Climate change is a major challenge for the global tourism sector, affecting destinations worldwide. Greece, known for its scenery and abundant cultural history, is particularly vulnerable to these impacts. Tourism is a key driver of Greece’s economy, yet climate change threatens both natural environments and cultural sites. To evaluate the impacts of climate change on different types of Greek tourism (beach, sightseeing, winter tourism in mountainous areas), the widely used Holiday Climate Index (beach and urban versions) alongside three additional climatic indices customized for Greek climatic conditions, namely the Urban Climate Comfort Index, the Beach Utility Index, and the Mountainous Winter Climate Index were utilized for top tourist destinations of Greece. The results indicate that urban tourism may face challenges during peak summer months due to rising temperatures, but the shoulder seasons (April–May and September–October) will offer improved conditions, potentially extending the tourist season. For beach tourism, favorable conditions are expected to increase from April to October, with significant gains in June and September. Winter tourism in mountainous areas, especially snow-dependent activities like skiing, is at risk due to the declining snow availability. Overall, the study highlights both the challenges and opportunities posed by climate change for Greece’s tourism sector. It emphasizes the importance of adaptation strategies, including infrastructural improvements and promoting alternative activities, to minimize negative impacts and enhance the future attractiveness of Greek tourism.