The study of organic fluids under supercritical conditions has been less extensive than that of supercritical carbon dioxide and water. In addition, most studies on supercritical heat transfer have focused on horizontal or vertical channels, with limited research on inclination angles. Therefore, the focus of this study was to investigate the supercritical heat transfer of organic fluid (Novec 649) in a miniaturized channel across various inclination angles. The experimental findings reveal that the heat transfer coefficient (HTC) increases with an increase in the fluid's bulk temperature at a given mass flux and with an increase in the mass flux at a given bulk temperature. Notably, the HTC in horizontal flow channels marginally surpasses that in non-horizontal channels. The buoyancy effect, found to be non-dominant in a studied channel, does not lead to heat transfer deterioration. In vertical flow channels, under the experimental conditions, the acceleration parameters exceeded the threshold values, suggesting a potential significance of the acceleration effect. Particularly at higher mass fluxes, the acceleration parameter peaked as the film temperature approached the fluid's pseudocritical value. We further developed the supercritical heat transfer correlation by introducing an inclination angle parameter, achieving a mean absolute error of 12.7 %.