Human-nonhuman Animal Research Articles

489 Increase in Broadband Power Is an Electrophysiologic Marker of Focal Thalamic Activity During Movement

INTRODUCTION: The architecture of the human thalamus is currently indirectly inferred from human histopathologic and non-human animal studies. Given that movement-related increases in broadband power from electrocorticography recording have been previously shown to identify specific motor cortical subregions involved with a particular movement, we explored whether this phenomenon can also be used to localize motor subregions of thalamus. METHODS: We performed serial human thalamic local field potentials recordings using an electrode moved through the lateral thalamusduring deep brain stimulation surgery in 10 subjects. During the recording at each location, subjects alternated between 5 second epochs of rest and 5 second periods of contralateral hand movement. Power spectra were generated for each epoch using Welch’s overlapping periodogram method (1 second window, 50% overlap). Spectra from all movement and rest epochs were separately averaged. The difference between the power in the 65 to 95 Hz band during movement versus rest was used as a proxy for task-related change in broadband activity. Task-related differences in prominent low-frequency oscillations (patient-specific sub-ranges within 5 to 30 Hz) were analyzed per individual oscillation and in aggregate. Significance was determined using unpaired T tests at a threshold of p = 0.05. RESULTS: We find that recording sites showing statistically significant increases in broadband power during movement tend to tightly cluster in areas predicted to represent motor thalamus, whereas sites showing statistically significant reduction in the power (desynchronization) of low frequency oscillations are more diffusely distributed. This finding is replicated across all subjects. CONCLUSIONS: These results suggest that a task-dependent increase in broadband power is an electrophysiologic marker of focal thalamic activity and may be useful to delineate specific thalamic subregions on an individual subject basis.

MIGRACIONA LIRIKA U NASTAVI KNJIŽEVNOSTI NA NEMAČKOM JEZIKU: TEORIJSKI OKVIR I PREDLOZI DIDAKTIZACIJE

The paper presents an analysis of the novel Memoirs of a Polar Bear (Etüden im Schnee, 2014) by Japanese-German author Yōko Tawada (多和田葉子) in light of the theories of migration literature and ecocriticism. The migration literature is in the broadest sense literature about migration, while ecocriticism studies the representations of nature and ecological issues in literature and art, including the study of the literary human-nonhuman animal depictions. The goal of the paper is to provide insight into the existing research of the novel, as well as to emphasize the necessity of an interdisciplinary approach to the interpretation which would take into account the animal experience of the migration phenomenon in order to examine the traditional marginalization of the animal Other, the contemporary efforts to perceive the perspective of a nonhuman being and the constant process of movement: as part of the circus, as part of a particular animal species and as an everyday part of life in our Eurocentric and anthropocentric world.

Eating E.T.: Carnism and Speciesism

This article takes as its point of departure an event in which a plant-based version of the space alien, the Extra-Terrestrial (‘E.T.’), from the science fiction film bearing its name, was barbecued and served as a meal to participants at a conference. The soy dish produced different reactions: some laughed, while others seemed appalled. These different sentiments provide the basis for a broad green cultural criminology analysis of the traditions of meat-eating, tracing its role in human history and in the barbecue. The purpose of this is to explore why humans treat different categories of animals so differently. To understand the reactions the meal produced, the article addresses two contrasting aspects of the human–non-human animal relationship—‘carnism’ and ‘pet-keeping’—and contemplates these in relation to the reactions to eating E.T. The goal is to expand on the study of the human–animal relationship, particularly speciesism—understood as ideology and practice that legitimise and produce animal abuse through the analytical concept categorical discriminatory speciesism.

A history of whales in contemporary Brazil: A study of media reports on deaths of cetaceans

This essay seeks to understand the sensitive responses of contemporary perspectives and experiences in dealing with whales washed up on beaches killed largely by plastic pollution in our seas and oceans. Identified in Brazilian online mass-circulation periodicals and denounced by environmentally engaged art, the interactions between the bodies of whales and culture are interpreted in the light of studies of the history of human–non-human–animal relationships, human sensibilities triggered by this contact, and media reports denouncing the current environmental crisis and raising awareness of the importance of protecting species, in this case cetaceans. Through the Brazilian periodical press, one can see, in the record of whale deaths, the sensitivity toward non-human animals and the concern with the explanations of this phenomenon.

