Hydrogel Films Research Articles

Sensitivity-enhanced optical fiber probe-type humidity sensor based on CaAlg film

Optical fiber probe-type humidity sensors based on calcium alginate (CaAlg) hydrogel films are proposed. The sensor is based on the Michelson interferometer (MI) and constructed by splicing a tapered multimode fiber (MMF) in the middle of two single-mode fibers (SMFs). One of the 1.5 cm long SMFs is coated with CaAlg hydrogel film and can be regarded as the sensor probe. The sensitivity of the sensor is 0.31015 nm/%RH. The high sensitivity, low temperature crosstalk, compact probe structure, and stability of the sensor allow it to be used for humidity monitoring in a variety of complex environments.

Tailoring smart hydrogels through manipulation of heterogeneous subdomains

The mechanical interactions among integrated cellular structures in soft tissues dictate the mechanical behaviors and morphogenetic deformations observed in living organisms. However, replicating these multifaceted attributes in synthetic soft materials remains a challenge. In this work, we develop a smart hydrogel system featuring engineered stiff cellular patterns that induce strain-driven heterogeneous subdomains within the hydrogel film. These subdomains arise from the distinct mechanical responses of the pattern and film domains under applied mechanical forces. Unlike previous studies that incorporate reinforced inclusions into soft matrices to tailor material properties, our method manipulates the localization, integration, and interaction of these subdomain building blocks within the soft film. This enables extensive tuning of both local and global behaviors. Notably, we introduce a subdomain-interface mechanism that allows for the concurrent customization and decoupling of mechanical properties and shape transformations within a single material system—an achievement rarely accomplished with current synthetic soft materials. Additionally, our use of in-situ imaging characterizations, including full-field strain mapping via digital imaging correlation and reciprocal-space patterns through fast Fourier transform analysis of real-space pattern domains, provides rapid real-time monitoring tools to uncover the underlying principles governing tailored multiscale heterogeneities and intricate behaviors.

Surface Molding Hydrogel Film Initiated by ZIF-8 with Ethylene Adsorption Performance for Preserving Perishable Fruits.

The quality deterioration of postharvest fruits is greatly influenced by ethylene, leading to food wastage worldwide. Therefore, it is urgent to develop an efficient packaging strategy to reduce ethylene concentration and prolong the shelf life of perishable fruits. In this work, a surface-molding hydrogel film was created using ZIF-8 in combination with carboxymethyl starch (CMS) and carboxymethyl chitosan (CMCS). Specifically, ZIF-8 is first anchored on CMS and then rapidly cross-linked in situ with CMCS, forming ZIF-8@CC on the fruit surface (within 10 s). The perfect tight-fitting effects of ZIF-8@CC were observed on various fruit surfaces with different roughness (Ra: ranges from 102 to 308 nm). ZIF-8@CC could absorb 57.3% endogenous ethylene from bananas, and the interaction mechanism between ethylene and ZIF-8 was studied by molecular dynamics simulations, providing insights into the ethylene adsorption capacity of ZIF-8@CC. Moreover, ZIF-8@CC presented excellent antibacterial properties and achieved satisfactory ultralong preservation effects on both nonclimatic and climatic fruits (12 days for strawberries and 14 days for bananas) at room temperature. Importantly, ZIF-8@CC is easily removed, washed, and degradable. These findings offer an efficient and potential food packing material with multifunctional properties for preserving perishable fruits.

Hydrogel Films with Impact Resistance by Sacrificial Micelle-Assisted-Alignment.

Various strategies are developed to engineer aligned hierarchical architectures in polymer hydrogels for enhanced mechanical performance. However, chain alignment remains impeded by the presence of hydrogen bonds between adjacent chains. Herein, a facile sacrificial micelle-assisted-alignment strategy is proposed, leading to well-aligned, strong and tough pure chitosan hydrogels. The sacrificial sodium dodecyl sulfate micelles electrostatically interact with the protonated chitosan chains, enabling chain sliding and alignment under uniaxial forces. Subsequently, sacrificial micelles can be easily removed via NaOH treatment, causing the reforming of H-bond in the chain networks. The strength of the pure chitosan hydrogels increases 140-fold, reaching 58.9±3.4MPa; the modulus increases 595-fold, reaching 226.4±42.8MPa. After drying-rehydration, the strength and modulus further rise to 70.3±2.4 and 403.5±76.3MPa, marking a significant advancement in high-strength pure chitosan hydrogel films. Furthermore, the designed multiscale architectures involving enhanced crystallinity, well-aligned fibers, strong interfaces, robust multilayer Bouligand assembly contribute to the exact replica of lobster underbelly with impact resistance up to 6.8±1.0kJ m-1. This work presents a promising strategy for strong, tough, stiff and impact-resistant polymer hydrogels via well-aligned hierarchical design.

