Hydrogen Sulfide Molecules Research Articles

How Flexible Is the Hydrogen Sulfide Molecule Structure? Influence of Hydrogen Sulfide Molecule Geometry on Its Hydrogen Bonds.

The geometry of hydrogen sulfide was studied by calculating potential energy surface (PES) with over 1800 configurations. The calculations were performed at very accurate CCSD(T)/aug‐cc‐pvz5 level. The most stable geometry on PES has bond angle (H‐S‐H) of 92.40⁰ and bond length (S‐H) of 1.338 Å. PES shows that hydrogen sulfide is a quite flexible molecule. Namely, it can change the bonding angle (H‐S‐H) in the range of . 15.6⁰ (from 84.6⁰ to 100.2⁰) and the bond lengths (S‐H) in the range of 0.082 Å (from 1.299 Å to 1.381 Å) with an energy increase of only 1.0 kcal/mol. An influence of hydrogen sulfide geometry on its hydrogen bonds was studied on several hydrogen sulfide/hydrogen sulfide and water/hydrogen sulfide dimers. It showed that the change of hydrogen sulfide geometry does not influence the strength of hydrogen bond. Fully optimized geometries in gas and water solution phases revealed structural differences of both monomers and dimers in gas phase and water phase. SAPT analysis of the optimized dimer geometries showed that in all the dimers electrostatic is the most dominant contribution, while, in the dimers with hydrogen sulfide, the influence of dispersion contribution becomes quite pronounced.

Dynamics of the Decomposition of Gas Molecules Containing Sulfur and Nitrogen from Char-S and Char-N Structures in Combustion and Pyrolysis Reactions

ABSTRACT Combustion states of char-S (C14H16O4S) and char-N (C18H19NO3) sub function molecules in a limited number of oxygen environments and pyrolysis states at high temperatures were examined quantum mechanically. In the study, the formation of all gases, with or without carbon, were determined. All the dynamics in which the O2 molecule could be effective in the combustion mechanism and all the elements that could affect the decomposition in the pyrolysis event were determined. The dynamics of the formation and disappearance of the highly stable CO molecule and CH2O (formaldehyde) molecules were shown in detail. It has been shown that the CO molecule is a catalysis that can bond with hydrocarbon groups and decompose them into small hydrocarbon groups at high temperature. In this study, it was shown that high temperature-dependent vibration and rotational energies, CO molecule and H-atom transfers play a role in the decomposition in the pyrolysis system, and the aromatic carbon ring group is the last particle group to decompose. In addition, the formation and dissociation dynamics of sulfoxylic acid, thioformic acid, hydrogen sulfide molecules originating from the Char-S system, as well as the formation conditions of hydrogen cyanide and pyridinyl molecules originating from the Char-N system, were determined. The study also showed that since the N-atom is located in the aromatic carbon ring, it makes the emergence of the nitrous oxide molecule difficult in pyrolysis systems.

First-principles study of hydrogen sulfide decomposition on Sc-Ti3C2O2 single-atom catalyst.

Hydrogen sulfide gas poses significant risks to both human health and the environment, with the potential to induce respiratory and neurological effects, and a heightened fatality risk at elevated concentrations. This article investigates the catalytic decomposition of H2S on a Sc-Ti3C2O2 single-atom catalyst(SAC) using the density functional theory-based first-principles calculation approach. Initially, the adsorption behavior of H2S on Ti3C2O2-MXene was examined, revealing weak physical adsorption between them. Subsequently, the transition metal atom Sc was introduced to the Ti3C2O2 surface, and its stability was studied, demonstrating high stability. Further exploration of H2S adsorption on Sc-Ti3C2O2 revealed direct dissociation of H2S gas molecules into HS* and H*, with HS* binding to Sc and H* binding to O on the Ti3C2O2 surface, resulting in OH groups. Using the transition state search method, the dissociation of H2S molecules on the SAC's surface was investigated, revealing a potential barrier of 2.45eV for HS* dissociation. This indicates that the H2S molecule can be dissociated into H2 and S with the action of the Sc-Ti3C2O2 SAC. Moreover, the S atom left on the catalyst surface can aggregate to produce elemental S8, desorbing on the catalyst surface, completing the catalytic cycle. Consequently, the Sc-Ti3C2O2 SAC is poised to be an efficient catalyst for the catalytic decomposition of H2S. The Dmol3 module in Materials Studio software based on density functional theory is used in this study. The generalized gradient approximation method GGA-PBE is used for the exchange-correlation function. The complete LST/QST and the NEB methods in the Dmol3 module were used to study the minimum energy path of the dissociation of hydrogen sulfide molecules on the catalyst surface.

