotics group than in the clonidine group (12.7 ± 25.86 vs. 8.4 ± 13.15). The mid-term efficacy evaluation demonstrated that L.reuteri, when added to the treatment of children with chronic TDs, was more effective in improving tic symptoms than clonidine transdermal patch treatment. Additionally, it provided moderate improvement in hyperactivity symptoms. chictr.org.cn (registration numbers ChiCTR2200056708, ChiCTR2200056578).

Loneliness in Adolescents with Attention Deficit Hyperactivity Disorder (ADHD)

Introduction: Attention deficit hyperactivity disorder is a disorder of children’s growth and development with neurodevelopmental disorders characterized by symptoms of inattention, hyperactivity, and impulsivity. ADHD in children can persist into adolescence in about 2.6% of the general population. About more than half of people with ADHD experience loneliness, a condition that is often not reported by patients but is evident in the negative emotions and behaviors they display. To explain the risk factors and impact of loneliness in adolescents with ADHD. Methods: Literature review. Results: The use of gadgets in today’s digital era increases the risk of increasing internet usage so that more contact is made online, which causes obstacles for adolescents in fostering social relationships and an increased risk of loneliness. Adolescents with ADHD have a negative assessment of themselves; they feel useless, lack confidence, and lack intelligence when compared to their peers. Economically, low-income family conditions and inappropriate parenting increase the risk of loneliness in ADHD adolescents. Adequate treatment will cause it to develop into other mental disorders such as anxiety, depression, defiant attitude disorder, and adolescent behavior disorder. Conclusions: Adolescents with ADHD are prone to experiencing loneliness. Parenting problems, family socioeconomics, past trauma, bullying, and several internal factors such as low self-confidence, insecurity, low adaptability, and lack of emotional control can cause loneliness. Keywords: ADHD, Adolescents, Loneliness, Mental Health, Psychological Well-Being

Results of N = 1 randomized, double-blind, placebo-controlled, cross-over discontinuation trials embedded in clinical practice after longer term methylphenidate use: a pilot study.

Attention-deficit/hyperactivity (ADHD) guidelines recommend that the need for continued stimulant medication treatment of children and adolescents needs to be reviewed at least annually. We aimed to assess the outcomes in clinical practice of placebo-controlled discontinuation trials after long-term methylphenidate treatment. We asked clinicians to implement N = 1 randomized, double-blind, placebo-controlled, cross-over discontinuation trials after at least one year of methylphenidate treatment of children and adolescents (n = 26, 6-15 years of age). We analyzed the effectiveness of ongoing methylphenidate treatment compared to placebo on symptoms of ADHD, oppositional defiant disorder, and conduct disorder according to both parents and teachers, and the global improvement or deterioration according to the clinicians. We also assessed the proportion of individuals who continued using methylphenidate after the discontinuation trial. Teacher-rated hyperactivity and impulsivity symptoms were significantly lower during methylphenidate treatment compared to placebo (β = 3.80, SD = 1.69, t = 2.25, p =.04). No other significant differences were found between methylphenidate and placebo. Almost two-thirds (n = 16, 61.5%) of individuals continued using methylphenidate after the discontinuation trials, of which seven did not deteriorate during placebo according to their clinician. Our findings support the need for regular evaluations of methylphenidate treatment effectiveness and emphasize the importance of including the school setting when evaluating treatments. Better guidance for clinicians when to continue or cease methylphenidate treatment is urgently needed.

Complex Attention-Deficit Hyperactivity Disorder in a 4-Year-Old With Repaired Critical Congenital Heart Disease and Autism Spectrum Disorder.

