Endovascular reconstructions of the femoropopliteal artery (FPA) demonstrate high rates of failure. Poor durability of repair is often attributed to severe mechanical deformations that occur with limb flexion and inability of stent designs to accommodate these deformations. Stent-artery interactions associated with limb flexion-induced FPA deformations may contribute to arterial wall injury and intimal hyperplasia. We measured limb flexion-induced deformations of human cadaveric FPAs before and after stenting with seven different commercially available peripheral artery stents. Retrievable nitinol markers were deployed into 28 in situ FPAs of 14 human cadavers. Limbs were perfused with 37°C fluid, and thin-section computed tomography images were acquired with limbs in the standing (180°), walking (110°), sitting (90°) and gardening (60°) postures. Image segmentation and analysis allowed comparison of relative spatial locations of each intra-arterial marker for determination of baseline FPA axial compression, bending, and torsion. Markers were then retrieved from the arteries, and the FPAs were stented with pre- and post-balloon dilatation. Zilver, Absolute Pro, Innova, Smart Control, SmartFlex, Supera stents, and Viabahn stent grafts were deployed across the adductor hiatus. Four unique limbs received each stent type with only one stent type per artery. After stenting, markers were redeployed in stented FPAs and imaged in the same postures. Comparison of the baseline and stented FPA deformations allowed determination of the influence of specific stent type (Fig). Smart Control, Smart Flex, Zilver, Supera, and Absolute Pro restricted axial compression of the FPA within the stented segment by 56%, 45%, 42%, 26%, and 22%, respectively (P < .05). Smart Flex, Smart Control, and Zilver exacerbated FPA compression distal to the stent by 61% (P < .01), while no differences were observed proximally. Within the stented segment, maximum torsion was restricted by Supera 4° to 12°/cm (P < .05), and exacerbated by Smart Flex 10° to 15°/cm (P < .05). Torsion of the FPA proximal and distal to the stented region was not affected by stenting. Stents reduced bending of the FPA by an average of 42% (P < .01) within the stented segment, but no differences were observed proximally or distally. Different stent designs significantly affect limb flexion-induced deformations of the FPA not only within the stented segment but also distal to it. Stents that better match natural limb flexion-induced FPA deformations may mitigate arterial injury and potentially improve clinical outcomes of endovascular peripheral artery disease treatments. These data can be used to help more rationally select stent designs specific to arterial segments and patient conditions.