Cystathionine β-Synthase Suppresses NLRP3 Inflammasome Activation via Redox Regulation in Microglia.

Aims: Cystathionine β-synthase (CBS) is essential for homocysteine (Hcy) transsulfuration, yielding cysteine as a common precursor of hydrogen sulfide (H2S), glutathione (GSH), and other sulfur molecules, which produce neuroprotective effects in neurological conditions. We previously reported a disruption of microglial CBS/H2S signaling in a Parkinson's disease (PD) mouse model. Yet, it remains unclear whether CBS affects nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome activity and other pathologies in PD. Results: Microglial CBS expression decreased after lipopolysaccharide (LPS) stimulation. Elevated GSSG (the oxidized GSH) content and decreased H2S generation were found in the brains of microglial cbs conditional-knockout (cbscKO) mice, whereas serum and brain Hcy levels remained unaltered. Moreover, microglial cbscKO mice were susceptible to NLRP3 inflammasome activation and dopaminergic neuron losses caused by LPS injection into the substantia nigra, whereas cbs overexpression or activation produced opposite effects. In vitro studies showed that cbs overexpression or activation suppressed microglial NLRP3 inflammasome activation and interleukin (IL)-1β secretion by reducing mitochondrial reactive oxygen species (mitoROS) level. Conversely, ablation of cbs enhanced NLRP3 expression and mitoROS generation and augmented microglial NLRP3 inflammasome activity in response to adenosine triphosphate challenge, which was blocked by the mitoROS scavenger. Innovation and Conclusion: The study demonstrated an elevated GSSG level and reduced H2S generation, which correlated with a susceptible status of microglia in the brain of cbscKO mice. Our findings reveal a critical role of CBS in restraining the microglial NLRP3 inflammasome by controlling redox homeostasis and highlight that activation or upregulation of CBS may become a potential strategy for PD treatment.

Monitoring disease-implicated hydrogen sulfide in blood using a facile deproteinization-based electrochemiluminescence chemosensor system

Hydrogen sulfide (H2S), an antioxidant and cell signaling molecule, plays a critical role in redox reactions in the biological system, and its imbalances in blood levels have been implicated in various diseases. Here, we demonstrate a novel chemosensor-based “turn-on” electrochemiluminescence (ECL) system for the selective and sensitive detection of H2S in a type 1 diabetes rat model. Our luminogenic chemosensor (Probe) is a redox-stable cyclometalating iridium (III) complex with emission-quenching 2,4-dinitrophenyl ether (DNP) that shows a significant enhancement in emission intensity upon cleavage of DNP by selective reaction towards H2S. To achieve robust and reliable ECL emission of Probe for biological analysis, we developed a facile deproteinization protocol based on organic solvent-induced protein precipitation/syringe filtration that eliminates uncontrolled protein adsorption on the electrode surface from protein-rich biological samples. Our deproteinization-assisted ECL chemosensor system showed effectiveness in detecting disease-associated H2S levels in biological media with a linear response in the range of 0–250 µM (R2: 0.992). It enables reliable in vitro monitoring of H2S level changes in blood samples of a type 1 diabetes rat model (P = 0.0296). This strategy to integrate chemosensor-based ECL and facile deproteinization protocol provides a sensitive and rapid disease-monitoring platform for detecting small-molecule biomarkers.

