Hospital In Kathmandu Research Articles

Assessing and Prioritizing Perceived Service Quality in Healthcare Settings in Nepal: A Multi-Criteria Decision Analysis Using Analytical Hierarchy Process (AHP)

This study uses the Analytical Hierarchy Process (AHP) to compare and assess different private healthcare facilities in Nepal according to perceived service quality. For methodology, first, the criteria for the study were established and rated. Then sensitivity analysis was carried out to evaluate the decision using AHP to rank healthcare according to the characteristics of service quality and the relative positions. The data were collected from eleven hospitals in Kathmandu, Nepal. SERVQUAL dimensions were used in order to comprehend the Perceived Service Quality. The analytical procedure was carried out using Expert Choice software. The study shows that Private Teaching Hospitals have the highest Perceived Service Quality among patients, followed by Public Teaching Hospitals and that patients value tangibility over other service aspects. The study provides insights into the characteristics of service quality in Nepalese hospitals. The findings help healthcare managers to understand the factors that patients consider important to improve service quality.

A Decade-Long Analysis of Trends in Antimicrobial Resistance in a Neurosurgical Hospital in Kathmandu, Nepal.

Multidrug-resistant (MDR) bacteria cause infections with higher risks of morbidity, mortality, and financial burden. Understanding the antimicrobial resistance patterns of these pathogens is crucial for effective treatment and managing resistance. Therefore, this retrospective study examined the prevalence, causes, and trends in antimicrobial resistance in bacterial infections at a neurosurgical hospital in Nepal. We analyzed the demographics, bacteriological profiles, and antimicrobial susceptibility results in patients who visited Dirghayu Guru Hospital and Research Center, Kathmandu, Nepal, between January 2014 and January 2024, using SPSS, version 17.00. Among 4758 patients, 465 (9.77%) had infections caused by 571 bacteria. Of them, 435 (93.55%) patients had urinary tract infections, 89 (19.14%) had bloodstream infections, and 31 (6.67%) had respiratory tract infections. Klebsiella pneumoniae (n = 172, 30.12%) was the predominant bacteria. Proportions of drug-resistant Enterobacterales and gram-positive cocci among drug-resistant bacteria against tetracyclines were 83.33% and 45.83%, cephalosporins were 78.02% and 40.45%, quinolones were 72.25% and 50.00%, aminoglycosides were 65.14% and 43.53%, carbapenems were 62.96% and 30.00%, penicillins were 54.55% and 57.89%, and penicillin with beta-lactamase inhibitors (PwBLIs) were 40.54% and 42.31%, respectively. Proportions of drug-resistant nonfermenters among drug-resistant bacteria showed 100.00% resistance to these antimicrobials. MDR isolates (n = 118, 20.67%) were 100.00% susceptible to piperacillin-tazobactam and 83.33% to polymyxin B. Over the years, resistance increased for cephalosporins (48.15%-60.53%) but decreased for carbapenems (50.00%-33.33%), penicillins (64.29%-42.31%), PwBLIs (50.00%-12.50%), aminoglycosides (60.00%-49.12%), tetracyclines (100.00%-16.67%), and polymyxins (76.22%-16.67%). One-tenth of hospital-visiting patients had bacterial infections, with three-fourths involving Enterobacterales and one-fifth involving MDR bacteria. In recent years, resistance to cephalosporins has increased, whereas resistance to other beta-lactams, aminoglycosides, and polymyxins has decreased.

Investigation the Role of Calcium and Vitamin D3 And Some Biochemical Parameters in Patients with Renal Failure of Renal Failure

Coronavirus Disease 2019 is a primarily respiratory illness that can cause thrombotic disorders. Elevation of D-dimer is a potential biomarker for poor prognosis in COVID-19, though optimal cutoff value for D-dimer to predict mortality has not yet been established. This study aims to assess the accuracy of admission D-dimer in the prognosis of COVID-19 and to establish the optimal cutoff D-dimer value to predict hospital mortality. Clinical and laboratory parameters and outcomes of confirmed COVID-19 cases admitted to four hospitals in Kathmandu were retrospectively analyzed. Admitted COVID-19 cases with recorded D-dimer and definitive outcomes were included consecutively. D-dimer was measured using immunofluorescence assay and reported in Fibrinogen Equivalent Unit (μg/ml). The receiver operating characteristic curve was used to determine the accuracy of D-dimer in predicting mortality, and to calculate the optimal cutoff value, based on which patients were divided into two groups and predictive value of D-dimer for mortality was measured. D-dimer levels were higher in COVID-19 patients and were related with markers of inflammation, and after treatments, D-dimer levels decreased which was synchronous with hsCRP levels in patients with good clinical prognosis. Also, the low correlation between Padua VTE score and D-dimer levels weakened the role of D-dimer in the prediction of thrombosis.The abnormal changes of D-dimer and inflammatory factors suggest that aggressive anticoagulant therapy might be needed.

