This study investigates the efficiency and combustion characteristics of a hydrogen port fuel injection (PFI) spark ignition (SI) engine under various load levels, excess air ratios and intake pressures. Experiments were conducted on a single-cylinder research engine to evaluate the effects of throttle opening and supercharging on pumping work and combustion parameters. The key findings indicate that abnormal combustion events are more closely related to the relative air-fuel ratio (λ) than to load, further limiting load increases during de-throttled operation. Additionally, combustion variability compromised mixture enleanment in both naturally aspirated and supercharged conditions. The gross indicated efficiency was approximately 40.7% across the range of 2.2 < λ < 3.5 with minimal variation. Efficiency gains were linked to reduced heat transfer losses in lean conditions, as validated by computational heat transfer, thermodynamic and fluid dynamic models on Gamma Technologies GT-ISE software. Moreover, nitrogen oxides (NOx) emissions were nearly zero for all test conditions when λ was above 2.2. These findings provide crucial insights into optimizing hydrogen engine performance under various intake pressures, highlighting the potential for achieving high efficiency and low emissions.