Human Evolution Research Articles

Signatures of selection with cultural interference

Human evolution is intricately linked with culture, which permeates almost all facets of human life from health and reproduction, to the environments in which we live. Nevertheless, our understanding of the ways in which stably transmitted, evolutionarily relevant human cultural traits might interact with the human genome is incomplete, and methods to detect such interactions are limited. Here, we describe some rules of cultural transmission which could pertain to both humans and cultural nonhuman animals that could lead to the formation and maintenance of stable associations between cultural and genetic traits. Next, we show that, in the presence of such associations, a process analogous to genetic hitchhiking is possible in gene–culture systems. These could leave signatures in the human genome similar to, and perhaps indistinguishable from, those left by selection on genetic traits. Finally, we model selective interference between cultural and genetic traits. We show that selective interference between a cultural trait under selection and a genetic trait under selection can reduce the efficacy of natural selection in the human genome, both in terms of the probability of fixation of beneficial alleles and the dynamics of selective sweeps. We then show that the efficiency of selection at genetic loci can, however, be increased in the presence of strong cultural transmission biases. This implies that the signatures of gene–culture interactions in genetic data may be complex and wide-ranging in gene–culture coevolutionary systems.

A tale of two cultures: How L. Luca Cavalli-Sforza bridged the gap between science and the humanities

This article retraces the career of geneticist L. Luca Cavalli-Sforza, from his days as a student researcher to his tenure as a Stanford University professor, and beyond. We show how Cavalli-Sforza’s untiring curiosity, enthusiasm, and global knowledge led him to make incisive contributions to topics as diverse as bacterial genetics and human evolution, both biological and cultural. In an academic world where hyperspecialization is the norm, Cavalli-Sforza stood out as a scientist unafraid to promulgate and apply multidisciplinary approaches to complex issues of human origins and culture.

Social tolerance and success-biased social learning underlie the cultural transmission of an induced extractive foraging tradition in a wild tool-using primate

The last two decades have seen great advances in the study of social learning (learning from others), in part due to efforts to identify it in the wild as the basis of behavioral traditions. Theoretical frameworks suggest that both the dynamics of social tolerance and transmission biases (or social learning strategies) influence the pathways of information diffusion in social groups. Bearded capuchins ( Sapajus libidinosus ) inhabiting the semiarid seasonal caatinga biome of the Serra da Capivara National Park (SCNP) form highly tolerant societies that possess the largest “tool-kit” described for monkeys, a feat likely facilitated by social learning. Here, we used social network analysis and an open diffusion experiment using an extractive foraging task to identify the occurrence of social learning and describe the pathways of social transmission of information in two wild primate populations. The dynamics of social tolerance outside of task introductions predicted opportunities for social learning, but it was tolerance during task introductions that predicted the actual pathways of social information diffusion. Our results also indicated that the capuchins mainly learned from others via direct observation and naïve individuals exhibited an observation bias toward successful males. This study supports the claims of cultural transmission in robust capuchins and empirically supports the role of social tolerance and social learning strategies in human and nonhuman primate cultural evolution.

Potential impacts of AluYa5 (ACE & PROGINS) and AluYb8 (MUTYH) insertions in panic disorder

Objective: The human genome contains numerous active transposable elements (TEs), including the inserts of young Alus such as AluYa5 and AluYb8. The rapid, human lineage-specific evolution of brain size may be influenced by natural selection and the genomic variation of TEs, which can act as catalysts of evolution. Given their potential effects on human brain development, Alu elements may also be relevant in exploring complementary approaches for psychiatric disorders. This study analyzed the potential impacts of three specific Alu insertions (AluYa5-ACE, AluYa5-PROGINS, and AluYb8-MUTYH) on the susceptibility to panic disorder (PD). Materials and Methods: Alu insertions were determined with Polymerase Chain Reaction (PCR) method in 120 PD patients and 120 healthy control individuals and analyzed with logistic regression. The associations of the investigated Alus with both categorical and quantitative demographic-clinical variables including the Panic Disorder Severity Scale (PDSS) were analyzed using Fisher's exact and Kruskal-Wallis tests. Results: AluYa5-PROGINS and AluYb8-MUTYH did not show an association with panic disorder risk. For AluYa5-ACE, a statistically significant association was determined; logistic regression analysis proved the highly protective effect (47.9%) of I/D genotype against PD compared with D/D genotype (p=0.030, OR=0.521, 95% CI=0.290-0.937). Alu insertions were not associated with panic disorder severity (p>0.05). Conclusion: This is the first combined study in which the potential effects of three Alu insertions in terms of both PD susceptibility and possible association with several disease parameters were evaluated. Further studies about the roles of the Alu elements in the etiology PD are highly recommended.

