History Of Hormonal Contraceptive Use Research Articles

Correlation between Risk Factors and Protein Expression of ER, PR, and HER-2 in Breast Cancer Patients: A Population-Based Study in Makassar Indonesia

Background: Breast cancer is a condition characterized by abnormal and uncontrollable growth of cells in breast tissue. According to Global Cancer Statistics 2020, it ranks as the leading cause of female cancer mortality. The disease has four subtypes defined by protein expression, namely Luminal A (ER/PR (+), HER2 (-)), Luminal B (ER/PR (+), HER2 (+)), triple-negative/basal-like (ER, PR, HER2 (-)), and HER2-enriched (ER (-), PR (-), HER2 (+)), each with distinct characteristics influenced by various risk factors. Therefore, this study aimed to explore the correlation between breast cancer risk factors and protein expression of ER, PR, and HER2. Methods: The cross-sectional analytical study was conducted in Makassar, Indonesia, using secondary data from 259 breast cancer patients. Information on ER, PR, HER2 expression, and patient risk factors such as age, history of hormonal contraceptive use, and family history of breast cancer were extracted from medical records and subjected to statistical analysis using the Chi-square test, with significance set at p < 0.05. Results: The results showed that there was a significant correlation between age ≥ 40 years and the expression of ER, PR, and HER2 (p < 0.005). However, no significant correlations were observed between family history and hormonal contraceptive use with ER, PR, and HER2 expression. Conclusions: This study established a meaningful correlation between risk factors of age and breast cancer subtypes based on ER, PR, and HER2 expression.

Morphologic alterations of the fear circuitry: the role of sex hormones and oral contraceptives.

Endogenous sex hormones and oral contraceptives (OCs) have been shown to influence key regions implicated in fear processing. While OC use has been found to impact brain morphology, methodological challenges remain to be addressed, such as avoiding selection bias between OC users and non-users, as well as examining potential lasting effects of OC intake. We investigated the current and lasting effects of OC use, as well as the interplay between the current hormonal milieu and history of hormonal contraception use on structural correlates of the fear circuitry. We also examined the role of endogenous and exogenous sex hormones within this network. We recruited healthy adults aged 23-35 who identified as women currently using (n = 62) or having used (n = 37) solely combined OCs, women who never used any hormonal contraceptives (n = 40), or men (n = 41). Salivary endogenous sex hormones and current users' salivary ethinyl estradiol (EE) were assessed using liquid chromatography - tandem mass spectrometry. Using structural magnetic resonance imaging, we extracted surface-based gray matter volumes (GMVs) and cortical thickness (CT) for regions of interest of the fear circuitry. Exploratory whole-brain analyses were conducted with surface-based and voxel-based morphometry methods. Compared to men, all three groups of women exhibited a larger GMV of the dorsal anterior cingulate cortex, while only current users showed a thinner ventromedial prefrontal cortex. Irrespective of the menstrual cycle phase, never users exhibited a thicker right anterior insular cortex than past users. While associations with endogenous sex hormones remain unclear, we showed that EE dosage in current users had a greater influence on brain anatomy compared to salivary EE levels and progestin androgenicity, with lower doses being associated with smaller cortical GMVs. Our results highlight a sex difference for the dorsal anterior cingulate cortex GMV (a fear-promoting region), as well as a reduced CT of the ventromedial prefrontal cortex (a fear-inhibiting region) specific to current OC use. Precisely, this finding was driven by lower EE doses. These findings may represent structural vulnerabilities to anxiety and stress-related disorders. We showed little evidence of durable anatomical effects, suggesting that OC intake can (reversibly) affect fear-related brain morphology.

Perbedaan Karakteristik Demografi dan Klinis Ibu Hamil Overweight dan Obesitas Tipe I


 
 