Congenital heart disease (CHD) is a risk factor for developmental delay and for attention-deficit hyperactivity disorder (ADHD). The Cardiac Neurodevelopmental Outcome Collaborative has developed recommendations for ongoing monitoring of this at-risk population to be able to detect developmental, learning, and behavioral concerns, as they become apparent as a child ages. A 4-year-old boy with tetralogy of Fallot with a ventricular septal defect repaired in infancy was followed periodically in the cardiac neurodevelopmental follow-up clinic and diagnosed with autism spectrum disorder as well as additional developmental and medical issues. He received early childhood special education and therapeutic interventions as well as social skills training and applied behavior analysis. At age 4 years, Alex presented with symptoms of hyperactivity, inattention, impulsivity, and immediate safety concerns for elopement. The clinician diagnosed him with ADHD-combined type. He was recommended to start medication in addition to behavioral and developmental supports. Managing medications in a child with CHD and ADHD presents unique challenges, and medication decisions were carefully made in collaboration with the child's cardiologist. After some medication adjustments and ongoing behavioral therapy to address behaviors associated with ADHD and autism spectrum disorder, the child is doing well academically and socially. Attention-deficit hyperactivity disorder medications can be safely prescribed in patients with CHD. However, pharmacotherapy for co-occurring ADHD and CHD needs an additional level of oversight and collaboration between cardiology and prescribing clinicians. Behavioral therapies can be transdiagnostic and address challenges associated with autism and symptoms related to ADHD.

Preschoolers with Symptoms of Hyperactivity and their Mothers: Comparing Meditation and Music Interventions

This article compares meditation and music interventions for dyads of mothers and their preschoolers with reported symptoms of hyperactivity using a pre- and post-test design. Post-test hyperactivity symptoms reduced significantly for both cohorts, but the meditation group reported a greater comparative decrease. In the music group, hyperactivity symptoms reduced and parenting self-efficacy scores improved particularly for preschool boys and their mothers, and dyads with higher intervention compliance. For the meditation cohort, apart from reduced hyperactivity symptoms and better parenting self-efficacy scores, child-parent relationships also improved with reported increase in closeness, decreased dependence and conflict, and better parenting and family adjustment.

Exploring the Nature of ADHD Comorbidity in Tic Disorders

Introduction: Tic disorders (Tics) are childhood-onset neurodevelopmental conditions, and approximately half of this population also have an ADHD diagnosis. Some of the clinical symptoms of Tics resemble ADHD which could explain the high comorbidity rate. Objectives: This research aims to investigate if the ADHD symptoms seen in children with both Tics and ADHD (Tics+) are true comorbid ADHD or a result of their Tics. Methods: Participants from a community-based study of children aged 6-18 reported their ADHD symptoms using the Strengths and Weaknesses of ADHD Symptoms and Normal Behavior Scale (SWAN). Their cognitive control was assessed using the Stop Signal Task. The symptom profiles of those with Tics and no ADHD diagnosis (Tics-, n=192), ADHD (n=2416), Tics+ (n=119) and controls (n=31908) were compared using logistic regressions. A linear regression model was used to determine if Tics+ was associated with greater cognitive control deficits, a well-established correlate of ADHD. Results: Tics+ demonstrated higher ADHD traits, specifically for hyperactive symptoms (p<0.001). 6 of 9 hyperactive symptoms were reported at significantly higher rates in Tics+ compared to ADHD. Cognitive control was equal between Tics+ and ADHD while both groups had significant deficits compared to Tics- and controls. Conclusion: Children with Tics+ have more hyperactive symptoms which were not associated with worse cognitive control than ADHD. The cognitive control deficits observed in Tics+ were consistent with a true comorbid ADHD. It is of interest to explore shared risk factors to explain the high prevalence of ADHD among this group.

Frailty and Behavioral and Psychological Symptoms of Dementia: A Single Center Study.

Background: During the time-course of cognitive decline, Behavioral and Psychological Symptoms of Dementia (BPSD) may arise, negatively impacting the outcomes. Methods: The aim of this single center, longitudinal study was to evaluate the correlation between frailty and BPSD in a population of older patients with dementia. BPSD were classified into three clusters: "mood/apathy" (depression, apathy, sleep disturbances, appetite disturbances), "psychosis" (delusions, hallucinations, and anxiety), and "hyperactivity" (agitation, elation, motor aberrant behavior, irritability, disinhibition). Using the Clinical Frailty Scale (CFS), patients were categorized as "severely frail", "mild/moderately frail" and "robust" (CFS ≥ 7, 4-6, and ≤ 3, respectively). Results: In total, 209 patients (mean age 83.24 ± 4.98 years) with a clinical diagnosis of dementia were enrolled. BPSD were prevalent among the severely frail patients. A positive correlation at regression analysis was found between frailty and "hyperactivity" cluster at baseline and follow-up visits (p < 0.001, p = 0.022, p = 0.028, respectively), and was confirmed at the network analysis. Loss of independence in IADL was correlated to hyperactivity and psychosis symptoms (p < 0.001 and p = 0.013, respectively). Conclusions: Scarce literature is available regarding the correlation between frailty and BPSD, which in our study is significant, especially for symptoms in the hyperactivity cluster. Frailty assessment may help identify patients at the highest risk for developing BPDS who might benefit from targeted intervention in the earliest phases of the disease.

