Pain is one of the most dreaded signs of colic in horses. The aim of this work is to facilitate understanding of the pathophysiology of this pain in order to improve therapeutic choices in equine clinics. The knowledge of the anatomy, physiology and innervation of the digestive tract will enable you to deal more effectively with algology during colic: understanding the pathophysiology, management of visceral pain during equine colic and well-being of horses. In this way, the management of a horse suffering from colic will be easier and more appropriate, by anticipating the deterioration in the animal's general condition and avoiding the side effects of the molecules to be used.