To obtain the lower toxic residue on the medical titanium alloy surface in chemical mechanical polishing process, a new green polishing solution was proposed and evaluated in this study. The humoral fluid was selected as the basic solution in which the silica abrasive particles were used for the grinding particles, and the H2O2 was added as the oxidant. A chemical mechanical polishing test was carried out for its performance investigation with titanium alloy material. Then the surface roughness and material remove ratio of test samples were analyzed and compared with that of existed polishing solution condition. At last, the toxic residue of the titanium alloy samples was obtained by scanning electron microscopy technology. The experimental results indicated that the better material removal rate and surface roughness of medical titanium alloy with humoral polishing solution are obtained comparing with existed polishing solution condition. More importantly, the content of toxic elements on the sample surface was significantly reduced due to the more aluminum and vanadium ions dissolved in polishing solution, which is more beneficial for its application in the medical prosthetics field. This study provides a new reference for the toxic residue reduction on the material surface of medical titanium alloy in chemical mechanical polishing process.