The Conditions Matter: The Toxicity of Titanium Trisulfide Nanoribbons to Bacteria E. coli Changes Dramatically Depending on the Chemical Environment and the Storage Time.

In this work, we present an analysis of the antibacterial activity of TiS3 nanostructures in water and 0.9% NaCl solution suspensions. TiS3 nanoribbons 1-10 µm long, 100-300 nm wide, and less than 100 nm thick were produced by the direct reaction of pure titanium powder with elemental sulphur in a quartz tube sealed under vacuum. For the toxicity test of a bioluminescent strain of E. coli we used concentrations from 1 to 0.0001 g L-1 and also studied fresh suspensions and suspensions left for 24 h. The strongest toxic effect was observed in freshly prepared water solutions where the luminescence of bacteria decreased by more than 75%. When saline solution was substituted for water or when the solutions were stored for 24 h it resulted in a considerable decrease in the TiS3 antibacterial effect. The toxicity of TiS3 in water exceeded the toxicity of the reference TiO2 nanoparticles, though when saline solution was used instead of water the opposite results were observed. In addition, we did not find a relationship between the antibacterial activity of water suspensions of nanoribbons and the stability of their colloidal systems, which indicates an insignificant contribution to the toxicity of aggregation processes. In 0.9% NaCl solution suspensions, toxicity increased in proportion to the increase in the zeta potential. We suppose that the noted specificity of toxicity is associated with the emission of hydrogen sulphide molecules from the surface of nanoribbons, which, depending on the concentration, can either decrease or increase oxidative stress, which is considered the key mechanism of nanomaterial cytotoxicity. However, the exact underlying mechanisms need further investigation. Thus, we have shown an important role of the dispersion medium and the period of storage in the antibacterial activity of TiS3 nanoribbons. Our results could be used in nanotoxicological studies of other two-dimensional nanomaterials, and for the development of novel antibacterial substances and other biomedical applications of this two-dimensional material.

Spectroscopic study of the F[formula omitted] outer well state in H2, HD and D2

Two-photon UV-photolysis of hydrogen sulfide molecules is applied to produce hydrogen molecules in highly excited vibrational levels in the X1Σg+ electronic ground state, up to the dissociation energy and into the quasibound region. Photolysis precursors H2S, HDS and D2S are used to produce vibrationally hot H2, HD and D2. The wave function density at large internuclear separation is excited via two-photon transitions in the F1Σg+ - X1Σg+ system to probe ro-vibrational levels in the first F1Σg+ outer well state of gerade symmetry. Combining with accurate knowledge of the X1Σg+ (v,J) levels from advanced ab initio calculations, energies of rovibrational levels in the F1Σg+ state are determined. For the H2 isotopologue a three-laser scheme is employed yielding level energies at accuracies of 4×10−3 cm−1 for F(v=0,J) up to J=21 and for some low J values of F(v=1). A two-laser scheme was applied to determine level energies in H2 for F(v=0−4) levels as well as for various F levels in HD and D2, also up to large rotational quantum numbers. The latter measurements in the two-laser scheme are performed at lower resolution and the accuracy is strongly limited to 0.5 cm−1 by ac-Stark effects. For H2 a new quasibound resonance X1Σg+ (v=6, J=23) is detected through the Q(23) and O(23) transitions in the F0-X6 band. Also a quasi-bound resonance in D2 is assigned, for the first time in this species: X1Σg+ (v=17 , J=15). The experimental results on F(v,J) level energies are compared with previously reported theoretical results from multi-channel quantum-defect calculations as well as with results from newly performed non-adiabatic quantum calculations.

