Human Cognitive Flexibility Research Articles

RHYTHMS: Real-time Data-driven Human-machine Synchronization for Proactive Ergonomic Risk Mitigation in the Context of Industry 4.0 and Beyond

Human-machine work system (HMWS) represents a composite system that integrates machine precision and strength with human cognitive abilities, flexibility, and adaptability, aiming to achieve enhanced performance in various tasks aligned with a common goal, which is getting smarter in the era of Industry 4.0 (I4.0) and has received extensive attention from academia and industry. However, the lack of real-time information sharing during HMWS implementation and operation, coupled with uncertainties stemming from human instability and the complexities introduced by smart networking environments in the context of I4.0, poses challenges to the synchronous coordination of this distributed human-centric manufacturing system. Failure in synchronization not only compromises overall system integrity, leading to unrealistic decision-making and potential harm to human health but also goes against the principles of Industry 5.0 (I5.0), which proposes placing human well-being at the center of the production process for human-centric smart manufacturing in the future. In this context, this research presents real-time data-driven hyper objects orchestrating for the human-machine synchronization (RHYTHMS) based on a service-oriented human-to-machine architecture (SOH2M) and a model reference adaptive fuzzy control for real-time information sharing and synchronous coordination of the smart HMWS. Based on these, a real-life assembly case is carried out by a full-scale HMWS prototype to quantitatively analyze the benefits of the proposed approach in proactive ergonomic risk mitigation (PERM), contributing to the human-centric value-oriented I5.0 era.

Thalamic regulation of frontal interactions in human cognitive flexibility.

Interactions across frontal cortex are critical for cognition. Animal studies suggest a role for mediodorsal thalamus (MD) in these interactions, but the computations performed and direct relevance to human decision making are unclear. Here, inspired by animal work, we extended a neural model of an executive frontal-MD network and trained it on a human decision-making task for which neuroimaging data were collected. Using a biologically-plausible learning rule, we found that the model MD thalamus compressed its cortical inputs (dorsolateral prefrontal cortex, dlPFC) underlying stimulus-response representations. Through direct feedback to dlPFC, this thalamic operation efficiently partitioned cortical activity patterns and enhanced task switching across different contingencies. To account for interactions with other frontal regions, we expanded the model to compute higher-order strategy signals outside dlPFC, and found that the MD offered a more efficient route for such signals to switch dlPFC activity patterns. Human fMRI data provided evidence that the MD engaged in feedback to dlPFC, and had a role in routing orbitofrontal cortex inputs when subjects switched behavioral strategy. Collectively, our findings contribute to the emerging evidence for thalamic regulation of frontal interactions in the human brain.

Age effect in expert cognitive flexibility in Guinea baboons (Papio papio)

Cognitive flexibility in non-human primates is traditionally measured with the conceptual set shifting task (CSST). In our laboratory, Guinea baboons (N = 24) were continuously tested with a CSST task during approximately 10 years. Our task involved the presentation of three stimuli on a touch screen all made from 3 possible colours and 3 shapes. The subjects had to touch the stimulus containing the stimulus dimension (e.g., green) that was constantly rewarded until the stimulus dimension changed. Analysis of perseveration responses, scores and response times collected during the last two years of testing (approximately 1.6 million trials) indicate (1) that the baboons have developed an “expert” form of cognitive flexibility and (2) that their performance was age-dependent, it was at a developing stage in juveniles, optimal in adults, declining in middle-aged, and strongly impaired in the oldest age group. A direct comparison with the data collected by Bonté , Flemming & Fagot (2011) on some of the same baboons and same task as in the current study indicates that (3) the performance of all age groups has improved after 10 years of training, even for the now old individuals. All these data validate the use of non-human primates as models of human cognitive flexibility and suggest that cognitive flexibility in humans has a long evolutionary history.

Task Switching and the Role of Motor Reprogramming in Parietal Structures

Human behaviour amazes with extraordinary flexibility and the underlying neural mechanisms have often been studied using task switching. Despite extensive research, the relative importance of “cognitive” and “motor” aspects during switching is unclear. In the current study we examine this question combining EEG analysis techniques and source localization to examine whether the selection of the response, or processes during the execution of the response, contribute most to switching effects. A clear dissociation was observed in the signal decomposition, since codes relating to motor aspects play a significant role in task switching and the scope of the switching costs. This was not the case for signals that denote reaction selection or decision processes that respond to selection or basic stimulus processing codes. On a functional neuroanatomical level, these modulations in motor processes showed a clear temporal sequence in that motor codes are processed primarily in superior parietal regions (Brodman area 7) and only then in premotor regions (Brodman area 6). The observed modulations may reflect motor reprogramming processes. The study shows how EEG signal analysis in combination with brain mapping methods can inform debates on theories of human cognitive flexibility.

