Home Base Research Articles

Massed treatment of posttraumatic stress disorder, traumatic brain injury, and co-occurring conditions: the Home Base intensive outpatient program for military veterans and service members.

The two-week Home Base Intensive Clinical Program (ICP) provides treatment to veterans and active duty service members suffering from primary diagnoses of posttraumatic stress disorder (PTSD), traumatic brain injury (TBI), anxiety, or depression. First launched in 2015, this paper provides a programmatic update, including new treatment components implemented since inception, and examines outcomes for all participants who entered the program from September 2015 to July 2024 (n = 2561). The Home Base ICP provides a massed care approach through daily individual Prolonged Exposure, Cognitive Processing Therapy, Unified Protocol, or cognitive rehabilitation, along with groups targeting coping skills. Participants entering the program are provided with core group programming, as well as individualized therapy sessions tailored to their unique needs and symptom presentation. Supplemental dual recovery support is also available for all participants with co-occurring substance use or behavioral addiction concerns. Participants' support people receive education, support, and case management services. Participants have a multidisciplinary team comprising therapists, psychopharmacology providers, case managers, nurses, and wellness providers. Results demonstrate that program participants exhibited statistically significant reductions in PTSD symptoms (Cohen's d = 0.80), depression (d = 0.68), post-concussion symptoms (d = 0.71), and increased satisfaction in social roles (d = -0.65). Completion rate was 94.60% (n = 2422), suggesting that the Home Base ICP is a well-received and effective model of care for veterans and service members.

DATA INVESTIGATION OF PK-LQP AIRPLANE VERTICAL DEVIATION USING CLASS 1 AND TIER 1 DATASETS

The vertical deviation is one of the important stages in commercial aircraft flights because indications of malfunction can be detected faster by the pilot rather than in other flight phases. The purpose of this study is to investigate whether the PK-LQP airplane experienced unusual altitude movements during the vertical deviation phase since the airplane taking off from Seattle (Boeing Manufacture's home base) until the airplane crash. The airplane, which is of the type B737 MAX8, had operated for 83 days, during which it completed 438 flights using a total of 107 flight codes, and it travelled to 36 airports. According to the findings of an investigation of the data, we found that only 69 (39%) were included in tier 1, which had an ADS-B data update interval message below 10 seconds, complying with ICAO and FAA-AVN standards. With this class 1 and tier 1 dataset, we conducted an EDA to find the data insight, which revealed that there was a disturbance in the speed and altitude indications on the airplane instrumentation, causing a misperception for the pilot and causing the airplane to drastically drop in altitude (more than 100 feet).

High-intensity body weight interval training modifies neurochemistry in AD disease: Preliminary data from a randomized control trial

BackgroundAlzheimer's disease (AD) is an incurable condition characterized by cognitive and neurochemical impairments, necessitating the exploration of alternative interventions. Physical exercise shows promise, but the effects of high-intensity protocols on the neurochemical aspects of AD-related neurodegeneration remain poorly explored. ObjectiveThis study examines the effects of high-intensity body weight interval training (PMED) on brain-derived neurotrophic factor (BDNF) and phosphorylated-TAU protein (p-TAU) in AD disease. MethodsThirty-four elderly individuals diagnosed with AD disease were divided into two groups of 17 subjects: GCP, which participated in PMED (30 min at 80–90 % of maximal cardiac frequency three times per week), and GCS, which had no interventions. Pre- and post-measurements of BDNF and p-TAU were conducted. ResultsThe GCS group showed no changes in his neurochemical factors (p > 0.05). In contrast, the GCP group experienced increased BDNF levels and decreased p-TAU blood concentrations (p < 0.0001 for both). ConclusionsPMED increased BDNF and reduced p-TAU concentrations, improving neurochemistry in AD disease. This can open an avenue of new interventions using high-intensity body weight interval training, including, in home base programs, which can be an advantage to engagement.