Breaking the cycle between caregiver mental health and child behavioral issues: Does food insecurity matter?

Food insecurity is a key determinant of not only caregiver’s mental health but also children’s emotional problems and hyperactivity symptoms. Although substantial studies have explored such a relationship, it is unclear to us whether this relation would vary when considering that caregiver’s mental health and aforementioned children’s behavioral issues can be the cause and effect of each other. Addressing this research gap is a key to advancing our understanding of how to promote a healthier family dynamic, especially for those facing material needs. This research applies the family stress model to explore how food insecurity affects caregiver psychological distress and child emotional problems and hyperactivity symptoms, while considering the reciprocal relationships between caregiver mental health and these child behavioral issues. Utilizing data from the 2019 Panel Study of Income Dynamic and 2019-2020 Child Development Supplements, this study conducts path analyses applied with propensity score weighting to support causal inference. Results support the family stress model framework, where food insecurity significantly predicts an increase in psychological distress in caregivers, which in turn leads to more severe child emotional problems and hyperactivity symptoms. This study also shows that food insecurity is a risk factor resulting in a reciprocal association between caregiver psychological distress and child emotional problems, where the strength of both directions is similarly harmful to each other. These findings underscore the need to address food insecurity, not only to meet material needs but also to break the harmful cycle of mental health and behavioral issues within families

Exploring the Relationship of Smartphone Addiction on Attention Deficit, Hyperactivity Symptoms, and Sleep Quality Among University Students: A Cross-Sectional Study.

The prevalence of smartphone usage is steadily rising, leading to the potential development of addiction due to problematic use. This study examined the relationship between smartphone addiction, self-perceived attention deficit and hyperactivity symptoms, and sleep quality among 443 university students at Bingöl University. Participants completed several questionnaires, including the Smartphone Addiction Scale-Short Version, the Pittsburgh Sleep Quality Index, and the Adult ADHD Self-Report Scale. This study examined 443 participants, with a mean age of 20.97±3.29, of whom 72.7% (n=322) were female. Results showed that the majority of participants primarily used smartphones (94.8%, n=420) for social media browsing (49.9%, n=221). Factors such as smoking, preference for smartphone screens, and prolonged screen exposure significantly affected sleep quality. Smartphone addiction rates were notable, with 50.4% (n=61) of males and 47.2% (n=152) of females being affected; this addiction was associated with poorer sleep quality. Correlations were found between age, sleep duration, and scores on smartphone addiction, sleep quality, and attention deficit scales. Linear regression analysis revealed that age, attention deficit scores, and sleep quality scores significantly influenced levels of smartphone addiction. These findings contribute valuable insights into the impact of smartphone addiction on attention and sleep in university students.

An investigation of the Bernstein’s strengths Scale: factorial validity and network analysis of attention-deficit/hyperactivity symptoms, mental health, and the strengths of the healthy adult self