Frontoparietal action-oriented codes support novel instruction implementation

A key aspect of human cognitive flexibility concerns the ability to convert complex symbolic instructions into novel behaviors. Previous research proposes that this transformation is supported by two neurocognitive states: an initial declarative maintenance of task knowledge, and an implementation state necessary for optimal task execution. Furthermore, current models predict a crucial role of frontal and parietal brain regions in this process. However, whether declarative and procedural signals independently contribute to implementation remains unknown. We report the results of an fMRI experiment in which participants executed novel instructed stimulus-response associations. We then used a pattern-tracking procedure to quantify the contribution of format-unique signals during instruction implementation. This revealed independent procedural and declarative representations of novel S-Rs in frontoparietal areas, prior to execution. Critically, the degree of procedural activation predicted subsequent behavioral performance. Altogether, our results suggest an important contribution of frontoparietal regions to the neural architecture that regulates cognitive flexibility.

Analyze the factors influencing human-robot interaction using MCDM method

Robots play a key role in medical equipment manufacturing industry by safeguarding human workers from hazardous environment and risky jobs. Human robot interaction (HRI) is one of the robotic features that are enhanced in industrial robots. They mimic human behavior while arriving at a decision, contributing to the proficiency of the product. Tasks involving human cognitive skills and flexibility in the workers are combined with robots to obtain high-level accuracy, repeatability, and speed. Further, more challenges are to be met for achieving an effective human-robot interaction. In this paper, risk factors affecting the interaction between both robot and humans are discussed, and a contextual case is performed in a top south Indian medical equipment manufacturing industry. Industrial experts' inputs and relevant literature are considered to recognize the risk factors. Multi-Criteria decision-making method (MCDM) like DEMATEL (Decision Making Trial and Evaluation Laboratory) is used to analyze the risk factors influencing HRI in the assembly section. The paper's findings show that automation level and reliability of the robot are the most influential factor in the assembly section and need more attention to control and reduce the risk factor for the effective assembly.

Attentional prioritization reconfigures novel instructions into action-oriented task sets

An astonishing aspect of human cognitive flexibility concerns the ability to efficiently convert complex symbolic instructions into novel behaviors. In such ability, the rapid transformation of relevant content into action plans is particularly crucial as it allows for reflexive, automatic-like execution of merely instructed task sets. However, little is known about the mechanisms that give rise to this transformation. In the current study, we test the hypothesis that novel instructions held in working memory are reformatted into action-oriented representations when selective attention prioritizes their content. To do so, we devised a paradigm in which participants first encoded 4 S-R mappings and later, a retro-cue selected two of them. We first found that participants can benefit from retro-cues during the implementation of novel task-sets. Then, across two preregistered experiments, we observed that cued mappings (but not uncued ones) induced intention-based reflexivity, suggesting that only these entered an action-oriented state. Altogether, our results reveal that selective attention prioritizes relevant novel instructed content, playing an important role in its prospective reformatting into an action-bound task set.

Self-reported nutritional status, executive functions, and cognitive flexibility in adults

Objectives. The purpose of this study was to investigate the relationship between nutrition status, executive cognitive functions, and cognitive flexibility; and to analyze the role of gender, age, and nutrition status in the prediction of executive cognitive functions and cognitive flexibility in a sample of Iranian adults. Background. This study is based on the hierarchy of needs, health beliefs, developmental, cognitive and psychophysiological conceptualizations of nutrition and their plausible influences on human cognitive functions and cognitive flexibility.

Cognitive caching promotes flexibility in task switching: evidence from event-related potentials.

Time-consuming processes of task-set reconfiguration have been shown to contribute to the costs of switching between cognitive tasks. We describe and probe a novel mechanism serving to reduce the costs of task-set reconfiguration. We propose that when individuals are uncertain about the currently valid task, one task set is activated for execution while other task sets are maintained at a pre-active state in cognitive cache. We tested this idea by assessing an event-related potential (ERP) index of task-set reconfiguration in a three-rule task-switching paradigm involving varying degrees of task uncertainty. In high-uncertainty conditions, two viable tasks were equally likely to be correct whereas in low-uncertainty conditions, one task was more likely than the other. ERP and performance measures indicated substantial costs of task-set reconfiguration when participants were required to switch away from a task that had been likely to be correct. In contrast, task-set-reconfiguration costs were markedly reduced when the previous task set was chosen under high task uncertainty. These results suggest that cognitive caching of alternative task sets adds to human cognitive flexibility under high task uncertainty.