Toward Comparative Collective Behavior to Discover Fundamental Mechanisms Underlying Behavior in Human Crowds and Nonhuman Animal Groups

This article provides comparative perspectives on collective behaviors that are widely found throughout the animal kingdom, ranging from insect and crustacea swarms, fish schools, bird flocks, and mammal herds to human crowds. Studies of nonhuman animal and human collective behaviors have progressed almost separately even though they have a similar history. Theoretical studies have investigated the reproduction of collective phenomena from simple inter-individual rules, and subsequent empirical and experimental studies have found diverse and complex collective behaviors that are difficult to explain with classical theoretical models. As a consequence, a wide variety of interaction rules have been proposed. To determine models to be implemented in nature and find fundamental mechanisms of collective behaviors, this paper argues that we should compare collective behaviors among various species while adopting Tinbergen’s four questions regarding mechanism, function, development, and evolution as a methodological basis. As an example of a comparative collective behavior paradigm, we introduce our studies in which a mutual anticipation mechanism inspired by nonhuman animal collective behaviors can be linked to a self-organization function in human collective behaviors. We expect that the study of comparative collective behaviors will expand, the methodology will become more sophisticated, and new perspectives regarding the multitemporal features of collective behaviors will emerge.

Metz’s Relational Moral Theory and Environmental Ethics

Abstract Metz’s contribution to environmental ethics is a novel theory of moral status, which he argues explains the intuition that although we have direct moral duties to some nonhuman animals, our duties to fellow human beings are always weightier. The theory takes the moral status of an individual to depend on it being the subject and object of friendly relations with human. This paper argues that the account of moral status explains the intuition about the existence and relative weight of duties to nonhuman animals only if evidence of human-nonhuman animal cooperation is ignored. The paper argues additionally that a focus on the moral status of individual nonhuman animals offers no insight into one the most pressing environmental problems of our time, the threat of mass species extinction. Finally, the duties that would seem to follow from the account of moral status are contrary a traditional environmental concern of nature preservation.

Chinchorro fibre management in the Atacama Desert and its significance for understanding Andean textilization processes

Textilization processes envisioned as technological transformation of animal fibres and the incorporation of textiles into human bodies, is analyzed among Chinchorro hunter gatherers, along the hyperarid Pacific coast of the Atacama Desert throughout the Holocene (ca. 7800–3500 cal BP). The Chinchorro, as producers and consumers of South American camelid fibres and textiles, created a range of textilized mortuary corporealities. We studied bodies (Artificially Treated Bodies, Statuettes, Figurines), tools and textiles. Based on technological analysis of textiles dressing the bodies, we address the technological procedures employed in textile production. We defined: (a) textilization of Chinchorro bodies, (b) the entailed social relations and technological practices and, and (c) the temporal variability of camelid fibre textile production. These results are discussed within the broader context of early Andean textile fibre management and camelid domestication. From a worldwide perspective, we highlighted how Chinchorro textilization processes, as a microhistory, can be seen in the flow of human-nonhuman animal mutual interactions that gave rise to domestication and the later textile industry. We conclude that progressively ties between people and camelids intensified, by increasing the incorporation of fibres and textiles in the bodies, and the development of communities of practice which shared a concern for textile embodiment.

The post-disaster transformation of interspecies dependencies: From talkative buffalo to desemiotized cows on the slope of Mt. Merapi

This paper suggests how natural disasters may serve as the final propulsion for changes already taking place within a society. While focusing on shifts in human–non-human animal relations, this text also discusses their embedding in broader transformations of human–environment relations and the underlying economic and cultural change. It carves out interspecific dependencies that constitute an agro-ecosystem and follows their demise as the agricultural species are switched to market economic production in a post-disaster context. It thereby suggests that the human-facilitated semiotic fitting of the agricultural species is replaced by human-imposed fitting in which the species composition is largely determined by the market prices. At the same time, the paper draws attention to the cessation and transformation of human–non-human communication as a marker, but also an experiential corollary, of modernization and market economy. As a case study, it focuses on the 2010 Mt. Merapi eruption in Indonesia and its aftermath in the villages on its slope. The study analyses how the shift from using plough buffalo to utilizing market economic cattle farming reflects not just an economic, but also an affective and semiotic change stemming from a shift in the intensity and kind of human–animal relations.

