Homogeneous Wall Research Articles

High-frequency ultrasound with superb microvascular imaging: a potential tool for ultrasound assessment in patients with giant cell arteritis.

The objective of this study was 2-fold: first, to evaluate whether superb microvascular imaging (SMI) could be used to visualize neovascularization in temporal arteries, and, second, to evaluate the diagnostic performance of high frequency ultrasound with SMI using an extended protocol in patients with suspected giant cell arteritis (GCA). This retrospective study comprised 120 patients consecutively examined with an extended CDU protocol (temporal, facial, axillary, subclavian, brachiocephalic, and carotid arteries) between 2020 and 2022. Of all patients, 107 had no previous GCA diagnosis and 13 had a previous GCA diagnosis. SMI was used to evaluate neovascularization in the temporal arteries. Arteritis were characterized as low- or medium-echogenic, homogeneous wall thickening, with or without a positive compression sign in the temporal arteries. The Halo count, i.e., the number of temporal and axillary artery segments with signs of arteritis, was evaluated. The reference was clinically diagnosed GCA confirmed after ≥6-month follow-up. Of the eligible 107 patients with new suspected GCA, 33 (31%) received a clinical GCA diagnosis. Neovascularization was detected in 14 patients (43%). Patients with neovascularization displayed a higher halo count [median 6 (25th-75th percentile 4.75-7) vs. 3 (2-4-4), p = 0.005]. CDU of only the temporal arteries showed sensitivity and specificity (95% confidence intervals) of 94% (80-100%) and 100% (95-100%), respectively. The addition of extra-cranial arteries increased the sensitivity to 100%. Of the 13 patients investigated for suspected relapse, three had a clinically confirmed relapse. One of them displayed neovascularization together with other signs of inflammation. We show for the first time that inflammatory neovascularization of the temporal arteries can be detected by SMI. Neovascularization is associated with a more-widespread cranial disease. The value of neovascularization should be further investigated, especially for the detection of GCA relapse.

Computational Simulation and Modelling of Arterial Drug Delivery From Half-Embedded Drug-Eluting Stents in Single-Layered Homogeneous Vessel Wall

Computational Simulation and Modelling of Arterial Drug Delivery From Half-Embedded Drug-Eluting Stents in Single-Layered Homogeneous Vessel Wall

Vessel wall imaging in the diagnosis of antiphospholipid syndrome presenting as Moyamoya syndrome-A case report.

Objectives: We describe a case of anti-phospholipid syndrome (APLS) vasculopathy presenting with Moyamoya syndrome (MMS) and show the associated intracranial vessel wall MRI (VWI) findings. Methods: A 37-year-old-woman presented with acute onset dizziness and left-sided weakness. Neurologic exam revealed a left facial droop and left hemiparesis. She underwent a comprehensive laboratory work-up for stroke. Neuroimaging included a CT head, CT angiogram, VWI, and digital subtraction angiography. Results: Work-up revealed a triple-positive APLS antibody profile. CT of the head showed an acute right basal ganglia infarction and right frontal subarachnoid hemorrhage. CT angiogram revealed severe stenosis of the right internal carotid artery terminus in a Moyamoya pattern. Intracranial VWI showed long-segment concentric vessel wall thickening and homogeneous vessel wall enhancement and T2-hyperintense wall edema of the stenotic right ICA terminus, M1 middle cerebral artery, and A1 anterior cerebral artery. She was treated with long-term anticoagulation with warfarin and a right superficial temporal artery to middle cerebral artery bypass. Discussion: We present intracranial VWI features of vessel wall pathology in a patient with primary APLS presenting with MMS.