Post-Entry Changes: Unraveling Home Base Diversity and Learning Effects on Commitment Increases

Post-Entry Changes: Unraveling Home Base Diversity and Learning Effects on Commitment Increases

A Tailored Self-Management App to Support Older Adults with Cancer and Multi-Morbidities: Development and Usability Testing.

Cancer self-management interventions improve symptom management and confidence, but few interventions target the complex needs of older adults with cancer and multi-morbidities. Despite growing evidence of digital health tools in cancer care, many such tools have not been co-designed with older adults to ensure that they are tailored to their specific needs. The objective of the study was to design a self-and symptom-management app to support older adults with cancer and multi-morbidities. Utilizing a user-centered design thinking framework, we recruited 2 caregivers and 18 older adults with lived experiences of cancer to design a medium-fidelity app prototype. Participants highlighted the importance of tracking functions to make sense of the information about their symptoms, clear displays, and reminders to mitigate concerns related to polypharmacy. This app will create a 'home base' for symprtom management and support for older adults with cancer and multi-morbidities.

Innovative outpatient treatment for veterans and service members and their family members.

In 2009, Massachusetts General Hospital and the Red Sox Foundation launched Home Base, a nonprofit dedicated to providing care to veterans, service members, and their loved ones who struggle with the invisible wounds of war free of charge. Significant needs exist for mental health services in each of these populations, and a need for innovative approaches to address shortcomings in existing treatment models. Three inventive components of our programming are highlighted herein: a Veteran Outreach Team, which helps to engage patients in care, programming, and services specifically for family members, and an intensive outpatient substance use treatment program. More than 4,000 patients, 3,031 veterans and service members, and 1,025 family members have engaged in treatment at Home Base. Patients were asked to complete post-treatment self-measures, including a satisfaction questionnaire via an electronic data collection system. The vast majority of individuals who engaged in our treatment model were satisfied with the care they received (>92%) and would refer their peers to the Home Base program (>75%). Data from 78 individuals who completed the dual diagnosis services demonstrated large effect sizes in reductions in alcohol use and comorbid mental health symptoms. These data suggest that novel components to the standard outpatient mental health model might provide substantive benefits for the patients served. While internal data is prone to a lack of generalizability, these additional offerings help ameliorate patients' expressed shortcomings with existing models; present literature that describes the benefits that these additions provide is also reviewed. The lessons learned and limitations are discussed.

An allocentric human odometer for perceiving distances on the ground plane.

We reliably judge locations of static objects when we walk despite the retinal images of these objects moving with every step we take. Here, we showed our brains solve this optical illusion by adopting an allocentric spatial reference frame. We measured perceived target location after the observer walked a short distance from the home base. Supporting the allocentric coding scheme, we found the intrinsic bias , which acts as a spatial reference frame for perceiving location of a dimly lit target in the dark, remained grounded at the home base rather than traveled along with the observer. The path-integration mechanism responsible for this can utilize both active and passive (vestibular) translational motion signals, but only along the horizontal direction. This asymmetric path-integration finding in human visual space perception is reminiscent of the asymmetric spatial memory finding in desert ants, pointing to nature's wondrous and logically simple design for terrestrial creatures.

Reusable Smart Lids for Improving Food Safety at Household Level with Programmable UV-C Technology

The worldwide food industry faces the multiple challenges of providing food security while also reducing environmental and health consequences. This requires transitioning to chemical-free techniques of preserving food with a long shelf life that emphasize human health. Even though millions of people are experiencing hunger, the substantial amount of food that is being wasted is impeding the advancement towards UN Sustainable Development Goal 12, which aims to reduce food waste by 50% by the year 2030. On the other hand, conventional food preservation techniques still frequently depend on chemical additives, which might give rise to persistent health issues and potentially undermine nutritional quality. This emphasizes the necessity for inventive, non-chemical remedies that prioritize both prolonged storage duration and the safety of food. Consumer storage conditions, which are the ultimate phase of the food chain, still generate substantial waste because of the proliferation of mold and bacteria on fruits and vegetables, which presents health hazards. Enhancing storage conditions and extending shelf life is important. Low-frequency ultraviolet (UV-C) light technology provides a non-thermal and highly efficient method for fighting foodborne microorganisms such as mold. This method renders pathogens inactive while maintaining product quality, providing a cost-efficient and easily available alternative. This study proposes the development of a programmable “Smart-Lid” SLID storage system that utilizes upcycled home base glass jars with UV-C light-emitting lids to prevent mold growth on various open food items, including milk- and sugar-based food, sauces, and possibly dry meals. The research seeks to assess the efficacy and potential influence of the SLID solution with UV-C light’s potential with programmable applications in this preserving environment at the home level.

