Honey Supplementation Research Articles

The Effect of Honey Supplementation On Aphthous Ulcers In Egyptian Children..

The Effect of Honey Supplementation On Aphthous Ulcers In Egyptian Children..

The Therapeutic Mechanisms of Honey in Mitigating Toxicity from Anticancer Chemotherapy Toxicity: A Review.

Within the domain of conventional oncochemotherapeutics, anticancer chemotherapy (AC) has emerged as a potent strategy for the treatment of cancers. AC is the mainstay strategy for solid and non-solid cancer treatment. Its mechanistic action targets the blockage of DNA transcription and the dysregulation of cell cycle machinery in cancer cells, leading to the activation of death pathways. However, the attendant side effect of toxicity inflicted by AC on healthy tissues presents a formidable challenge. The crucial culprit in the AC side effect of toxicity is unknown, although oxidative stress, mitochondrial impairment, inflammatory cascades, autophagy dysregulation, apoptosis, and certain aberrant signaling have been implicated. Honey is a natural bee product with significant health benefits and pharmacological properties. Interestingly, the literature reports that honey may proffer a protection mechanism for delicate tissue/organs against the side effect of toxicity from AC. Thus, this review delves into the prospective role of honey as an alleviator of the AC side effect of toxicity; it provides an elucidation of the mechanisms of AC toxicity and honey's molecular mechanisms of mitigation. The review endeavors to unravel the specific molecular cascades by which honey orchestrates its mitigating effects, with the overarching objective of refining its application as an adjuvant natural product. Honey supplementation prevents AC toxicity via the inhibition of oxidative stress, NF-κB-mediated inflammation, and caspase-dependent apoptosis cascades. Although there is a need for increased mechanistic studies, honey is a natural product that could mitigate the various toxicities induced by AC.

Effect of Triadica cochinchinensis honey supplementation on liver metabolomics and gut microbiota in naturally aging mice

This study assessed the effects of dietary intervention of Triadica cochinchinensis honey (TH) on blood lipid profiles, hepatic lipid metabolism, and the gut microbiota in mice undergoing natural aging. All mice were fed a standard diet, supplemented with TH at a dosage of 5 g/kg BW over nine months until the mice were 18 months old. The findings of the study indicated that administering TH significantly decreased the levels of circulating triglycerides (TG), cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C). Additionally, TH imparted hepatoprotective effects by mitigating liver damage, decreasing the activity of antioxidative enzymes, and suppressing the expression of inflammatory markers, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6). The lipidomic study revealed that administering TH considerably altered lipid synthesis and metabolism in the aging liver. These changes were characterized by an increase in the levels of 56 lipids and a reduction in the levels of 52 lipids, primarily consisting of TGs. Additionally, TH consumption significantly modified the structure and composition of the gut microbiota. The intervention restored the reduced abundance of Akkermansia in elderly mice and increased the relative abundances of Bacteroidaceae, Sutterellaceae, Burkholderiales, and Gammaproteobacteria. These findings highlighted the high activity of TH and its beneficial effect on aging, providing strong empirical support for the application of TH in the fields of nutrition and pharmaceuticals.

Bee Honey as an Adjuvant Therapeutic Modality for Children with Functional Dyspepsia

Abstract Background Functional dyspepsia (FD) is a constellation of diverse gastrointestinal disturbing symptoms with multifactorial feature, that are not attributable to organic causes after proper medical assessment. Treatment options are unsatisfactory due to the lack of identifiable pathophysiology as well as the pharmacological therapy are less effective, so using an additional reliable non- pharmacological therapy would be promising. Bee honey has been used as a complementary and alternative medicine for its several benefits in different health aspects. Objective To assess the effect of bee honey as an adjuvant therapy among children with functional dyspepsia. Patients and Methods In this randomized controlled clinical trial (RCT) 30 patients aged (8-18) years old according to Rome IV criteria from Gastroenterology Clinic in Children’s Hospital, Ain Shams University, Egypt. Patients were randomly allocated into 2 groups; both groups received proton pump inhibitor (PPI) for 4 weeks and the intervention group received honey in addition. Both groups were re-assessed after this period. All patients were subjected to thorough history taking, physical examination and follow-up assessment which was done every week during the study period. Assessment of the severity of dyspepsia was done by using "Modified Glasgow Dyspepsia Severity Score" (MGDS) score. Results There were no significant differences in the baseline sociodemographic characteristics and total scores at the beginning of the study among both groups(p > 0.05). A significant beneficial effect of honey combined with PPI in improvement of FD and decrease severity of symptoms in intervention group which was evident from significant decreases in total score interpretation (P < 0.05). There was statistically significant difference between both groups as regards to the percentage of improvement, where the patients who received honey showed a higher percentage of cure rate (P < 0.05). Conclusion Honey supplementation combined with PPI could be used as a novel therapeutic modality in children with functional dyspepsia with high cure rate.