Physiochemical and In-Vitro Bioactivity Characterization of Polyvinyl Alcohol / Halloysite Nanotube / Collagen (PVA/HNT/Col) using Freeze-Thawing Method and Spin Coated Technique for Wound Healing Applications

Hydrogels are still relevant instruments that can support and improve the dynamic biological process of wound healing. This paper modified hydrogel film by combining polyvinyl alcohol (PVA), halloysite nanotube (HNT), and collagen using simple freeze-thawing and spin-coating techniques. The modification aims to improve the physiochemical and in-vitro bioactivity of the PVA/HNT hydrogel films via the inclusion of different concentrations of collagen. 0.092 mm PVA/HNT/Col3 hydrogel film was suggested to have excellent morphological properties with 94.11 % porosity. It also has good tensile properties with excellent hydrophilicity performance at 38.40o contact angle and 83.528% swelling capacity compared to other modified films. In-vitro bioactivity suggested that the PVA/HNT/Col3 are safe and non-toxic toward host tissue and can promote healing at 93.12% wound closure after 24 hours of treatment. Hence, this material displays huge potential as a wound healing matrix template.

Synthesis and characterization of novel carboxymethyl tamarind kernel gum - Poly (vinyl alcohol)/guar gum-based hydrogel film loaded with ciprofloxacin for biomedical applications

The current study delineates the synthesis of hydrogel films comprised of carboxymethyl tamarind kernel gum (CMTKG), poly (vinyl alcohol) (PVA), and guar gum (GG) using glutaraldehyde (GL) as cross-linker. The hydrogel films were evaluated in terms of equilibrium swelling ratio (ESR), moisture content, thickness, wetting analysis, thermal, and mechanical analysis. The tensile strength value lies in the range of 95.80 to 149.07 MPa while elongation at break value lies in the range of 1.51 to 5.20 %. The FTIR spectroscopy confirmed the presence of hydrogen bonding between CMTKG, PVA, and GG components of hydrogel film. FE-SEM micrographs indicated the rough surfaces of hydrogel film. TGA-DTA analysis confirmed that the thermal stability of hydrogel film was found to be increased by incorporating the ciprofloxacin (CFX) drug into the hydrogel matrix. CFX was embedded in the best-swelled hydrogel film and in-vitro drug release behavior was studied at alkaline pH 7.4 phosphate buffer solution. It was found that the maximum drug release was to be 73 % after 24 h at pH 7.4. Moreover, the release data was fitted in various kinetic models such as the First-order, Higuchi, and Korsmeyer-Peppas models. The best-fitted Korsmeyer-Peppas model suggested that the release of the drug follows Fickian diffusion and the value of diffusion exponent (n) was determined to be 0.38. The cytocompatibility of the hydrogel film was analyzed by MTT assay while the antibacterial behavior of the hydrogel film against E. coli and S. aureus showed clear zone of inhibition area. Thus, the overall results indicated that CMTKG/PVA/GG hydrogel film have potential to be used in the biomedical applications.

Preparation and characterization of an antibacterial CMC/PCL hydrogel films containing CIP/Cur: In vitro and in vivo evaluation of wound healing activity

Wound healing process significantly impeded by prolonged inflammation responses, infection at the wound site, and insufficient angiogenesis. The sustained release of anti-inflammation and anti-bacterial drugs has the potential to control immune responses, improve angiogenesis, accelerate wound healing, and re-epithelialization. In this research a multifunctional hydrogel containing carboxy methyl cellulose (CMC) and polycaprolactone (PCL), along with Ciprofloxacin (CIP) and Curcumin (Cur) was developed. Physicochemical characteristics as well a biological one such as antibacterial and drug release properties, Collagen deposition, inflammatory responses, angiogenesis, and epidermal regenerated thickness were investigated via in vitro and in vivo assay. The results revealed that the CMC/PCL-based wound dressing has the potential to provide an appropriate level of water absorption (~300 %) to absorb wound exudate and ideal WVTR in range of 2279–2363 g/m2 for wound healing application. Addition of CIP and Cur to CMC/PCL hydrogel improved the skin cell proliferation, cell migration, and antibacterial activity. It also led to superior Collagen I synthesis (~2–4 times), controlled pro-inflammatory and improved anti-inflammatory cytokine secretion of macrophages, and accelerated wound healing in comparison to CMC/PCL hydrogel. In conclusion, the engineered multifunctional hydrogel showed a potential effect for accelerating wound healing and skin regeneration.