Thinking through the Middle Stone Age of sub-Saharan Africa

Together with the disciplines of palaeoanthropology and genetics, archaeological finds and studies on material dating to the Middle Stone Age of sub-Saharan Africa have changed the way scholars think about ancient Africans and the later stages of human evolution. In general, it shows that anatomically modern humans have evolved by ∼200 ka in the region, and that relatively high levels of symbolic behaviour, and behavioural and cognitive complexity were achieved long before the previous 40–50 ka benchmark. The main focus of the paper is on aspects of post-100 ka archaeological material and how it can assist in the reconstruction of hypotheses and models regarding human cognitive and behavioural evolution. Some of the explored topics include fire as engineering tool, the manufacture and use of technologies such as compound adhesives, composite tools, bow-and-arrow sets and snares, and Middle Stone Age housekeeping. Although not central to the paper, an updated list of most Middle Stone Age stone tool assemblages is presented in Appendix A as context for sites, regions and topics mentioned throughout the text. On a theoretical level, the ratchet analogy as blanket explanation for behavioural and cognitive evolution is critiqued. Instead, the rugged fitness landscape model is brought to mind and combined with a mountaineering analogy to better explain human cognitive and behavioural flexibility as reflected in the Middle Stone Age record of sub-Saharan Africa.

Human cognitive flexibility depends on dopamine D2 receptor signaling

RationaleAccumulating evidence indicates that the cognitive effects of dopamine depend on the subtype of dopamine receptor that is activated. In particular, recent work with animals as well as current theorizing has suggested that cognitive flexibility depends on dopamine D2 receptor signaling. However, there is no evidence for similar mechanisms in humans.ObjectivesWe aim to demonstrate that optimal dopamine D2 receptor signaling is critical for human cognitive flexibility.MethodsTo this end, a pharmacological pretreatment design was employed. This enabled us to investigate whether effects of the dopamine receptor agonist bromocriptine on task-set switching were abolished by pretreatment with the D2 receptor antagonist sulpiride. To account for individual (genetic) differences in baseline levels of dopamine, we made use of a common variable number of tandem repeat (VNTR) polymorphism in the 3′-untranslated region of the dopamine transporter gene, DAT1. ResultsBromocriptine improved cognitive flexibility relative to placebo, but only in subjects with genetically determined low levels of dopamine (n = 27). This beneficial effect of bromocriptine on cognitive flexibility was blocked by pretreatment with the selective dopamine D2 receptor antagonist sulpiride (n = 14).ConclusionsThese results provide strong evidence in favor of the hypothesis that human cognitive flexibility implicates dopamine D2 receptor signaling.Electronic supplementary materialThe online version of this article (doi:10.1007/s00213-011-2340-2) contains supplementary material, which is available to authorized users.

Mechanisms and Dynamics of Cortical Motor Inhibition in the Stop-signal Paradigm: A TMS Study

The ability to stop ongoing motor responses in a split-second is a vital element of human cognitive control and flexibility that relies in large part on prefrontal cortex. We used the stop-signal paradigm to elucidate the engagement of primary motor cortex (M1) in inhibiting an ongoing voluntary motor response. The stop-signal paradigm taps the ability to flexibly countermand ongoing voluntary behavior upon presentation of a stop signal. We applied single-pulse TMS to M1 at several intervals following the stop signal to track the time course of excitability of the motor system related to generating and stopping a manual response. Electromyography recorded from the flexor pollicis brevis allowed quantification of the excitability of the corticospinal tract and the involvement of intracortical GABA(B)ergic circuits within M1, indexed respectively by the amplitude of the motor-evoked potential and the duration of the late part of the cortical silent period (SP). The results extend our knowledge of the neural basis of inhibitory control in three ways. First, the results revealed a dynamic interplay between response activation and stopping processes at M1 level during stop-signal inhibition of an ongoing response. Second, increased excitability of inhibitory interneurons that drives SP prolongation was evident as early as 134 msec following the instruction to stop. Third, this pattern was followed by a stop-related reduction of corticospinal excitability implemented around 180 after the stop signal. These findings point to the recruitment of GABA(B)ergic intracortical inhibitory circuits within M1 in stop-signal inhibition and support the notion of stopping as an active act of control.