Dengue virus surveillance in Nepal yields the first on-site whole genome sequences of isolates from the 2022 outbreak

BackgroundThe 4 serotypes of dengue virus (DENV1-4) can each cause potentially deadly dengue disease, and are spreading globally from tropical and subtropical areas to more temperate ones. Nepal provides a microcosm of this global phenomenon, having met each of these grim benchmarks. To better understand DENV transmission dynamics and spread into new areas, we chose to study dengue in Nepal and, in so doing, to build the onsite infrastructure needed to manage future, larger studies.Methods and resultsDuring the 2022 dengue season, we enrolled 384 patients presenting at a hospital in Kathmandu with dengue-like symptoms; 79% of the study participants had active or recent DENV infection (NS1 antigen and IgM). To identify circulating serotypes, we screened serum from 50 of the NS1+ participants by RT-PCR and identified DENV1, 2, and 3 – with DENV1 and 3 codominant. We also performed whole-genome sequencing of DENV, for the first time in Nepal, using our new on-site capacity. Sequencing analysis demonstrated the DENV1 and 3 genomes clustered with sequences reported from India in 2019, and the DENV2 genome clustered with a sequence reported from China in 2018.ConclusionThese findings highlight DENV’s geographic expansion from neighboring countries, identify China and India as the likely origin of the 2022 DENV cases in Nepal, and demonstrate the feasibility of building onsite capacity for more rapid genomic surveillance of circulating DENV. These ongoing efforts promise to protect populations in Nepal and beyond by informing the development and deployment of DENV drugs and vaccines in real time.

Human immunodeficiency virus-1 genome from patient with fever, Nepal.

A patient with fever presented to the referral infectious disease hospital in Kathmandu, Nepal. Metagenomic sequencing of the patient's serum recovered a near-complete genome of human immunodeficiency virus-1 (HIV-1), distinct from previous HIV-1 genomes from Nepal in GenBank. It shared 92.48% nucleotide identity with an HIV-1 subtype C isolate from India.

Histopathological study of scaly plaque over palm and sole in patients attending a tertiary care Hospital in Kathmandu

Background: Dermatoses of palms and soles are frequently encountered as palms and soles have non-hairy skin. Scaling skin could be a symptom of many medical conditions including psoriasis, eczema, contact dermatitis, ichthyosis, actinic keratosis, lichen planus, tinea, etc. Psoriasis must be differentiated from its non-psoriatic lesions. Histopathological examination often serves as a confirmative part of the diagnosis. Materials and methods: This was a hospital-based retrospective study carried out in the Department of Pathology and Department of Dermatology of Nepal Medical College Teaching Hospital. A total of 139 cases of scaly plaque skin lesions of the palm and sole from January 2020 to December 2022 were included in the study. The histopathological diagnosis was correlated with the clinical diagnosis. Results: Among 139 persons presenting with scaly lesions, the median age was 36 years with an age range from 15 years to 80 years. A female preponderance (59%) was observed. The odds of Psoriasis were 2.5 times higher (OR CI: 1.21 to 5.17) among those aged 36 years and above (P value 0.011). There was a significant association between age categories and histological diagnosis of scaly lesions. The agreement was significant between the clinical and histological diagnosis for psoriatic (63.0%) and non-psoriatic lesions (76.3%) with a Cohen’s kappa coefficient of 0.38 (SE: 0.084), P value < 0.0001. Conclusions: Both psoriatic and non-psoriatic lesions can present as scaly plaque skin lesions, hence the knowledge of these clinical mimickers is important for the proper diagnosis. The histopathological examination will give the confirmatory diagnosis.

Mini-thoracotomy Approach for Heart Surgery in Tertiary Care Hospital of Nepal.

