You have accessJournal of UrologyInfertility: Epidemiology & Evaluation1 Apr 2016MP91-12 VASECTOMY AND RISK OF PROSTATE CANCER IN A SCREENING TRIAL Jonathan Shoag, Sameer Mittal, Joshua Halpern, Daniel Shoag, Daniel Lee, Padraic O'Malley, Bobby Najari, Brian Eisner, Jim Hu, Douglas Scherr, Peter Schlegel, and Christopher Barbieri Jonathan ShoagJonathan Shoag More articles by this author , Sameer MittalSameer Mittal More articles by this author , Joshua HalpernJoshua Halpern More articles by this author , Daniel ShoagDaniel Shoag More articles by this author , Daniel LeeDaniel Lee More articles by this author , Padraic O'MalleyPadraic O'Malley More articles by this author , Bobby NajariBobby Najari More articles by this author , Brian EisnerBrian Eisner More articles by this author , Jim HuJim Hu More articles by this author , Douglas ScherrDouglas Scherr More articles by this author , Peter SchlegelPeter Schlegel More articles by this author , and Christopher BarbieriChristopher Barbieri More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2599AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Vasectomy has been implicated as a risk factor for prostate cancer in multiple epidemiologic studies over the past 25 years. Whether this relationship is causal or due to unaccounted for bias remains unclear. The Prostate, Lung, Colorectal, Ovarian (PLCO) Cancer Screening Trial provided a unique opportunity to assess the relationship between vasectomy and prostate cancer in a modern cohort of men who were uniformly screened for prostate cancer. METHODS A retrospective analysis of 13 year prostate cancer screening and outcomes data from the PLCO cancer screening trial. Vasectomy status was available for 73,180 subjects, of whom 19,965 (27.3%) reported a history of vasectomy. Analysis was stratified by study arm and age at vasectomy in order to assess, and control for, detection bias. Cox proportional hazards models adjusted for baseline demographics, including prior history of PSA screening and rectal examination were utilized. RESULTS There was an increased risk of prostate cancer in men who had undergone vasectomy and were randomized to the usual care arm of the study (adjusted hazard ratio (HR) 1.11, 95% CI 1.03 to 1.20, p=0.008). There was no association between vasectomy and diagnosis of prostate cancer in men randomized to the screening arm. The association between vasectomy and prostate cancer was present only for Gleason 2-6 prostate cancers in the control arm, but not more aggressive cancers. Only men undergoing vasectomy at an older age in the control arm of the study were at increased risk of being diagnosed with prostate cancer (adjusted HR 1.10, 95% CI 1.04-1.17, p=0.002). CONCLUSIONS In a contemporary cohort, the association of vasectomy and prostate cancer is limited to low risk disease, and is likely related to increased detection of prostate cancer based on patterns of care rather than a biological effect of vasectomy on prostate cancer development. © 2016FiguresReferencesRelatedDetailsCited byRandall S, Boyd J, Fuller E, Brooks C, Morris C, Earle C, Ferrante A, Moorin R, Semmens J and Holman C (2018) The Effect of Vasectomy Reversal on Prostate Cancer Risk: International Meta-Analysis of 684,660 Vasectomized MenJournal of Urology, VOL. 200, NO. 1, (121-125), Online publication date: 1-Jul-2018. Volume 195Issue 4SApril 2016Page: e1157-e1158 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Jonathan Shoag More articles by this author Sameer Mittal More articles by this author Joshua Halpern More articles by this author Daniel Shoag More articles by this author Daniel Lee More articles by this author Padraic O'Malley More articles by this author Bobby Najari More articles by this author Brian Eisner More articles by this author Jim Hu More articles by this author Douglas Scherr More articles by this author Peter Schlegel More articles by this author Christopher Barbieri More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...