Investigation the sensing behavior of pristine and Ti-doped C2N monolayer toward H2S gas

As a group of chemicals and air contaminants, volatile organic compounds or VOCs have a threatening impact upon the ecological environment and the human well-being. One of the encouraging technologies to enrich, separate and use VOCs is their adsorption. Within this study, density functional theory (DFT) computations were undertaken for inspecting how the molecules of VOCs were adsorbed on the pure C2N monolayer (P-C2NML) and the Ti-doped C2N monolayer (T- C2NML) since its specific surface is large and it has a porous structure. The results revealed that the hydrogen sulfide (H2S) molecule could be adsorbed on the P-C2NML with a weak energy of adsorption. However, this adsorption ability could be enhanced by forming a chemical bond which is strong. The best adsorption capacity (AC) for the H2S molecule on the T-C2NML surface with adsorption energy of − 1.987 eV was larger compared with that of the P-C2NML. Moreover, the results of electronic distribution and DOS analysis revealed that doped Ti acted as a bridge between the H2S molecule and the C2NML and strengthen the interaction between them, which can substantially improve the AC. Hence, the T-C2NML can be considered an encouraging adsorbent to enrich and use VOCs.

Thermodynamics of hydrogen sulfide adsorption in Zeolite LiX

Sulfur compounds adversely affect the technological process of oil and gas refining, as well as the release of sulfur-containing compounds into the atmosphere, polluting the environment. Oil and gas processing is carried out using microporous adsorbents with high sorption capacity in the purification of gases containing sulfur. This is one of the most efficient methods in oil refining and gas processing. In research work, the adsorption of gases containing sulfur in their composition is carried out in various ways. When determining the formation complex, the main centers of Li-ionic molecules, it was possible to obtain a more accurate idea of the adsorption mechanism at the stages of absorption of hydrogen sulfide molecules into Li-zeolites using a highly sensitive adsorption calorimeter. In our study, in the process of adsorption of hydrogen sulfide on the LiX zeolite, the results of differential adsorption heat, isotherm, entropy, and thermal equilibrium time (thermokinetics) based on obtained in a high vacuum adsorption device are accurately revealed. Based on exact formulas, it was proved how many hydrogen sulfide molecules are adsorbed in the zeolite that died under vacuum conditions.

Thermodynamics of hydrogen sulfide adsorption in Zeolite Lix

Sulfur compounds adversely affect the technological process of oil and gas refining, as well as the release of sulfur-containing compounds into the atmosphere, polluting the environment. Oil and gas processing is carried out using microporous adsorbents with high sorption capacity in the purification of gases containing sulfur. This is one of the most efficient methods in oil refining and gas processing. In research work, the adsorption of gases containing sulfur in their composition is carried out in various ways. When determining the formation complex, the main centers of Li-ionic molecules, it was possible to obtain a more accurate idea of the adsorption mechanism at the stages of absorption of hydrogen sulfide molecules into Li-zeolites using a highly sensitive adsorption calorimeter. In our study, in the process of adsorption of hydrogen sulfide on the LiX zeolite, the results of differential adsorption heat, isotherm, entropy, and thermal equilibrium time (thermokinetics) based on obtained in a high vacuum adsorption device are accurately revealed. Based on exact formulas, it was proved how many hydrogen sulfide molecules are adsorbed in the zeolite that died under vacuum conditions.

Ab Initio Microkinetics of H2S Interactions with Clean and Sulfided Au(110) at Low Temperature: A Strong Assistance in Partial Dissociation from Single Sulfur Atoms