Heat transfer through a three-layer wall considering the contribution of phase change: A novel approach to the modelling of the process

A novel analytical solution to the time-dependent heat transfer equation for a multi-layer wall considering the contribution of phase change is obtained. Based on this solution a new numerical algorithm is developed for the analysis of variations in temperature and heat flux in a three-layer wall of a building in the presence of transient ambient temperature. In this algorithm, the new analytical solution at the end of the previous time step is used as the initial condition for the following time step with adjusted values of input parameters (ambient temperature). The novel algorithm is verified based on a comparison of the predictions of COMSOL Multiphysics (version 6.1) with its predictions for the same input parameters assuming that the time dependence of the ambient temperature follows the sine law. The new code is used for the analysis of heat transfer through a three-layer building wall assuming typical continental climate conditions. The inner and outer layers were filled with polyurethane foam, while a thin middle layer, located in the centre of the wall, was filled with the phase-change material (paraffin). Using the new numerical algorithm it is demonstrated that the presence of the thin paraffin layer in the wall leads to two orders of magnitude reduction in the amplitude of temperature oscillations on the room side of the wall compared to those on its outer side. It is shown that the presence of paraffin layer in the wall leads to an increase in the phase shift between the temperature on the outer side of the wall and the heat flux on the room side from about 1 hour (homogeneous wall) to about 5.5 hours (wall with the paraffin layer).

Impact behaviour of bio-inspired sandwich panels integrally manufactured from 3D printed continuous carbon fibre reinforced polyamide

This paper studies the effect of several design parameters on the impact performance of fully 3D printed sandwich panels with a core cell unit inspired by the trabecular structure of the forewing of a beetle. The key finding is that the asymmetric sandwich panel, which featured a thicker face sheet at the back and a core with a variating cell wall thickness of weak-to-strong, exhibited the highest impact energy dissipation. Specifically, 98.1 J was dissipated with 6970 N of peak load. This surpassed the performance of the sandwich panel with homogeneous cell wall thickness and asymmetric face sheets, which dissipated only 72.1 J and failed at 5406 N. In general, asymmetric configurations were found to dissipate greater energy than symmetric face sheets, and for sandwich plates with homogenous cores, the configuration with the thickest back face sheet proved more resistant to damage than the opposite asymmetric configuration.

Flow resistance over heterogeneous roughness made of spanwise-alternating sandpaper strips

The Reynolds number dependent flow resistance of heterogeneous rough surfaces is largely unknown at present. The present work provides novel reference data for spanwise-alternating sandpaper strips as one idealised case of a heterogeneous rough surface. Experimental data are presented and analysed in direct comparison with drag measurements of homogeneous sandpaper surfaces and numerical simulations. Based on the homogeneous roughness data, the related challenges and sensitivities for the evaluation of roughness functions from experiments and simulations are discussed. A hydraulic channel height is suggested as an alternative measure for the drag impact of rough surfaces in internal flows. For the investigated heterogeneous roughness, it is found that turbulent flow does not exhibit a fully rough flow behaviour, indicating that the assignment of an equivalent sand grain height as commonly applied for homogeneous roughness is not possible. A prediction of the drag behaviour of rough strips based on an average between rough and smooth drag curves appears promising, but requires further refinement to capture the impact of turbulent secondary flows and spatial transients linking smooth and rough surface parts. While turbulent secondary flow induced by the roughness strips yield significant spanwise variation of the mean velocity profile for the investigated rough strips, we show that the spanwise averaged velocity profiles collapse reasonably well with a smooth or homogeneous rough wall flow. This allows to extract a global roughness function from the spanwise averaged flow field in good agreement with the one deduced from global pressure drop measurements.

Direct numerical simulation of momentum and scalar internal boundary layers

Direct numerical simulations (DNS) of turbulent open channel flow are performed to study and compare momentum and scalar internal boundary layers (IBL). An internal boundary layer (IBL) forms when a turbulent boundary layer is subjected to heterogeneous surface conditions. For example, a momentum IBL forms with a change in surface roughness and a scalar IBL forms due to a localised heat flux. Momentum IBLs are simulated using both a streamwise-varying roughness body forcing technique and a streamwise-varying wall shear stress. Passive scalar IBLs are simulated using both streamwise-varying scalar wall values and wall fluxes, for a homogeneous smooth wall. The roughness body forcing model is shown to reproduce the same IBL features as with the explicitly resolved roughness study of Rouhi et al. (2019), but at a reduced cost. Three common IBL detection methods are employed to estimate the power-law exponents in the growth rates of the IBL. The exponents for the momentum IBL cases are typically less than 0.7 for these methods, smaller than for the scalar-analogues of these methods. Furthermore, we analyse the streamwise variation of the root-mean-square wall-normal (vertical) velocity. We find that the ‘diffusion analogy’, or that momentum and scalar IBLs behave similarly, may not be an appropriate assumption, especially for rough-to-smooth transitions for momentum IBLs.

