The human state in human–machine systems should be monitored to improve system performance. In monitoring it is preferable to use physiological cues such as skin temperature. The sensing capabilities of human skin were analyzed. The sensing system of human skin was modeled, and inspired the design of a Nano-Skin for physiological measurement in dynamic human–machine contact for human state recognition. The Nano-Skin involves a flexible bottom layer, sensors, special integrated circuit, interconnection between sensors and special integrated circuit, and flexible top layer. The requirements for the sensors of a Nano-Skin are summarized, and compared with common sensors, MEMS sensors, and nano sensors. A Nano-Skin with deposited platinum was manufactured. The manufacturing process is shown to be feasible and repeatable. The Nano-Skin with deposited platinum was used to measure skin temperature. Its performance was investigated using experiments. The results verified that the accuracy of the Nano-Skin sensors will not be lower than Pt1000Ω. Smaller sensors in a Nano-Skin generally have better performance.