A microkinetic model built on first-principles calculations is developed to clarify an ongoing experimental controversy regarding whether hydrogen sulfide (H2S) molecules are intact or dissociated on pristine and S-covered Au(110) surfaces at 120 K. From the simulation, we prove that only associative adsorption of H2S on the defect-free, flat (110) facet of gold occurs in the exposure region under investigation, whereas its reaction with sulfur adsorbed as single atoms straightforwardly proceeds to yield relatively strongly bound SH radicals for the surface precovered with elemental S. The sulfur assistance of neighboring H2S to decompose is ascribed to the stability of the corresponding transition state in which three-center hydrogen bonding interactions are being formed. One-dimensional zigzag chains of divalent sulfur are shown as structural units of the c(2 × 4) superstructure observed experimentally in inactive sulfur islands for the S + H2S reaction. The sensitivity of H–S bond cleavage in surface H2S to the aggregation state of coadsorbed sulfur may, in part, be rationalized by the change in valency of these adatoms. This is the first time that a clear theoretical picture of the chemistry of H2S on such an open Au surface is provided, which is beneficial to elucidate more complicated reaction processes, such as sulfur-poisoning tolerance of gold nanocatalysts.

A ratiometric lysosome-targeted fluorescent probe for imaging SO2 based on the coumarin-quinoline-julolidine molecular system

Similar to nitric oxide (NO) molecule, carbon monoxide (CO) molecule and hydrogen sulfide (H2S) molecule, sulfur dioxide (SO2) is also considered to be another important endogenous signaling molecule. SO2 derivatives are widely used as food antioxidants and antimicrobial agents. However, SO2 is also a toxic environmental pollutant and intake of elevated levels of sulfites can lead to diarrhea, low blood pressure and allergic and asthmatic reactions in susceptible people. The specific physiological effects and transformation processes of SO2 and its derivatives are not well understood due to the limitations of existing detection methods. Therefore, it is an urgent need to develop highly sensitive, high-resolution, real-time in situ assays. Herein, we specifically designed a ratiometric near-infrared fluorescent probe CQT for detecting SO2 derivatives. After the reaction of CQT with HSO3−/SO32−, a gradual decrease in red fluorescence at 662 nm accompanied by an enhanced blue fluorescence at 489 nm, reaching a detection range of 2.8–80 μM. In addition, we found that CQT had high energy transfer efficiency, large Stokes shift and low detection limit, which meant that CQT could sensitively monitor small changes of SO2 concentration in cells and accurately target lysosomes.

Influence of heat treatment on H2S gas sensing features of NiO thin films deposited via thermal evaporation technique

In this study, NiO thin films are prepared on Ni foil using thermal evaporation method and the effect of deposition conditions on structural, morphological and H2S gas sensing properties of NiO thin films is investigated. Structural analysis of the NiO films are conducted by means of X-ray diffraction (XRD), and the films are found to have the FCC phase with preferred (111) and (200) Bragg reflections. Based on XRD and scanning electron microscopy results, it is shown that the crystallite size and the size of homogeneous nanoclusters on the surface of the films increase after increasing oxidation temperature. Also, the EDS patterns of NiO films demonstrate a rise in the intensity of O peak upon increasing the oxidation temperature due to the enhancement of oxygen in the NiO films. The Raman spectrum of NiO thin films several bands correspond to Ni–O vibrations. The obtained gas sensing results demonstrate the sensing response to 20 ppm of hydrogen sulfide at 700 °C. Upon increasing the amount of hydrogen sulfide gas to more than 20 ppm, the fabricated sensors show no significant change in their response, indicating that no additional active sites were exist to interplay with hydrogen sulfide molecules for the higher concentration of hydrogen sulfide. The response of the sensors, recorded 10 s after H2S gas exposure, depended on the deposition temperature. The current study shows that NiO thin films-based sensors prepared by a simple thermal evaporation method are potentially useful for the detection of H2S gas.

