In today’s rapidly evolving healthcare landscape, the integration of innovative technologies is becoming increasingly essential to enhance patient care, medication and overall healthcare outcomes. Quick Response (QR) codes have emerged as a versatile tool with significant potential to revolutionize such aspects of the healthcare industry. Through a review of 30 studies, we uncover the significant impact of integrating QR codes into healthcare systems. Across various domains, QR codes prove instrumental in enhancing patient care, streamlining workflows, and improving communication between healthcare professionals and patients. Notable findings include the role of QR in ensuring medication safety and advancing education as well as training within healthcare settings. Despite some challenges, user satisfaction remains high, underscoring QR codes’ effectiveness in optimizing healthcare delivery and outcomes from a human-centred perspective. This includes considering usability, cognitive load, and ergonomic design, all of which are crucial for maximizing the benefits of QR code technology in healthcare.