Hue Central Hospital Research Articles

Study of bone mineral disorders in hemodialysis patients at Hue Central Hospital

Study of bone mineral disorders in hemodialysis patients at Hue Central Hospital

Varicella zoster infection in Pediatric oncology patients in Hue Central Hospital, Vietnam

Abstract Background Varicella zoster infection in pediatric oncology patients presents a big challenge. It could lead to a severe, prolonged and disseminated infection with complications in multiple organs. This study aimed to investigate varicella zoster infection in pediatric oncology patients at Hue Central Hospital, Vietnam in order to describe demographic, epidemiological, clinical features and complications. Methods Varicella zoster infections among children with cancer were identified between January 8 to November 4, 2023, at Hue Central Hospital. Varicella zoster infection was diagnosed clinically based on the presence of typical skin manifestations. Data were abstracted from patient medical records and analyzed in SPSS v.18.0 (IBM Corp., Armonk, NY, USA). Results From January 8 to November 4, 2023, a total of 20 patients with malignancies were identified as having varicella zoster, with a median age of 3.5 years (range: 1 years to 16 years). All these patients did not received varicella zoster vaccine. Almost half of the patients had solid tumor (n=11, 55.0%), and other half had leukemia (n=9, 45.0%). Some of them (n=7, 35.0%) were receiving chemotherapy, and other (n=13, 65%) just finished chemotherapy. Most children were hospitalized (n=16, 80.0%) and they were given oral acyclovir (n=18, 90.0%). Three children (15.0%) required critical care (severe infection, acute pancreatitis, and multiorgan failure (MOF)), and one (5.0%) died from disseminated and progressive varicella with MOF and suspected varicella zoster meningitis. Chemotherapy was delayed or omitted due to varicella in 70.0%. Some of the children with varicella acquired from their parents. There were 5 parents who got varicella zoster when taking care patients at the hospital. All patients were likely to expose other patients in the wards. Conclusion Children with cancer are at extra risk of varicella zoster infection and progression to severe disease due to their immunocompromised status. Optimizing vaccination of care providers, such as their relatives, will prevent transmitting virus to the patients.

Clinical manifestations and laboratory findings in late-onset neonatal sepsis at a neonatal intensive care unit in Vietnam. A prospective cross-sectional observational study

Background and objectives. Late-onset neonatal sepsis (LOS) is one of the significant causes of morbidity and mortality in newborns. Early diagnosis is essential for treatment, prognosis, and mortality reduction. This study investigates the clinical manifestations and laboratory findings of LOS. Materials and methods. A cross-sectional study was carried out on 158 neonates with LOS hospitalized at the Neonatal Unit of Hue Central Hospital between May 2018 and September 2020. LOS is defined as sepsis occurring at or after 72 hours of life. Data on age, gender, clinical symptoms, and laboratory tests were analyzed. Results. One hundred and eight neonates with late-onset neonatal sepsis were enrolled in this study. Enterocolitis accounted for the highest percentage (32.9%), followed by pneumonia (29.7%) and omphalitis (17.7%). Bacterial meningitis accounted for 2.5%. Fever represented 58.9%, and there was no hypothermia. Anemia, leukocytosis, leukocytopenia, and C-reactive protein (CRP) positive results were found in 41.1%, 8.4%, 4.3%, and 18.4%, respectively. Bacterial cultures were positive in 12 (10.3%) of 117 neonates tested. Conclusions. The clinical signs and symptoms of late-onset neonatal sepsis should be considered an essential part of the early diagnosis of LOS. The routine laboratory findings varied, and bacterial cultures were positive in a small number of neonates. Therefore, we should monitor closely to detect and provide treatment properly.

The factors associated with mortality in sepsis adult patients at Hue Central Hospital 2021 - 2022

The factors associated with mortality in sepsis adult patients at Hue Central Hospital 2021 - 2022

Diagnostic performances of the Ovarian Adnexal Reporting and Data System, the Risk of Ovarian Malignancy Algorithm, and the Copenhagen Index in the preoperative prediction of ovarian cancer: a prospective cohort study.