Probing the chemical reactivity of the B2O3 -I (1 0 1) Surface: Interaction with H2O and H2S

Diboron trioxide is of interest because of its unique unreactive functionality properties. In this work we have studied – via computational first-principle techniques - the adsorption and dissociation mechanisms of two hydrogen chalcogenides, namely water (H2O) and hydrogen sulfide (H2S) molecules, over the B2O3 -I (101) surface. We show that the water molecules undergo dissociative adsorption over diboron via an activation energy of 39 kJ/mol. Furthermore, desorption of both molecularly adsorbed and dissociated structures of water molecules from the B2O3 -I (101) surface requires activation energies of 124–127 kJ/mol. Our investigation on the other hydrogen-chalcogenide compound, i.e. H2S, reveals that diboron trioxide attracts H2S molecules and forms molecular adsorption via sp3 hybridisation between the lone pair electron of the H2S and the empty p orbital of the Bsurf atom without encountering an activation barrier. However, the energy barrier required to dissociate H2S over the B2O3 -I (101) surface appears exceedingly high at 310 kJ/mol. The present insight resolves the two different behaviours of B2O3 concerning hydrogen chalcogenides reported in the literature. While acting as a water scavenger to generate dissociated radicals, it exhibits an inhibitor characteristic towards the dissociation of H2S molecules, representing an ideal reactor wall coating for desired pure gas phase reactions.

Stability and electronic properties of V-doped ruthenium nanoclusters and their adsorptive properties towards hydrogen sulphide and serine molecules

The stability and electronic properties of the RunV (n = 2–10) nanoclusters and their interaction with hydrogen sulphide and serine molecules were conducted using DFT calculations at the PBE/LanL2DZ/6-311G(d,p) level of theory. The results indicate that the Ru3V, Ru5V and Ru7V clusters were found to be more stable than their neighbouring clusters, and the V atom in the binary clusters has been viewed as the most favourable adsorption site for a nucleophilic attack. The interaction of H2S with the clusters easily leads to its dissociation into *SH and *H moieties, indicating that the dissociative adsorption was found to be more favourable than the molecular adsorption. This finding suggest that these clusters could be employed as nanocatalysts for the H2S decomposition reaction. In contrast, the serine adsorption over the surface of the RunV clusters was carried out without dissociation with adsorption energies which vary from - 29.3 to - 58.7 kcal mol−1, suggesting a chemisorption process. The adsorption of the serine molecule on the RunV (n = 3, 7 and 10) clusters causes a significant change in their energy gaps, indicating a high electronic sensitivity of these clusters towards the serine molecule.

Theoretical Study of the Isotope and Homologue Effects on Nuclear Magnetic Shielding in Water and Hydrogen Sulfide Molecules

Abstract The hydrogen/deuterium isotope and oxygen/sulfur homologue effects on the absolute nuclear magnetic shielding constants were theoretically analyzed for five 17O-water isotopologues and five hydrogen sulfide isotopologues. Using both ab initio calculations and anharmonic vibrational structure calculations based on vibrational quantum Monte Carlo theory, we confirmed that the changes in the atomic charges are strongly correlated with the enhancements of the absolute nuclear magnetic shielding constants.

A theoretical study of H2S adsorption and dissociation mechanism on defected graphene doped with Pt

The adsorption and dissociation of hydrogen sulfide (H2S) molecule on Pt or Pt4 cluster doped graphene with different vacancy (VG), as well as their geometric and electronic structures have been investigated by density functional theory (DFT). It has found that H2S and H atom are weakly adsorbed on Pt/Pt4-VG, while HS and S atom are strongly chemisorbed on different surfaces. By using climbing nudged elastic band method (CI-NEB), three elementary processes have been studied: (I) H2S(gas)→H2S(ads); (II) H2S(ads)→HS(ads) + H(ads); (III) HS(ads) → H(ads)+ S(ads). The energy barriers to break the first H–S bond in H2S on four different surfaces (Pt-MVG, Pt-DVG, Pt4-MVG, Pt4-DVG) are 1.69, 0.52, 0.01 and 0.24 eV respectively. In contrast, the energy barriers to break the second H–S bond in HS are 2.34, 1.08, 0.81 and 1.12 eV respectively. It is suggested that the control step of the complete dissociation of H2S is the second H–S bond rupture process. The trend shown in this study reveals that single Pt atom doped defected graphene is favored for adsorption of H2S, but is disadvantage for dissociation. Pt cluster doped defected graphene with bigger vacancy can successfully adsorb and easily eliminate H2S molecule, which is expected to be the ideal material for the adsorption and dissociation.