BackgroundBernstein’s heuristic model of personal strengths describes 16 positive attributes of the healthy adult self, grouped into four higher-order factors: self-directedness (identity, self-reflection, self-confidence, self-assertion, imagination/creativity), self-regulation (emotional balance, resilience, self-control, self-care, reality testing), connection (empathy, compassion, humour, responsibility), and transcendence (gratitude and wisdom). The study aimed to explore the factorial validity of Bernstein’s Strengths Scale developed for the assessment of these constructs. Furthermore, we explored the association of strengths with attention-deficit hyperactivity (ADHD) symptoms and mental health in a nonclinical sample using a network approach.MethodsFive hundred and twenty-eight adults filled out an online questionnaire, including Bernstein’s Strengths Scale (BSS), the Mental Health Continuum – Short Form (MHC-SF), and the Adult ADHD Self-Report Scale (ASRS).ResultsThough our data showed an acceptable fit to the 16-factor model, the Self-control subscale and item 28 of the Compassion subscale were excluded because of reliability issues. The final model with 15 factors and 44 items showed excellent fit, χ2(797) = 1130.149, p < .001, RMSEA = 0.028, 90% CI [0.024, 0.032], SRMS = 0.049, CFI = 0.993, TLI = 0.991. Principal component analysis revealed three instead of four second-order factors. In the network model, Self-confidence and Wisdom emerged as the most influential nodes. ADHD symptoms were negatively connected to Responsibility, Self-care, Identity, Emotional balance, Self-confidence, and mental health, while they had positive edges with Humor, Self-reflection, and Imagination/creativity. Mental health was positively related to several strengths, with the strongest association being between mental health and Gratitude.ConclusionThe BSS has acceptable factorial validity and is a reliable tool for assessing the personal strengths of the healthy adult self. ADHD symptoms in adults may be associated with deficits in personal strengths, but protective factors could also be identified. Addressing personal strengths in psychosocial interventions for ADHD in adults may improve patients’ emotional well-being and everyday functioning.

Relations Between Distinct Dimensions of Physical Activity and Preschoolers’ ADHD Symptoms

Objective: This study examined the unique and interactive effects of PA volume and within-person fluctuations in PA volume (i.e., intraindividual variability in PA volume; PA-var) on preschoolers’ (N = 141; 47.5% girls) ADHD symptoms. Method: Preschoolers wore accelerometers during the school day over a 2-week period. Teachers reported on children’s hyperactive, impulsive, and inattentive symptoms on the ADHD Rating Scale-IV Preschool Version. Results: In the context of regression models, higher levels of PA-var were linked with lower levels of impulsive symptoms. Higher levels of PA volume were linked with higher levels of hyperactive and inattentive symptoms, but only when PA fluctuation (i.e., PAvar) was relatively low. Post hoc analyses with teacher-reported impairment as the outcome revealed a significant interaction such that the positive association between PA volume and impairment was stronger at lower, as compared to higher, levels of PA-var. Conclusion: Larger fluctuations in preschoolers’ PA volume may indicate lower risk for displaying impulsive symptoms. Moreover, preschoolers with high levels of PA that remain relatively consistent throughout the day may be at increased risk for exhibiting hyperactive and inattentive symptoms and related impairment, suggesting they are unable to regulate their activity to meet expectations in the school environment.

BEHAVIOURAL PATTERNS OF CHILDREN IN KADUNA STATE ORPHANAGES: A COMPARATIVE ANALYSIS

Background The plight of orphans, exacerbated by conflict, disease, and socioeconomic factors, remains a pressing global issue, particularly in sub-Saharan Africa. Nigeria, notably impacted by the HIV/AIDS epidemic, terrorism, and natural disasters, has witnessed a substantial increase in orphan populations. These children face severe challenges, including child abuse, malnutrition, limited access to education, stigmatization, and a range of psychological and behavioural disorders. Despite some interventions, orphanages primarily address material needs, often neglecting comprehensive medical, social, and psychosocial support. This study explores the behavioural patterns of orphans in Kaduna, Nigeria, and examines how their medical and social challenges compare across various orphanages. Methodology A cross-sectional, comparative analysis was conducted among 100 orphans from selected orphanages in Kaduna. Data were collected through interviewer-administered questionnaires assessing socio-demographics, medical conditions, behavioural patterns, stigma, psychosocial status, and coping strategies. Results The mean age of respondents was 10 years, with 68% being male. Nutritional issues were prevalent, with 53.7% classified as underweight despite 54.9% reportedly consuming balanced diets. Medical concerns were significant, with 33.7% showing clinical signs of illness and 46.7% not fully immunized. Behavioural issues were prominent, including hyperactivity symptoms (27.0%), enuresis (22.3%), and depressive symptoms (1.8%). Socially, most respondents (83.3%) reported positive peer relationships, though bullying (11.4%) and stigmatization (9%) were also observed. Educational access was generally high, with only 2.2% not attending school. However, social support systems varied, with 35.2% reporting strong support and 46.8% adapting their goals as a coping mechanism. Conclusion The findings highlight the complex medical and behavioural challenges faced by orphans in Kaduna's orphanages, underscoring the need for integrated interventions that provide medical, psychosocial, and educational support. A holistic approach is crucial to improving their overall well-being and future prospects.

