Hydroxyl Phenyl Research Articles

Effect Of Solvents On Stability Constants of Fe(II) and Ni(II) Transition Metal Ions Chelates With Some Substituted Pyrazoles

The reaction of Fe(II) and Ni (II) metal ions with L1 : 3 (2’- chlorophenyl) - 4- benzoyl - 5 (2-hydroxy phenyl) pyrazole, L2: 3 (2’-chlorophenyl) - 4- pyridoyl -5 (2-hydroxy phenyl) pyrazole , L3: 3 (2’-aminophenyl)- 4-pyridoyl - 5 (2- hydroxyl phenyl) pyrazole and L4: 3 (4’-chlorophenyl) -4-Benzoyl -5(2-hydroxy-phyenyl) pyrazole, at 0.1M ionic strength at 28 ± 0.10C in 70% ethanol -water mixture and 70% dioxane-water mixture have been studied pH-metrically. The data obtained were used to estimate the values of proton-ligand (pK) and metal-ligand (logK) stability constants in different solvents. It is observed that the pK and logK values in 70% dioxane-water mixture are greater than in 70% ethanol -water mixture. Fe(II) and Ni(II) metal ions formed 1:1 and 1:2 complexes with all the ligands in both solvent medium.

Ultrasonic-Assisted Diels-Alder Reaction Exfoliation of Graphite into Graphene with High Resveratrol Adsorption Capacity.

Scalable preparation of graphene with high adsorption capacity is an important prerequisite for fully realizing its commercial application. Herein, we propose an environmentally friendly route for exfoliation of graphene, which is established based on the Diels–Alder reaction. In our route, N-(4-hydroxyl phenyl) maleimide enters between the flakes as an intercalating agent and participates in the Diels–Alder reaction as a dienophile to increase the interlayer spacing of graphite. Then, graphite is exfoliated into graphene with the aid of ultrasound. The exfoliated product is hydroxyl phenyl functionalized graphene with a thickness of 0.5–1.5 nm and an average lateral size of about 500–800 nm. The exfoliation process does not involve any acid or catalyst and would be a safe and environmentally friendly approach. In addition, the exfoliated graphite shows high resveratrol adsorption capacity, which is ten times that of macroporous resins reported in the literature. Thus, the method proposed herein yields exfoliated graphite with high resveratrol adsorption capacity and is of great significance for the mass production of graphene for practical applications.

Controlling effect of hydroxyl phenyl aminopropyl cationic surfactants on the catalytic and biological performance of AgNPs

Three Hydroxy phenyl aminopropyl cationic surfactants with different carbon tail length; 8 (HPAPO), 12 (HPAPD), and 16 (HPAPH) have been synthesized successfully. The hydrophobic tail showed a pivotal impact on the morphological structure of the prepared silver nanoparticles (AgNPs) in terms of particles size, stability and yields as confirmed by TEM, DLS and UV-Vis spectroscopy measurements. The prepared AgNPs by HPAPH surfactant has a uniform structure with smaller particles size, and higher stability compared to that prepared by shorter chain length surfactants HPAPO and HPAPD. The HPAPH surfactant lead to formation AgNPs with size 12.9 ± 3.5 nm with high zeta potential 75.9± 6.4 mV indicating for highest stability. The surface and thermodynamic properties of the HPAPO, HPAPD and HPAPH surfactants are dependent on temperature and the hydrophobic tail length. The adsorption affinity is enhanced as temperature or chain length is increased. Increasing the surfactant hydrophobic tail or the solution temperature lead to decreasing the critical micelle concentration (CMC) of the surfactant solution. The hydrophobic chain exhibited a significant impact on the catalytic activity of the AgNPs toward removal some toxic pollutants such as methylene blue (MB) and p-nitrophenol (p-NP). The synthesized AgNPs using longer surfactant tail (HPAPH/AgNPs) showed highest catalytic activity compared to that prepared via shorter chain, which consider a promising study in terms of surfactant chain influence on the catalytic performance. The prepared cationic surfactants have good biological activity which is enhanced in case of in-cooperation with AgNPs. Both HPAPH Surfactant and HPAPH/AgNPs nano-hybrid system trigger maximum inhibition zone against all inspected microorganism, compared to surfactant with shorter chain.