Carboxymethyl chitosan/polyvinyl alcohol hydrogel films by incorporating MSNs as ε-PL carrier with pH-responsive controlled release and antibacterial properties

A hydrogel film with pH-responsive release and excellent antibacterial properties was developed by utilizing mesoporous silica nanoparticles (MSNs) as carriers for ε-PL. Carboxymethyl chitosan (CMCS) is grafted onto aminated-MSNs through amine-bond reaction mediated, which is subsequently bound to polyvinyl alcohol (PVA) by esterification reaction. The addition of MSNs and optimization of CMCS proportion improved the dispersion stability of CMCS/PVA, resulting in a TSI value of 0.6 for 1.6CMCS/0.8PVA@MSNs-ε-PL, which is significantly lower than other groups. The proportion increase of CMCS improved the thermal stability and water oxygen barrier capacities of the 1.6CMCS/0.8PVA@MSNs-ε-PL by enhancing cross-linking with MSNs. The 1.6CMCS/0.8PVA@MSNs-ε-PL exhibited pH-responsive release behavior, with the extent of release increasing proportionally with higher pH levels. The 1.6CMCS/0.8PVA@MSNs-ε-PL exhibited significant antibacterial activity against Pseudomonas azotoformans MN10 in vitro, attributed to the ε-PL's ability to damage the bacterial membrane structure. Hence, the 1.6CMCS/0.8PVA@MSNs-ε-PL exhibits significant potential in food preservation.

Tough strippable hydrogel films based on acrylic acid/acrylamide/zirconyl chloride for surface radioactive decontamination at low temperatures

Strippable films are extensively utilised for the decontamination of radioactive surfaces because of their cost-effectiveness, ease of operation, and minimal liquid waste. However, traditional strippable detergents are formulated for use at normal ambient temperatures and typically lose their efficacy at low temperatures because of poor performance or excessively long film-forming time. In this study, we have developed an anti-freezing and sprayable AMZW detergent based on acrylic acid (AA), acrylamide (AM), zirconyl chloride octahydrate (ZrOCl2·8H2O), and water (H2O), which possesses a freezing point of approximately −34 ℃ due to the solvation interaction between Zr4+ and H2O. Even at temperatures as low as −25 ℃, the AMZW detergent can be easily sprayed using a conventional apparatus and rapidly cured into a strippable hydrogel film under irradiation by 365 nm UV LED light (LED@365 nm), household LED panel light, or sunlight. The coordination bond formed between Zr4+ and the carboxyl group of the polymer chain imparts excellent mechanical properties to the hydrogel while the carboxyl group can complex with uranyl nitrate hexahydrate (UO2(NO3)2·6H2O)—a radioactive simulant. As a result, the strippable hydrogel film demonstrates high tensile strength (6.1 ∼ 19.3 MPa), excellent flexibility (elongation of 90 ∼ 855 %), moderate peel strength (0.05 ∼ 3 N/cm, room temperature (RT)), and high decontamination efficiency (>91.6 % on stainless steel and glass; >81.3 % on concrete) over a wide range of temperatures (−25 ∼ 25 ℃). This work presents a novel approach for producing anti-freezing, fast-forming, flexible, and high-strength strippable hydrogel films for surface radioactive decontamination at low temperatures.

Preparation and Properties of Crosslinked Quaternized Chitosan-Based Hydrogel Films Ionically Bonded with Acetylsalicylic Acid for Biomedical Materials.