The usual surgical technique for heart surgery has been median sternotomy, which provides excellent exposure of all cardiac structures and facilitates the establishment of cardiopulmonary bypass with central cannulation. A number of alternative surgical techniques, including the right anterolateral thoracotomy, posterolateral thoracotomy, and partial sternotomy, have been suggested. We want to share our experience with right anterior mini-thoracotomy versus right axillary mini-thoracotomy for closing an atrial septal defect. The study was a retrospective cross-sectional study conducted in a hospital. The study comprised patients with atrial septal defect admitted to Green City Hospital in Kathmandu, Nepal. From May 2016 until September 2021. Data was extracted to MS excel sheet, and then transported to the STATA version 17 for analysis. First, we computed descriptive analysis which included calculation of frequency, percentage, mean and median for presentation of socio-demographic variables. Continuous data were tested for normality using Shapiro-Wilk test. A total of 25 patient were included in the study with median age 26 years (20-32). The median aortic cross clamp time was 25 minutes ranging 20-35 min. The median duration of cardiopulmonary bypass time ranging from 31to 161 minutes. The median time of Ax was 25 minutes and 26 minutes for right anterior mini-thoracotomy and right axillary mini-thoracotomy respectively. The median duration of hospital stay was 4 days ranging from 3-4 days. Nearly 36% study participants were associated with abnormal body mass index. (Either under nutrition or over nutritional status). There were no significant differences between the duration of intensive care unit and hospital stays, aortic cross clamp time, and complications between the two groups. However, the possibility of less blood loss during surgery and of cosmetic appearance in axillary incision is of special importance.

Prevalence of Perinatal Depression and Its Associated Risk Factors among Nepalese Women in Kathmandu, Nepal.

Perinatal mental health is a major public health issue that arises during pregnancy and/or after birth, with substantial implications for social, parental, and maternal functioning, as well as overall quality of life. The study aimed to determine the prevalence of perinatal depression and its associated risk factors among women who visited a maternity hospital in Kathmandu, Nepal. A cross-sectional study was conducted at the Paropakar Maternity and Women's Hospital in Kathmandu. A total of 300 women in their perinatal period were interviewed. The Edinburgh Perinatal Depression Scale (EPDS) was used to measure perinatal depression. The Poisson regression model was used to determine risk factors associated with perinatal depression. The mean age of respondents was 25.5 (SD 4.5) years; average age during their first pregnancy was 23.5 (SD 3.7) years; and 53.7% of respondents were in the antenatal period. The prevalence of depressive symptoms (EPDS ≥ 10) was 40% (95% CI 31.4% to 45.8%). Unsupportive family members (adjusted prevalence ratio [aPR] 2.23; 95% CI 1.75-2.86), postnatal period (aPR 2.64; 95% CI 1.97-3.53), complications faced during delivery (aPR 1.76; 95%CI 1.30-2.39), history of intimate partner violence (aPR 0.48; 95% CI 0.36-0.64), and first pregnancy at the age of ≤25 years (aPR 0.61; 95% CI 0.42-0.88) were identified as key risk factors of perinatal depression. Strong family support and the active involvement of partners in counselling can contribute to alleviating perinatal depression symptoms. Targeted interventions in health and well-being services should be implemented to address mental health burden during both pregnancy and postpartum periods.

Decision Making Status regarding Antenatal Care among Women in a Tertiary Level Hospital of Kathmandu

Introduction Women’s decision making is one of the important indicators of maternal health which directly influence their utilization of antenatal care services resulting on reduction maternal morbidity and mortality. The aim of this study was to find out the decision making status regarding antenatal care among women. MethodsA cross-sectional study was conducted among 180 antenatal women of third trimester from Gynae/Obs OPD of Tribhuvan University Teaching Hospital (TUTH). Non probability purposive sampling technique was adopted. Data was collected by using semi-structure interview questionnaire Data were analyzed using descriptive statistic and inferential statistics using chi square and fisher’s exact test. ResultsMore than two-thirds research participant (68.3%) had medium level of decision making on antenatal care, whereas few respondents (16.7%) had high level of decision making. The study revealed that there was statistical association between level of decision making with women’s age (p=0.009), type of family (p=0.01), duration of marriage (p=0.002), economic status (p=0.009), education (p=0.007) and number of children (< p=0.001). ConclusionsFew of the antenatal women have high level of decision-making status regarding their Antenatal care. Furthermore the lowest level of decision making observed concerning on autonomy in financial matter thus the importance of advocacy for promoting women’s decision-making status in Nepalese context is necessary.

