In this manuscript, we develop the counterpart of Tsallis holographic dark energy (THDE) model in F(R,T) theory (where R represents Ricci scalar and T is trace of energy momentum tensor (EMT)) using the two IR-cutoffs namely Hubble horizon (HH) and Granda-Oliveros (GO). The THDE is proposed on the basis of Tsallis entropy (Tsallis and Cirto, 2013) and the holographic hypothesis (Tavayef, 2018). Cosmic evolution is analyzed using the equation of state (EOS) parameter which results in both quintessence and phantom regimes. The stability analysis of reconstructed models is also made with the help of squared speed of sound. Moreover, we study the thermodynamic picture and developed constraints for the validity of generalized second law of thermodynamics (GSLT). It is remarked that these reconstructed models can be useful to further explore the cosmic issues.