Sizing up sustainability: Influence of battery size and cell chemistry on battery-electric trucks’ life-cycle carbon emissions

Customers and legislators will increasingly demand monitoring and reducing the carbon footprint of logistic companies in the coming years. Besides the fundamental decision for a battery-electric truck, the choice of battery size and cell chemistry should be approached with the goal of minimizing the carbon footprint of the supply chain. Therefore, this paper analyzes the impact of battery size and cell chemistry on the carbon footprint and which factors influence this the most. To quantify this footprint, emissions from production, potential replacements based on battery aging, energy generation, and reuse in second-life applications for both LFP and NMC cell chemistries are considered. The results show that use phase emissions from energy generation have the largest leverage on life-cycle emissions, whereas production emissions play a minor role. If electricity with lower emissions at the home depot compared to the public electricity is available, oversizing the battery capacity tends to be the emission optimal choice. If more than 8% additional renewable energy at the home base for NMC and more than 38% for LFP is available, the largest possible battery is emission-optimal. For smaller shares, the smallest possible battery should be selected. Significant dependence on purchase year and share of second-life usage can be observed.

Pendampingan Unit/Wadah Organisasi Model Pencatatan Transaksi Keuangan dalam Pembukuan Sederhana

The aim of this community service program is to provide assistance and education to the community in Kiera Hamlet, Southwest Maluku Regency regarding recording financial transactions in simple bookkeeping in accordance with applicable financial accounting standards. This program will take place on Saturday 3 to face in Kiera Hamlet, Moa Island, Southwest Maluku Regency. This activity was carried out with the presence of all Kiera hamlet staff, chair of the church congregation council. Church staff, village community and home base lecturers as well as students of the PSDKU Accounting study program, Southwest Maluku Regency. The method used in this activity is a participatory learning method. After carrying out this service, the community will gain knowledge about bookkeeping in managing finances so that the recording process can be carried out regularly.

Footloose and fancy-free in FinTech? Internationalization strategies of born regional and born global firms in the European financial service sector

AbstractDue to economic globalization and technological advancements, businesses are increasingly required to navigate complex international markets. One type of firm that has emerged in response to these trends is the born global, which initiates foreign activities almost from the very start. While these startups expand their reach by pursuing pro-active internationalization strategies, it is unclear whether startups creating the FinTech revolution also belong to this category. This study investigates five key components of the internationalization strategies of European FinTech startups: the speed and scope of internationalization, the drivers of internationalization, international market selection, the mode of market entry, and the challenges involved in internationalization. While born globals use a systematic approach to international market selection and entry, European FinTechs use a quasi-systematic and opportunistic approach to searching and seizing their geographical markets. Their common approach includes quickly going beyond their home base to adjacent markets, followed by gradual experimentation and substantive growth in their home region, and becoming born-regional firms (with some evolving into born-global firms later).