Film symbiosis: Embodied spectatorship and sensory (auto)ethnography in Lucien Castaing-Taylor and Ilisa Barbash’s Sweetgrass

This article explores the 2009 observational-ethnographic documentary film Sweetgrass by Lucien Castaing-Taylor and Ilisa Barbash. Focusing on visual cues within the observational form (a film that documents the herding of sheep across the Absaroka-Beartooth Mountains for the last time), the article draws on ethnographic and autoethnographic strains to explore the relationship between the embodied spectator and on-screen animal. Sweetgrass, in addition to several moving image works, is explored as sensory ethnography that incorporates a form of spectator address based on the idea of symbiosis. The article situates ‘the nonhuman stare’ as fundamental to this, drawing on the film phenomenology of Vivian Sobchak to consolidate this view. Sweetgrass, the article maintains, aestheticizes the non-human for specific reasons. It adds an ethical purpose to the observational documentation of herding sheep across the mountains – a salvage operation of type – and a sensory experience of ‘living with’ associated with the farming culture represented on-screen. In addition to exploring the film as a sensory object in this way, the article devises a methodology bringing autoethnographic research concerning symbiotic human–non-human animal relationships, in line with explorations of the embodied film spectator.

Stable isotopes of archaeological and modern semi-terrestrial crabs (Potamon potamios) provide paleoecological insights into brachyuran ecology and human resource acquisition in late Holocene Jordan

Archaeological remains of brachyurans (e.g. crabs) are often overlooked as potential paleoenvironmental and paleoclimatical proxies in contrast to other marine and terrestrial invertebrates such as mollusks and landsnails. The potential for fine-scale regional paleoclimate reconstruction based upon these organisms' behavioral ecology has yet to be examined. We present novel isotopic analyses of the remains of a semiterrestrial freshwater crab (Potamon potamios) endemic to southwest Asia recovered from the archaeological site of Khirbat al-Mudayna al-’Aliya (KMA). KMA lies on a southern tributary of the Wadi al-Mujib in the Hashemite Kingdom of Jordan, approximately 40 km east of the Dead Sea. Excavations here recovered architecture, artifacts, and ecofacts dating to a single-period occupation during the early Iron Age (∼1000 cal BCE). Oxygen and carbon isotopes from these brachyuran remains were analyzed in conjunction with a two-year isotopic and morphometric study of the modern potomonautid population near the archaeological site and at nearby wadi systems to assess whether the isotopic values of modern crab populations correlated with variables such as temperature, including isotopic study of the pools in which crabs were found. In turn, these data could be used to reconstruct paleoclimate or paleoenvironment in the archaeological population. The high correlation in oxygen isotope values between crab carapaces and the water of the pools in which they were sampled suggest that variability in isotopic values of crab specimens recovered from KMA is tracking ancient human capture of these organisms across potentially different pools. Further, intra-year variability in isotopic values in modern crab carapaces as well as the similarity of isotopic values across wadi systems with different environments suggest that P. potamios remains cannot be used as reliable paleoenvironmental indicators. The implications of this research will have significance for archaeologists and other researchers in the study of paleoenvironment and paleoecology, and bears upon human mobility, resource acquisition, and human-nonhuman animal relationships.

Clarifying the Ethics and Oversight of Chimeric Research

This article is the lead piece in a special report that presents the results of a bioethical investigation into chimeric research, which involves the insertion of human cells into nonhuman animals and nonhuman animal embryos, including into their brains. Rapid scientific developments in this field may advance knowledge and could lead to new therapies for humans. They also reveal the conceptual, ethical, and procedural limitations of existing ethics guidance for human-nonhuman chimeric research. Led by bioethics researchers working closely with an interdisciplinary work group, the investigation focused on generating conceptual clarity and identifying improvements to governance approaches, with the goal of helping scholars, funders, scientists, institutional leaders, and oversight bodies (embryonic stem cell research oversight [ESCRO] committees and institutional animal care and use committees [IACUCs]) deliver principled and trustworthy oversight of this area of science. The article, which focuses on human-nonhuman animal chimeric research that is stem cell based, identifies key ethical issues in and offers ten recommendations regarding the ethics and oversight of this research. Turning from bioethics' previous focus on human-centered questions about the ethics of "humanization" and this research's potential impact on concepts like human dignity, this article emphasizes the importance of nonhuman animal welfare concerns in chimeric research and argues for less-siloed governance and oversight and more-comprehensive public communication.

Dog Dreams: Oneiric Representations of Interspecies Sociality among Middle-Class Young Adults in the United States

Abstract The investigation of human dreaming offers significant insights to scholars of human-nonhuman animal studies. This article proposes that the ways in which companion species appear in humans’ dreams reveal the implicit ontological assumptions that undergird waking-life interspecies relationships. Focusing on dreams about dogs among middle-class U.S. college students, the analysis develops an updated model of dreaming that is synthesized from recent neuroscientific and anthropological theory-building. Themes of warm companionship, anxiety about dogs’ welfare, and preoccupations about their mortality suggest that dreams about dogs simulate and rehearse interspecies sociality in a cultural frame. They demonstrate both interspecies intersubjectivity and the significant place of canine persons in U.S. middle-class dreamers’ conceptualizations of their social networks. Such dreams challenge the public ideology of human exceptionalism, and suggest that human-canine sociality – in both waking and oneiric modes – may emerge as much from “egomorphic” as from anthropomorphic dispositions.