A Review of Post-Stroke Cognitive Impairment and the Potential Benefits of Stingless Bee Honey Supplementation.

Post-stroke cognitive impairment (PSCI) is a common decline in cognitive abilities that occurs within 3 months after a stroke. During recovery, stroke survivors often experience varying degrees of cognitive decline, with some patients experiencing permanent cognitive deficits. Thus, it is crucial to prioritise recovery and rehabilitation after a stroke to promote optimal protection of and improvement in cognitive function. Honey derived from stingless bees has been linked to various therapeutic properties, including neuroprotective effects. However, scientific evidence for the mechanisms through which these honey supplements enhance cognitive function remains limited. This narrative review aims to provide an overview of the causes of PSCI, current treatments, the biomarkers influencing cognition in post-stroke patients and the potential of stingless bee honey (SBH) as a neuroprotective agent against the progression of PSCI.

Benchtop NMR Coupled with Chemometrics: A Workflow for Unveiling Hidden Drug Ingredients in Honey-Based Supplements.

Recently, benchtop nuclear magnetic resonance (NMR) spectrometers utilizing permanent magnets have emerged as versatile tools with applications across various fields, including food and pharmaceuticals. Their efficacy is further enhanced when coupled with chemometric methods. This study presents an innovative approach to leveraging a compact benchtop NMR spectrometer coupled with chemometrics for screening honey-based food supplements adulterated with active pharmaceutical ingredients. Initially, fifty samples seized by French customs were analyzed using a 60 MHz benchtop spectrometer. The investigation unveiled the presence of tadalafil in 37 samples, sildenafil in 5 samples, and a combination of flibanserin with tadalafil in 1 sample. After conducting comprehensive qualitative and quantitative characterization of the samples, we propose a chemometric workflow to provide an efficient screening of honey samples using the NMR dataset. This pipeline, utilizing partial least squares discriminant analysis (PLS-DA) models, enables the classification of samples as either adulterated or non-adulterated, as well as the identification of the presence of tadalafil or sildenafil. Additionally, PLS regression models are employed to predict the quantitative content of these adulterants. Through blind analysis, this workflow allows for the detection and quantification of adulterants in these honey supplements.

Efficacy of Randu Honey Supplementation on Callus Formation in Closed Fractures of the Tibia in Wistar Rats

Introduction: Tibial fracture is one of the most common injuries. Randu honey has the potential to speed up fracture healing. This study aims to determine the efficacy of randu honey supplementation on callus formation in closed fractures of the tibia in Wistar rats.
 Methods: This research uses a true experimental design with post test only control group design. A total of 36 Wistar rats were divided into two groups, namely the control group and the treatment group which were given 200g/BW(gram)/day of randu honey. Fractures were made on the rat tibia and callus diameter was measured at 3 weeks after treatment.
 Results: The callus diameter in the treatment group was significantly larger than the control group (p<0.05) in radiological and macroscopic measurements.
 Conclusion: Supplementation with randu honey is effective in the formation of callus in closed fractures of the tibia in Wistar rats.

Natural honey supplementation in Tris-egg yolk diluent as Carbohydrate source replacing Fructose in Etawah Crossbred Goat semen

This study aims to identify the substitution of native honey as an energy source to replace fructose in Tris-KT diluent to improve the quality of spermatozoa of Etawah crossbreed goats (PE). The study was conducted at the Nekamese Vocational School and the Wiliams and Laura Foundation Biological and Reproductive Laboratory for 2 months. In this study, four PE male goats were used as a source of semen. Cement is accommodated twice a week. The semen obtained was evaluated macroscopically and microscopically then diluted with T-KT diluent with the addition of honey divided into P0 (control), P1 (T-KT + 0.25 w/v honey), P2 (T-KT + 0.50 w/v honey) and P3 (T-KT + 0.75 w/v honey). After dilution the cement is stored at a temperature of 3-5°C. Semen is evaluated post-dilution and post-storage every 24 hours, until the movement of spermatozoa is at least 40%. The variables tested were motility and viability of spermatozoa. P3 provides the best results in maintaining cement quality. The results showed that honey substitution in Tris-KT diluent exerted a marked effect on the motility and viability of spermatozoa (P<0.05) during storage.