This study aimed to assess the diagnostic performance of the Risk of Ovarian Malignancy Algorithm (ROMA), Copenhagen Index (CPH-I), and Ovarian Adnexal Reporting and Data System (O-RADS) for the preoperative prediction of ovarian cancer (OC). A prospective cohort study was conducted on 462 patients diagnosed with ovarian tumors admitted to the Departments of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy Hospital, and Hue Central Hospital from May 2020 to December 2022. ROMA and CPH-I were calculated using cancer antigen 125 (CA125), human epididymal protein 4 (HE4) levels, and patient characteristics (age and menopausal status). O-RADS criteria were applied to describe ovarian tumor characteristics from ultrasound findings. Compared with histopathological results, the predictive values of ROMA, CPH-I, and O-RADS alone or in combination with CA125/HE4 for OC were calculated. Among 462 patients, 381 had benign tumors, 11 had borderline tumors, and 50 had OC. At optimal cut-off points, ROMA's and CPH-I's areas under the curves (AUCs) were 0.880 (95% confidence interval [CI]=0.846-0.909) and 0.890 (95% CI=0.857-0.918), respectively, and ROMA and CPH-I sensitivities/specificities (Se/Sp) were 68.85%/95.01% and 77.05%/91.08%, respectively. O-RADS ≥3 yielded an AUCs of 0.949 (95% CI=0.924-0.968), with Se/Sp of 88.52%/88.98% (p<0.001). Combining O-RADS with CA125 demonstrated the highest predictive value, with AUCs of 0.969 (95% CI=0.949-0.983) and Se/Sp of 98.36%/86.09% (p<0.001). The ROMA, CPH-I, O-RADS, O-RADS + CA125, and O-RADS + HE4 models demonstrated good predictive values for OC; the combination of O-RADS and CA125 yielded the highest values.

Feasibility of laparoscopic modified Frey procedure for chronic pancreatitis: a prospective 6 case series.

Chronic pancreatitis (CP) is characterized by longstanding inflammation of the pancreas. Several authors have reported minimally invasive treatment of this CP (pancreaticoduodenectomy, lateral pancreaticojejunostomy, Frey procedure) with promising short-term outcomes. This is a case series of 6 patients diagnosed with CP and treated using the laparoscopic modified Frey procedure at Hue Central Hospital, Vietnam. Six patients (5 males and 1 female) with CP and operated on using modified Frey's procedure. The median age was 45 years old. The mean of Body Mass Index was 16.3 kg/m2. The median preoperative duration of symptoms was 3.3 years. All patients were presented with a dilated main pancreatic duct (mean diameter of 7.8 mm). The median time to first bowel movement was 1.5 (1-2) days. The median postoperative hospital stay was 7 (5-11) days. No reoperation or mortality was recorded. The laparoscopic modified Frey procedure is feasible and safe with good short-term and mid-term outcomes for chronic pancreatitis.

Laparoscopic complete mesocolic excision in colon cancer: a prospective cohort study

Introduction: Compared to conventional colon cancer surgery, laparoscopic complete mesocolic excision (CME) increases the likelihood of lymph node dissection. However, this surgery is not yet considered a safe strategy. The authors study this topic to evaluate the safety and feasibility of this surgery. Methods: A prospective cohort study was performed on patients undergoing laparoscopic CME surgery at the Hue University of Medicine and Pharmacy Hospital and Hue Central Hospital. Results: Demographic data, surgical features, and postoperative complications. Evaluate different clinicopathological factors determining the number and distribution of lymph nodes; and the rate of lymph node metastasis by tumor location and lymph node groups. Three-year overall survival and disease-free survival follow-up after surgery. Conclusion: The results of laparoscopic CME colectomy surgery are safe, with a reliable maximum number of harvested nodes.

Prevalence and associated factors of bacterial vaginosis among pregnant women in Hue, Vietnam.