Numerical Simulation of Heat Transfer through Uniform Multilayer Walls using ANSYS

The paper presents a study on modelling the main heat transfer parameters through opaque building elements. The need for models to assess the thermal behavior of a building has increased greatly in recent years, primarily to allow a more accurate determination of the energy consumption of buildings to evaluate the performance of heating systems. In recent times, mathematical models and software have been implemented to obtain simulations that are very close to the real functioning of the main components of buildings. The present article consists in modeling a multi-layer homogeneous wall, which separates the interior space of an enclosure (rooms) from the outside environment. The article aims to carry out a series of simulations on the structure of a non-homogeneous multilayer wall using the ANSYS program. The simulations have been performed highlight how the values vary (both numerically and graphically) for a series of characteristic parameters such as heat fluxes, temperatures, convection coefficients. The values of the parameters obtained with the ANSYS program were also compared with those obtained by classical numerical calculations.

Development of FEMAXI-ATF for analyzing PCMI behavior of SiC cladded fuel under power ramp conditions

FEMAXI-ATF is being developed for fuel performance modeling of SiC cladded UO2 fuel with focuses on modeling pellet-cladding mechanical interactions (PCMI). The code considers probability distributions of mechanical strengths of monolithic SiC (mSiC) and SiC fiber reinforced SiC matrix composite (SiC/SiC), while it models pseudo-ductility of SiC/SiC and propagation of cladding failures across the wall thickness direction in deterministic manner without explicitly modeling cracks based on finite element method in one-dimensional geometry. Some hypothetical BWR power ramp conditions were used to test sensitivities of different model parameters on the analyzed PCMI behavior. The results showed that propagation of the cladding failure could be modeled by appropriately reducing modulus of elasticities of the failed wall element, so that the mechanical load of the failed element could be re-distributed to other intact elements. The probability threshold for determination of the wall element failure did not have large influence on the predicted power at failure when the threshold was varied between 25 % and 75 %. The current study is still limited with respect to mechanistic modeling of SiC failure as it only models the propagation of the cladding wall element failure across the homogeneous continuum wall without considering generations and propagations of cracks.

The velocity field behavior and the nature of deposition of microparticles in a thin layer of colloidal solution at wall heating from one and two laser beams

To date, heat transfer, convection and particle deposition have been mainly investigated for the case of homogeneous wall heating. Convection and particle deposition during local heating, when there are one or more local heating sources, have not been practically studied. Experimental studies of free convection and particle deposition in a layer of colloidal solution have been carried out. Convection was created by heating the liquid using one and two laser beams. The colloidal solution consisted of water and microscopic TiO2 particles. The novelty of the work is the demonstration of the effectiveness of local heating in creating high rates of convection and particle deposition at low energy costs. With two-point laser heating, the convection rate is higher than with single-point heating. When using two laser beams, the Marangoni number increases in comparison with single-point laser heating. As a result, the Bo number becomes lower than the critical value and the stability of the velocity field increases. In contrast to single-point heating, the use of two laser beams does not change the vortex flow pattern with increasing layer height. The particle deposition rate is higher when using a single laser beam than when using two beams and is two orders higher than the deposition without convection. An expression linking the deposition rate with time, layer height and fluid velocity is derived. The obtained results on the use of local heating sources are applicable for enhancing convection, as well as in technologies for cleaning solutions from solid impurities.