Protective Effects of Apis Dorsata Honey Supplementation on Kidney Histopathology in Mice with Monosodium Glutamate Exposure

This study was conducted to investigate the protective effects of Apis dorsata honey on the histopathological changes of the kidney in mice exposed to monosodium glutamate. This study used 25 male mice as the experimental animal which were divided into five groups with five replication, respectively i.e. (C-) was administered basal diet, (C+) was administered 4 mg/g BW MSG, (T1) was administered A. dorsata honey of 53.82 mg/20g BW followed by MSG 4 mg/g BW, (T2) was administered A. dorsata honey of 107.64 mg/20g BW followed by MSG 4 mg/g BW, and (T3) was administered A. dorsata honey of 161.46 g/20g BW followed by MSG 4 mg/g BW. All treatments were carried out orally for 52 days. This study was observed tubular epithelial hydropic degeneration, epithelial necrosis, and glomerular necrosis. Data were analyzed using Kruskal-Wallis test followed by the Mann-Whitney test. As a result, for the epithelial and glomerular necrosis variables, the T3 group showed significant results when compared with C+, T1, and T2 groups. Moreover, T3 was not significantly different from the C- group. It can be concluded that A. dorsata honey in T3 group could protect mice kidneys from the damaging effect of MSG.

Improved Feed Efficiency and Nutritional Property Effects of Honey from Apis mellifera L. as an Additive for Broiler Chickens’ Drinking Water

Antimicrobial usage is particularly high in poultry production. Honey as a water supplement to poultry has been explored as a natural and safe antibiotic alternative. This study aimed to investigate the effects of different levels of honey as a water supplement on broilers' growth performance and chemical properties. Five dietary treatments were used: no supplement (T1), commercial electrolytes (T2), 5mL honey (T3), (7.5mL honey (T4), and 10mL honey (T5) per liter of water. The experiment used 150 1-day-old Cobb-400 broiler chicks, assigned to five treatments with three replications of ten (10) birds each (N=30) employing the Complete Block Design (RCBD) in three blocks. Results indicated that 5mL/L-10mL/L honey supplementation led to a significant (p < 0.05) decrease of 4.3% to 7% in feed consumption compared to those with electrolytes. Similarly, using 5mL/L of honey showed 12.5% lower FCR compared with T2 and 24.3% compared with T1. However, a higher level of honey was comparable to T2, indicating that honey supplementation improved feed utilization and reduced feed cost at a certain level. Results of the proximate analysis, particularly on moisture content (MC), crude protein (CP), crude fat (CF), and total carbohydrates ((TC), revealed numerical differences. Samples with 5mL/L to 7.5mL/L levels of honey showed a higher MC, CP, and TC content and lower CF than T2. This implies that honey as a drinking water supplement offers practical advantages in feed consumption and efficiency and in improving the chemical and nutritional properties of chicken meat. A choice for healthier production.

Effects of Honey Supplementation on Sports Performance among Recreational Runners

This study was conducted to investigate the effects of honey supplementation on sports performance among recreational runner. Fifteen subjects (weight: 70.1 ± 10.5 kg, height: 169.7 ± 7.9 cm; body mass index (BMI): 24.3 ± 2.8 kg.m-2) participated in this randomized-crossover study. Subjects consumed honey supplementation or placebo 1 hour prior the sports performance test. During the sports performance trial, subject performed fitness tests such as 2.4 km run, planks core strength, push-ups, and sit-ups tests. Time to complete 2.4 km run and plank core strength test were measured and recorded. The number times doing push-ups and sit-ups in one minute were counted. Pair-t test was used to determine the differences of the measured parameter between the two trials. This present study discovered honey supplementation trial has a significantly shorter time to complete 2.4 km run in comparison with the placebo trial (p<0.05). However, there was no significant improvement in the plank core strength, push-ups and sit-ups in the honey trial compared to the placebo trial (p>0.05). In conclusion, this present study discovered that honey supplementation has an ergogenic effects on 2.4 km run performance but did not enhance plank core strength, sit-ups and push-ups among recreational runner.