Epidemiology and management of motorbike chain-related fingertip injuries: A retrospective study at B&B Hospital, Kathmandu

Fingertip injuries, particularly those resulting from motorbike chain accidents, pose significant challenges due to their impact on daily life activities. This retrospective study conducted at B&B Hospital in Kathmandu from January 2018 to December 2022 aimed to explore the epidemiology and management of motorbike chain-related fingertip injuries. Among the 256 cases of fingertip injuries studied, 136 were attributed to motorbike chain accidents. Males comprised the majority of cases, and the index and middle fingers were the most frequently injured. Various surgical procedures were employed for treatment, with V–Y Plasty being the most common. These findings underscore the complexity of managing these injuries and highlight the importance of preventive measures and patient-centered care.

Intestinal parasitic infection among children less than five year of age visiting Children’s Hospital of Kathmandu.

Intestinal parasitic infection among children less than five year of age visiting Children’s Hospital of Kathmandu.

Problems faced by clients and factors affecting post-operative recovery after open-heart surgery in selected hospitals in Kathmandu

Problems faced by clients and factors affecting post-operative recovery after open-heart surgery in selected hospitals in Kathmandu

Prevalence and risk factors of postpartum depression in mothers attending child immunization clinic of a Teaching Hospital in Kathmandu

Prevalence and risk factors of postpartum depression in mothers attending child immunization clinic of a Teaching Hospital in Kathmandu

Clinico-Laboratory Profile and Outcome of Kawasaki Disease in Children in a Tertiary Care Hospital in Kathmandu

Introduction: Kawasaki disease (KD) is one of the most common vasculitis of childhood. It contributes significantly to acquired heart disease in children and results in coronary artery abnormalities including aneurysm in 25% of untreated children. This study aims to retrospectively assess the clinical course, laboratory results, and presenting symptoms of patients with complete and incomplete KD treated at tertiary care hospital in Kathmandu.Method: This retrospective study was conducted in the Department of Pediatrics. Data from January 2020 to December 2020 were retrieved from medical records department of the hospital and analyzed using Microsoft excel.Result: The total number of cases evaluated in our study was 9. The median age at the time of the diagnosis of KD was 24 months (median age for incomplete KD-21 months, complete KD-37 months). Male to female ratio was 1.2:1. The peak season of KD occurrence was Spring (March – May). Mean duration of stay in the hospital was 7 days. All children presented with fever, with an mean fever duration of 7 days at the time of presentation. Fever was present in every case. The most common principal symptom was a polymorphous skin rash, observed in 88% of the cases. Elevated CRP levels (≥3 mg/dl) were noted in all 9 cases. Cardiovascular complications were present in 88% of the patients, with coronary artery aneurysm (CAA) detected in 11%, coronary artery dilation in 22%, and mild pericardial effusion documented in 66% of the cases. Eight patients (88%) received IVIG, all 9 patients (100%) received aspirin, and 2 patients received steroids. There were no fatalities.Conclusion: KD is a common vasculitis in children which do not have significant sex predilection in oppose to most of the studies. Majority of cases occurred in spring season. The most common symptom was polymorphous rash. A high level of suspicion for diagnosing KD is essential, and early treatment is crucial to prevent complications and reduce the future economic burden on families and the nation.

Adherence to antihypertensive medication and its associated factors among patients with hypertension attending a tertiary hospital in Kathmandu, Nepal.

Hypertension is a major risk factor for cardiovascular disease, which is the leading cause of premature mortality and morbidity globally. Despite the evidences of the availability of effective treatment for hypertension, its management remains suboptimal. Medication adherence is the most crucial factor for blood pressure control. It is important to identify the factors associated with adherence to antihypertensive treatment for better management. Hence, this study assessed the level of antihypertensive medication adherence and its associated factors among patients with hypertension visiting a tertiary-level hospital in Kathmandu, Nepal. An analytical cross-sectional study was carried out among 308 diagnosed patients with hypertension who were prescribed antihypertensive medication. The Morisky Medication Adherence Scale (MMAS-8) was used to assess medication adherence. Data was collected through face-to-face interviews and analysed using SPSS v26. A bivariate and multivariate logistic regression model was used to assess the factors associated with low medication adherence. More than half (61%) of the study participants had moderate to high levels of medication adherence. Upon bivariate analysis, there was a significant association between presence of side effects, blood pressure status, forgetfulness, high cost, fear of taking medicine lifelong and irregular follow-up with a low level of adherence. Upon multivariate the logistic regression analysis, forgetfulness [Adjusted Odd's Ratio (AOR) 22.5, 95% Confidence Interval(CI) 10.56-47.86], high cost (AOR 3.8, 95%CI 1.25-11.60) and fear of taking medicines lifelong (AOR 6.04, 95%CI 2.96-12.33) were found to be associated factors of low level of adherence. There is an urgency to develop evidence-based strategies to improve the level of adherence to antihypertensive medications among patients with hypertension. Strategies like reminder messaging, setting alarms, expanding the scope of national health insurance and proper counselling to reduce fear could help to improve medication adherence. Hence, the feasibility and effectiveness of such intervention should be explored in future studies.