Synthesis of New Furanone Derivatives with Potent Anticancer Activity

New compounds based on Furanone derivatives were synthesized by reaction of 3-(4-nitrobezylidine)-5-phenylfuran-2(3H)-one with various reagents as malononitrile then D-glucose, thiosemicarbazide then D-glucose, ethyl acetoacetate, acetyl acetone, ethyl cyanoacetate, hydrazine hydrate/acetic acid, thiourea, o-phenylene diamine, hydrazine hydrate/ethanol then 2-naphthalene thionylchloride and/or thiourea. Also, 3-(4-nitrobezylidine)-5-phenylfuran-2(3H)-one was reacted with benzyl amine to afford the 1,3-dihydro-2H-pyrrol-2-one derivative which was reacted with hydroxyl amine and/or phenyl hydrazine to afford compounds the oxazole and/or pyrazole derivatives respectively. Finely, 6-(4-nitrophenyl)-5-(2-oxo-2-phenylethyl)-2-thioxotetrahydro-pyrimidin-4(1H)-one was allowed to react with 2-oxo-N-phenylpropanehydrazonoyl chloride yielding [1,2,4]triazolo[4,3-a]pyrimidin-7(1H)-one derivative. The anti-cancer activity of some of some of the new synthesized compounds towards breast carcinoma cells (MCF-7) was evaluated that demonstrated good to moderate results. Also, we had evaluated the cytotoxicity of the new tested compounds against the normal cells (MRC-5) which showed low toxicity on them.

FI-Spectrophotometric determination of Cu (II) ions in analytical sample Via reaction with a new reagent HPEDN

A new Spectrophotometric flow injection method has been established for the determination of Cu (II) ions in analytical sample . The method is based on the reaction of Cu (II) ions with 1- (4-( 1- ( 2- hydroxyl phenyl amino) ethyl ) phenyl) diazenyl ) naphthalene-2- ol ( HPEDN) reagent in the presence of a Buffer solution has PH equal to 9 to form a red-water-soluble stable complex, that has a maximum absorbance at 500 nm . Beer’s law is obeyed in the range of 0.5-10 μg.ml-1 with a limit of detection (signal/noise=3) of 0.2213 μg.ml-1 and limit of quantification of 0.7377 μg.ml-1 and relative standard deviations of 0.65 %, The effect of chemical and physical parameters have been carefully considered and the proposed procedure was successfully applied to the determination of Cu (II) ions in analytical sample with a good precision and accuracy.

Synthesis, Photophysical Studies of Blue‐Light‐Emitting Alternating Polymers from Substituted 9‐Sila Fluorenes and Substituted p‐Phenylacene

AbstractFive new alternating polymers were synthesized from 2,7‐dibromo‐3,6‐dimethoxy‐9‐sila fluorene with varied alkyl and aryl groups substituted at 9‐position and 2‐tert butyl‐9,10‐di (p hydroxyl phenyl) anthracene. The monomers and the polymers were synthesized in good yields at each stage of preparation and with high degree of reproducibility. The copolymers were soluble in common organic solvents like toluene, xylene, THF and chloroform. Chemical and optoelectronic characterizations of the polymers were done by 1H and 13C NMR, GPC, UV absorption, photoluminescence and cyclic voltammetric studies. Pure blue light emission, with the maximum absorption wavelength in the range of 445 to 457 nm and the PL quantum efficiency in the range of 0.55 to 0.91 were recorded for the synthesized copolymers in their solution in CHCl3. The ITO/CuPc/α‐NPD/ copolymer/ Alq3/LiF/Al devices fabricated from the polymers gave pure blue light emission irrespective of the substitution on silicon atom of the silafluorene moiety. The properties both photophysical and electrochemical, of the synthesized alternating polymers are quite suitable for the development of blue light emitting devices.

