Hold Back Research Articles

United States Healthcare System

United States Healthcare System

Dynamic Placement in Refugee Resettlement

Boosting Employment of Resettled Refugees Whether a resettled refugee finds employment in the United States depends in no small part on which host community they are first welcomed to. Every week, resettlement agencies are assigned a group of refugees who they are required to place in communities around the country. In “Dynamic Placement in Refugee Resettlement,” Ahani, Gölz, Procaccia, Teytelboym, and Trapp develop an allocation system that recommends where to place an incoming refugee family with the aim of boosting the overall employment success. Should capacities in high-employment areas be used up as quickly as possible, or does it make sense to hold back for a perfect match? The simple algorithm, based on two-stage stochastic programming, achieves over 98% of the hindsight-optimal employment, compared with under 90% for the greedy-like approaches that were previously used in practice. Their algorithm is now part of the Annie™ MOORE optimization software used by a leading American refugee resettlement agency.

Astrocytes as Neuroimmunocytes in Alzheimer's Disease: A Biochemical Tool in the Neuron-Glia Crosstalk along the Pathogenetic Pathways.

This work aimed at assessing Alzheimer's disease (AD) pathogenesis through the investigation of the astrocytic role to transduce the load of amyloid-beta (Aβ) into neuronal death. The backbone of this review is focused on the deepening of the molecular pathways eliciting the activation of astrocytes crucial phenomena in the understanding of AD as an autoimmune pathology. The complex relations among astrocytes, Aβ and tau, together with the role played by the tripartite synapsis are discussed. A review of studies published from 1979 to 2023 on Scopus, PubMed and Google Scholar databases was conducted. The selected papers focused not only on the morphological and metabolic characteristics of astrocytes, but also on the latest notions about their multifunctional involvement in AD pathogenesis. Astrocytes participate in crucial pathways, including pruning and sprouting, by which the AD neurodegeneration evolves from an aggregopathy to neuroinflammation, loss of synapses and neuronal death. A1 astrocytes stimulate the production of pro-inflammatory molecules which have been correlated with the progression of AD cognitive impairment. Further research is needed to "hold back" the A1 polarization and, thus, to slow the worsening of the disease. AD clinical expression is the result of dysfunctional neuronal interactions, but this is only the end of a process involving a plurality of protagonists. One of these is the astrocyte, whose importance this work intends to put under the spotlight in the AD scenario, reflecting the multifaceted nature of this disease in the functional versatility of this glial population.

Centriselect – A novel approach for centrifugal cell separation

Abstract The separation of bio-suspensions, such as blood, is of great interest for many biomedical applications, such as the extraction of leucocytes from whole blood, the laboratory analysis of specific cells or a mixed cell suspensions from bioreactors or the preparation of cellular products for cellbased therapy. In particular, mechanical separation processes have been established for the rapid separation of biosuspensions. The principle of mechanical separation is based on the specific density of the particles or the particle size. Thus, the corresponding processes are based on centrifugation and/or filtration. The standard process to prepare blood products from whole blood donations contains several steps. First the blood is separated into different phases by centrifugation and then further separated by filters containing specific filtration layers. The shortcomings of this process is the low yield due to bio-particles remaining in the filter and the high costs for equipment due to the use of multiple devices for centrifugation and filtration. Here we present the proof of principle of an adaptive, size-selective filter that addresses the above mentioned shortcomings. The filter is designed to combine the filtration and centrifugation process within one step. Therefore a novel filtration device was designed that can be used within a standard centrifugation tube. During centrifugation, the centrifugal force changes the filtration coefficient of the filter. This can be used to separate different sized of bio-particles at different centrifugation speeds. Moreover, the cells that were hold back in the filter can be removed afterwards by increasing the centrifugation speed. In this way, the filter is created to gradually release cells of a specific size yielding in a high purity of different cell fractions.

A message that Explains the Issue of Destiny by the Scholar Al-Safawi, may God have mercy on him: A Study and Investigation


 
 
 
 The issue of the topics of belief that all people were interested in, ancient and modern, and in which the difference spoke, and because of the importance of this topic, the scholar Al-Safavi, may God have mercy on him, legislated for this topic through this manuscript, which he called (Risala in Explanation of the Question of Destiny) can take into account the following: ( Remembrance of fate, so hold back.) Or that God created it in them. They should send commands with them. And it is earned for the servant, and he said: What he wants is to get his purpose by comparing his ability and his will. Without any of them having an effect and an entrance into his existence other than his being a subject of it. Al-Safawi discussed the saying of Abu Ishaq Al-Asfarini: The action of the servant is fulfilled by the two abilities, the ability of God Almighty and the ability of the servant.
 