Bacterial vaginosis (BV) is the most frequent vaginal infection affecting women of childbearing age worldwide. It is associated with significant adverse healthcare outcomes, especially during pregnancy. Although screening for BV could reduce potential pregnancy-related obstetric complications, there is no routine screening of pregnant women for BV in Vietnam. We aimed to identify the prevalence of BV among pregnant women and the associated factors in two tertiary hospitals in Hue, Vietnam. This cross-sectional descriptive study included 885 pregnant women in third trimester, who received routine antenatal care in the Hue Central Hospital and Hue University Hospital of Medicine and Pharmacy, Hue city, Thua Thien Hue province, Vietnam. Gram-stained vaginal smears were used for calculating the Nugent score and recording the fungal elements. In total, 435 (49.1%) women had a normal BV score, 352 (39.8%) had intermediate vaginal microbiota, and 98 (11.1%) had BV. Among the 98 women with BV, 71 (72.4%) also had fungal infection. There was a significant association of BV with discharge (p = 0.004) and abnormal cervix (p = 0.014). BV was significantly more frequent among the women who reported previous abortion or miscarriage (p = 0.007). About a tenth of women in Thua Thien Hue province have BV in the third trimester of pregnancy being associated with previous adverse outcome. Discharge with fishy odour is still a characteristic feature among subtle clinical presentations of BV. Better awareness about this disease and routine test-and-treat management during pregnancy may improve pregnancy outcome.

Quality of life of patients one month after open heart surgery according to the sf-36 health scale

ABSTRACT Introduction: Quality of life after open heart surgery shows the level of impact on the patients; moreover, it also reflects physical, functional, and psychosocial decline caused by diseases of the entity. This study evaluates the characteristics of quality of life of patients one month after open heart surgery according to the SF-36 health scale at Hue Central Hospital. Methods: This was a cross - sectional descriptive study of 217 patients who underwent open heart surgery at the Cardiovascular Center, Hue Central Hospital, from August 1, 2022, to April 30, 2023. Results: The mean general quality of life score was 64.21 ± 15.71, and the mean physical and mental component summary scores were 69.44 ± 16.08 and 58.98 ± 15.74, respectively. The average of eight health domains scores was physical functioning (84.42 ± 12.21); role physical (86.17 ± 22.41); bodily pain (46.77 ± 20.47); general health (60.38 ± 14.17); vitality (62.05 ± 27.01); role emotional (58.54 ± 11.27); mental health (64.22 ± 12.74); social functioning (51.09 ± 14.51). The mean anxiety disorder and perceived level of social support scores were 9.28 and 65.14, respectively. Conclusion: The quality of life of patients after open heart surgery is quite good, anxiety disorders and perceived levels of social support are high.

Effective spiritual care of elderly patients following the Kaigo method at Hue Central Hospital

ABSTRACT Background: Elderly care according to the Kaigo method is a specialized care system developed in Japan. It aims to provide holistic nursing support for the elderly, encompassing physical, psychological, and social needs. This research aimed to evaluate the effectiveness of the Kaigo method in the mental care of elderly patients at the Department of General Internal Medicine and Geriatrics, Hue Central Hospital. Methods: An intervention study without a control group was conducted, involving pre - and post - intervention monitoring of 114 patients over 60 years old receiving inpatient treatment. Results: The average happiness index according to WHO-5 before and after the intervention was 42.26 ± 10.45 and 84.12 ± 12.1, respectively. The average quality of life score according to the EQ 5D5L scale before and after the intervention was 17.54 ± 1.22 and 11.25 ± 3.06, respectively. The inpatient experience score before the intervention was 3.14 ± 0.73 and 3.92 ± 0.91 after the intervention. Factors related to the change in the happiness index in the intervention group included the quality of life and inpatient experience scores. Conclusion: Spiritual care for elderly patients using the Kaigo method significantly improved the happiness index and quality of life and inpatient experience.

Assessment of sleep quality in patients after abdominal surgery

ABSTRACT Objectives: Evaluating the sleep quality of patients after abdominal surgery at the General Surgery Department, Hue Central Hospital Base 2. Investigating some factors related to the sleep quality of the study subjects. Methods: Description of a cross-sectional study on 92 post-abdominal surgery patients at the Hospital from February 1, 2023, to August 31, 2023, using a single random sampling method. Results: The average sleep quality score of post - abdominal surgery patients on the second day was moderate (84.31 ± 30.16). Factors influencing patients’ sleep quality such as postoperative pain, level of anxiety, and the impact of the care environment were statistically significant (p &lt; 0.05) and had a 64.1% influence (correlation coefficient R = 0.641; p &lt; 0.001) on the sleep quality on the second night after surgery (F = 55.25; p &lt; 0.001). Among these factors, the highest influencing factor on sleep quality in post-abdominal surgery patients was the level of anxiety (β = -0.42; p &lt; 0.001). Conclusion: Developing patient - centered care programs focusing on improving sleep hygiene, enhancing access to sleep treatment methods, and educating patients about the benefits of good sleep