The Effect of Clover Honey Supplementation on the Anthropometric Measurements and Lipid Profile of Malnourished Infants and Children

Background Malnutrition in children is an increasing problem worldwide which may result in both short and long term irreversible negative health outcomes. Objective This study was to assess the effect of clover honey supplementation on the anthropometric measurements and lipid profile of malnourished infants and children. Subjects & Methods This was prospective interventional clinical trial done on 20 malnourished infants and children whose ages ranged between 1-5 years. The patients with primary malnutrition only included in our study and we excluded patients with secondary malnutrition or who had any diseases as (diabetes, GIT diseases, severe systemic illness or inborn error of metabolism).The patients were recruited from the Pediatric Nutrition Clinic Ain Shams University. The children received honey supplementation for 3 months and anthropometric measurements (weight, height, body mass index, head circumference and mid arm circumference) and fasting serum cholesterol level were measured baseline and after 3 months honey supplementation in a dose of 1.75ml/kg/dose twice weekly for 3 months to ensure compliance. Results The 3-month honey consumption has statistically highly significant effect on increasing weight, height, and body mass index and lowering fasting serum cholesterol level in primary malnourished infants and children. The statistical measurements of mean ± SD regarding weight, height, body mass index and fasting serum cholesterol level before honey consumption were (9.49 ± 2.03, 81.45 ± 8.31, 14.24 ± 2.15, 178.00 ± 20.91) and after 3 months honey consumption were (10.91 ± 2.11, 84.80 ± 8.23, 15.07 ± 2.05, 162.45 ± 19.73) respectively with P-value< 0.01. Conclusion Honey is a natural substance with a lot of benefits for nutrition and health. Our results showed a significant effect of consuming honey on changes in the nutritional status based on weight, height, and body mass index, and has a favorable effect on lowering fasting serum cholesterol level.

Effect of Honey, Coenzyme Q10, and β-Carotene/α-Tocopherol as Novel Additives in Rabbit-Sperm Cryopreservation Extender.

The effectiveness of rabbit-sperm cryopreservation is still below average compared to other domestic species. After the sperm cryopreservation process, post-thawing parameters like motility and membrane integrity are significantly compromised. The use of new extender constituents is an approach that can be used to improve the effectiveness of cryopreservation. Accordingly, we used honey (1.25, 2.5, 5, and 10%), coenzyme Q10 (100 and 200 μM), and β-carotene/α-tocopherol (500 μM/620 μM and 250 μM/310 μM) as candidate components for rabbit-sperm extenders during cryopreservation. Ejaculates from commercial adult rabbit bucks (n = 5) were cryopreserved using conventional freezing. Several post-thawing sperm parameters were assessed, including total motility, membrane integrity, viability, nuclear membrane integrity, acrosome reaction, and mitochondrial membrane potential and activation. Additionally, we performed hormonal analyses of the seminal plasma. Moreover, we analyzed the post-thawing levels of a molecular marker of sperm quality, proAKAP4, which was used in rabbits for the first time. Our findings showed that the 2.5% honey supplementation increased the post-thawing sperm motility (13.75 ± 3.75%) compared to the greater concentrations employed. However, the post-thawing motility was negatively affected by the coenzyme Q10 (0%, in both groups) but was not affected by the β-carotene/α-tocopherol supplementation (22 ± 18.15%, and 11.67 ± 10.17%). In conclusion, the cryopreservation protocols of this study did not help to maintain the sperm parameters after thawing. Further studies are required to identify novel protocols to mitigate the damage caused to rabbit sperm during cryopreservation.

Effect of Honey, Palm Oil and NPK Fertilizer on the Growth of Oyster Mushrooms Cultivated on Sawdust

The study was carried out to determine the effect of honey, palm oil and NPK fertilizer on the growth of Pleurotus pulmonarius (Fr.) Quel. and Pleurotus ostreatus (Jack.) Kumm. on Celtis zenkeri Engl. sawdust. Composted sawdust was supplemented with honey, palm oil and NPK fertilizer at 0%, 2%, 4%, 6% and 8% on the dry weight basis and inoculated with 5% spawn. The substrate amended with 4% palm oil was fully colonized by Pleurotus ostreatus and P. pulmonarius after 26.0±2.1 and 32.2±1.3 days, respectively. The mushroom took shorter time (43 days) for primordial emergence at 6% palm oil. Average of 55 fruitbodies of P. ostreatus was harvested from 4% palm oil supplemented sawdust. The best mushroom yield was recorded from 8% palm oil (278.5 ±5.0 g) and 8% honey (270.1±2.7 g). The highest biological efficiency was observed at 8 % palm oil (77.36±1.5 %) and 8 % honey (75.03±2.5 %) for P. ostreatus. The two mushrooms species performed significantly (p=0.05) with palm oil and honey supplementation. The best performance was observed at 6% and 8% supplementation with palm oil and honey. The research has shown that supplementation of sawdust substrate with honey and palm oil at 4 - 8% can be a good formulation for commercial cultivation of oyster mushrooms.

