SARS-CoV-2 infection can generate different responses in patients, ranging from asymptomatic virus shedding to severe pneumonia associated with high mortality. To evaluate the potential prognostic role of a recently introduced Lung Ultrasound (LUS) protocol in this context, a cohort of 52 consecutive laboratory-confirmed COVID-19 patients underwent LUS examination upon the admission and before the discharge in an Internal Medicine ward. LUS score was derived from 14 body-landmarks (2 anterior, 2 lateral and 3 posterior per hemithorax). Specific scores were assigned depending on the sole presence of horizontal artifacts (0), the presence of isolated vertical artifact only (1), the evidence of sub-pleural consolidations (2), the presence of confluent vertical artifact and/or confluent/large consolidations (3). We then investigated the association between the total LUS score severity and worsening, defined as a combination of high flow oxygen support, intensive care unit admission, or 30-day mortality as primary endpoint. Preliminary results of the study show that worsening outcome was reached by 20 (39%) patients during the observation period; average LUS score was 20.4 (SD 8.4) and 29.2 (SD 7.3) in patients without and with worsening, respectively. At univariable analysis, the total LUS score at admission was associated with higher odds of worsening.