Effectiveness of remote dietary counseling intervention on cancer patients with enteral tube feeding undergoing chemotherapy

ABSTRACT Background: Hue Central Hospital is a special-grade central - level hospital that has been and is promoting comprehensive patient care. The teamwork between treating physicians, nursing care, clinical pharmacists and nutritionists has initially shown positive patient treatment outcomes. Recognizing that cancer patients frequently enter and exit the hospital between chemotherapy cycles, remote nutritional counseling intervention is an effective measure to help patients adhere to a reasonable diet at home and prepare their physical condition for the next chemotherapy cycle. Therefore, we conducted this study to evaluate the effectiveness of remote nutritional counseling intervention on cancer patients with enteral feeding undergoing chemotherapy at the Oncology Center, Hue Central Hospital. Methods: A non - controlled interventional dietary study was conducted on 22 patients diagnosed with cancer and admitted for multiple chemotherapy cycles with enteral feeding indication at Hue Central Hospital Cancer Center from January to April 2024. Results: The nutritional status characteristics of the study subjects according to the clinical index Albumin &lt; 25g/L accounted for 4.5%; BMI &lt; 18.5 accounted for 27.3% and 90.9% of patients were assessed as malnourished according to PG-SGA. After nutritional intervention, most patients had positive changes in anthropometric and clinical parameters (p &gt; 0.05). Conclusions: Remote home - based dietary intervention has demonstrated positive effects for patients.

Herbal footbaths for insomnia treatment in cancer patients

ABSTRACT Background: Sleep disorders and insomnia are frequent concerns among cancer survivors, presenting a notable challenge. Herbal footbaths are a complementary and alternative medicine that provides good results in managing insomnia, with few adverse effects and low costs. This study aims to assess the effectiveness and safety of herbal footbaths therapy for insomnia treatment in cancer patients. Methods: A cross - sectional descriptive study was carried out on 63 inpatients with cancer undergoing treatment at the Oncology Center in Hue Central Hospital. The primary outcome was the Insomnia Severity Index (ISI). The secondary outcome was adverse therapy reactions. Results: The ISI scale reduced significantly to 4.92 ± 2.55 (p &lt; 0.01). No adverse reactions were found during the study. Conclusion: Herbal footbaths are an effective and safe treatment for insomnia in cancer survivors.

Role of magnetic resonance imaging in staging of rectal cancer and application AJCC 8th staging

Purpose: To evaluate the role of MRI in staging of rectal cancer according to AJCC 8th staging. Material and Methods: A cross sectional study with 31 histiologically proven rectal cancer patients treated at Hue Central Hospital from 01/2022 to 05/2023. Results: The accuracy of MRI in diagnosing stage T rectal cancer according to the AJCC 8th staging is 93.5% with Kappa coefficient = 0.866. The sensitivity, specificity, and accuracy of each stage were T1-T2: 75%, 100%, 75%; T3: 100%, 81,8%, 90,9%; T4: 100%, 100%, 100%. About 12.9% of patients invaded the mesorectal fascia (MRF +) on MRI. There was only 1 case of EMVI+. The sensitivity, specificity, and accuracy of MRI in dectecting lymph node metastasis was 80%, 66,7%,71%. Conclusion: MRI appears to be a highly accurate modality so when application AJCC 8th staging be can preoperative staging and decision-making treatment of rectal cancer Key words: magnetic resonance imaging, AJCC 8th staging, rectal cancer.

