A three-phased study and program development on HIV and Mental Health were conducted for a period of two years. This study encompasses a baseline survey of mental health issues among people living with HIV (PLHIV), the design and development of virtual learning modules on mental health and HIV for health providers, and a pre-implementation qualitative study on the delivery of online modules to target health workers. The results of the quantitative survey reveal moderately high self-reported depression, anxiety, and suicide ideation among patients with HIV. After the survey, topics for e-modules on mental health were identified including self-help modules for health workers. These mental health modules were consolidated with modules pertaining to HIV treatment. A qualitative study on the acceptability and feasibility of the use of the e-modules was conducted by interviewing health workers from different HIV treatment and care sites. Significant insights into the learning experiences among health workers gave researchers a deeper understanding of the cognitive acceptance and resistance towards virtual and self-paced modules.