Effects of Nitric Oxide on Bladder Detrusor Overactivity through the NRF2 and HIF-1α Pathways: A Rat Model Induced by Metabolic Syndrome and Ovarian Hormone Deficiency.

Metabolic syndrome (MetS) includes cardiovascular risk factors like obesity, dyslipidemia, hypertension, and glucose intolerance, which increase the risk of overactive bladder (OAB), characterized by urgency, frequency, urge incontinence, and nocturia. Both MetS and ovarian hormone deficiency (OHD) are linked to bladder overactivity. Nitric oxide (NO) is known to reduce inflammation and promote healing but its effect on bladder overactivity in MetS and OHD is unclear. This study aimed to investigate NO's impact on detrusor muscle hyperactivity in rats with MetS and OHD. Female Sprague-Dawley rats were divided into seven groups based on diet and treatments involving L-arginine (NO precursor) and L-NAME (NOS inhibitor). After 12 months on a high-fat, high-sugar diet with or without OVX, a cystometrogram and tracing analysis of voiding behavior were used to identify the symptoms of detrusor hyperactivity. The MetS with or without OHD group had a worse bladder contractile response while L-arginine ameliorated bladder contractile function. In summary, MetS with or without OHD decreased NO production, reduced angiogenesis, and enhanced oxidative stress to cause bladder overactivity, mediated through the NF-kB signaling pathway, whereas L-arginine ameliorated the symptoms of detrusor overactivity and lessened oxidative damage via the NRF2/HIF-1α signaling pathway in MetS with or without OHD-induced OAB.

Exploring Screen Time and Its Effects on Children's Mental Health: A Cross-Sectional Study.

Background The increasing prevalence of screen-based activities among children has raised concerns about potential mental health effects. This study investigates the relationship between screen time and mental health outcomes in children aged 6 to 14 years in Saudi Arabia and Bahrain, focusing on emotional symptoms, conduct problems, hyperactivity, peer problems, and depressive symptoms. Methods A cross-sectional study was conducted with 670 children recruited through stratified random sampling. Data were collected using self-reported questionnaires and parental surveys from January to June 2024. Screen time was assessed across four activities: TV viewing, smartphone usage, computer/tablet use, and video game playing, recorded separately for weekdays and weekends. Mental health was evaluated using the Strengths and Difficulties Questionnaire (SDQ) and the Children's Depression Inventory (CDI). Descriptive statistics and Pearson correlation coefficients were used to analyze the data. Results Participants reported a mean total screen time of 7.25 ± 2.4 hours on weekdays and 8.4 ± 2.65 hours on weekends. Smartphone usage (2.75 ± 1.3 hours/day) was the most common activity. Emotional symptoms, conduct problems and depressive symptoms were significantly correlated with both weekday and weekend total screen time (weekday r = 0.43, r = 0.31, and r = 0.49, respectively, p < 0.001; weekend r = 0.47, r = 0.33, and r = 0.54, respectively, p < 0.001). Smartphone usage had the strongest association with depressive symptoms (r = 0.46, p < 0.001). Conclusion This study identifies a significant positive correlation between increased screen time and adverse mental health outcomes in children, particularly emotional symptoms and depressive symptoms. The findings emphasize the need for public health strategies to manage screen time and promote healthier digital habits to mitigate the potential negative effects on children's mental health.

Early ultra-processed foods consumption and hyperactivity/inattention in adolescence.

To investigate the relationship between childhood consumption of ultra-processed foods and symptoms of hyperactivity/inattention in adolescents from São Leopoldo, a city in southern Brazil. Data were collected at four distinct stages: when participants were 12-16 months old in 2001 and 2002 and later when they were 3-4, 7-8, and 12-13 years old. During the interview at 12-16 months, mothers were asked about the introduction of sugar in their child's diet. Two 24-hour recall surveys were conducted with children aged 3-4, 7-8, and 12-13 years to assess their consumption of ultra-processed foods. At the age of 12-13 years, the participants completed the Hyperactivity/Inattention subscale of the Strengths and Difficulties Questionnaire (SDQ), which screens for mental health problems. Among the 173 adolescents, 22.5% exhibited hyperactivity symptoms. The consumption of ultra-processed foods in grams, kilocalories, and as a percentage of energy intake at 3-4 years old were found to be predictors of hyperactivity/inattention symptoms (RR: 0.81, 95%CI: 0.69-0.95; RR: 1.01, 95%CI: 1.00-1.02; RR: 1.02, 95%CI:1.01-1.02; RR: 1.25, 95%CI:1.04-1.51, respectively). The consumption of ultra-processed foods at an early age was associated with hyperactivity and inattention symptoms in adolescence.