장위공 서희 묘역의 고고학적 의미

Goryeo’s grave remains that have been designated and managed as state-designated cultural properties since the establishment of the state include Goryeo’s old tomb group in Pyeonggeo-dong, Jinju designated as Historic Site No. 164 in 1968 and the tomb of General Yun Gwan designated as Historic Site No. 323 in 1988 only, and the criteria for designating these two remains as historic sites exhibit several problems. In general, the status of a state-designated cultural property has the historicity and symbolicity that can represent a specific period, and importantly, the irreplaceable scarcity and uniqueness of the value of existence should be equipped at the same time. Nevertheless, the tomb of General Yun Gwan which lost the original form as Gwaninbunmyo in Goryeo could be designated as a historical site because of the figure’s symbolicity in overcoming the national crisis. Looking at Seo Hee’s tomb from this point of view, we can find the aspect that it was transformed into Joseon’s Gwaninbunmyo while maintaining part of the appearance of Goryeo’s Gwaninbunmyo. This aspect of Seo Hee’s tomb is understood to show that the graveyard was first formed in Goryeo and then maintained and managed continuously in Joseon, too. Next, according to the results of archaeological examination on Seo Hee’s tomb, it is questionable whether early Goryeo officials uniformly preferred Gaegyeong and Geungi areas as burial sites as shown in previous studies. In this regard, this study reinvestigated the material of epitaphs put in graves in Goryeo. According to the findings, the time when Goryeo officials used Gaegyeong and areas around it as burial sites in earnest was from the time of King Munjong. Then, during the time before King Munjong in Goryeo when various systems were legislated in Goryeo and Gaegyeong’s status was newly established, it seems that Goryeo officials still maintained a bond with where they were born even though they moved their home base to Gaegyeong. Therefore, it is highly likely that Seo Hee’s tomb was built in Yeoju, Gyeonggi-do during the time before King Munjong in Goryeo.

Tailored Self-Management App to Support Older Adults With Cancer and Multimorbidity: Development and Usability Testing.

Globally, cancer predominates in adults aged older than 60 years, and 70% of older adults have ≥1 chronic condition. Cancer self-management interventions can improve symptom management and confidence, but few interventions target the complex needs of older adults with cancer and multimorbidity. Despite growing evidence of digital health tools in cancer care, there is a paucity of theoretically grounded digital self-management supports for older adults. Many apps for older adults have not been co-designed with older adults to ensure that they are tailored to their specific needs, which would increase usability and uptake. We aim to report on the user evaluations of a self- and symptom-management app to support older adults living with cancer and multimorbidity. This study used Grey's self-management framework, a design thinking approach, and involved older adults with lived experiences of cancer to design a medium-fidelity app prototype. Older adults with cancer or caregivers were recruited through community organizations or support groups to participate in co-designing or evaluations of the app. Data from interviews were iteratively integrated into the design process and analyzed using descriptive statistics and thematic analyses. In total, 15 older adults and 3 caregivers (n=18) participated in this study: 10 participated (8 older adults and 2 caregivers) in the design of the low-fidelity prototype, and 10 evaluated (9 older adults and 1 caregiver) the medium-fidelity prototype (2 older adults participated in both phases). Participants emphasized the importance of tracking functions to make sense of information across physical symptoms and psychosocial aspects; a clear display; and the organization of notes and reminders to communicate with care providers. Participants also emphasized the importance of medication initiation or cessation reminders to mitigate concerns related to polypharmacy. This app has the potential to support the complex health care needs of older adults with cancer, creating a "home base" for symptom management and support. The findings from this study will position the researchers to conduct feasibility testing and real-world implementation.

Organization of spontaneous spatial behaviors under dark conditions is unaffected in adult male and female long-Evans rats after moderate prenatal alcohol exposure.

Prenatal alcohol exposure can produce disruptions in a wide range of cognitive functions, but it is especially detrimental to spatial navigation. In open environments, rodents organize their spatial behaviors around centralized locations, termed home bases, from which they make circuitous and slow locomotor trips (progressions) into the rest of the environment. Open-field behaviors are organized even under darkened test conditions, suggesting a role for self-motion cues (vestibular, motor, etc.). The impact of moderate prenatal alcohol exposure (mPAE) on the organization of spontaneous open-field behaviors under darkened conditions has not been investigated. Here we tested adult female and male rats with mPAE or saccharin control exposure in a circular open field for 30 min in a testing room that was made completely dark. While general locomotion, as measured by reductions in travel distance and increased stop duration, decreased across the test session, the organization of these behaviors, as measured by stop duration, home base establishment, home base stability, progression accuracy, and scaling of peak speeds with progression length, did not differ between mPAE and saccharin control rats. Together, the findings strongly suggest that spontaneous movement organization in relation to self-motion cues remains intact in adult mPAE rats. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Implementation of a Randomized, Placebo-Controlled Trial of Live Attenuated Malaria Sporozoite Vaccines in an Indonesian Military Study Population.