Interplay of human ABCC11 transporter gene variants with axillary skin microbiome functional genomics.

The human armpit microbiome is metabolically entangled with skin cell physiology. This "meta-organism" symbiotic mutualism results in sweat either with or without odor (osmidrosis), depending on host ABCC11 gene haplotypes. Apocrine metabolism produces odorless S-glutathione conjugate that is transferred by ABCC11 transporters into secretory vesicles, deglutamylated to S-Cys-Gly-3M3SH thiol, and exuded to skin surface. An anthropogenic clade of skin bacteria then takes up the thiol and bioconverts it to malodorous 3-methyl-3-sulfanylhexan-1-ol (3M3SH). We hypothesized a familial meta-organism association of human ABCC11 gene non-synonymous SNP rs17822931 interplaying with skin microbiome 3M3SH biosynthesis. Subjects were genotyped for ABCC11 SNPs, and their haplotypes were correlated with axilla microbiome DNA sequencing profiles and predicted metagenome functions. A multigeneration family pedigree revealed a Mendelian autosomal recessive pattern: the C allele of ABCC11 correlated with bacterial Cys-S-conjugate β-lyase (PatB) gene known for Staphylococcus hominis biosynthesis of 3M3SH from human precursor; PatB was rescinded in hosts with homozygous TT alleles encoding ABCC11 loss-of-function mutation. We posit that a C allele encoding functional ABCC11 is key to delivering host conjugate precursors that shape heritable skin niche conditions favorable to harboring Staphylococcus having genomics of odor thiol production. This provides existential insights into human evolution and global regional population ancestries.

Domestication and Human/Wildlife Mutualism

In this study, I discuss recent studies of human/wildlife mutualisms and suggest that several cases considered to represent domestication that has arisen through commensalism would be better considered as examples of mutualism between humans and various wild species. Species discussed include the only domesticated carnivores: cats (Felis sylvestris) and wolves (Canis lupus and C. dingo). I also discuss species over which there is considerable debate about whether they are domesticated or not: African (Loxodonta) and Asiatic elephants (Elphas). All of these species’ interactions include niche construction on the part of both species and influence human evolution at least a cultural level. I further argue that most contemporary domestic species currently exist in mutualistic relationships with humans because even though all of these species have been selected to benefit humans, all domestica species have also benefitted in terms of increased global and local population sizes and from more secure living conditions than can be found in their wild ancestors.

Leveraging ancient DNA to uncover signals of natural selection in Europe lost due to admixture or drift.

Large ancient DNA (aDNA) studies offer the chance to examine genomic changes over time, providing direct insights into human evolution. While recent studies have used time-stratified aDNA for selection scans, most focus on single-locus methods. We conducted a multi-locus genotype scan on 708 samples spanning 7000 years of European history. We show that the G12 statistic, originally designed for unphased diploid data, can effectively detect selection in aDNA processed to create 'pseudo-haplotypes'. In simulations and at known positive control loci (e.g., lactase persistence), G12 outperforms the allele frequency-based selection statistic, SweepFinder2, previously used on aDNA. Applying our approach, we identified 14 candidate regions of selection across four time periods, with half the signals detectable only in the earliest period. Our findings suggest that selective events in European prehistory, including from the onset of animal domestication, have been obscured by neutral processes like genetic drift and demographic shifts such as admixture.

Transforming Cybersecurity Infrastructure : A Multi-dimensional Approach to Risk, Culture, and Technological Integration

The rapid acceleration of digital transformation has exposed critical limitations in traditional cybersecurity approaches, particularly in their reactive nature and disconnection from broader organizational strategies. This article critically examines current cybersecurity practices in IT infrastructure management, identifying significant gaps in the integration of security measures with business objectives, organizational culture, and emerging technologies. Through a mixed-method analysis of industry practices and empirical data from multiple case studies, The article proposes a comprehensive framework that transcends conventional security paradigms. The article introduces a proactive, risk-based approach that integrates cultural transformation, emerging technologies, and resilience building while fostering strategic partnerships across stakeholder groups. Initial implementation across various organizational contexts demonstrates significant improvements in security posture, incident response times, and overall business alignment. The findings contribute to both theoretical understanding and practical application of integrated cybersecurity management, offering valuable insights for practitioners and researchers in the field of IT security and organizational resilience. This article addresses a critical gap in current literature by providing a holistic approach that aligns cybersecurity initiatives with organizational transformation while considering human factors and technological evolution.