6645 Paraganglioma or Benign Ectopic Thyroid Tissue?

Abstract Disclosure: J.A. Dower: None. R. MacLeod: None. B. Cardoso: None. C. Matouk: None. S. Mehra: None. G. Riccio: None. L. Williams: None. S.K. Majumdar: None. Introduction: During gestation, cells destined to form the thyroid descend through the thyroglossal duct; ectopic thyroid tissue may deposit anywhere along this route from tongue base to mediastinum (1). Less commonly, thyroid tissue can be found lateral to the duct, either alone or in association with a lymph node (2). We present a case of lateral ectopic thyroid tissue mimicking paraganglioma. Clinical Case: A healthy 32-year-old woman presented to ENT with cervical adenopathy persisting for several months after a flulike illness. FNA showed no evidence of malignancy. A neck CT with contrast ordered for further evaluation revealed a 3.2 x 2.3 x 1.5 cm enhancing mass within the right carotid space, splaying the external and internal carotid artery branches, most concerning for paraganglioma. A second, smaller lesion was noted inferiorly. Neck MRI confirmed these findings and revealed a subcentimeter T2 lesion within the right thyroid lobe. The patient was referred to endocrine for further workup. She had no symptoms of sympathetic hyperactivity and no family history suggestive of pheochromocytoma or paraganglioma. Biochemical workup was largely within normal limits: plasma metanephrines 53 pg/mL (57), normetanephrines 94 pg/mL (148), calcitonin &amp;lt;2 pg/mL, TSH 1.210 uIU/mL (0.27-4.2), FT4 1.52 ng/dL (0.8-1.7). Follow-up 24-h urine studies were also unremarkable: metanephrines 166 mcg (36-190), normetanephrines 159 mcg (35-482). Brain MRI, chest CT, and abdomen/pelvis MRI were negative for additional masses. DOTATATE PET/CT was completed to determine if the thyroid lesion was another potential paraganglioma requiring resection versus a nodule amenable to biopsy; uptake was confined to the carotid space lesions, so FNA of the thyroid nodule was considered safe. Thyroid FNA revealed FLUS with genetic testing indicating low likelihood of malignancy. The patient underwent tumor embolization followed by neck dissection with successful removal of both the larger and smaller masses identified on imaging. Frozen and permanent tissue section revealed that both masses consisted of benign thyroid tissue without associated lymphoid tissue. The patient experienced jaw pain with eating after surgery and is under consideration for Botox injection. Conclusion: Benign thyroid tissue can deposit in unexpected places, mimicking malignancy and paraganglioma, alike. Even a very thorough workup can mistake the identity of a mysterious mass; only the tissue itself can make the diagnosis.

Impact of educational interventions on mothers’ awareness and communication with their attention–deficit hyperactivity disorder children

ABSTRACT Objective: The objectives of this study are to evaluate the effects of the educational intervention on mothers’ knowledge, awareness, and communication difficulties experienced with their children and mothers’ capacity to successfully interact with their affected child before and after the intervention. Materials and Methods: A quasi-experimental research design was used. A total of 30 mothers and their children complaining of attention-deficit hyperactivity disorder from four Dawadmi primary schools were included. Data were collected through a self-developed questionnaire from September 2023 to January 2024 after study acceptance by Shaqra University’s scientific deanship. Intervention prepared according to subjects’ needs and current scientific base and demonstrated in 10 sessions in schools. Results: Regarding mothers’ age, more than one-fourth of them (26.7%) ranged from 31 to 35 year old, and about a third (36.7%) had secondary education. Regarding mother’s job, about 76.7% do not work, and the majority of affected children (66.6%) were male, there were significant improvements in mothers’ knowledge pre- and postintervention also a significant improvement in mothers’ awareness about symptoms of poor attention, hyperactivity, and impulsivity pre- and postintervention was found. Significant differences were found before and after the intervention regarding the impact of the intervention in decreasing mothers’ challenges. Conclusion: The study hypothesis was accepted, and the intervention improved mothers; knowledge, awareness, and communication challenges. The intervention should be conducted and followed up for a long period of time to manage all mother’s and children’s daily challenges, improve children’s daily activities, and stabilize effective communication patterns between children and their family members.