Physical characteristics and factors affecting in pediatric thalassemia

Background: Thalassemia, one of the most common genetic diseases globally, can contribute to physical developmental delays in pediatric patients due to various factors. Chronic anemia, transfusional iron overload and chelation toxicity are key influences on the growth of children with thalassemia. Objective: This study aims to describe the physical development of pediatric thalassemia patients and assess the factors associated with their physical indices. Methods: A cross-sectional study involving 44 pediatric thalassemia patients receiving treatment at the Pediatric Center, Hue Central Hospital, was conducted from February 2023 to December 2023. Results: The study included 44 participants with an average age of 7.5 ± 4.3 years and an equal distribution of males and females. Of these, 64.5% were transfusion-dependent thalassemia patients. Serum ferritin levels exceeded 1000 ng/ml in 43.2% of participants, and the mean hemoglobin concentration was 67.4 ± 16.1 g/L. Of the evaluated children, 31.8% had height-for-age below -2SD, and 43.2% had weight-for-age below -2SD. Statistically significant associations were observed between height-for-age, weight-for-age, and both blood transfusion dependence and serum ferritin concentration (p &lt; 0.05). However, no significant differences were detected between physical indices and disease type or hemoglobin concentration (p &gt; 0.05). Conclusions: This study found that 31.8% of pediatric thalassemia patients experienced stunting, and 43.2% experienced wasting malnutrition. The degree of blood transfusion dependence and serum ferritin concentration were identified as factors associated with a higher prevalence of stunting and wasting malnutrition in children with thalassemia. Key words: Children, thalassemia, physical index, transfusion-dependent thalassemia, non-transfusion-dependent thalassemia.

Screening and assessment of nutritional status and some related factors in patients who have laparoscopic surgery for colon cancer

Background: Preoperative malnutrition is a significant problem for cancer and colon cancer patients, so screening, monitoring, and supporting this condition becomes increasingly essential in the surgical field. In colorectal cancer, malnutrition is significantly associated with several consequences, including mortality and increasing the length of hospital stay after surgery. The NRS 2002 and SGA scores are practical malnutrition assessment tools widely used in clinical practice today. Materials and methods: A cross-sectional descriptive study was performed on 53 patients undergoing laparoscopic surgery due to colon cancer at Hue University of Medicine and Pharmacy Hospital and Hue Central Hospital. The NRS-2002 tool was used for risk screening, and the SGA was used to assess the patient’s nutritional status. Information about the disease and related factors are referenced from medical records combined with asking the patient. Results: The average age was 61.5±14.5, of which 50.9% were male. ASA 1 accounted for the majority at 66.0%. Complications of surgical site infection accounted for 11.3%. Two patients with subcutaneous emphysema accounted for 3.8%, and one with urinary retention accounted for 1.9% were treated with conservative treatment. One patient had early postoperative small bowel obstruction due to abdominal drainage and was successfully treated medically, accounting for 1.9%. There were no major complications requiring reoperation and short-term mortality. The average hospital stay was 7.4 ± 2.1 days. According to the 2002 NRS score, there were 19 (35.8%) cases of nutritional at-risk; the SGA rating had 1.9% SGA-C and 15.1% SGA-B cases. There was a relationship between NRS-2002 and the patient’s blood albumin concentration. Conclusion: The prevalence of patients at nutritional risk and malnutrition is quite common. It is necessary to carry out routine screening and nutritional risk assessment to support colon cancer treatment. Key words: malnutrition, colorectal cancer, NRS 2002, SGA score.

Evaluate the results of treatment of lower calyces stones by flexible ureteroscopy

Objective: To evaluate the results of the treatment of the lower calyces stones by flexible ureteroscopy and investigate some factors that affect the results of the treatment of the lower calyces stones through flexible ureteroscopy. Materials and methods: A prospective cohort study was performed in 30 patients with 31 kidney stones having lower calyces that were treated with flexible ureteroscopes at Hue Central Hospital from 3/2023 to 3/2024. Results: The average age of the patients was 52.77 ± 14.24 years. The average stone size in computed tomography images is 12.83 ± 3.93 mm. Regarding the number of stones, cases with only one kidney stone account for 51.60%. As for the inferior pelvic angle, 74.20% of the cases had an angle ≥ 45°, while 25.80% had an angle &lt; 45°. The stone-free rate reached 76.70% with stones ≤ 20 mm. Conclusions: the treatment of lower calyx stones by flexible ureteroscopy demonstrated a stone -free rate of 76.70% after 1 month for stones ≤ 20 mm. Factors such as stone size, number of stones and lower pole infundibulopelvic angle all affect the treatment results of flexible endoscopy. Key words: lower calyces, lower pole infundibulopelvic angle, flexible ureterosopy.