Human socio-technical evolution through the lens of an abstracted-wheel experiment: A critical look at a micro-society laboratory study.

Micro-society experimental setups are increasingly used to infer aspects of human behavioural evolution. A key part of human society today is our dependence on, and use of, technology-whether simple (such as a knife) or complex (such as the technology that underpins AI). Previously, two groups of researchers used an abstracted-wheel experiment to explore the evolution of human technical behaviour, reaching fundamentally different outcomes. Whereas one group saw their results as indicating social learning only (void of causal understanding), the other inferred non-social technical reasoning as part of human technical behaviour. Here we report on the third generation of the micro-society abstracted-wheel experiment. We argue that causal reasoning is inseparable from both social learning and technical reasoning, and that these traits probably co-evolved into the current human socio-technical niche. Based on our outcomes, we present a critical assessment of what this experiment may (or may not) reveal about the evolution of human technical behaviour. We show that the abstracted-wheel experiment reflects behavioural output only, instead of testing for cognition. It is therefore limited in its ability to inform on aspects of human cognitive evolution, but it can provide useful insights into the interrelatedness of social learning, technical reasoning, and causal reasoning. Such a co-evolutionary insight has the potential to inform on aspects of human socio-technical evolution throughout the Pleistocene.

Stay social, stay young: a bioanthropological outlook on the processes linking sociality and ageing.

In modern human societies, social interactions and pro-social behaviours are associated with better individual and collective health, reduced mortality, and increased longevity. Conversely, social isolation is a predictor of shorter lifespan. The biological processes through which sociality affects the ageing process, as well as healthspan and lifespan, are still poorly understood. Unveiling the physiological, neurological, genomic, epigenomic, and evolutionary mechanisms underlying the association between sociality and longevity may open new perspectives to understand how lifespan is determined in a broader socio/evolutionary outlook. Here we summarize evidence showing how social dynamics can shape the evolution of life history traits through physiological and genetic processes directly or indirectly related to ageing and lifespan. We start by reviewing theories of ageing that incorporate social interactions into their model. Then, we address the link between sociality and lifespan from two separate points of view: (i) considering evidences from comparative evolutionary biology and bioanthropology that demonstrates how sociality contributes to natural variation in lifespan over the course of human evolution and among different human groups in both pre-industrial and post-industrial society, and (ii) discussing the main physiological, neurological, genetic, and epigenetic molecular processes at the interface between sociality and ageing. We highlight that the exposure to chronic social stressors deregulates neurophysiological and immunological pathways and promotes accelerated ageing and thereby reducing lifespan. In conclusion, we describe how sociality and social dynamics are intimately embedded in human biology, influencing healthy ageing and lifespan, and we highlight the need to foster interdisciplinary approaches including social sciences, biological anthropology, human ecology, physiology, and genetics.

Carl Sagan and libraries: An original thinker remembered

This article considers the legacy of astronomer Carl Sagan (1934–1996), whose book The Dragons of Eden presents a complete etiology of the library in the context of human evolution. Essential to Sagan's theory of the origins of the library is the concept of extrasomatic information, or knowledge stored outside the body. Surprising evidence on behalf of Sagan's theory has been presented in recent years by Nobel-Prize-winning neuroscientist Eric Kandel and others: that the human brain has not significantly grown for 50,000 years, presumably not due to evolutionary stagnation, but because cultural evolution has superseded biological evolution in Homo sapiens, an advance which has led to us becoming the dominant species on Earth.

