Exploring drought propagation relationships and thresholds is crucial for drought control and mitigation. However, previous studies have overlooked the impacts of regime shifts in trends of hydrometeorological variables over time on drought propagation and its thresholds. This study proposes an integrated framework focusing on drought propagation from meteorological to hydrological drought. The regime shift periods, both increasing and decreasing trends, were identified using the cumulative difference curve-rank test on precipitation and streamflow at an annual time scale. The Standardized Precipitation Index (SPI) and Standardized Streamflow Index (SSI) were used as meteorological and hydrological drought indices, respectively. Additionally, the propagation relationships and thresholds from meteorological drought to hydrological drought were identified and compared across various regime shift periods. The integrated framework’s applicability was verified by applying it to the Three-Rivers Headwaters region of China, which encompasses the Yellow River, Yangtze River, and Lancang River. This region is strategically important for China and has relatively little human activity. The framework revealed the variability in drought propagation and thresholds during different regime shift periods. The response sensitivity of SSI to SPI and the probabilities and thresholds for propagation from meteorological to hydrological drought differed between periods of increasing and decreasing trends in hydrometeorological variables. When regime shift characteristics were considered, the thresholds for meteorological drought propagating to hydrological drought were 2.81 %–16.90 % higher. These results indicated that, when examining drought propagation relationships and thresholds, accounting for regime shifts in hydrometeorological variables can improve early drought warning and enhance drought control and mitigation efforts.