Heritage with cows. Conserving Nordic human and nonhuman animals

ABSTRACT This paper takes a critical heritage approach to understanding the ways that the conservation of Nordic Mountain cows gets animated as a form of Nordic heritage. Today, Nordic Mountain cows are found in the Northern regions of Norway, Finland, and Sweden. Based on an archive of mediated material (websites, YouTube videos, and social media activism), policy documents as well as interviews with Nordic farm animal genetic resources directors, the paper analyzes how conservation becomes imagined. Viewing the conservation of Nordic Mountain cows as entangled with imaginaries of traditional ways of life, a Northern Nordic (endangered) landscape, and the potential for high quality, ethically sound Nordic heritage products; conservation gets imagined as a rescue technology preserving ‘native’ and ‘endangered’ breeds in the making of sustainable consumer goods and Nordic cultural heritage. The conservation of Nordic Mountain cows goes beyond the potentially endangered species, however, to the reiteration of Nordic exceptionalism and the promise of a pure (and white) Nordic biocultural refuge of human-nonhuman animal relations.

Becoming (Non)Human. Animal Representations in the ATU 514 Fairy Tale

"Within the rising ecocriticism in literary studies, a valuable resource for reconfiguring what it means to be (non)human is found in fairy tales, featuring animal agency, transspecies interactions, hybridities, and shapeshifting. With this in mind, the present paper tackles the nonhuman imaginary in the Romanian version of the ATU 514 tale type, i.e. shift of sex, which clearly deviates from the heroic pattern, since the protagonist is the emperor’s daughter, who is cross-dressed and then metamorphosed into Prince Charming. But does this relaxation of gender norms generate a similar disruption of the position of the animal in magical thinking? In a close reading of the fairy tale corpus, human-nonhuman animal relations are examined bidirectionally, focusing on the one hand, on the master initiator’s transbiology (the emperor disguised in animal form) and on the other hand, on two opposite anthropomorphic animals (the wise guide vs. the villain, the horse vs. the genie). Through a hybrid methodology, these transgressive possibilities are explored by combining ritualistic-anthropological, corporeal, and psycho-social aspects with current posthuman concerns. Overall, the analysis of such ontologically ambiguous narratives reveals one of the ways in which these old tales can still be read today to subvert traditional anthropocentric structures. Keywords: animal studies, fairy tales, posthumanism, ATU 514 tale type, human-animal relations "

Animals: Hierarchies of Life and Death

Animals: Hierarchies of Life and Death

Electrophysiological Analysis of Brain Organoids: Current Approaches and Advancements.

Brain organoids, or cerebral organoids, have become widely used to study the human brain in vitro. As pluripotent stem cell-derived structures capable of self-organization and recapitulation of physiological cell types and architecture, brain organoids bridge the gap between relatively simple two-dimensional human cell cultures and non-human animal models. This allows for high complexity and physiological relevance in a controlled in vitro setting, opening the door for a variety of applications including development and disease modeling and high-throughput screening. While technologies such as single cell sequencing have led to significant advances in brain organoid characterization and understanding, improved functional analysis (especially electrophysiology) is needed to realize the full potential of brain organoids. In this review, we highlight key technologies for brain organoid development and characterization, then discuss current electrophysiological methods for brain organoid analysis. While electrophysiological approaches have improved rapidly for two-dimensional cultures, only in the past several years have advances been made to overcome limitations posed by the three-dimensionality of brain organoids. Here, we review major advances in electrophysiological technologies and analytical methods with a focus on advances with applicability for brain organoid analysis.

Art Education Beyond Anthropocentricism: The Question of Nonhuman Animals in Contemporary Art and Its Education

In this article, I explore human relationships to nonhuman animals through posthumanism, contemporary art, and critical animal studies (CAS), offering perspectives for contemporary art education beyond anthropocentricism. I investigate the question of human–nonhuman animal relationships by discussing the ideas of posthumanism and speciesism as forms of discrimination, similar to other forms of oppression. Challenging the grounds of discrimination leads to a better understanding of human relationships with nonhuman lives. Given the environmental, ecological, ethical, and social justice concerns of our current times, I argue that posthumanism and CAS offer a specific entry point for contemporary art education theory and practice. Humanist understanding and superiority over nonhuman animals are problematized through discussing artwork by four artists. The discussion concentrates on how art education might become an important site through which to challenge the issues of animal subjection and human relationships with the other inhabitants of this planet.