Cut a Tree, Cut a Man: Charcoal Production as a Bane to Green Economy in Nigeria

Symbiotically speaking, cutting a tree is akin to cutting a man or any of its counterparts in the animal kingdom. Besides solar energy, heat energy's role in humans’ daily life calls for its taming, artificial ignition, and fuelling of same for its reuse as and when due. Hence, humans’ ability to ignite and fuel fire marked a significant achievement in human evolution. Meanwhile, wood was the most traditional source of fuel in human history, which is, mainly, of two forms: firewood and charcoal. Dried wood was the common source of fuel for domestic cooking and commercial use both in the rural and urban areas in the primitive era. Although, firewood has relatively little burden on nature, charcoal, which has more adverse effects on the environment, is now taking over. Sadly, the discovery of better alternative sources such as LPG and electricity could not bring about a remarkable shift in many developing nations, including Nigeria, despite their efficiency. Taking expository and critical analysis methodologies, this paper argues that wood-fuelling hinders the achievement of the green economy in Africa, and it persists for many reasons; poor state of electricity, unavailability and/or unaffordability of the LPG, poverty, poor environmental awareness, unsophisticated and poor enforcement of environmental laws and lack of compensation for the conservators among others. In addition to the ever-suggested solutions, this paper recommends a ‘carrot and cane' system. By this, the offenders should not only be accordingly penalised but also the conservers be compensated duly. It also recommends the use of briquettes as viable alternatives.

From stone tools to fMRI, studying human cognitive evolution when the mind doesn't fossilize

From stone tools to fMRI, studying human cognitive evolution when the mind doesn't fossilize

A history of multiple Denisovan introgression events in modern humans.

The identification of a new hominin group in the Altai mountains called Denisovans was one of the most exciting discoveries in human evolution in the last decade. Unlike Neanderthal remains, the Denisovan fossil record consists of only a finger bone, jawbone, teeth and skull fragments. Leveraging the surviving Denisovan segments in modern human genomes has uncovered evidence of at least three introgression events from distinct Denisovan populations into modern humans in the past. Each of them presents different levels of relatedness to the sequenced Altai Denisovan, indicating a complex relationship between these sister lineages. Here we review the evidence suggesting that several Denisovan populations, who likely had an extensive geographical range, were adapted to distinct environments and introgressed into modern humans multiple times. We further discuss how archaic variants have been affected by demographic history, negative and positive selection and close by proposing possible new lines of future research.

Mental disorders may prevent, not cause, suicide.

We challenge a prevalent belief that depression causes suicide and propose that certain symptoms of depression and other psychopathologies may function to prevent lethal self-injury. Theoretical and empirical evidence supports this position. As suicide posed an extreme fitness hazard throughout human evolution, our species evolved special-purpose psychological defences that continuously monitor and manage this danger. Last-ditch protections may present as diverse psychiatric phenomena. Mobilising in adolescence and adulthood in response to chronic distress, these usually stop suicidal thoughts from escalating into deadly actions. The theory is testable. We point to important implications for the clinical management of suicide and psychopathology.

Handedness and the control of human technology and language

The impact of handedness on neural substrates of common tool processing and tool use skills as proxies to the mechanisms underlying modern reciprocal relationships among humans and their brains, the tools they create and use, and technologies they implement and utilise, has only recently started to be elucidated. Yet, as most of the reports on lateralisation of such processing or skills focused on a single task, and sharp divisions of participants into right-, left-, and mixed-handed, or non-righthanded for the latter two groups combined, little is known about interrelationships between the neuronal underpinnings of different skilled manual actions—e.g., manual praxis skills in the form of disparate hand-tool interactions, including their most common neural phenotypes in the population at large. Here, in 62 individuals with different handedness status, we studied the laterality of two praxic abilities involving common tools. Even though their neural substrates were expected to be closely linked, we identified numerous cases (in 7/28 righthanders [RH] – 25%, and in 6/21 lefthanders [LH] – 29% of participants) with hemispheric dissociations in the underlying mechanisms. They involved both right-lateralised functional grasp planning vs. left-lateralised visual tool use (8% of all tested cases, 3/28 RH: ~11%, and 2/21 LH: ~10%), and vice versa (13% of all cases, 4/28 RH: ~14%, and 4/21 LH: ~19% of participants). The laterality/organisation of these praxic skills was also compared to the laterality/organisation of productive language, with only few cases of dissociations identified. The observed phenotypes are discussed in the context of coevolutionary hypotheses linking ancient toolmaking and tool use skills, the associated cultural evolution, technological innovations, and language to the cortical expansion and functional lateralisation in human evolution.