 
 Indonesia is also experiencing a nutritional transition, namely increased overweight and obesity. This trend has a big impact on both mothers and the babies born. There has been no research that reveals differences in the demographic and clinical characteristics of overweight and obese pregnant women, so appropriate management cannot be carried out according to the characteristics of pregnant women. The aim of this study is to explain the differences in demographic and clinical characteristics of overweight and obese type 1 pregnant woman in Kediri City.. This research uses a comparative analytical design. The research was conducted at nine Kediri City health centers, namely Campurejo, Banjarmlati, Pesantren I, Pesantren II, North Region City, South Region City, Ngletih, and Mrican health centers, from June to August 2023. The research population in June was composed of third-trimester pregnant women (102 pregnant women). Determining the sample using a simple random sampling technique, 86 pregnant women were obtained and divided into groups, namely overweight (n = 59) and type 1 obesity (n = 27). The research inclusion criteria include willingness to be a respondent, age 20–35 years, having ANC at least once in the first trimester and once in the second trimester, LILA > 23.5 cm, BMI > 25, and the exclusion criteria is pregnancy with comorbidities. Data analysis in this study used the Mann-Whitney, Fisher Exact, and Chi-Square tests with a significance value of 0.05 using SPSS 26. The research results showed that in the demographic characteristics of the overweight group compared to obesity type I, there were differences in age (p < 0.001), family history of obesity (p = 0.007), and there were no differences in education level (p = 0.0617), employment status (p = 0.096), income level (0.0353), and family support score (p = 0.587). Data on clinical characteristics in the overweight group compared to obesity type I showed differences in the history of hormonal contraceptive use (p = 0.049) and diet (p = 0.035), but there were no differences in gestational age (p = 0.157) or parity (p = 0.530). The differences in demographic and clinical characteristics between the two groups can be used as a reference for service providers so that pregnant women can control weight gain according to their body mass index.
 
 
 
 

Characteristics and hormonal contraception use patterns of levonorgestrel 13.5 mg intrauterine device users in Sweden 2014–2016

ObjectivesThe levonorgestrel-releasing intrauterine device containing 13.5 mg of levonorgestrel (LNG 13.5 mg IUD), Jaydess, was approved for contraception by the European Medicines Agency in 2013. We aimed to describe the characteristics of new users of LNG 13.5 mg IUD in Sweden within the first 3 years after approval (2014–2016). Study designWe conducted an observational, population-based study using data from the Swedish national registers. Women with the first pharmacy dispensation of LNG 13.5 mg IUD between 2014 and 2016 were followed until December 31, 2020. Descriptive analyses included demographic characteristics, duration of the use of first-time LNG 13.5 mg IUD, and contraceptive switching patterns. ResultsWe included 38,327 women, with mean age at first-time LNG 13.5 mg IUD use of 26 (SD: 7) years. Over 80% were prescribed LNG 13.5 mg IUD by a midwife. The most common comorbidities in the year prior to LNG 13.5 mg IUD use (2%–3% prevalence) were depression, anxiety, premenstrual syndrome, and menorrhagia. The median duration of first-time LNG 13.5 mg IUD use was 2.6 years, and after use, more than 50% of women opted to continue using a hormonal intrauterine device. ConclusionsIn this postmarketing drug utilization study, there were over 38,000 first-time LNG 13.5 mg IUD users in Sweden between 2014 and 2016, with an estimated median duration of use of 2.6 years. First-time LNG 13.5 mg IUD users consisted mostly of young, healthy individuals with a history of hormonal contraceptive use. Over half of the women continued using a hormonal IUD after the first LNG 13.5 mg IUD. ImplicationsThe median duration of LNG 13.5 mg IUD use was 2.6 years, approaching the 3-year indicated use limit. The majority of users continued with another hormonal intrauterine device after LNG 13.5 mg IUD use.

Former long-term use of combined hormonal contraception and glucose metabolism disorders in perimenopausal women: A prospective, population-based cohort study.

Current use of combined hormonal contraceptives worsens glucose tolerance and increases the risk of type 2 diabetes mellitus at late fertile age, but the impact of their former use on the risk of glucose metabolism disorders is still controversial. This was a prospective, longitudinal birth cohort study with long-term follow-up consisting of 5889 women. The cohort population has been followed at birth, and at ages of 1, 14, 31 and 46. In total, 3280 (55.7%) women were clinically examined and 2780 also underwent a 2-h oral glucose tolerance test at age 46. Glucose metabolism indices were analyzed in former combined hormonal contraceptive users (n = 1371) and former progestin-only contraceptive users (n = 52) and in women with no history of hormonal contraceptive use (n = 253). Compared with women with no history of hormonal contraceptive use, those who formerly used combined hormonal contraceptives for over 10 years had an increased risk of prediabetes (odds ratio [OR] 3.9, 95% confidence interval [CI]: 1.6-9.2) but not of type 2 diabetes mellitus. Former progestin-only contraceptive use was not associated with any glucose metabolism disorders. The results persisted after adjusting for socioeconomic status, smoking, alcohol consumption, parity, body mass index and use of cholesterol-lowering medication. Former long-term use of combined hormonal contraceptives was associated with a significantly increased risk of prediabetes in perimenopausal women, which potentially indicates a need of screening for glucose metabolism disorders in these women.

The Effect of Hormonal Contraception Use on Ovarian Reserve Markers and the Uptake of Assisted Reproductive Technology in Individuals Seeking an Infertility Evaluation.