Follicular cholangitis mimicking a common bile duct cancer: a case report

BackgroundFollicular cholangitis (FC) is a benign bile duct disease that was first reported 2003. Pathologically, it is characterized by lymphoplasmacytic infiltration with multiple lymphoid follicle formations under the mucosal layer of the biliary tract. However, as this disease is extremely rare, little is known about its etiology and pathogenesis.Case presentationA 77-year-old woman was diagnosed with middle bile duct stenosis and potential increases in alkaline phosphatase (ALP) and γ-glutamyl transpeptidase levels (γ-GTP). Carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9) and IgG4 levels were all within the normal limits. Contrast-enhanced computed tomography (CE-CT) and magnetic resonance imaging (MRI) revealed bile duct dilation from intrahepatic to upper common bile duct and an irregular mass lesion in distal bile duct. Additionally, multiple overlapping leaf-like folds were detected. 18F-fluorodeoxyglucose positron emission tomography–computed tomography (18F-FDG-PET/CT) did not demonstrate fluorodeoxyglucose uptake. Subtotal stomach-preserving pancreaticoduodenectomy with regional lymph node dissection was performed because common bile duct cancer could not be ruled out. The resected specimen showed diffuse homogeneous middle bile duct wall thickening. Microscopically, the lesion exhibited thick fibrosis with several invaded lymphoplasmacytic cells, and lymphoid follicle formations were detected under the mucosal layer. Immunohistochemical staining (IHC) revealed positive for CD3, CD4, CD20 and CD79a, and these findings led to a final diagnosis of FC. The patient has not experienced recurrence to date (42 months postoperatively).ConclusionsCurrently, accurate preoperative diagnosis of FC is difficult. More cases must be accumulated to generate additional knowledge on its precise diagnosis and proper treatment.

Sambucus adnata Polysaccharide SPS-1 Inhibits Growth of Transplanted Lung Cancer via Polarizing Tumor Associated Macrophage From M2 into M1

Macrophages are the primary immune cells in the tumor microenvironment, where they exhibit the immunosuppressive M2 phenotype to support tumor development. Reshaping M2 tumor-associated macrophages (TAMs) into the antitumor M1 phenotype is a promising approach in tumor immunotherapy. We had previously demonstrated that a high-purity homogeneous Sambucus adnata wall polysaccharide SPS-1 isolated from S. adnata exerted a good immunoregulatory effect. In the present study, we explored whether SPS-1 can remodel TAMs and inhibit the development of lung cancer. In the tumor mouse model transplanted with Lewis lung cancer, SPS-1 promoted the apoptosis of tumor cells and inhibited angiogenesis in tumor tissues by remodeling M2 macrophages in the tumor microenvironment into M1 macrophages, which exerted effective antitumor effects. Therefore, SPS-1 may be used as a novel immunostimulator in tumor immunotherapy, and our study also provides a novel pathway and material for reshaping immune defense to prevent and treat tumors.

Contrast Venography Versus Intravenous Ultrasound in Hemodialysis Arteriovenous Access Dysfunction

Contrast Venography Versus Intravenous Ultrasound in Hemodialysis Arteriovenous Access Dysfunction

Two-Dimensional C-V Heat Conduction Investigation of an FG-Finite Axisymmetric Hollow Cylinder

In the present work, we implement a graded finite element analysis to solve the axisymmetric 2D hyperbolic heat conduction equation in a finite hollow cylinder made of functionally graded materials using quadratic Lagrangian shape functions. The graded FE method is verified, and the simple rule of the mixture with power-law volume fraction is found to enhance the effective thermal properties’ gradation along the radial direction, including the thermal relaxation time. The effects of the Vernotte numbers and material distributions on temperature waves are investigated in depth, and the results are discussed for Fourier and non-Fourier heat conductions, and homogeneous and inhomogeneous material distributions. The homogeneous cylinder wall made of SUS304 shows faster temperature wave velocity in comparison to the ceramic-rich cylinder wall, which demonstrates the slowest one. Furthermore, the temperature profiles along the radial direction when n = 2 and n = 5 are almost the same in all Ve numbers, and by increasing the Ve numbers, the temperature waves move slower in all the material distributions. Finally, by tuning the material distribution which affects the thermal relaxation time, the desirable results for temperature distribution can be achieved.

Through-the-Wall Radar under electromagnetic complex wall: A deep learning approach

This paper employed deep learning to do two-dimensional, multi-object locating in Through-the-Wall Radar under conditions where the wall is treated as a complex electromagnetic medium. We made five assumptions about the wall and two about the number of objects. There are two object modes available: single target and double targets. The wall scenarios include a homogeneous wall, a wall with an air gap, an inhomogeneous wall, an anisotropic wall, and an inhomogeneous–anisotropic wall. Target locating is accomplished through the use of a deep neural network technique. We constructed a dataset using the Python FDTD module and then modeled it using deep learning. Assuming the wall is a complex electromagnetic medium, we achieved 97.7% accuracy for single-target 2D locating and 94.1% accuracy for two-target locating. Additionally, we noticed a loss of 10% to 20% inaccuracy when noise was added at low SNRs, although this decrease dropped to less than 10% at high SNRs.

