Due to the typically high flow rate of nozzles on large sprinkler machines, direct use for pesticide application can lead to pesticide waste and non-point source pollution. To fulfill the multifunctional needs of large sprinkler machines for irrigation, fertilization, and pesticide application, this study installed atomizing micro-sprinklers on the machines to enable their pesticide application capabilities. Based on the spraying patterns of the atomizing micro-sprinklers, three types were selected for this study: hollow cone, solid cone, and fan-shaped micro-sprinklers. Three working pressure levels were set at 0.2 MPa, 0.3 MPa, and 0.5 MPa, with the height of the micro-sprinklers above the ground set at three levels: 0.8 m, 1.2 m, and 1.5 m. A completely randomized design was used for the experiment, which included hydraulic performance tests and software simulation. The results indicated that the spray volume of the hollow cone, solid cone, and fan-shaped atomizing micro-sprinklers approximately presented a hollow conical, solid conical, and normal distribution, respectively. The spray intensity (average and maximum values) of the atomizing micro-sprinklers increased with the increase in pressure, while the median showed an initial increase followed by a decrease as pressure increased. Under the same pressure conditions, the spray intensity of the different atomizing micro-sprinklers decreased with the increase in height above the ground, while the spray width increased with height. By comparing the spraying characteristics of micro-sprinklers with various patterns, large sprinkler machines can select atomizing micro-sprinklers in different spraying statuses according to actual conditions and determine the optimal height of the atomizing micro-sprinklers above the ground to achieve efficient and uniform pesticide application effects. This reduces the evaporation and drift loss of liquid medicine. The research findings provide a scientific basis for achieving the pesticide application function of large sprinkler machines and expanding their usage capabilities.