The utilization of functionally graded graphene platelet-reinforced composites (FG-GPLRC) and honeycomb sandwich constructions is prevalent in the field of engineering. Therefore, it is crucial to investigate the buckling and vibration properties of these materials under heat circumstances. This paper specifically focuses on the vibration and thermal buckling characteristics of a novel multi-arc concave honeycomb sandwich plate (MACHSP) equipped with an adjustable positive-negative Poisson’s ratio. The governing equations of motion for the system are derived based on the first-order shear deformation theory in conjunction with Hamilton’s principle. The formulation of the system’s characteristic equation involves the establishment of displacement functions that satisfy distinct boundary conditions. Using computational programming, natural frequencies, mode shapes, and critical buckling temperatures of MACHSP with three different FG-GPLRC distributions under thermal influences are determined. Subsequently, these results are compared with outcomes from finite element simulations and findings from previously published literature. Additionally, the amplitude-frequency response characteristics of the structure under harmonic excitation are analyzed, followed by a discussion of the impact of structural parameters on its buckling and vibration characteristics. The results indicate that the established theoretical model for predicting the buckling and vibration characteristics of MACHSP with FG-GPLRC distribution aligns well with simulation models and prior research. In contrast to solid plates, MACHSP not only achieves a substantial reduction in weight but also demonstrates a significant increase in natural frequency. Furthermore, graphene platelets have the potential to enhance the structure’s natural frequency values and critical buckling temperatures. Lastly, various structural parameters exert a notable influence on the structure’s performance.