Removal of Lead by Tetra Hydroxyl Phenyl Porphyrin-Linked Magnetic Nanoparticles: Process Optimization by Using Taguchi Design Method

Fe3O4@SiO2@THPP (MSTHPP) nanocomposite was prepared as an adsorbent for the removal of lead ions. The structural characteristics of thisnanocomposite were determined using Fourier transform-infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy, x-ray diffraction, vibrating sample magnetometry (VSM), and N2 adsorption-desorption analyses. SEM images showed that the magnetic nanoparticles have uniform morphologies with a mean size of 20 nm. The magnetic properties of the synthesized nanocomposite were measured on a VSM with maximum saturation magnetization values of 40 emug-1 and 10 emug-1 for Fe3O4@SiO2 and MSTHPP nanocomposites, respectively. MSTHPP has been efficiently used to remove lead ions from aqueous solutions. After the lead sorption process, the nanocomposite was magnetically separated from the mixture and showed good reusability. The effects of pH, contact time, adsorbent dosage and initial concentration of lead in the removal of lead were investigated. Optimization of the parameters was performed by using Taguchi design method to obtain the maximum removal efficiency. The optimized condition can be achieved when pH, contact time, adsorbent dosage and initial concentration of lead are 5.3 min, 30 min, 50 mg, 20 ppm, respectively. The M, MS, and MSTHPP lead removal efficiency was found to be 18%, 25%, and 97%, respectively.

Hydroxyl phenyl imino modified phenanthro[9,10-d] imidazole: An AIEE-active sensor for determination of Cu2+ in water samples and subsequent "turn-on" recognition of Cr3+ with logic gates.

A 2-hydroxyl phenyl imino modified phenanthro[9,10-d]imidazole probe (PPIP) was synthesized and its aggregation-induced emission enhancement (AIEE) phenomenon in aqueous medium was characterized by the Tyndall phenomena, morphologies of scanning electron microphotograph (SEM) as well as the enhanced fluorescence intensities. The AIEE-active PPIP in aggregated states exhibited a sensitive detection for Cu2+ along with the elimination of fluorescence intensity; subsequently, in situPPIP-Cu2+ complex showed selective fluorescence "turn-on" for Cr3+, providing a potential platform for tandem recognition of Cu2+ and Cr3+. The 1:1 M ratio between PPIP and Cu2+ was confirmed by Job's plot, 1H NMR spectra, mass spectra and density functional theory (DFT) calculations. The detection limits for Cu2+ and Cr3+ were 4.127 × 10-2 μM and 9.404 × 10-1 μM, respectively. Moreover, this successive recognition could be utilized to construct the molecular logic gates by the fluorescence changes. In addition, PPIP was successfully employed for quantitative detecting Cu2+ in real water samples with satisfactory results.

Synthesis of Some Novel 2-Azetidinones/4-Thiazolidinones Bearing 1, 3, 4- Thiadiazole Nucleus and Screening for its Anti-Imflammatory Activity

Objective: The objective of the study was to synthesize a series of 3-chloro-4-(substituted phenyl)-1-(5-styryl-1, 3, 4-thiladiazole-2-yl) azetidin-2-one / 2-(substituted phenyl)-3-(5-styryl-1, 3, 4- thiadiazole-2-yl)-thiazolidin-4-one and screened for their possible anti-inflammatory activity by carrageenan induced paw edema in rats. Method: The synthesis of 2-amino-5-styryl-1, 3, 4-thiadiazole, an intermediate was carried out by oxidative cyclization method. In the current study, thiosemicarbazone (I) was subjected to oxidative cyclization using ferric chloride as an oxidising agent, to get 2- amino- 5- styryl -1, 3, 4-thiadiazole (II). Futhermore, compound (II) was reacted with different aromatic aldehydes in methanol to form N-(4-sustituted)- 5- styryl- 1, 3, 4-thiadiazol-2-amine (III a-h). Compound (III ah) was reacted with chloroacetyl chloride in triethylamine to form 2-azetidinone derivatives bearing 1, 3, 4-thiadiazole nucleus (IV a-h). Compound (III a-h) on cyclocondensation with mercaptoacetic acid leads to the formation of 4- thiazolidinone derivatives bearing 1, 3, 4-thiadiazole nucleus (V a-h). Results: The synthesis of the targeted compounds IVa-h and Va-h was confirmed through their MP, IR, 1H-NMR and mass spectrum studies. Compounds IVa, IVb and IVc (56.32, 61.11 and 58.24 % inhibition) exhibited significant antiinflammatory activity than that of diclofenac (65.13% inhibition). Conclusion: It may be concluded that the presence of methoxy, nitro and hydroxyl phenyl groups substituting 2- azetidinone bearing 1, 3, 4-thiadiazole showed significant anti-inflammatory activity. Keywords: Anti-inflammatory activity, diclofenac, 2-Azetidinone, 4-Thiazolidinone, 1, 3, 4-Thiadiazole, carrageenan induced paw edema.