Enhancing high school human evolution education: Harnessing “sapiens: a brief history of humankind” as an effective learning resource

Understanding human evolution can be challenging for students and may lead to misconceptions, often stemming from the learning materials employed. Current learning resources commonly include textbooks, images, and the internet. The popular science book "Sapiens: A Brief History of Humankind" offers potential as an educational tool for teaching human evolution. This study aims to assess the suitability of "Sapiens" for high school Biology education and its potential as a resource for teaching human evolution in senior high school. Employing a qualitative descriptive method with a content analysis approach, data is gathered through documentation techniques. Primary data is derived from the documentation and content analysis of "Sapiens: A Brief History of Humankind." Data analysis follows the model proposed by Miles and Huberman (1983), encompassing data reduction, presentation, and conclusion drawing. The findings indicate that the book effectively addresses 7 out of 9 (77.78%) sub-topics of human evolution commonly taught in high school Biology. Importantly, the book replaces outdated terms like Pithecantropus and Megantropus paleojavanicus, found in traditional textbooks. Moreover, the book fulfills the five criteria for selecting learning resources as outlined by Djohar (1987). Consequently, "Sapiens" can serve as a valuable learning resource for high school Biology, particularly regarding the study of human evolution.

Making ourselves understood: Translation as a creative task

Human evolution in groups has given us language. But it has also led to a present where it appears increasingly difficult to understand each other. Language can be used to clarify or to obscure; it can unite or separate. It is as if we speak different languages. (This is written in English as my own second language as a German.) Can thinking about actual linguistic differences help? A foreign language can be a barrier to communication—and learning or translating the language can become a bridge. Similarly, on a personal level (and in psychotherapy), a second language can be used defensively, when it creates a distance to the internal world—and it can be used creatively to rethink it. Group analysis in particular is faced with this dual potential, when members do not all share the same background. Foulkes himself had to struggle with the English language, and (I suggest) turned the challenge into an opportunity for creative new ideas. Foulkes’s concept of translation embodies this creativity and carries it into the group-analytic model. This specific Foulkesian translation originates in the group-analytic situation and goes beyond the polarity of the passively translated and the active translator. The mutual task is unavoidable in our polyphonic international group of GASi.

Recent Research Advancements in Carbon Fiber‐Based Anode Materials for Lithium‐Ion Batteries

Energy consumption is a critical element in human evolution, and rapid advances in science and technology necessitate adequate energy. As human society evades, the advancement of energy storage components has become critical in addressing societal challenges. Lithium‐ion batteries (LIBs) are promising candidates for future extensive use as optimal energy storage devices. However, the current limitations of LIBs pose a challenge to their continued dominance. Researchers are constantly exploring new materials to enhance the performance of LIBs, and carbon fiber (CF) is a dominant contender in this pursuit. The high electrical conductivity of carbon‐based materials benefits the battery system by facilitating efficient electron transfer and improving overall performance. CF‐based materials provide enhanced energy storage capacity and cycling stability in LIBs. Progress in carbon‐based materials has resulted in electrodes with increased surface areas, enabling greater rates of charging and discharging. In addition, the exceptional corrosion resistance of CF ensures the durability and robustness of LIBs. A comprehensive review is carried out on the correlation between the material's structure and its electrochemical performance, with a special emphasis on the uses of pure carbon fibers, transition metal oxides, sulfides, and MXene carbon‐based transition metal compounds in LIBs.

Study on the causes and coping strategies of adolescent mental illness

In recent years, especially since the epidemic, there has been an explosive increase in the incidence of adolescent mental disorders, which has aroused the attention of the whole society. From the perspectives of evolution, humanism, and psychodynamics, this paper analyzes the deep-rooted causes of the increasing incidence of psychological disorders in adolescents and explores various dilemmas adolescents face. From an evolutionary point of view, the current rate of social progress exceeds the rate of human evolution and the rate of cognitive improvement of young people, making it difficult for young people to adapt to complex social environments. In humanitarian terms, excessive academic pressure places a heavy burden on young people. From the perspective of psychodynamics, the conflict between standard, ego, and superego can cause mental illness in adolescents. In addition, this paper points out that adolescent mental illness marks the evolution of social awareness of mental health, and all parties in society need to build a supportive policy framework to foster widespread awareness of mental health.