Knowledge of Tooth Discoloration and Tooth Bleaching amongst Adult Patients Visiting a Dental Hospital in Kathmandu, Nepal

A beautiful smile increases the self-confidence and well being of an individual. Tooth discoloration is one of the cause for a patient to stop smiling, be less interactive with other people and the person might feel neglected from the society. Many people don’t know about the various causes of tooth discoloration and the treatment options. Bleaching is a very conservative method to whiten the teeth. Until now limited studies have been done to assess the knowledge of tooth discoloration and vital tooth bleaching in context to Nepal. Hence, the objective of this study was to assess the knowledge of tooth discoloration and tooth bleaching amongst adult patients. This cross sectional study was done on 326 patients of 18 years and above. Personal interviews using a structured and validated questionnaire were conducted to collect the following information: demographic data, the participant’s level of satisfaction of their tooth color, the participant’s level of knowledge on tooth discoloration and tooth bleaching. Data were analyzed using Chi square test and descriptive statistics were calculated. It was found that majority of the study participants (63.8%) were satisfied with the color of their teeth and most of them (58.9%) had not heard about tooth bleaching. It was seen that there was no association of different aspects of bleaching as well as etiology of tooth discoloration with gender, age group, level of education and marital status.

Knowledge and Prevalence of Plantar Fasciitis among Nurses of Selected Hospital of Kathmandu, Nepal

An uncomfortable foot ailment called plantar fasciitis is brought on by an inflammation of the plantar fascia. When this band of tissue is overworked or overextended, plantar fasciitis develops. This results in tiny rips in the fascia's fibers, particularly where it connects to the heel bone. This study set out to determine how much the nurses at the Civil Service Hospital in Kathmandu knew about plantar fasciitis and how common it was. At the Civil Service Hospital in Kathmandu, 58 nurses participated in a descriptive cross-sectional research. Data were gathered using a self-administered questionnaire and the windlass test. SPSS version 20 was used to analyze the data, which included frequency and percentage using a descriptive statistical approach. The results showed that majority of respondents (53.4%) of nurses were age group of 18 to 25 years. Maximum respondents (93.1%) had normal BMI, maximum (46.6%) had 1 to 4 years work experience and majority of respondents (74.1%) worn flats during duty hours. Out of 58 respondents (56.9%) had poor knowledge, (29.3%) satisfactory and (13.8%) had good knowledge regarding plantar fasciitis with positive prevalence of windlass test (63.80%) and (36.2%) had negative windlass test. In the present study, it is concluded that majority of the respondents had (56.9%) poor knowledge, (29.3%) satisfactory and (13.8%) had good knowledge regarding plantar fasciitis with positive prevalence of windlass test (63.80%) and (36.2%) had negative windlass test, which means majority have plantar fasciitis.

An incidental finding of a hemoglobin E variant in a diabetic patient with an abnormal glycated hemoglobin level: a case report