Attention-Deficit Hyperactivity Disorder Prediction by Artificial Intelligence Techniques

Attention-Deficit Hyperactivity Disorder (ADHD), a neurodevelopmental disorder affecting millions of people globally, is defined by symptoms of hyperactivity, impulsivity, and inattention that can significantly affect an individual's daily life. The diagnostic process for ADHD is complex, requiring a combination of clinical assessments and subjective evaluations. However, recent advances in artificial intelligence (AI) techniques have shown promise in predicting ADHD and providing an early diagnosis. In this study, we will explore the application of two AI techniques, K-Nearest Neighbors (KNN) and Adaptive Boosting (AdaBoost), in predicting ADHD using the Python programming language. The classification accuracies obtained were 96.5% and 93.47%, respectively, before applying balancing to the data. In addition, 98.59% and 97.18%, respectively, after applying the balancing technique The extreme gradient boosting (XGBoost) technique had been applied to selecting the important features and the Pearson correlation for finding the correlation between features.

Therapeutic efficacy of the BKCa channel opener chlorzoxazone in a mouse model of Fragile X syndrome.

Fragile X syndrome (FXS) is an X-linked neurodevelopmental disorder characterized by several behavioral abnormalities, including hyperactivity, anxiety, sensory hyper-responsiveness, and autistic-like symptoms such as social deficits. Despite considerable efforts, effective pharmacological treatments are still lacking, prompting the need for exploring the therapeutic value of existing drugs beyond their original approved use. One such repurposed drug is chlorzoxazone which is classified as a large-conductance calcium-dependent potassium (BKCa) channel opener. Reduced BKCa channel functionality has been reported in FXS patients, suggesting that molecules activating these channels could serve as promising treatments for this syndrome. Here, we sought to characterize the therapeutic potential of chlorzoxazone using the Fmr1-KO mouse model of FXS which recapitulates the main phenotypes of FXS, including BKCa channel alterations. Chlorzoxazone, administered either acutely or chronically, rescued hyperactivity and acoustic hyper-responsiveness as well as impaired social interactions exhibited by Fmr1-KO mice. Chlorzoxazone was more efficacious in alleviating these phenotypes than gaboxadol and metformin, two repurposed treatments for FXS that do not target BKCa channels. Systemic administration of chlorzoxazone modulated the neuronal activity-dependent gene c-fos in selected brain areas of Fmr1-KO mice, corrected aberrant hippocampal dendritic spines, and was able to rescue impaired BKCa currents recorded from hippocampal and cortical neurons of these mutants. Collectively, these findings provide further preclinical support for BKCa channels as a valuable therapeutic target for treating FXS and encourage the repurposing of chlorzoxazone for clinical applications in FXS and other related neurodevelopmental diseases.

The Effect of Running Training on Improving Classroom Attention in Children with ADHD

Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder characterized by symptoms of inattention, hyperactivity, and impulsivity that adversely affect children’s academic performance and behavior in classroom settings. Current ADHD management strategies, primarily pharmacological and behavioral, have limitations, prompting the exploration of alternative interventions. This study investigates the effects of a 12-week structured running training program on improving classroom attention in children with ADHD. Thirty children aged 7 to 12 years participated in a single-group intervention study, with attention, behavior, mood, and physical fitness assessed at baseline, post-intervention, and follow-up. Results showed significant improvements in classroom attention, as evidenced by reduced scores on the Conners’ Teacher Rating Scale-Revised (CTRS-R) and fewer errors on the Continuous Performance Test (CPT). Secondary outcomes indicated notable reductions in hyperactive-impulsive behaviors, anxiety, and depressive symptoms, as well as enhanced physical fitness. These findings suggest that structured running programs may be an effective non-pharmacological intervention for enhancing attention and behavior in children with ADHD. Further research should explore the long-term effects and underlying mechanisms of such interventions and investigate their integration into comprehensive ADHD management plans.