In this study, a new robust homography-based visual tracking control approach for the quadrotor unmanned aerial vehicle (UAV) is developed. Specifically, employing the homography matrix as feedback, a hierarchical homography-based visual servoing (HBVS) scheme with a new command attitude extraction method to account for the underactuation of UAV is proposed. On this basis, a smooth hyperbolic tangent function is fulfilled as an augmented part of the backstepping control scheme, which guarantees the non-negative total thrust and avoid singularity. Additionally, a cascaded filter-based estimator and adaptive laws with integrable functions are embedded to counteract uncertainties including external perturbations, unknown acceleration of the moving target, and unknown image depth, and to facilitate the system’s asymptotic stability simultaneously. The theoretical analysis testifies that the whole close-loop system is asymptotically stable. Simulations further verify that the proposed HBVS controller can realize the visual tracking with a superior performance.