Two Mechanisms for Task Switching in the Prefrontal Cortex

Measuring the cognitive and neural sequelae of switching between tasks permits a window into the flexible functioning of the executive control system. Prolonged reaction times (RTs) after task switches are accompanied by increases in brain activity in the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (dlPFC), but the contribution made by these regions to task level control remains controversial. Here, subjects performed a hybrid spatial Stroop/task-switching paradigm, requiring them to respond with a joystick movement to congruent or incongruent spatial/verbal cues. Relative to the previous trial, the active task either switched or remained the same. Calculating switch costs as a function of current and previous trial congruency, we observed both a general RT increase on every switch trial, and additional slowing and impairment to performance when the switch occurred on the second of two successive incongruent trials (iI trials). Imaging data revealed corresponding neural concomitants of these two switch costs: the ACC was activated by task switches regardless of trial type (including congruent trials in which task-relevant and task-irrelevant information did not clash), whereas the caudal dlPFC exhibited a switch cost that was unique to iI trials. We argue that the ACC configures the priorities associated with a new task, whereas the dlPFC tackles interference from recently active, rivalrous task sets. These data contribute to a literature arguing that human cognitive flexibility benefits from the setting of new priorities for future action as well as the overcoming of interference from previously active task sets.

Polymorphisms in the 3′ UTR of the serotonin transporter are associated with cognitive flexibility in rhesus macaques

The serotonin system is an important neurophysiological mediator of many behavioral phenotypes. Genetic variation within this system is thought to contribute not only to the natural range of behavioral differences, but also to neuropsychiatric pathologies. Cognitive flexibility, the ability to change patterns of response as reward context shifts, is an important trait that underlies many complex social interactions. Environmental manipulations of the serotonin system have been shown to alter performance on tests measuring cognitive flexibility. Variation at the serotonin transporter promoter region (5HTTLPR) has recently been shown to associate with the performance of rhesus monkeys on an object discrimination reversal learning task [Izquierdo et al., 2007]. Here, we demonstrate that functional genetic variation at the serotonin transporter 3' untranslated region, independent of 5HTTLPR, also associates with performance in an object discrimination reversal learning task in rhesus macaques. The polymorphisms comprising the T:G:T haplotype (T1970, G1991, and T2327) were associated with fewer errors on a reversal learning test and greater levels of cognitive flexibility. We have previously demonstrated that the T:G:T haplotype renders lower levels of gene expression in vitro, paralleling the functionality of human 3' UTR haplotypes, as well as the short allele of 5HTTLPR found in both macaques and humans. The 3' UTR haplotypes are independent and in linkage equilibrium with the 5HTTLPR locus. Together, these data lead to the intriguing possibility that differences observed in human cognitive flexibility, whether naturally or in pathological states, may be associated with genetic variation in the serotonin transporter 3' untranslated region also.

A cognitive approach to safe violations

Classically, humans have been perceived as a source of faults in systems. Modern ergonomic views are promoting a somewhat different idea according to which humans are a factor of safety in unexpected situations. The safety of a system cannot be achieved without taking into account these two sides of cognition which compose what is called cognitive flexibility. In this paper, we will consider the cases of a nuclear accident and a plane crash-landing where human cognitive flexibility has impacted the final safety of the system. We aim to discuss the violations that humans have performed in these cases with the assumption that these violations do not always deteriorate system safety. The discussion gravitates around a core argument according to which violations per se do not inform on the safety impairments in a system. Some other dimensions have to be taken into account. We are of the opinion that, among these other dimensions, the accuracy of the operators' mental model plays a key role, allowing some violations to improve system safety in emergency situations.

Frontal lobe and frontal-striatal substrates for different forms of human cognitive flexibility

Frontal lobe and basal ganglia lesions have been associated with similar cognitive impairments, although their specialized roles in behavior are likely to be different. We examined whether these structures mediate distinctive or overlapping aspects of a complex behavioral process that has been associated with both neural sites, i.e. cognitive flexibility. Patients with focal ischemic lesions to the frontal lobe and basal ganglia were compared on two forms of cognitive flexibility: (1) shifting response set (i.e. reactive flexibility), and (2) producing a diversity of ideas (i.e. spontaneous flexibility). Results indicated that frontal lobe and basal ganglia damage each caused a similar degree of impairment in reactive flexibility, both groups performing at a significantly lower level than posterior cortical lesion and normal comparison groups. However, frontal lobe damage markedly disturbed spontaneous flexibility, while performance after basal ganglia lesion was significantly higher and comparable to posterior cortical lesions. Findings suggest that the frontal lobe and basal ganglia participate differently in the neural substrate of cognitive flexibility. The frontal lobe appears to mediate spontaneous flexibility. The production of diverse ideas may require direct cortical-cortical interactions by the frontal lobe in order to access knowledge systems with novel strategies that transcend the most common semantic linkages. In contrast the corticostriate system appears to mediate reactive fexibility, as the frontal lobe, basal ganglia and their interconnections are required for its operation.