Background and objective The effects of hormonal contraception (HC) use on ovarian reserve (OR) markers in individuals seeking an infertility evaluation and the success of assisted reproductive technology (ART) warrantfurther investigation. Therefore, the aim of this study was to determine if women seeking an evaluation for unexplained infertility who used long-term (≥2 years) HC have lower ovarian reserve (OR) markers and higher uptake of ART compared to short-term (<2 years) or never HC users. Methods We performed a cross-sectional patient survey involving a retrospective medical chart review of patients seeking an evaluation for unexplained infertility at the University of Colorado Advanced Reproductive Medicine (CU ARM) clinic. Results Most participants (87%; 107/123) reported a history of HC use with 98 (79.7%) reporting long-term continuous use for two or more years. Median OR markers were similar between long-term and short-term/never HC users [anti-Müllerian hormone (AMH): 2.4 vs. 3.2, p=0.20; antral follicle count (AFC): 18 vs. 26, p=0.10; follicle-stimulating hormone (FSH): 7.6 vs. 6.3, p=0.26] and remained so after adjusting for age and diagnosis of polycystic ovarian syndrome (PCOS) or primary ovarian insufficiency (POI) in linear regression models. However, amongHC users aged less than 30 years(n=9), those who had discontinued HC between two and three years prior to the assessment of their OR markers had a 6.20 ng/mL increase in AMH level compared to those whohad discontinued HCless than two years prior to the assessment (p=0.02). Additionally, there was a marginally increased use of ART overall among long-term HC users compared to short-term/never HC users (64.3% vs. 44.0%, p=0.06), specifically in the use of in vitro fertilization (IVF) (58.7% vs. 18.2%, p=0.01). Among long-term HC users, ovulation induction was less likely to result in live birth compared to short-term/never HC users (8.9% vs. 62.5%, p<0.001); however, after adjusting for age, PCOS, POI, and type of ART used, there was no difference in the odds of live birth after ART between long-term HC users and short-term/never users. Conclusion While long-term HC users report increased use of ART, in particular IVF, the overall conception rates and live birth outcomes among ART users do not appear to be significantly affected by a history of long-term HC use.

Relationship between history of hormonal contraceptive use and anaemia status among women in sub-Saharan Africa: A large population-based study.

Anaemia among women has been reported to be a significant contributor to hemorrhage, exacerbated risk of stillbirths, miscarriages, and maternal mortalities. Hence, understanding the factors associated with anaemia is imperative to develop preventive strategies. We examined the association between history of hormonal contraceptive use and risk of anaemia among women in sub-Saharan Africa. We analyzed data from the recent Demographic and Health Surveys (DHS) of sixteen countries in sub-Saharan Africa. Countries with recent DHSs conducted from 2015 to 2020 were included in the study. A total of 88,474 women of reproductive age were included. We used percentages to summarize the prevalence of hormonal contraceptives and anaemia among women of reproductive age. We used multilevel binary logistic regression analysis to examine the association between hormonal contraceptives and anaemia. We presented the results using crude odds ratio (cOR) and adjusted odds ratios (aOR), with their respective 95 percent confidence intervals (95% CIs). On the average, 16.2% of women are using hormonal contraceptives and this ranged from 7.2% in Burundi to 37.7% in Zimbabwe. The pooled prevalence of anaemia was 41%, ranging from 13.5% in Rwanda to 58.0% in Benin. Women who used hormonal contraceptives were less likely to be anaemic compared to those who were not using hormonal contraceptives (aOR = 0.56; 95%CI = 0.53, 0.59). At the country-level, hormonal contraceptive use was associated with a reduced likelihood of anaemia in 14 countries, except for Cameroon and Guinea. The study underscores the importance of promoting the use of hormonal contraceptives in communities and regions that have a high burden of anaemia among women. Specifically, health promotion interventions aimed at promoting the use of hormonal contraceptives among women must be tailored to meet the needs of adolescents, multiparous women, those in the poorest wealth index, and women in union as these sub-populations were at significantly higher risk of anaemia in sub-Saharan Africa.

Associations between reproductive history, hormone use, APOE ε4 genotype and cognition in middle- to older-aged women from the UK Biobank.