 
 

Habitual Herbal Water Recipes to Hold Back Waterborne Contagious Diseases

Background: Water - the elixir of life is also being a medium to spread many communicable diseases. The scarcity and lack of safe drinking water have been the cause for high prevalence of death rate than war or terrorism in the world. Objective: The study reviews effects of water pollution, usage and ailing effects of plastics in provision of safe drinking water at hospitality sector and gives alternative and initiative suggestions to overcome those environmental crises by formulating natural and traditional methods of water treatment to serve healthy herbal water. Method: Natural ayurvedic ingredients apt for treating water are explored, a systematic method of water treatment is formulated with the identified ingredients. The water is served to 30 panelist members with no regard to their age or gender. The opinion about their preference towards the organoleptic quality of the served water is recorded. The test is done with water from various part of the city. Result: Water samples being served have a good score of acceptance among the panel list members Nannari water (Sample 1) has the prime acceptance than other samples. Conclusion: The study exposes treating water with these natural ingredients inhibits infectious organism present in water and improves the micronutrients and nutritional value of drinking water. Besides promoting the human health it also reduces the usage of plastics and sustains the environmental wellness.

Renewable energy and transitioning towards sustainable tourism: Inferences from kernel density and nonparametric approach

This study considered a panel of twenty countries characterized by tourist glut to investigate the role of renewable energy towards sustainable tourism transition. We used a nonparametric kernel density approach to facilitate the analysis and examine the distributional dynamics; besides, using a nonparametric quantile regression approach to trace nexus through different strata. Kernel density estimates reflect multimodality character across the countries. Quantile estimates reveal the negative impact of economic growth on carbon emissions across all quantiles. The coefficient of the international tourist arrival is positive and significant in lower quantiles; nevertheless, it turns out to be negative at higher quantiles implying tourist arrivals reduce carbon emissions. Non-renewable energy consumption positively affects carbon emissions but negatively impacts international tourist arrivals. On the other hand, renewable energy consumption negatively affects carbon emissions but affects the international tourist arrivals positively. This study intends to guide policymakers to hold back fossil fuel dependence for sustainable tourism.

The Pleasure and Pain of Passing as (Dis)abled: Rudi Dutschke’s Exile in the United Kingdom (1968–1971) and the Ableism of the West German Student Movement

The Pleasure and Pain of Passing as (Dis)abled: Rudi Dutschke’s Exile in the United Kingdom (1968–1971) and the Ableism of the West German Student Movement

Never let racism hold back your career

As a migrant nurse, I used my initiative to create professional development opportunities to further my nursing journey

Exploration of potato starches from non-commercial cultivars in ready to cook instant non cereal, non glutinous pudding mix

The present study aimed at exploring different properties of starches, isolated from commercial and non-commercial potato cultivars and to determine their suitability for developing a non-cereal pudding mix. The physico-chemical, functional and pasting properties of extracted starches varied significantly (p < 0.05) when compared with corn starch. Potato starches exhibited higher swelling power (27.69–34.54 g/g) and solubility (14.63%–20.43%), lower gelatinization temperature (69.75–70.89 °C), higher peak (5825–9239 cP) and final viscosities (4411–4891 cP) and lower set back viscosities (357-735 cP). The FTIR spectra observed for potato and corn starch was similar in terms of form and intensity of major peaks. Starch isolated from Kufri Pukhraj, an underutilized potato cultivar was selected for making non-cereal pudding mix based upon its distinct pasting properties i.e. higher peak (9239 cP), hold (4188 cP), final (4891 cP), and lower set back (703 cP) viscosity. Formulated mix was compared with pudding mix prepared with corn starch (control). Both samples (p < 0.05) differed significantly in terms of physico-chemical, functional and pasting properties. Sensory evaluation showed non-significant (p < 0.05) difference between non cereal pudding mix and control, indicating high potential of potato starch to replace corn starch in pudding formulations. Storage studies indicated that non cereal pudding mix can be stored for 12 months without impacting quality.

A cost effective technology for isolation of potato starch and its utilization in formulation of ready to cook, non cereal, and non glutinous soup mix

Commercial starch extraction is a multi-step process which requires high capital cost and infrastructure. The present study aimed at exploring a low cost process for small scale/on-farm processing of potato for isolation of starch which included potato grinding, slurry filtration, starch settling, increased number of starch washings to obtain maximum yield and purity followed by starch drying. Two commercial cultivars (Kufri-Chipsona-3 and Lady Rosette) and two commonly grown cultivars (Kufri Pukhraj and Kufri Ganga) were used for the experiments. The isolated starches varied significantly (p < 0.05) in terms of their physico-chemical, functional and pasting properties. Starch isolated from Kufri Pukhraj, an underutilized potato cultivar was selected for making non-cereal soup mix based upon its distinct pasting characteristics such as higher peak (9239 cP), hold (4188 cP), final (4891 cP), and lower set back (503 cP) viscosities. Four different formulations of soup mixes were prepared by varying the proportion (40–55%) of potato starch. Formulation containing 40% potato starch was found to be most suitable on the basis of functional, rheological, pasting and sensory characteristics. Storage studies indicated that 40% potato starch soup mix can be stored safely for 4 months. The developed process holds potential to extract starch from commercial as well as non-commercial cultivars on a farm gate level with a high yield of 11.48–16.51% and it can prove to be a commercial viable venture with cost of production of 1 kg starch 0.61 USD (INR 44.84) corresponding to sale price of 0.82 USD (INR 60) for the Indian market and it can be calculated likewise for other markets.