In vitro dissection of anti-diabetic effects of compound a, a dissociating glucocorticoid receptor ligand

Compound A (CpdA), or 2-(4-acetoxyphenyl)-2-chloro-N-methyl-ethyl-ammonium chloride, is a stable analog of the hydroxyl phenyl aziridine precursor found in the Namibian shrub Salsola tuberculatiformis Botschantzev. It belongs to the group of so-called ?dissociated? GC receptor ligands that downmodulate pro-inflammatory gene expression via the transrepression mechanism, but without physically binding to DNA. We have recently reported that the in vivo administration of CpdA exerts a strong protective effect in a pharmacological model of type 1 diabetes in mice. The goal of this study was to investigate in more detail the effects of CpdA on multiple immune system components, as well as on target pancreatic beta cells in direct in vitro exposure. The utility of CpdA in diabetes prevention was evaluated through its addition to mitogen-activated spleen, lymph node and peritoneal cells of C57BL/6 mice, and to murine pancreatic islets and INS-1 and RINm5F beta cell lines. CpdA modulated immune cell-derived cytokine production in vitro by restraining the pro-inflammatory M1/Th1/Th17 response and switching it towards an anti-inflammatory Th2 profile. However, it did not preserve beta cells from the cytotoxic action of inflammatory cytokines. Thus, the anti-diabetic properties of CpdA are mediated through the modulation of immune cell differentiation pathways rather than through rescue of target cells from autoimmune attack.

Rapid identification of polymer additives by atmospheric solid analysis probe with quadrupole time-of-flight mass spectrometry.

A method using an atmospheric solid analysis probe (ASAP) combined with quadrupole time-of-flight mass spectrometry (QTOFMS) assisted by a pre-built MS library was found to be efficient in fast and direct analysis of additives for polymers. By this method, sample pretreatment could be eliminated from the additives identification process. Some crucial parameters, such as desolvation gas temperature, corona current, sample cone voltage and collision energy, should be optimized. A MS library of 100 polymer additives, including phenols (Irganox 1010, Irganox 1076), hydroxyl phenyl benzotriazole derivatives (Tinuvin 326, Tinuvin 327, Tinuvin 328), hindered amines (Tinuvin 944, Tinuvin 770) and plasticizers, was built based on the optimized conditions. To verify the application of the MS library, the ASAP-QTOFMS method was applied to identify complex additives, a simulated polypropylene (PP) sample and a real polymethylmethacrylate (PMMA) sample purchased from a local market. By searching the exact mass, and comparing the MS and MS/MS spectra of samples with standards in the MS library, complex additives such as Irganox GX 2921, as well as additives in PP and PMMA samples, could be identified quickly and easily. The determination of mass accuracy increased the confidence of peak identification as well. Moreover, the results also provided information of the characterization for PP and PMMA polymers. A rapid identification method has been developed for polymer additives by ASAP-QTOFMS. A MS library of 100 polymer additives was built by this method. Using ASAP-QTOFMS assisted by the pre-built MS library, polymer additives can be quickly identified. This method was found to be a promising tool in the rapid analysis of additives in polymers and polymer matrices.