Relative to men, women are at a higher risk of developing age-related neurocognitive disorders including Alzheimer's disease. While women's health has historically been understudied, emerging evidence suggests that reproductive life events such as pregnancy and hormone use may influence women's cognition later in life. We investigated the associations between reproductive history, exogenous hormone use, apolipoprotein (APOE) ε4 genotype and cognition in 221,124 middle- to older-aged (mean age 56.2 ± 8.0 years) women from the UK Biobank. Performance on six cognitive tasks was assessed, covering four cognitive domains: episodic visual memory, numeric working memory, processing speed, and executive function. A longer reproductive span, older age at menopause, older age at first and last birth, and use of hormonal contraceptives were positively associated with cognitive performance later in life. Number of live births, hysterectomy without oophorectomy and use of hormone therapy showed mixed findings, with task-specific positive and negative associations. Effect sizes were generally small (Cohen's d < 0.1). While APOE ε4 genotype was associated with reduced processing speed and executive functioning, in a dose-dependent manner, it did not influence the observed associations between female-specific factors and cognition. Our findings support previous evidence of associations between a broad range of female-specific factors and cognition. The positive association between a history of hormonal contraceptive use and cognition later in life showed the largest effect sizes (max. d = 0.1). More research targeting the long-term effects of female-specific factors on cognition and age-related neurocognitive disorders including Alzheimer's disease is crucial for a better understanding of women's brain health and to support women's health care.

KARAKTERISTIK MENOPAUSE PADA PERAWAT DI RSUP SANGLAH DENPASAR TAHUN 2021

The age of menopause varies in each woman, due to differences in the characteristics of certain factors that are thought to have an effect. This study aims to determine the age of menopause and the characteristics of education level, marital status, parity, age of menarche, age of first birth, history of hormonal contraceptive use, and Body Mass Index in postmenopausal nurses at Sanglah General Hospital Denpasar in 2021. This study is an observational descriptive study with a cross-sectional approach. The sample consisted of 60 respondents who were collected by total sampling method. Data were collected through interviews using a questionnaire. The results showed that 88,3% experienced menopause at the age of &gt;45 years with the most distribution at the age of 50 years (30%). The characteristics of respondents were as follows, namely 100% in married, 88,3% completed D3/S1/S2/S3, 73,3% had given birth to 1-2 children, 88,3% gave birth to their first child at the age of 20-29 years, 58,3% menarche at age &gt; 14 years, 61,7% never used hormonal contraception, 51,7% are obese I. The results of this study are expected to be used as a basis for further research to determine the association between the characteristics of a woman and menopausal age.&#x0D; Keywords : menopause, menopausal age, characteristics.

FAKTOR RESIKO PREEKLAMSIA PADA IBU HAMIL: LITERATURE REVIEW

Background: The maternal mortality rate in Indonesia in 2020 reached 462 per 100,000 live births. Preeclampsia is some specific symptoms that only appear during pregnancy at 20 weeks of gestation (except for trophoblastic problems), these symptoms include hypertension accompanied by the presence of protein in the urine. The impact of preeclampsia on pregnant women can cause a decrease in consciousness, if preeclampsia is severe it can be accompanied by seizures. The purpose of this study is to determine the risk factors that influence the occurrence of preeclampsia. Subjects and Methods: This was a literature reviews study. The articles used were obtained from PubMed, and Google Scholar. Several passwords were used: "pregnant women" OR "mothers in labor" AND preeclampsia OR eclampsia OR eclampsia AND "risk factors" OR "risk factors" This method aims to increase understanding of the topics discussed by summarizing the topics to be discussed. This method provides insight into new facts/analyses as well as a literature review providing a summary of good and relevant publications that are further compared with the results that have been presented in the article. Results: of 11 articles that met the inclusion and exclusion criteria, 8 articles with a case-control study design, 2 cross-sectional articles, and 1 retrospective cohort study article. Conclusion: Risk triggers that have a relationship with the incidence of preeclampsia include the age of pregnant women at risk for nulliparity, primigravida, economic factors, previous history of preeclampsia, parity, level, education, use of ANC, gestational period, BMI before pregnancy, history of abortion, history of hormonal contraceptive use, Heredity, Multiple pregnancies, Medical history (chronic hypertension, diabetes, kidney disease, and obesity), Hypertension, Diabetes, Obesity

Association of Hormonal Contraception with Meningioma Location in Indonesian Patients.