Microtubule nucleation complex behavior is critical for cortical array homogeneity and xylem wall patterning

Plant cell walls are versatile materials that can adopt a wide range of mechanical properties through controlled deposition of cellulose fibrils. Wall integrity requires a sufficiently homogeneous fibril distribution to cope effectively with wall stresses. Additionally, specific conditions, such as the negative pressure in water transporting xylem vessels, may require more complex wall patterns, e.g., bands in protoxylem. The orientation and patterning of cellulose fibrils are guided by dynamic cortical microtubules. New microtubules are predominantly nucleated from parent microtubules causing positive feedback on local microtubule density with the potential to yield highly inhomogeneous patterns. Inhomogeneity indeed appears in all current cortical array simulations that include microtubule-based nucleation, suggesting that plant cells must possess an as-yet unknown balancing mechanism to prevent it. Here, in a combined simulation and experimental approach, we show that a limited local recruitment of nucleation complexes to microtubules can counter the positive feedback, whereas local tubulin depletion cannot. We observe that nucleation complexes preferentially appear at the plasma membrane near microtubules. By incorporating our experimental findings in stochastic simulations, we find that the spatial behavior of nucleation complexes delicately balances the positive feedback, such that differences in local microtubule dynamics-as in developing protoxylem-can quickly turn a homogeneous array into a banded one. Our results provide insight into how the plant cytoskeleton has evolved to meet diverse mechanical requirements and greatly increase the predictive power of computational cell biology studies.

Mechanical Analysis of Frozen Wall with Trapezoidal Temperature Field Distribution Based on Unified Strength Theory

In order to study the elastic–plastic stress field distribution of a double-row-pipe frozen wall, the temperature field of the double-row-pipe frozen wall is equivalent to a trapezoidal distribution, and the frozen wall is regarded as an elastic–plastic thick-walled cylinder with functionally gradient material (FGM) characteristics in the radial direction. Considering that the elastic modulus and cohesion of the frozen wall material change linearly with the radius, the elastic–plastic analysis of the frozen wall is carried out based on unified strength theory. The analytical solutions of the elastic–plastic stress field distribution, the elastic ultimate bearing capacity, the plastic ultimate bearing capacity, and the relative radius of the plastic zone of the frozen wall are derived. The analytical solution is calculated based on the engineering case and compared with the numerical solution obtained based on COMSOL. At the same time, the influence of strength theory parameters on the mechanical properties of heterogeneous and homogeneous frozen walls is analyzed. The results show that the analytical solution and the numerical solution are in good agreement, and their accuracy is mutually verified. The external load on the frozen wall of the selected layer is greater than its elastic ultimate bearing capacity and less than its plastic ultimate bearing capacity, which indicates that the frozen wall is in a safe state of stress. The radial stress increases with the increase in the strength theoretical parameter b and the relative radius r, the tangential stress increases with the increase in the strength theoretical parameter b, and first increases and then decreases with the increase in the relative radius r. The larger the strength theoretical parameter b, the smaller the relative radius of the plastic zone of the frozen wall. The strength theoretical parameter b increases from 0 to 1, the elastic ultimate bearing capacity and plastic ultimate bearing capacity of the heterogeneous frozen wall increase by 33.3% and 40.8%, respectively, and the elastic ultimate bearing capacity and plastic ultimate bearing capacity of the homogeneous frozen wall increase by 33.3% and 41.0%, respectively. Therefore, considering the influence of intermediate principal stress, the potential of materials can be fully exerted and the ultimate bearing capacity of frozen walls can be improved. This study can provide theoretical reference for the design and construction of frozen wall.

Carotid Artery Stiffness Mechanisms in Hypertension and Their Association with Echolucency and Texture Features: The Multi-ethnic Study of Atherosclerosis (MESA).

