Abstract Hydrogen compressed with natural gas pipeline for gas mixture delivery is an effective way to realize large-scale, low-cost delivery of hydrogen. The Internet of Things (IoT) technology is one of the important supporting technologies for smart energy transformation, and the low power wide area network (LPWAN) represented by LoRa will play a key role. In this paper, a LoRa-based hydrogen compressed natural gas safety monitoring system is designed, which can collect, transmit, and analyze multiple types of data, such as ambient temperature and humidity, gas concentration, pipeline and equipment vibration, etc., and store the data and configure the alarm thresholds through the cloud server, and finally complete the real-time safety monitoring in the application layer. The system is characterized by high efficiency, high precision, low power consumption, and intelligence, which will have a positive effect on the safe transportation of hydrogen.