A bridge hybrid isolation system, integrating both active and passive control strategies, is proposed and investigated to enhance seismic performance. The system is modeled as a two-layer structure, with the upper layer subjected to active control via a Proportional–Integral–Derivative (PID) controller, and the lower layer employing a conventional passive base isolation system. The displacement response of the superstructure is minimized by the control forces generated by the PID controller, which also accounts for the reaction forces transmitted to the lower isolation layer. To optimize the controller’s performance, a genetic algorithm is implemented for real-time tuning of the PID parameters. Numerical simulations, conducted using the Newmark method, are employed to assess the influence of active control on the lower isolation system. The results reveal that, while active control increases the peak displacement of the superstructure to some extent, it significantly prolongs the structural period, thus enhancing the system’s overall seismic resilience and stability.