Physicians and their families are often conflicted about the task of meeting their responsibilities at work and at home. This is the stress of work-life balance. It is a topic that is rarely addressed directly in formal medical education seminars or lectures but one that frequently arises during informal discussions within groups of housestaff and more senior physicians—but rarely between these groups. My objectives in dedicating the Joseph W. St Geme Jr lecture to this topic are to (1) shine a bright light on the issues of work-life balance and, thus, open communication and discussion about it within the medical community, (2) suggest a new framework for thinking about work-life balance, and (3) make some practical suggestions that might help to lessen its stress. The issues of work-life balance are complex and can generate great emotion, so perhaps a 20-minute award-reception speech does not do it justice. On hearing the term “work-life balance” most people immediately conjure the image of the balanced (or sometimes unbalanced) scales (Fig 1). In this model the scales are in a dependent relationship with one another. Add weight to one side of the scales, and immediately the balance changes, altering the position of the other side of the fulcrum. One of my objectives is to change that image to a bigger vision—beyond just 2 sides to the balance—and thus, my title, “Striving for Polygamy.” What does this mean? The “polygamy” I intend here is a metaphor for conducting 3 simultaneous “marriages.” I obviously do not intend for anyone to break the marriage laws of their state or to encourage extramarital relationships. The “polygamy” I would like to strive for is one that has been addressed in a book by David Whyte.1 Mr Whyte is a poet, and for a thorny conundrum like the issue … Address correspondence to Stephen Ludwig, MD, Division of General Pediatrics, 12NW-82, Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104. E-mail: ludwig{at}email.chop.edu