The aim of this study is to examine the stress and pressure experienced by individuals working in human resources, focusing on the unique challenges that this work entails. This research is therefore guided by the question: what are the characteristics of work-related stress and burnout for individuals working in human resources? This study employed a mixed-methods approach, incorporating both qualitative and quantitative research methods. Initially, semi-structured interviews were conducted with eight human resources professionals, comprising an equal number of women and men. Subsequently, a survey was administered to a broader group of human resources personnel. The quantitative analysis utilized the “Copenhagen Burnout Inventory” as a measurement tool, alongside background questions regarding the participants’ gender, age, job title, field of work, and seniority. The findings from both the qualitative and quantitative research indicate that employees in human resource roles exhibit significant stress symptoms. A majority of the interviewees reported experiencing mental and/or physical symptoms attributable to work-related stress. Specifically, the quantitative data revealed that 65.7% of the participants sometimes or often feel mentally exhausted, while 40.3% report similar levels of physical exhaustion. Notably, despite these challenges, only 8.7% of the participants identify as being burnt-out in their roles. The quantitative results also highlight gender as a significant factor affecting the mental and physical well-being of human resources employees, with women reporting lower levels of well-being compared to men.