In the recently boosted scenario, the eventual settlement in extreme extra-terrestrial environments, notably the Moon and Mars, stands as critical objective driving the forefront of space exploration endeavours: the possibility of realizing a lunar settlement is currently under study by NASA Artemis Program and others active subjects in the aerospace sector (Schrunk et al., 2008) [1]. As mission duration tends to increase, the wellness of crew members emerges as a stronger concern, affecting the habitat features and driving the design towards solutions that still must face environmental constraints. A wide exploration in the aerospace field has been conducted, starting from the experience accumulated in more than 50 years of experimentation and activity on board of the active and decommissioned space stations.In recent years, several pioneering concepts for human living structures on our satellite have been proposed, with an extensive adoption of transparent inflatable or deployable shells. Even if these proposals can lead the way for optimized solution identification, the technical characterization of these shells has not been extensively explored yet, and it represents a mandatory step in the path for achieving the best possible prototype to be built on the Moon surface. Our research aims to assess the viability of employing transparent or translucent inflatable-type envelopes within the harsh conditions of extra-terrestrial environments.The research background has been extensively investigated in order to identify best practices and promising solutions, which have been proposed here. Where no previous tests were conducted, traditional Earth-related engineering tools where utilized. The result of this work is a multilayer membrane to be deployed through internal air pressurization, with the correct size of each of the composing layers calculated by employing multi-physics simulations employing multi-physics simulations and computational.The outcome of this work represents not a definitive design, but an introductive experience with the aim to launch wider investigations to reach higher TRLs. Finally, we aimed to identify the limits of this research that need to be addressed in order to make an inflatable multilayer membrane feasible to be adopted for long permanent human missions on the Moon.