Crystallization and structural analysis of 2-hydroxyacid dehydrogenase from Ketogulonicigenium vulgare

L-2-Hydroxyacid dehydrogenase (HDH) from Ketogulonicigenium vulgare Y25 was cloned and overexpressed in Escherichia coli. The protein was purified and crystallized by the sitting-drop vapour-diffusion method with polyethylene glycol 3350 as precipitant. The crystal structure of HDH was determined at 1.64Å resolution using the molecular replacement method with the crystal structure of hydroxyl (phenyl) pyruvate reductase from Coleus blumei Benth as the search model. The overall structure of HDH was similar to that of hydroxyl(phenyl)pyruvate reductase, consisting of two compact domains separated by a deep active cleft. The most significant structural divergence is located around the pocket gate comprising residues A210, T211 and R212, which is located on top of the catalytic triad.

Determination of the Stability Constants for some First Transition Elements Complexes with 3-(2- hydroxyl phenyl ) -2 – Pyrazoline In Aqueous Solution

Determination of the Stability Constants for some First Transition Elements Complexes with 3-(2- hydroxyl phenyl ) -2 – Pyrazoline In Aqueous Solution

Synthesis and spectral behavior of nanometric Ti(IV) complexes with nitrogen, sulfur, and oxygen donors

To study the spectral behavior of Ti(IV) complexes with sulfur donors, several new nano-sized mixed ligand complexes of Ti(IV) have been synthesized by the reaction of titanium(IV) salts with 3(2′-hydroxyl phenyl)-5-(4-substituted phenyl)pyrazolines and ammonium salts of dithiophosphates. Spectroscopic and X-ray diffraction studies reveal amorphous and monomeric complexes. The Ti(IV) complexes show octahedral geometry in which dithiophosphate and pyrazoline are bidentate. Transmission electron microscopic image shows that the particle size ranges from 50 to 90 nm.

Kinetic resolution of (±)-diethyl- and dibenzyl hydroxy(phenyl)methanephosphonates and their acyl derivatives with lipases

A wide variety of commercially available lipases and microbial whole cells were tested for biotransformations of (±)-diethyl and dibenzyl hydroxyl(phenyl)methanephosphonates. Biocatalytic hydrolysis of acylated hydroxyphosphonates by whole cells of Bacillus subtilis gave optically active compounds with 95%ee S. Enantioselectivities obtained when using commercially available enzymatic preparations were less satisfactory, leading to both compounds with an enantiomeric excess in the range 15 35%. Screening lipases for their ability to acylate these phosphonates or to hydrolyze their acylated derivatives enabled selection of enzymes and organisms suitable for use in both processes.

Study on the Interaction of Fluorescent Probe 2-(2'-<i>Chloro Phenyl</i>)-5-(2'-<i>Hydroxyl Phenyl</i>)1,3,4-Oxadiazole with DNA

The interaction between self-synthesized fluorescent probe 2-(2'- Chloro phenyl)- 5- (2'- hydroxyl phenyl)1,3,4-oxadiazole (HOXD) and Calf thymus DNA was studied using UV absorption spectra and fluorescence quenching spectra．The data of fluorescence quenching of HOXD by DNA were analyzed according to Stern-Volmer equation and Lineweaver-Burk double-reciprocal equation．The results indicated that the fluorescence quenching of HOXD might be static one attributed to the formation of adduct from HOXD and DNA, which was confirmed by the data of temperature effect experiment. Further results presented in the paper showed that intercalation binding might be the interaction mode between HOXD and DNA.

2-(2'- Chloro Phenyl)- 5- (2'-Hydroxyl Phenyl)-1,3,4-Oxadiazole as a Florescent Probe for DNA Determination

In recent years, fluorescence spectrometry was widely used in quantitative determination of DNA. In this paper, a convenient synthesis of a new fluorescent 2-(2'- Chloro phenyl)- 5- (2'- hydroxyl phenyl)-1,3,4-oxadiazole (HOXD) was realized. Experimental data showed that fluorescence of HOXD could be quenched by DNA and the decreased fluorescence intensity of HOXD resulting from fluorescence quenching is proportional to DNA concentrations suggesting that HOXD could be used as a new fluorescent probe for quantitative determination of DNA. Optimal experimental conditions for DNA analysis were also studied in the paper.