The aim of the current study is to develop chitosan-based biomaterials which can sustainably release acetylsalicylic acid while presenting significant biological activity. Herein, an innovative ionic bonding strategy between hydroxypropyl trimethyl ammonium chloride chitosan (HACC) and acetylsalicylic acid (AA) was proposed, skillfully utilizing the electrostatic attraction of the ionic bond to achieve the controlled release of drugs. Based on this point, six crosslinked N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan acetylsalicylic acid salt (CHACAA) hydrogel films with varying acetylsalicylic acid contents were prepared by a crosslinking reaction. The results of 1H nuclear magnetic resonance spectroscopy (1H NMR) and scanning electron morphology (SEM) confirmed the crosslinked structure, while the obtained hydrogel films possessed favorable thermal stability, mechanical properties, and swelling ability. In addition, the drug release behavior of the hydrogel films was also investigated. As expected, the prepared hydrogel films demonstrated the capability for the sustainable release of acetylsalicylic acid due to ion pair attraction dynamics. Furthermore, the bioactivities of CHACAA-3 and CHACAA-4 hydrogel films with acetylsalicylic acid molar equivalents of 1.25 and 1.5 times those of HACC were particularly pronounced, which not only exhibited an excellent drug sustained-release ability and antibacterial effect, but also had a higher potential for binding and scavenging inflammatory factors, including NO and TNF-α. These findings suggest that CHACAA-3 and CHACAA-4 hydrogel films hold great potential for applications in wound dressing, tissue engineering scaffolds, and drug carriers.

Preparation and characterization of smart hydrogels (magnetic field responsive)

Iron nanoparticles were prepared by using the co-precipitation process, and then used to fabricate magnetic field-responsive hydrogel films. The magnetic nanoparticles' structural, physical-chemical, morphological, and magnetic characteristics and the effect of hydrogel films' coating concentration were studied. The properties of the hydrogel film responsive to the magnetic field were investigated using Fourier analysis spectroscopy infrared (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and a vibration sample magnetometer (VSM). The results indicated that all samples showed good inter-integration of the constituent materials and their functional groups. The hydrogel film samples which were polycrystalline, had broad diffraction peaks and showed constant particle size with nearly spherical particles with rounded edges. The SEM image of the magnetic nanoparticles with and without coating was established for the accumulation of numerous nanoparticles with a 17 nm mean diameter. In addition, the magnetic properties of the magnetic field-sensitive hydrogel films were evident and sufficient for drug delivery to the desired location.

Development of cellulose-based self-healing hydrogel smart packaging for fish preservation and freshness indication

Biomass-based composite packaging materials loaded with functional fillers have good application prospects in food preservation and freshness detection. Self-healing hydrogel packaging films based on nanocellulose (CNF), polyvinyl alcohol (PVA), and ZIF-8 embedded with curcumin (Cur@ZIF-8) were developed in this study. The synthesis of Cur@ZIF-8 was demonstrated by characterization experiments. The addition of Cur@ZIF-8 enhanced the water vapor barrier property, tensile strength, and elongation at break of hydrogel films by 49.2 %, 193.5 %, and 172.9 %, respectively, and endowed them with excellent antimicrobial, antioxidant, and ammonia sensitivity. In packaging tests with fish, hydrogel films loaded with Cur@ZIF-8 inhibited spoilage and microbial growth to extend the shelf life of fish to 9 days, and the color change of hydrogel films allowed for real-time monitoring of fish freshness. This study provided a new solution for smart packaging materials with dual functions of preservation and freshness indication.

Optimized Incorporation of Silver Nanoparticles onto Cotton Fabric Using k-Carrageenan Coatings for Enhanced Antimicrobial Properties.

The incorporation of bactericidal properties into textiles is a widely sought-after aspect, and silver nanoparticles (AgNPs) can be used for this. Here, we evaluate a strategy for incorporating AgNPs into a cotton fabric. For this purpose, a bactericidal textile coating based on a composite of AgNPs and kappa-carrageenan (k-CA) was proposed. The composite was obtained by heating the silver precursor (AgNO3) directly in k-CA solution for green synthesis and in situ AgNPs stabilization. Cotton substrates were added to the heated composite solution for surface impregnation and hydrogel film formation after cooling. Direct synthesis of AgNPs on a fabric was also tested. The results showed that the application of a coating based on k-CA/AgNPs composite can achieve more than twice the silver loading on the fabric surface compared to the textile subjected to direct AgNPs incorporation. Furthermore, silver release tests in water showed that higher Ag+ levels were reached for k-CA/AgNPs-coated cotton. Therefore, inoculation tests with the bacteria Staphylococcus aureus (SA) using the agar diffusion method showed that samples covered with the composite resulted in significantly larger inhibition halos. This indicated that the use of the composite as a coating for cotton fabric improved its bactericidal activity against SA.