Arterial stiffness, echolucency and texture features are altered with hypertension and associated with increased cardiovascular disease risk. The relationship between these markers and structural and load-dependent artery wall changes in hypertension are poorly understood. The Multi-ethnic Study of Atherosclerosis (MESA) is a longitudinal study of 6814 adults from six communities across the United States designed to study subclinical cardiovascular disease. From B-mode imaging of the right common carotid artery at the baseline MESA examination, we calculated carotid artery Young's elastic modulus (YEM, n=5894) and carotid artery gray-scale texture features (n=1403). The standard YEM calculation represented total arterial stiffness. Structural stiffness was calculated by adjusting YEM to a standard blood pressure of 120/80 mm Hg with participant-specific models. Load-dependent stiffness was the difference between total and structural stiffness. We found that load-dependent YEM was elevated in hypertensive individuals compared with normotensive individuals (35.7 ± 105.5 vs. -62.0 ± 112.4 kPa, p < 0.001) but that structural YEM was similar (425.3 ± 274.8 vs. 428.4 ± 293.0 kPa, p=0.60). Gray-scale measures of heterogeneity in carotid artery wall texture (gray-level difference statistic contrast) had small but statistically signification correlations with carotid artery stiffness mechanisms. This association was positive for structural YEM (0.107, p < 0.001), while for load-dependent YEM, the association was negative (-0.064, p=0.02). In conclusion, increased arterial stiffness in hypertension was owing solely to the non-linear mechanics of having higher blood pressure, not structural changes in the artery wall, and high load-dependent stiffness was associated with a more homogenous carotid artery wall texture. This is potentially related to arterial remodeling associated with subclinical atherosclerosis and future cardiovascular disease development. These results also indicate that gray-scale texture features from ultrasound imaging had a small but statistically significant association with load-dependent arterial stiffness and that gray-scale texture features may be partially load dependent.

Fluid-Structure Interaction Study of The Effect of Stent on Local Hemodynamics Parameters at The Stented Carotid Artery Bifurcation

Previous fluid-structure interaction (FSI) studies on carotid bifurcation focused on the effect of wall compliance on the predicted hemodynamic features in normal or atherosclerotic carotid arteries. However, FSI study on patient-specific post-stent carotid model is still lacking, and to the authors knowledge no such a study has been reported so far. This study attempts to simulate the full-scale patient-specific post- stent carotid bifurcation geometry with the hope to understand the effect of wall compliance on hemodynamic quantities. The FSI model was based on patient-specific geometry consisting of three components i.e., the carotid artery wall and stent as the solid domain, and blood in the fluid domain. Full FSI simulations incorporating patient-specific boundary conditions at the inlet and outlets, and realistic homogenous incompressible carotid wall and stent were completed to evaluate the flow patterns and wall shear stress. The FSI simulation results were compared with the corresponding rigid-wall model. The quantitative difference in time-averaged wall shear stress (TAWSS) distribution between the FSI and rigid-wall models shows that FSI model predicted 8% less of the area in the low TAWSS band (&lt;0.4%) compared 0.4 - 1.2 Pa. The results suggest that although the effect of wall compliance on flow patterns in the patient-specific post-stent carotid model is negligible, its quantitative effect on wall shear stress may not be trivial and should be considered in future studies

Evaluation of the Flexural Rigidity of Underground Tanks Manufactured by Rotomolding

This study focuses on the flexural properties of the layered wall structures of plastic tanks produced by rotational molding technology. The aim was to assess the possibility of replacing the homogeneous walls of rotationally cast large-volume underground tanks with structural walls for stability and warpage prevention. The possibilities of material saving by combining lightweight and non-lightweight tank wall layers were investigated. By applying the engineering theory of bending inhomogeneous layered walls, the flexural rigidity values of the walls of the tanks of different structures were determined. The values of the flexural rigidity of the tank wall samples produced by rotomolding technology were determined experimentally. Moreover, a comparison of the calculated and experimentally determined flexural rigidity values of the layered walls and optimization of these structures was carried out. In the case under study, it was theoretically and experimentally confirmed that the optimum ratio of compact layer thickness versus total wall thickness is given by the resulting value: t1OPT = 0.189 h.