Economic and Statistical Analysis of Stock Market Performance in Lebanon

Analysis of financial processes is an important and fast developing branch of statistics. Statistical analysis is a combined analysis. Statistical methodology refers to a system of techniques and methods aimed at studying quantitative patterns in the dynamics and relationships of socio-economic phenomena. The main feature of the statistical methodology is also the specificity of research, expressed in the inextricable connection of quantitative analysis with the establishment of a qualitative uniqueness of objects in the concrete historical conditions of place and time. The use of the techniques of mathematical statistics and other branches of mathematics (applied, in particular) becomes a technical means of implementation.&#x0D; Lebanese stock market today is inactive and is shrinking. Historically, Lebanon had a relatively vibrant capital market in the Middle East before the stock exchange was closed for twenty years due to the civil war (1975-1995). Since its reopening in 1996, the stock market has been contracting. The establishment of Solidere in late 1990s and the renaissance of commercial banks energized the stock market for a while before the volatility of the market hold back.&#x0D; The article analyzed the change in the main indicators of the Lebanese stock market for the period from 2012 to 2019. The study developed a statistical model for the decomposition of time series, which was led to identify the trend, seasonal, cyclical and random components.. The simulation results made it possible to establish the patterns of changes in the share prices of the three leading enterprises representing the construction, industrial and banking sectors of the Lebanese economy. The length and depth of short-period cycles in the studied indicators time series were measured. It was found that the depth of cyclical fluctuations increases with decreasing stock prices of Lebanon’s construction and industrial enterprises under the influence of both economic and political processes, while the cyclic recurrence of stock prices in the banking sector was less pronounced and was mainly determined by changes in the economy

Oscillation of damped second order quasilinear wave equations with mixed arguments

Following the previous work (Sui and Yu, AML, 2020), we investigate the impact of damping on the oscillation of smooth solutions to some kind of quasilinear wave equations with Robin and Dirichlet boundary conditions. By using generalized Riccati transformation and technical inequality method, we give some sufficient conditions to guarantee the oscillation of all smooth solutions. From the results, we conclude that positive damping can “hold back” oscillation. At last, some examples are presented to confirm our main results.

Pump elements recondition by electrolytic chromium plating

Improving the efficiency of maintenance production in agriculture closely connected to the creation and implementation of such methods of repair and recondition of elements that improve the physicomechanical and service properties of wear joint assemblies.The presence of a nitrided case on the surface of elements lays the groundwork for obtaining a complex covering based on chromium nitrides. Electrolytic chromium plating is one of the ways to recondition elements that increase the service life and machines reliability, and reduce maintenance cost. However, the widespread adoption of chromium plating for the recondition of worn elements is hold back by the low productivity of the process. Therefore, the intensification of chromium plating in reconditioning worn-out machine elements is an urgent problem. It is advisable to recondition critical parts subjecting to abrasive wear, for example, precision vapors of fuel injection equipment, with chromium plating. However, the low productivity and high-energy consumption of the process require the improvement of the electrolyte in order to increase the current output of chromium and the permissible cathode density. The article describes a method for improving the quality of an electrolyte, a method for increasing its versatility, namely the supplementation of various organic additives and complexing substances into it.

Hold Back the Tide by Melinda Salisbury

Reviewed by: Hold Back the Tide by Melinda Salisbury April Spisak Salisbury, Melinda Hold Back the Tide. Scholastic, 2021 [336p] Trade ed. ISBN 9781338681307 $18.99 E-book ed. ISBN 9781338681314 $11.99 Reviewed from digital galleys R Gr. 8-10 Alva, sixteen, has tiptoed around her father for years, since she is certain he murdered her mother. She has plans to finally escape him and their small Scottish town, but just as she's finalizing her details, a series of horrifying attacks draws her back in. Her father's role as caretaker of a loch suddenly becomes far more important than Alva ever realized, as one key part of that job is to make sure the water level stays high enough to keep monsters trapped underground. Overuse of the mill means that these creatures are now free, and they behave according to their nature, which is to kill some humans and transform others into their kind. Alva can't leave now, so she becomes a hero she never believed she could be, rousing the town to courage and putting herself at risk to save others. One key catalyst in her own growth is a new understanding about her father, a brutal moment of clarity about what he was actually doing all those years ago, given even more pathos by the fact that one of them only has a few more days to live so there is no chance for true reconciliation. The story is well told and the pace is impeccable, but the true beauty here lies in Salisbury's subtle, nuanced ways of highlighting the classic notion that monstrosity is not limited to monsters. [End Page 275] Copyright © 2021 The Board of Trustees of the University of Illinois