Normative Tensions in the Popular Representation of Children with Disabilities and Animal-Assisted Therapy


 
 
 This article contributes to the critical disability and human-nonhuman animal studies literatures through a discourse analysis of newspaper stories about animal-assisted therapy (AAT) and children with disabilities published in the United States and Canada. The articles in our corpus form a recognizable genre that we call AAT human-nonhuman animal interest stories. We pose two central questions of the genre: (1) how is the therapeutic value of AAT constituted? and (2) what are the effects, in discourse, of associating nonhuman animals and children with disabilities in narratives of therapeutic benefit? We emphasize the normative tensions associated with the representation of children with disabilities and nonhuman animals in news stories about AAT. On one hand, news articles objectify children with disabilities, inscribe their need to be made “normal” and silence their own experiences of AAT. On the other hand, they are written in ways that extend and strengthen the disabled body and self through connections with nonhuman therapy animals. They disrupt sharp species distinctions and present narratives of how interspecies relationships formed through participation in AAT co-constitute the agency of nonhuman therapy animals and children with disabilities. We argue that the normative tensions in the popular representation of AAT present important possibilities for intervening in public discourse about disability and nonhuman animals.
 
 

Basal forebrain volume reliably predicts the cortical spread of Alzheimer's degeneration.

Alzheimer's disease neurodegeneration is thought to spread across anatomically and functionally connected brain regions. However, the precise sequence of spread remains ambiguous. The prevailing model used to guide in vivo human neuroimaging and non-human animal research assumes that Alzheimer's degeneration starts in the entorhinal cortices, before spreading to the temporoparietal cortex. Challenging this model, we previously provided evidence that in vivo markers of neurodegeneration within the nucleus basalis of Meynert (NbM), a subregion of the basal forebrain heavily populated by cortically projecting cholinergic neurons, precedes and predicts entorhinal degeneration. There have been few systematic attempts at directly comparing staging models using in vivo longitudinal biomarker data, and none to our knowledge testing if comparative evidence generalizes across independent samples. Here we addressed the sequence of pathological staging in Alzheimer's disease using two independent samples of the Alzheimer's Disease Neuroimaging Initiative (n1 = 284; n2 = 553) with harmonized CSF assays of amyloid-β and hyperphosphorylated tau (pTau), and longitudinal structural MRI data over 2 years. We derived measures of grey matter degeneration in a priori NbM and the entorhinal cortical regions of interest. To examine the spreading of degeneration, we used a predictive modelling strategy that tests whether baseline grey matter volume in a seed region accounts for longitudinal change in a target region. We demonstrated that predictive spread favoured the NbM→entorhinal over the entorhinal→NbM model. This evidence generalized across the independent samples. We also showed that CSF concentrations of pTau/amyloid-β moderated the observed predictive relationship, consistent with evidence in rodent models of an underlying trans-synaptic mechanism of pathophysiological spread. The moderating effect of CSF was robust to additional factors, including clinical diagnosis. We then applied our predictive modelling strategy to an exploratory whole-brain voxel-wise analysis to examine the spatial specificity of the NbM→entorhinal model. We found that smaller baseline NbM volumes predicted greater degeneration in localized regions of the entorhinal and perirhinal cortices. By contrast, smaller baseline entorhinal volumes predicted degeneration in the medial temporal cortex, recapitulating a prior influential staging model. Our findings suggest that degeneration of the basal forebrain cholinergic projection system is a robust and reliable upstream event of entorhinal and neocortical degeneration, calling into question a prevailing view of Alzheimer's disease pathogenesis.

Francis’s animal brotherhood in Thomas of Celano’s Vita Prima

Francis of Assisi’s encounters with nonhuman animals in Thomas of Celano’s Vita Prima open into ‘contact zones’ between human and nonhuman animals that challenge traditional social hierarchies. Following Mary Louise Pratt’s and Donna Haraway’s foregrounding of these spaces as sites of contention and transformation, we explore the way that Francis’s behaviour with nonhuman animals draws attention to them as victims of economic, social, and moral inequalities. Within the contact zones found in Celano’s hagiography, Francis engages directly with orthodox ontologies articulated by Augustine and Aquinas that separate human and nonhuman. Indeed, Francis’s actions toward animals reimagine horizontal relationships between subjects who span the human-nonhuman animal distinction. Lastly, in exploring Francis’s encounters with nonhuman animals, we draw on Carol J. Adams’s notion of the absent referent to discuss the saint’s efforts to restore subjecthood to nonhuman animals whose subjectivity has been annihilated by medieval culture.