On-demand removable hydrogel film derived from gallic acid-phycocyanin and polyvinyl alcohol for fruit preservation

Postharvest spoilage of fruits accounts for significant losses ranging between 20 %–30 %, leading to considerable resource wastage and economic downturns. The development of an effective fresh-keeping packaging material is of paramount importance. This study introduces an innovative on-demand removable active fruit fresh-keeping film (GPP), created by embedding a GP (gallic acid-phycocyanin) fiber mesh hydrogel with functional properties into a polyvinyl alcohol (PVA) matrix. The resultant GPP hydrogel-based film demonstrates outstanding UV and water vapor barrier capabilities, mechanical stability, resistance to external mechanical stress, universal surface adhesion, antibacterial efficacy, and on-demand removal attributes, while being devoid of potential toxicity hazards. Utilizing grapes and blueberries as representative fruits, it is shown that the GPP hydrogel film significantly preserves the fruits' hardness, pH, total soluble solids content (TSS), and minimizes the rate of weight loss, thereby prolonging the shelf life to 13 days for grapes and 20 days for blueberries at ambient temperature. These results underscore the potential of this hydrogel-based film as an invaluable material for fruit preservation within the food industry.

Multi-Optical-State Hydrogel Film with a Nanometer-Sized Inverse Quasi-Amorphous Array for Information Security

Multi-Optical-State Hydrogel Film with a Nanometer-Sized Inverse Quasi-Amorphous Array for Information Security

Preparation, Physicochemical Properties, and Antibacterial Activity of Hydrogel Films Based on Starch and Poly(Vinyl Alcohol) with Added Ethonium

Preparation, Physicochemical Properties, and Antibacterial Activity of Hydrogel Films Based on Starch and Poly(Vinyl Alcohol) with Added Ethonium

Sustainable solution for wastewater management: Fabrication of cost-effective β-cyclodextrin incorporated chitosan polyvinyl alcohol composite hydrogel film for the efficient adsorption of anionic congo red and tartrazine dyes

Dyes are an integral part of leather, textiles, food, and packaging materials, providing aesthetic appeal to the finished article. These industries use large amounts of water, creating wastewater with harmful, toxic, and hazardous pollutants, posing significant health and environmental risks to the public and ecological system. Therefore, to resolve this issue, a superabsorbent β-cyclodextrin incorporated chitosan polyvinyl alcohol cross-linked with citric acid composite hydrogel film (β-CD/Ch/PVA) has been developed for the effective adsorption of congo red (CR) and tartrazine dyes (TG). The Fourier-transform infrared spectroscopic (FTIR) analysis confirmed the presence of –OH, –NH2 functional groups in hydrogel film. The rough surface morphology was obtained through Field emission scanning electron microscopic (FESEM) analysis. Brunauer-Emmett-Teller (BET) method gave the surface area of hydrogel, which is 17.34 m2/g with pore diameter of 4.12 nm, indicating its mesoporous nature. Adsorption parameters like contact time, temperature, pH, initial concentration of dyes, and dosage of hydrogel have been optimized by batch adsorption studies and the Box-Behknen Design Model. In batch experiments, the hydrogel film effectiveness was confirmed, achieving high removal efficiencies of 95.38 % and 96.3 % for CR and TG dyes at pH 7 and 6, respectively. The adsorption process followed the pseudo-second-order kinetics and Langmuir model at room temperature for both dyes, and the maximum adsorption capacity was found to be 366.34 mg/g, 1436.04 mg/g for CR and TG dyes, respectively. The thermodynamic study revealed that the adsorption of dyes was spontaneous and endothermic in nature. The electrostatic interactions and hydrogen bonding between the hydrogel and dye molecules were responsible for the adsorption. This hydrogel film can be reused for 5 consecutive adsorption–desorption cycles for both dyes, maintaining upto 85 % in removal efficiency. Hence, the synthesized β-cyclodextrin incorporated chitosan polyvinyl alcohol composite hydrogel film holds great potential for the remediation of wastewater effluents and addressing environmental issues.

