Abstract Background Women still face a higher mortality rate after a heart attack compared to men, and the reasons remain unknown. The project HeartGap aims to investigate the disparity between evidence-based guidelines and the integration of Gender-Sensitive Care (GSC+) in clinical settings. By exploring healthcare providers’ attitudes and knowledge on GSC+, the project seeks to develop holistic recommendations for its effective implementation. Methods The project HeartGap employs a mixed-methods approach, including a scoping review, qualitative focus group interviews, and quantitative surveys. The focus of this abstract will be on the qualitative survey. From June 13, 2023, to April 26, 2024, a total of 18 focus group interviews were conducted in 9 hospitals of varying sizes and levels of care in Germany. These interviews involved separate groups of 3-8 nurses or physicians to explore attitudes, knowledge including the european guidelines for cardiology and current implementation of GSC+ into clinical practice. Facilitating factors and barriers were also discussed and in which fields measures should be applied. The results were evaluated using a qualitative content analysis. Results The interviews revealed discrepancies in healthcare providers’ awareness of GSC+ and identified both facilitating and hindering factors in its implementation. Facilitating factors included increased awareness, more evidence by considering gsc+ in research, university and professional education, support from hospital leadership and politics. Barriers included a lack of time and knowledge, other priorities and vague content on GSC+ in medical and nursing guidelines. Conclusions Gender-sensitive care is crucial for personalized healthcare, yet its implementation remains inconsistent in clinical practice. Targeted strategies are necessary to enhance awareness, knowledge, and guidelines and policy support for GSC+. The Identified recommendations for action are transferable throughout Europe. Key messages • Gender-sensitive care is pivotal for addressing healthcare disparities but faces implementation challenges. • Comprehensive strategies, including awareness, teaching and policy support, are indispensable for integrating gender-sensitive care into clinical practice.