Effects of Aerobic Dance Exercise and Honey Supplementation Followed by Their Subsequent Cessation on Bone Metabolism Markers and Antioxidant Status in Young Collegiate Females.

Regular physical activity and proper nutritional intake are crucial for bone health. However, it is unclear if this health benefit is maintained after the removal of these stimuli. This study investigated the combined effects of aerobic dance exercise and honey supplementation, followed by their subsequent cessation on bone metabolism markers and antioxidant status in females. Forty-eight young female college students were assigned into four groups: i) 16S (16 weeks of sedentary activity); ii) 8E×8S (8 weeks of exercise followed by 8 weeks of sedentary activity); iii) 8H8S (8 weeks of honey supplementation followed by 8 weeks of sedentary activity) and iv) 8E×H8S (8 weeks of combined exercise and honey supplementation followed by 8 weeks of sedentary activity). Blood samples were collected from the participants prior to the intervention, at week 8 and at week 16 for the analysis of bone metabolism markers and antioxidant status. At the mid test, bone speed of sound (SOS) (P < 0.01), serum alkaline phosphatase (ALP) (P < 0.001) and serum osteocalcin (P < 0.01) were significantly higher in the 8E×H8S group as compared to 16S group. After 8 weeks of cessation of exercise and honey supplementation, bone SOS was also significantly higher (P < 0.001) in the 8E×H8S group as compared to 16S group. In addition, the serum total calcium (P < 0.001), serum ALP (P < 0.01), total antioxidant status (TAS) (P < 0.01) and glutathione (GSH) (P < 0.01) in the 8E×H8S group were significantly higher at the post-test as compared to their respective pre-test values. These findings demonstrate that there was improved maintenance of the beneficial effects induced by 8 weeks of combined exercise and honey supplementation on bone properties and the antioxidant status after 8 weeks of cessation of exercise and honey supplementation as compared to exercise and honey supplementation alone.

Studi Kepustakaan Pengaruh Suplementasi Madu dalam Pengencer Terhadap Kualitas Semen Ayam

Honey is a thick, sweet-tasting liquid containing about 70-80% natural sugars, minerals, vitamins and enzymes. The content of 65% sugar is in the form of simple monosaccharides (fructose, glucose and sucrose). The high sugar content in honey can be used as a source of nutrients besides honey also acts as an antioxidant. This study aims to determine the antioxidants and other active substances in honey so that their addition to the diluent can maintain the quality of chicken semen during storage. This literature study was carried out through searching and collecting various literatures using Google Schoolar and PubMed then arranged using Mendeley. Sources of literature are scientific journals, scientific articles, Ebooks and seminar proceedings with "keywords" the effect of honey supplementation in diluent on the quality of chicken semen. Based on the results of the study, kalliandra honey is one of the best alternatives as antioxidants in chicken semen diluents, while the best honey level is 2%. The content of antioxidants such as vitamin C, vitamin E and flavonoids in honey protects the sperm cell membrane of danger coldshock (cold shock), in addition to fructose and glucose can be made as a source of nutrients for spermatozoa during storage. The addition of honey in feed can improve the quality of chicken semen because it contains the minerals Zn (zinc), Se (selenium) and vitamins (E and C) which help in the process of spermatogenesis.

The effect of trigona honey supplement therapy on vascular cognitive impairment in acute ischemic stroke patients

The effect of trigona honey supplement therapy on vascular cognitive impairment in acute ischemic stroke patients

Effect of dietary honey supplementation on weight growth performance of Asian seabass (Lates calcarifer)

This study aimed to identify the effect of local bee (Apis dorsata) honey as a feed additive on the growth performance of Asian seabass (Lates calcarifer). The honey was supplemented at 1%, 2%, and 3% per kg diet. The test fish were reared for 35 days in a net placed in a floating-net cage (KJA). The results showed that the dietary honey supplementation affected the absolute weight and specific growth rate (p<0.05). The supplementation of 3% honey per kg diet obtained the highest growth performance compared to other treatments with the weight growth at 42.43 ± 12.78 g, specific growth rate at 1.21 ± 0.37 g/day and survival rate at 100%. The water quality parameters in the rearing tank of test fish were eligible based on the Indonesian National Standard (SNI) of 01-6493.1-2000 about water quality for Asian seabass grow-out rearing.