Исследование механизма взаимодействия бороуглеродного слоя BC3 c компонентами дыма SO2, H2S и CO

In this paper, we have studied the interaction between two-dimensional sheet BC3 with carbon monoxide (CO), hydrogen sulfide (H2S) and sulfur dioxide (SO2) molecules. These molecules are part of a fire smoke and are extremely hazardous to human health. The aim of our study is to find out the possibility of creating a sensor device based on the BC3 sheet material, which is capable to registers the presence of the molecules in the air. Carbon monoxide, which is also carbon monoxide, is considered the most dangerous in the event of a fire. Carbon monoxide, compared to oxygen, can be more effectively adjacent to hemoglobin, which entails a deterioration in the ability of blood to absorb oxygen. In this regard, oxygen starvation occurs. Sulfurous gas (SO2) is colorless, but has a rather sharp smell and is formed if sulfur is contained in combustible or explosive substances. In addition, sulfurous gas is poisonous, and can form sulfuric acid on the surface of the eyes or airways if affected. It can cause swelling of the larynx and lungs, inflammation of the bronchi. A dangerous concentration for life is only 0.05% even with short-term breathing. Hydrogen sulfide (H2S), like sulfur dioxide, is colorless. However, it has a sweet taste and smell. It is able to be released during fires and during rotting of organic substances. Extremely poisonous gas, affects the eyes and airways. A deadly concentration even in the case of short-term breathing is only 0.1%.

Role of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis.

Inflammation is a natural response to tissue injury. Uncontrolled inflammatory response leads to inflammatory disease. Acute pancreatitis is one of the main reasons for hospitalization amongst gastrointestinal disorders worldwide. It has been demonstrated that endogenous hydrogen sulfide (H2S), a gasotransmitter and substance P, a neuropeptide, are involved in the inflammatory process in acute pancreatitis. Cell adhesion molecules (CAM) are key players in inflammatory disease. Immunoglobulin (Ig) gene superfamily, selectins, and integrins are involved at different steps of leukocyte migration from blood to the site of injury. When the endothelial cells get activated, the CAMs are upregulated which leads to them interacting with leukocytes. This review summarizes our current understanding of the roles H2S, substance P and adhesion molecules play in acute pancreatitis.

A Facile Probe for Fluorescence Turn-on and Simultaneous Naked-Eyes Discrimination of H2S and biothiols (Cys and GSH) and Its Application.

Hydrogen sulfide and biothiol molecules such as Cys and GSH acted important roles in many physiological processes. To simultaneously detect and distinguish them was quite necessary by asuitable fluorescent probe. A novel chemosensor 4-(4-(benzo[d]thiazol-2-yl)-2-methoxyphenoxy)-7-nitrobenzo[c][1,2,5]oxadiazole (BMNO) was designed to detect H2S/Cys/GSH using the combination of nitrobenzofurazan (NBD) and benzothiazole fluorophores linked by a facile ether bond. The probe BMNO was developed for simultaneous identification of H2S, Cys and GSH. Noticeably, the color changes (from colorless to light purple, light orange and light yellow) of probe BMNO solutions for sensing H2S, Cys and GSH could be observed by naked eyes, respectively. The probe BMNO exhibited high selectivity and sensitivity for H2S, Cys and GSH showing distinct optical signal with detection limit as low as 0.15μM, 0.03μM and 0.14μM, respectively. The sensing mechanism was clarified by spectrum analysis and some controlled experiments. In addition, these outstanding properties of probe BMNO enabled its practical applications in detection H2S in beer, and in cell imaging for Cys and GSH as well.