Organization Constraints on Professional Development: An Exploration into How Institutional Frameworks Hold Back Teacher Training

Organization Constraints on Professional Development: An Exploration into How Institutional Frameworks Hold Back Teacher Training

Nilai-Nilai Pendidikan Sosial dalam Al-Qur’an Surat Ali Imran Ayat 134 (Analisis Tafsir Al-Qur’an Al-Azhim Karya Ibnu Katsir)

This study aims to determine: (1) the content of the al-Qur'an surah Ali Imran verse 134; (2) the values ​​of social education contained in al-Qur'an surah Ali Imran verse 134 according to Ibn Katsir's Tafsir al-Qur'an al-Azhim; (3) the relevance of the value of education in al-Qur'an surah Ali Imran verse 134 with today's education. This study uses the Maudhu'iy (thematic) method, namely the method of interpreting the verses of the Qur'an according to a particular theme or topic. Meanwhile, the data collection technique used in this research is literature study or documentation. The data analysis technique used in this study is the Moleong data analysis technique, which includes the stages of data reduction, data display, drawing conclusions and verification. After analyzing the data, the authors obtained the following conclusions: first, the contents of the al-Qur'an Surah Ali Imran verse 134 describes the characteristics of a pious person. Secondly, Ibn Kathir also said that the al-Qur'an surah Ali Imran verse 134 describes the characteristics of a pious person, including 1) Berinfaq in a field or narrow, happy or difficult. 2) Hold back anger when able to vent it. 3) Forgive those who wrong us even without being asked. 4) Do well. Apart from being the characteristics of a pious person, these four characteristics are also included in the values ​​of social education, where these traits cannot be realized without social interaction with other people. third, the values ​​of social education contained in al-Qur'an surah Ali Imran verse 134 when connected with contemporary education are very relevant, given the importance of these values ​​to be possessed by educators and students and society in general.

Stepping Aboard a Captured German U-boat

The Engineer didn’t hold back on its praise for a German U-boat at the end of the Second World War

Exploration of Christian Women’s Vocational Ministry Leadership and Identity Formation in Evangelical Churches on the West Coast

This empirical research explores adult identity formation through work experiences, gaining insight into structures and practices which allow women to thrive in leadership within the evangelical church ministry context. This qualitative research explores adult identity formation and gender role stereotypes in leadership domains within the evangelical church context on the West Coast. Twenty-five ( n = 25) women in vocational church leadership, aged 25–71, revealed what impedes or contributes to female leadership adult identity formation. Key findings revealed women leaders thrive and gain identity strength through agency found in union with Christ; hold back identity components and skills available to church leadership teams to fit the male work context; contextual factors impact women’s well-being in leadership including assumptions and mindsets adverse to women leading; and lead pastors and supervisors’ beliefs about women in leadership are critical to healthy identity formation. Therefore, this research is an exploration of what experiences assist women leaders to thrive or not thrive in evangelical vocational leadership on the West Coast and how their identity in Christ empowers their leadership.

Cytoplasmic APE1 promotes resistance response in osteosarcoma patients with cisplatin treatment.

Chemotherapy resistance has become a hold back and major clinical challenge in osteosarcoma cancer. The alteration and subcellular distribution of apurinic/apyrimidinic endonuclease 1 (APE1) has been reported to be involved in chemotherapy resistance in many cancers. Here, we report that the cytoplasmic distribution of APE1 plays a key role in the sensitivity of combination platinum chemotherapy in osteosarcoma. Interestingly, the prevalence of cisplatin-induced DNA damage and apoptosis in low cytoplasmic APE1 osteosarcoma cell lines was higher than in high expression of cytoplasmic APE1 cell lines. Overexpression of cytoplasmic APE1 protected the osteosarcoma cells from CDDP-induced apoptosis. In addition, clinical data also show that the level of cytoplasmic APE1 was negatively associated with sensitivity to combination chemotherapy of cisplatin in osteosarcoma patients. Our findings suggest that cytoplasmic APE1 plays a significant role in chemotherapy resistance. This role is a supplement to the extranuclear function of APE1, and cytoplasmic APE1 expression level could be a promising predictor of platinum treatment prognosis for osteosarcoma patients.