Studies on human perceptions of Lantana camara invasion are needed to inform management. This study used a two-pronged approach to assess perceptions, knowledge, and uses of L. camara in rural communities as well as evaluate its invasion extent in household yards of the Vhembe Biosphere Reserve, Limpopo province of South Africa. Results from 300 face-to-face household interviews and household ecological surveys showed that most villagers know of L. camara but are not aware that it is an invasive alien plant. Both people’s responses and ecological household yard surveys show that the plant is on properties and is expanding. Few benefits compared to negative impacts were mentioned. Local communities are implementing control measures; however, they need assistance from the government. The results highlight the need to incorporate local and individual clearing initiatives into the current broader national control programmes, such as the Working for Water clearing programme.