Extender ability to Store Chicken Sperm by using L-Carnitine, Methionine and Honey

This study was carried out to investigate the effect of L-Carnitine (LC), L-Methionine (LM) and Honey (H) supplementation on Lake’s diluent ability to store chicken sperm. Semen samples were collected from local meat type chicken males (n=20, by abdominal massage method. Two experiments were carried out. In Exp-I twelve treatments were prepared in Lake’s diluent mixing different concentrations of LC (i.e., 0.5mMLC, 1mMLC, 2mMLC and 4mMLC), LM (i.e., 0.5mMLM, 1mMLM, 2mMLM and 4mMLM) and H (i.e., 0.25%H, 0.5%H, 1%H and 2%H) while Lake’s diluent without any addition was used as control. In Exp-II four treatments were prepared by mixing different proportions of LC + LM + H in Lake’s diluent as followed: T1 (0.125mMLC + 0.125LM + 0.125%H), T2 (0.25mMLC + 0.25LM + 0.25%H), T3 (0.5mMLC + 0.5LM + 0.5%H) and T4 (1mMLC + 1mMLM + 1%H), while semen mixed only with Lake’s diluent was used as control (To). In both experiments semen was stored up till 48h at 5°C and sperm motility, viability, membrane integrity and abnormal morphology were assessed at 0, 12, 24 and 48h of storage. In Exp-I after 48h we recorded highest (P&lt;0.05) motility (62%) with 2mMLM, membrane integrity with 0.25%H and 0.5%H (43%), sperm viability with 0.25% H (70%) compared with all other treatments, while lowest morphological defects with 1mMLC (29%) and 1mMLM (29%). In Exp-II at 48h we observed highest (P&lt;0.05) motility (52%) and membrane integrity (48%) with T1 compared with all other treatments. We observed highest (P&lt;0.05) sperm viability (64%) with T2 while T1 and T2 had lowest morphological defects (Avg. 29%). It is concluded that 2mMLM supports high motility while honey support viability and membrane integrity till 48h. In addition to that a combination of 0.125mMLC + 0.125mMLM + 0.125%H gives good protection to sperm during liquid semen storage in Lake’s diluemt.

Comparable Benefits of Stingless Bee Honey and Caffeic Acid in Mitigating the Negative Effects of Metabolic Syndrome on the Brain.

There is mounting evidence that metabolic syndrome (MetS) contributes to the development of neurodegenerative disorders such as Alzheimer's disease. Honey, which has been used for generations, is high in antioxidants and has been demonstrated to benefit the brain and mental health by reducing oxidative stress and boosting cognitive outcomes. Honey from the stingless bees of Heterotrigona itama has been found to have higher phenolic content compared to other types of honeys. The aim of this study is to investigate the effects of stingless bee honey (SBH) supplementation and to compare it with a pure form of antioxidant, caffeic acid (CA), on MetS parameters and inflammatory markers in the brains of MetS-induced rats. A total of 32 male Wistar rats were divided equally into groups of control, high-carbohydrate high-fructose (HCHF) diet (MetS), HCHF + SBH supplemented (1 g/kg) (SBH), and HCHF + CA supplemented (10 mg/kg) (CA) groups. The total duration for SBH and CA supplementation was eight weeks. The HCHF diet was found to promote hypertension, hyperglycemia, and hypertriglyceridemia, and to increase brain TNF-α levels. Supplementation with SBH and CA significantly reversed (p &lt; 0.05) the hyperglycemic and hypertensive effects of the HCHF diet. Although both supplemented groups showed no significant changes to serum HDL or TG, SBH significantly reduced (p &lt; 0.05) brain TNF-α levels and increased (p &lt; 0.05) brain BDNF levels. Immunohistochemistry investigations of neurogenesis (EdU) and apoptosis (TUNEL) on the cornu Ammonis 1 (CA1) and dentate gyrus (DG) areas of the hippocampus showed no changes with SBH and CA supplementation compared to the control. These findings suggest that SBH and CA have the potential to mitigate HCHF-induced MetS effects and possess neuroprotective abilities.