Malaria eradication efforts prioritize safe and efficient vaccination strategies, although none with high-level efficacy against malaria infection are yet available. Among several vaccine candidates, Sanaria® PfSPZ Vaccine and Sanaria PfSPZ-CVac are, respectively, live radiation- and chemo-attenuated sporozoite vaccines designed to prevent infection with Plasmodium falciparum, the leading cause of malaria-related morbidity and mortality. We are conducting a randomized normal saline placebo-controlled trial called IDSPZV1 that will analyze the safety, tolerability, immunogenicity, and efficacy of PfSPZ Vaccine and PfSPZ-CVac administered pre-deployment to malaria-naive Indonesian soldiers assigned to temporary duties in a high malaria transmission area. We describe the manifold challenges of enrolling and immunizing 345 soldier participants at their home base in western Indonesia before their nearly 6,000-km voyage to eastern Indonesia, where they are being monitored for incident P. falciparum and Plasmodium vivax malaria cases during 9 months of exposure. The unique regulatory, ethical, and operational complexities of this trial demonstrate the importance of thorough planning, frequent communication, and close follow-up with stakeholders. Effective engagement with the military community and the ability to adapt to unanticipated events have proven key to the success of this trial.

Proses Terjadinya Adaptasi Ruang di Rumah Tinggal yang Mengubah Fungsi Ruang Rumah Menjadi Ruang Usaha di Jogokaryan, Kota Yogyakarta

Title: The Process of Space Adaptation in Residential Houses that Change the Function of Home Space into Business Space in Jogokaryan, Yogyakarta City&#x0D; Home Base Enterprises (HBE) is one of the businesses run by many Indonesians. HBE is a type of business carried out in residential homes, so adaptation is needed to meet the needs of space that changes its function as a business space. This research aims to discover the process of changing the space function because of the house owner's adaptation. The method used in this study is descriptive qualitative with simple random sampling of data collection. Of the four selected samplings, the result is that the process of forming space in HBE is based on cultural, physiological, and morphological adaptations. For the production business, the method uses an adaptation of extending space, while the trading business uses an adaptation of sharing space.

Emotion dynamics in current and remitted depression: an ecological momentary assessment study.

Individuals in a depressive episode and healthy controls exhibit robust differences on affect dynamics captured with ecological momentary assessment (EMA). However, few studies have explored affect dynamics in individuals in remission from depression, and results have been mixed. A community sample of 18-year-olds (N = 345) completed diagnostic interviews and EMA probing emotions and low interest/motivation 5× daily for 2 weeks. Affect home base, variability, and inertia were compared across currently depressed, remitted, and never-depressed groups. Both depression groups had a higher negative affect (NA) and low interest/motivation home base, lower positive affect (PA) home base, greater variability of NA, PA, and low interest/motivation, and greater NA and low interest/motivation inertia than never-depressed participants. Additionally, the currently depressed group had a higher sad home base specifically, greater variability across most negative emotions and low interest/motivation, and greater low interest/motivation inertia than the remitted group. The currently depressed and remitted groups did not differ in anxious, upset, or PA home base, anxious or PA variability, and inertia of all negative emotions and PA. Findings suggest that a number of abnormalities in emotion and reward functioning persist after a depressive episode resolves, however, the tendency to experience higher levels of sadness, greater range of a variety of negative emotions, and more variable and persistent low interest/motivation are exacerbated during depressive episodes. Conversely, greater intensity and persistence of some negative emotions (anxiety, upset) and blunted positive emotions appear to equally characterize depression in both the symptomatic and remitted state.