Molecular structure, conformational preferences and vibrational analysis of 2-hydroxystyrene: A computational and spectroscopic research

The molecular structure of 2-hydroxy-styrene has been investigated at DFT (B3LYP, mPW1PW91) and MP2 levels with an assortment of Pople’s and Dunning’s basis sets within the isolated molecule approximation. The presence of intramolecular hydrogen bonds has been theoretically characterized through a topological analysis of the electron density according to the Atom-In-Molecules, AIM, theory. The conformational equilibrium has been pursued by means of an analysis of the hydroxyl–phenyl and vinyl–phenyl internal rotation barriers. This analysis also allowed getting an insight into the effects governing the torsion barriers and the preferred conformations. A twofold scheme has been used for this goal, i.e. the total electronic energy changes and the natural bonding orbital, NBO, schemes. The vibrational spectrum was recorded and then calculated at DFT-B3LYP/6-31G∗ and cc-pVTZ levels. Two scaling methods, SQMFF and linear scaling, have been applied on the theoretical spectrum in order to analyse the experimental one. The results point out that at least three different conformers coexist at room temperature.

New Zinc Complexes bearing κ2-Heteroscorpionate Ligands: Influence of Second-Sphere Bonding Interactions on Reactivity and Properties

New zinc complexes (LOMe)ZnCl(2) (1) and (LOH)ZnCl(2)(2) of the heteroscorpionate ligands 1-[(3,5-di-tert-butyl-2-methoxyphenyl)(3,5-dimethyl-pyrazol-1-yl)methyl)]-3,5-dimethyl-pyrazole (LOMe) and 2,4-di-tert-butyl-6-[bis(3,5-dimethyl-pyrazol-1-yl)methyl]phenol (LOH) have been synthesized. The X-ray molecular structure of 2 was reported and compared with the one of the iron(II) complex (LOH)FeI(2) (3). The complexes 2-3 adopt a tetrahedral structure in the solid state in which the LOH ligand is kappa(2)-coordinated to the metal via the imino nitrogens of the two pyrazolyl rings. The hydroxyl phenyl group is not coordinated to the metal but found to be involved in an intermolecular hydrogen bond. The solution structures of 1 and 2 are consistent with this tetrahedral C(S) symmetric geometry. Dilution and (1)H-(1)H Nuclear Overhauser Effect Spectroscopy (NOESY) experiments revealed that the free ligands LOMe and LOH are involved in intra- and intermolecular hydrogen bonding interactions. Coordination of LOMe and LOH to ZnCl(2) was investigated by NMR titration methods. Association constants (K(a)) of (8.6 +/- 0.4) x 10(2) M(-1) and (7.8 +/- 0.3) x 10(2) M(-1) were obtained in methanol/water solutions (95:5) for LOMe and LOH, respectively. Coordination of bis(3,5-dimethyl-pyrazol-1-yl)methane (bpm) ligand to ZnCl(2) is weaker, as evidenced by the lower value of the association constant (5.3 +/- 0.3) x 10(2) M(-1). When bpm was added to solutions of 1 or 2, an equilibrium shifted toward the (bmp)ZnCl(2) species was observed. The thermodynamic parameters for this reaction were determined by VT NMR analysis. The optical properties of the ligands (LOMe, LOH) and of the corresponding zinc complexes 1 and 2 were also investigated by means of UV-vis and fluorescence spectroscopy to assess the potential use of these ligands as fluorescent sensors for Zn(2+) detection.

Synthesis of Functionalized Pyrano[3,2‐c]pyridines and Their Transformations to 4‐Hydroxy‐3[(1E)‐N‐hydroxyalkanimidoyl]pyridones

Reaction of 4‐hydroxy‐6‐methyl‐2(1H)‐pyridones 1a and 4‐hydroxy‐1,6‐dimethyl‐2(1H)‐pyridones 1b with diethyl malonates 2a–e leads to the formation of pyrano[3,2‐c]pyridines 4a–j. Degradation of 4a–i affords the corresponding ketones 6a–i. Condensation of ketones 6a–i with hydroxyl amine or phenyl hydrazine hydrochloride is described.