BackgroundGlycated hemoglobin is a well-known marker for evaluating long-term glycemic control. However, the accuracy of glycated hemoglobin measurement can be affected by the presence of hemoglobin variants, which makes the determination and interpretation of glycated hemoglobin values in terms of glycemic control not only difficult but also misleading. Here we present the first ever case of a patient with type 2 diabetes with hemoglobin E from Nepal, diagnosed incidentally because of spurious glycated hemoglobin levels.Case presentationA 45-year-old Hindu Mongolian female with a history of type 2 diabetes for around 9 years but not very compliant with follow-ups was referred to our facility for plasma fasting and postprandial blood glucose levels and glycated hemoglobin. Fasting and postprandial blood sugars were found to be high. A consistent very low glycated hemoglobin by two different high-performance liquid chromatography (HPLC) methods compelled us to call the patient for a detailed clinical history and for the records of investigations done in the past. The patient has been a known case of type 2 diabetes for around 9 years and presented irregularly for follow-up visits. Around 4 years ago, she presented to a healthcare facility with fatigue, severe headaches, pain in the abdomen, discomfort, and dizziness for a couple of months, where she was shown to have high blood glucose. She was referred to a tertiary-level hospital in Kathmandu, where she was prescribed metformin 500 mg once daily (OD). Due to her abnormal hemoglobin A1c reports, she was then sent to the National Public Health Laboratory for repeat investigations. Her blood and urine investigations were sent. Complete blood count findings revealed high red blood cell and white blood cell counts, a low mean corpuscular volume, and a high red cell distribution width-coefficient of variation. Other parameters, including serum electrolytes, renal function tests, liver function tests, and urine routine examinations, were within normal limits. A peripheral blood smear revealed microcytic hypochromic red cells with some target cells. Hemoglobin electrophoresis showed a very high percentage of hemoglobin E, a very low percentage of hemoglobin A2, and normal proportions of hemoglobin A and hemoglobin F. A diagnosis of homozygous hemoglobin E was made, and family screening was advised.ConclusionsClinicians should be aware of the limitations of glycated hemoglobin estimation by ion exchange high-performance liquid chromatography in patients with hemoglobin E and other hemoglobin variants. If the clinical impression and glycated hemoglobin test results do not match, glycated hemoglobin values should be determined with a second method based on a different principle, and glycemic status should be confirmed through alternative investigations, preferably those that are not influenced by the presence of hemoglobin variants (for example, boronate affinity chromatography, fructosamine test, glycated albumin test, the oral glucose tolerance test, continuous glucose monitoring, etc.). Consistent or even doubtful results should also raise the suspicion of a hemoglobin variant, which should be confirmed through further evaluation and investigations.

Dengue Virus Surveillance in Nepal Yields the First On-Site Whole Genome Sequences of Isolates from the 2022 Outbreak.

The 4 serotypes of dengue virus (DENV1-4) can each cause potentially deadly dengue disease, and are spreading globally from tropical and subtropical areas to more temperate ones. Nepal provides a microcosm of this global phenomenon, having met each of these grim benchmarks. To better understand DENV transmission dynamics and spread into new areas, we chose to study dengue in Nepal and, in so doing, to build the onsite infrastructure needed to manage future, larger studies. During the 2022 dengue season, we enrolled 384 patients presenting at a hospital in Kathmandu with dengue-like symptoms; 79% of the study participants had active or recent DENV infection (NS1 antigen and IgM). To identify circulating serotypes, we screened serum from 50 of the NS1 + participants by RT-PCR and identified DENV1, 2, and 3 - with DENV1 and 3 codominant. We also performed whole-genome sequencing of DENV, for the first time in Nepal, using our new on-site capacity. Sequencing analysis demonstrated the DENV1 and 3 genomes clustered with sequences reported from India in 2019, and the DENV2 genome clustered with a sequence reported from China in 2018. These findings highlight DENV's geographic expansion from neighboring countries, identify China and India as the likely origin of the 2022 DENV cases in Nepal, and demonstrate the feasibility of building onsite capacity for more rapid genomic surveillance of circulating DENV. These ongoing efforts promise to protect populations in Nepal and beyond by informing the development and deployment of DENV drugs and vaccines in real time.

Nurses’ Perception on Evidence Based Practice in Tertiary Hospital of Nepal: A Quantitative Cross-sectional Study

Background: The evidence-based practice movement has spread globally, prompting calls for evidence-based policymaking and public health. Health care being the dynamic discipline with research, is, intended to improve practice through evidence-based novel approaches. As evidence based practice (EBP) among nurses is essential for improving the quality of care, fewer pieces of evidence are available in Nepal. This study aimed to assess the perception of evidence-based practice among nurses of a tertiary hospital in Nepal. Methods: We conducted a quantitative cross-sectional study among the 100 nurses of Bir Hospital in Kathmandu. The self-administered questionnaires were applied using the survey instrument by Upton and Upton. A purposive sampling technique was employed. We calculated the mean score to assess the nurses’ perceptions in the three sub-scales of knowledge, attitude, and use of evidence-based practice. Bivariate analysis was performed to examine the relationship between subscales. Results: The majority (89.0%) of nurses did not receive training on evidence-based practices. The mean score of knowledge on EBP was 4.47±1.11, the mean score of attitude on EBP was 4.45±1.06, and the mean score of EBP use was 4.18±1.42. EBP knowledge, attitude, and use were not significantly associated with the selected demographic variables (age, work experience, EBP training and marital status). Conclusion: Nurses’ perceptions of evidence-based practice were moderate. The implementation of EBP use needs to be strengthened among the nurses. Nurses need to be more involved in the implementation of EBP. To incorporate evidence in practice, nurses require training and support from high authorities.