Differential methylation of linoleic acid pathway genes is associated with PTSD symptoms – a longitudinal study with Burundian soldiers returning from a war zone

Soldiers may be exposed to traumatic stress during combat deployment and thus are at risk for developing posttraumatic stress disorder (PTSD). Genetic and epigenetic evidence suggests that PTSD is linked to forming stress-related memories. In the current study, we investigated post-deployment associations of PTSD symptoms with differential DNA methylation in a sample of Burundian soldiers returning from the African Union Mission in Somalia’s war zone. We used a matched longitudinal study design to explore epigenetic changes associated with PTSD symptoms in N = 191 participants. PTSD symptoms and saliva samples were collected at 1–3 (t1) and 9–14 months (t2) after the return of the soldiers to their home base. Individuals with either worsening or improving PTSD symptoms were matched for age, stressful, traumatic and self-perpetrated events prior to the post-assessment, traumatic and violent experiences between the post- and the follow-up assessment, and violence experienced during childhood. A mixed model analysis was conducted to identify top nominally significantly differentially methylated genes, which were then used to perform a gene enrichment analysis. The linoleic acid metabolism pathway was significantly associated with post-deployment PTSD symptoms, after accounting for multiple comparisons. Linoleic acid has been linked to memory and immune related processes in previous research. Our findings suggest that differential methylation of linoleic acid pathway genes is associated with PTSD and thus may merit closer inspection as a possible mediator of resilience.

"This is fine": the impact of blowouts on subsequent game performance in the National Hockey League (NHL).

Blowouts in sports involve large margins of victory or loss between teams and have long been perceived as influencing subsequent performances by athletes, coaches, fans, and other stakeholders. Under the backdrop of the hot hand ph enomenon, the current study explores the impact of blowouts on subsequent game performance in the National Hockey League (NHL). Specifically, we examine the potential carryover of a "hot (or cold) hand" on the subsequent game following a large win or loss. In our study, we defined blowouts as outlying goal differentials for regular season games (i.e., a difference of approximately 6 goals between teams in a single game based on 3 standard deviations from the mean goal differential during the sampled period). Using this criterion, data from 285 games over the 2005-06 to 2018-19 NHL regular seasons were gathered for analysis. We performed a series of multiple regressions using blowout goal differential as the main predictor, adjusting for location of the subsequent game, number of time zones from the home base city, whether the subsequent game was a back-to-back, and winning percentages of the team and opponent. Our results revealed no significant over or under performance by teams that either won through a blowout or those that lost by a blowout. Our findings are consistent with previous work in other and similar sports contexts. Practical applications and future directions for research are discussed.

An efficient Analysis of the Fusion of Statistical-Centred Clustering and Machine Learning for WSN Energy Efficiency

Recently, wireless sensor networks on several challenging topics have piqued researchers’ attention. Maximising a network's lifetime requires just the right combination of cluster size and number of nodes. Data transmission from nodes to cluster leaders is energy intensive, even for a modest number of clusters. If there are several clusters, many leaders will be chosen, and many nodes will rely on long-distance transmission to communicate with the home base. Therefore, in order to maximise efficiency, it is necessary to strike a balance between these two factors. WSN's major challenge is improving its energy efficiency. This is because their energy consumption defines their lifespan, and it is difficult, if not impossible, to recharge their batteries. Therefore, it is crucial to develop algorithms that consume as little energy as possible in order to maximise the network's potential. The perfect clusters are essential for the longevity of the network. Therefore, an algorithm called statistical centre energy efficient clustering approach (SEECA) is presented to increase the network's lifetime while decreasing its energy consumption. The experimental findings show that the proposed methodology SCEECA outperforms the LEACH method by a wide margin, with gains of 32% in Residual energy, 16% in Network Lifetime, and 12% in Throughput.