Fast Responsive and Highly Sensitive Ethanol Gas Sensors Designed by Agar‐Laponite Hybrid Hydrogels

AbstractLaponite, a synthetic nanosilicate clay and agar, a natural polysaccharide, both imbibe large amount of water and form into hydrogels. Various physical and chemical stimuli elicit the hydrogel response, which has been applied in designing diverse sensors and biomedical systems. In this work, we exploit the change in hydrogel's ionic conductivity due to volatile organic compounds (VOCs) (e. g. ethanol) interaction with the surfaces of Laponite‐Agar hybrid hydrogel films. Gas sensing studies are carried out on silicon (Si) and flexible polyethylene terephthalate (PET) substrates by monitoring the resistance changes. Pristine Laponite hydrogel has shown increase in resistance as it interacted with the ethanol, whereas pure agar and Laponite‐Agar have shown decrease in resistance. Moreover, Laponite‐Agar gel films have exhibited high sensitivity, fast response (4 s) and recovery time (15 s) with lowest detection limit of 6 ppm. Selectivity test carried shows high ethanol sensing response and exhibited very good reproducibility. Observed responses and sensing mechanism are discussed based on changes in ionic conduction resulted due to interacting ethanol with the gel surface network structure. Present study paves the way for understanding and designing low cost, soft and flexible hydrogel gas sensors.

Fabrication of MIL-101(Fe)-embedded biopolymeric films and their biomedical applications

AbstractThe development of wound-dressing materials with superior therapeutic effects, controlled bioactive agent release, and optimal mechanical properties is crucial in healthcare. This study introduces innovative hydrogel films designed for the sustained release of the local anesthetic drug Procaine (PC), triggered by pH changes. These films are composed of MIL-101(Fe) particles and pectin polymers. MIL-101(Fe) was chosen for its high surface area, stability in aqueous environments, and biocompatibility, ensuring low toxicity to normal cells. MIL-101(Fe)-embedded-pectin hydrogels were synthesized and characterized using Fourier-transformed infrared (FTIR) spectroscopy, thermal gravimetric analysis (TGA), scanning electron microscopy (SEM), X-ray diffraction (XRD), inductively coupled plasma (ICP) spectrometry, particle size analysis, and goniometry. Rheological analysis assessed the hydrogels’ viscoelastic behavior, and UV-spectrophotometry was utilized for drug loading and release studies. The hydrogels exhibited shear-thinning properties, enhancing shape adaptability and recovery, crucial for wound-dressing applications. Controlled drug release was achieved by maintaining the PC solution’s pH between 8.2 and 9.8 during the drug-loading step. The hydrogel film’s impact on wound healing was evaluated through an in vitro wound healing assay, and cytotoxicity was assessed using a WST-1 cell proliferation assay with human dermal fibroblast cells. Results demonstrated that pectin composites enhance cell viability and support fibroblast cell migration without adverse effects, indicating their potential for effective wound healing applications. This study highlights the potential of MIL-101(Fe)-embedded-pectin hydrogels in advancing wound care technology. Graphical Abstract MIL-101(Fe)-embedded pectin film as wound dressing

Fiber-optic drug delivery strategy for synergistic cancer photothermal-chemotherapy

Chemotherapy is one of the conventional treatments for cancer in clinical practice. However, poor delivery efficiency, systemic toxicity, and the lack of pharmacokinetic monitoring during treatment are the critical limitations of current chemotherapy. Herein, we reported a brand-new antitumor drug delivery strategy that harnesses an optical fiber endoscopically therapeutic probe. The fiber probe carries photosensitizers in the fiber core and antitumor agents on the fiber surface mediated by a temperature-responsive hydrogel film, giving rise to an activable photothermal-chemotherapy that orchestrates the localized hyperthermia and thermal-stimuli drug release to the tumor lesion. Furthermore, the dynamical drug release and in-situ temperature can be real-time supervised through the built-in fiber sensors, including the reflective Mach–Zehnder interferometer and fiber Bragg grating, to visualize the therapy process and thus improve the safety of treatment. Compared with conventional methods, the fiber-optic drug delivery can adequately take advantage of the chemotherapeutics through collaboratively recruiting the photoheating-mediated enhanced permeability and the hydrogel particle-assisted high drug retention, shedding new light on a “central-to-peripheral” drug pervasion and retention mechanism to destroy tumors completely. The fiber-optic chemotherapy strategy incorporates precise drug delivery, accurate controllability of drug release, high drug permeability and retention in tumor, low off-target rate, and real-time drug release and temperature feedback, performing a straightforward and precise photothermal-chemotherapy pathway. More than that, the proposed strategy holds tremendous promise to provide a revolutionized on-demand drug delivery platform for the highly efficient evaluation and screening of antitumor pharmaceuticals.