Male sexual dysfunction in aged 40 - 60 years with diabetes

Objectives: The aims of this research are surveying the sexual dysfunction (MSD) including erectile disorder (ED) and premature ejaculation (PE) and exploring the relative factors in men with diabetes. Materials and Methods: This is a cross-sectional descriptive study of men 40 - 60 years old, diagnosed with diabetes according to the ADA standards 2020, examined at Hue Central Hospital from May 2022 to June 2023. Based on selection and exclusion criterias, we collect the administrative information, clinical and paraclinical examination and use the IIEF-5 and PEDT-5 scales to evaluate the MSD. Results: The research included 102 patients diagnosed with diabetes, of which ED and PE accounted for 70.6% and 14.7%, respectively. The duration of diabetes lasts and the poor ability to control the level of blood glucose directly effect ED (p &lt; 0.05). Diabetes accompanied by central obesity (waist circumference ³ 90cm) is closely related to ED and PE (p &lt; 0.05). In particular, BMI is a risk factor for PE (p = 0.049). Conclusions: Diabetes and related factors such as duration of disease, ability to control blood glucose level and accompanied by central obesity is significantly impact on MSD, mainly in erectile function. Key words: diabetes, male sexual dysfunction, aged 40 - 60 years, erectile disorder, premature ejaculation.

Outcomes and factors influencing the second stage of labour in singleton deliveries

Objective: To define the characteristics of the second stage of labour and the outcomes of labour. Study design: The study includes 725 cases of pregnant monitored during the second stage of labour at the Obstetrics Centers of Hue Central Hospital and the Hue University of Medicine and Pharmacy Hospital from January 2022 to August 2023. Inclusion criteria: Singleton pregnancy, cephalic presentation, gestational age between 37 and 41 weeks 6 days, height ≥ 145 cm. Exclusion criteria: Category 2 and 3 cardiotocography (CTG) during the first stage of labour, refusal to participate in the study. Methodology is a cross-sectional descriptive study with a convenient sample size. Results: The average duration of the second stage was 51.73 ± 22.55 minutes. The mean duration for vaginal deliveries was 46.45 ± 16.27 minutes, instrumental deliveries were 48.89 ± 22.65 minutes, and cesarean sections were 59.86 ± 28.75 minutes (p &lt; 0.05). Vaginal deliveries constituted 87.5%, cesarean sections 10.4%, and instrumental deliveries 2.2%. Non-engagement of the fetal head in the second stage was associated with a 19.5 higher risk of instrumental or cesarean delivery compared to engaged presentations (p &lt; 0.05). Occurrence of transverse or posterior positions had a 6.4 higher intervention rate for instrumental or cesarean deliveries than anterior positions (p &lt; 0.05). Less than 3 contractions during the second stage increased the risk of cesarean or instrumental delivery by 5.5 times compared to those with ≥ 3 contractions (p &lt; 0.05). Key words: Second stage of labour, cesarean delivery, instrumental delivery, fetal presentation.

Application of vacuum - assisted ureteral access sheath in retrograde intrarenal surgery: an initial experience of 48 cases

ABSTRACT Objectives: Reporting our initial experience of 48 cases in application of vacuum-assisted ureteral access sheath in the retrograde intrarenal surgery. Methods: Forty - eight patients who underwent retrograde intrarenal surgery at Department of Urology, Hue Central Hospital between May 2023 and May 2024 were evaluated retrospectively. The vacuum - assisted ureteral access sheath was applied in the procedure. Demographics, laboratory tests, peri - and postoperative and one-month follow- up results were analysed. Results: The mean stones size was 14.3 ± 4.9 mm. 77.1% of cases had stones located in the lower calyx. The mean operative time was 42.9 ± 17.1 minutes. The 1 - month post - operative stone - free rate was 89.6%. Two patients experienced post - operative fever. The average length of hospital stay was 3.06 ± 1.04 days. There was no unplanned readmission. Conclusions: Retrograde intrarenal surgery with vacuum-assisted ureteral access sheath is a safe and effective procedure, which can achieve excellent stone clearance.