Background:Meningioma is the most common primary intracranial tumor. Previous studies have shown the possible association between hormonal contraceptive use and meningioma location. Therefore, this study aimed to analyze the association between the history of hormonal contraceptive use and the location of meningioma in the Indonesian population. Methods:In total, 99 histologically confirmed female meningioma patients admitted to Dr. Sardjito General Hospital Yogyakarta, Indonesia, were included in this study. Data on hormonal contraception and other variables were collected from medical records. Meningioma locations were determined from brain Magnetic Resonance Imaging (MRI) or Computerized Tomography (CT) scan before surgery. Results:Seventy-two (72.7%) patients had a history of hormonal contraceptive use. The subjects consist of 83 (83.8%) WHO grade I and 16 (16.2%) WHO grade II and III tumors. A total of 57 (57.6%) tumors were located in the spheno-orbital region. We found a significant association between hormonal contraceptive use and meningioma location in the spheno-orbital region (Odds ratio (OR) 2.573, p=0.038). This resulted in the patients in the hormonal contraception group having more visual impairment (p=0.044). Conclusion:The use of hormonal contraception is associated with the location of meningioma in the spheno-orbital region.

Demographic, Clinical, and Tumor Profile Of Meningioma In Mohammad Hoesin Hospital Palembang, Indonesia

Introduction. Meningioma was the most frequently reported primary intracranial tumor. There had been a few reports about meningioma profile in Indonesia. The objective of this study is to identify the profile of meningioma based on demographic, clinical, and tumor characteristics. Methods. This is a cross-sectional study using secondary data from medical records. There were 67 meningioma patients based on histopathological examination at Mohammad Hoesin Hospital from January to December 2018. Various data were recorded, including demografic profile, history of hormonal contraceptive use, neurologic symptoms, and tumor characteristic. Results. During 2018, the incidence of meningioma was 68,3% of all primary CNS tumors. Meningioma was mostly found in the age group 35-44 years (44.8%). Most of the patients was female (92.5%) and 29 patients (46.8%) had a history of hormonal contraceptive use. Headache showed the highest rate of clinical manifestation in meningioma patient (34.3%). Based on the location, convexity meningioma was the most frequently found (65.7%). Of the 67 meningioma patients, only 26 datas were obtained regarding a history of radiation exposure and all without a history of radiation. There was only one patient (1.5%) with a family history of malignancy (breast tumor). Based on histopathological examination, 60 patients (89.6%) reported as WHO grade I, mostly the meningothelial subtype (40%). The outcome was generally good in most patients (88.1%). Conclusion. In our institution, meningioma is the most commonly found primary brain tumor. Headache was the most common clinical manifestation and these tumors were mostly located in convexity of the brain, with the majority being WHO grade I and meningothelial subtype.

Profile of Ovarian Cancer Patients In Mangusada Badung Regional Public Hospital

Background: Ovarian cancer is still one of the neoplasms within the gynecology scope. Besides, World Health Organization (WHO) states that ovarian cancer ranks fourth cancer in women with the lowest five-year survival rate (43%). Thus, this research aims to recognize the risk factors in patients with ovarian cancer and the commonly found characteristic.Methods: This cross-sectional observational research on 29 women diagnosed with ovarian cancer observed the age, parity, body mass index (BMI), contraception, character, and stadium. The medical record samples based on patients’ registers were obtained from the Obstetrics and Gynecologic Polyclinic in Mangusada Badung Regional Public Hospital in the January–December 2019 period, and the result data were distributed using contingency tables. Results: The data dominantly diagnosed ovarian cancer, with age distribution 51-60 years (34.5%), 44.8% with obesity, 44.8% nullipara, without a history of contraceptive use, menarche within 12 years old (41.4%), diagnosed stage IIIC (42.3%), and with serous epithelial tumor subclassification (65.5%).Conclusions: Predominant ovarian cancer is found at a late stage. The most common risk factors of developing ovarian cancer, including the age of 51–60, obesity, menarche within 12 years old, and no history of hormonal contraceptive use, are consistent with this research hypothesis about risk factors dominantly found in patients with ovarian cancer

USIA MENOPAUSE, RIWAYAT KONTRASEPSI, BERAT BADAN DENGAN TEKANAN DARAH PADA PEREMPUAN MENOPAUSE DI DESA ANGKATANLOR TAMBAKROMO PATI

Blood pressure is the most important part of the body’s circulation. Factors that affect blood pressure are hereditary factors, age, weight, gender, stress, unhealthy eating patterns, lack of physical activity, alcohol consumption, caffeine, smoking, history of hormonal contraceptive use, and other diseases. Indonesian Society of Hypertension (InaSH) survey conducted in may 2017 shows that hypertention cases tend to increase in erderly women. The purpose of this study was to determine the Relationship of age of menopause, contraceptive history, weight, withchanges in blood pressure in menopausal women in Angkatanlor Tambakromo Pati Village. This study was a quantitative research with correlational analysis and using a cross sectional and restropective approach. The sample used in this study was 120 respondents. Then, the data in this study was collected by questionnaire sheet by interview. The results of this study showed that there was relationship between age of menopause ( p = 0.001 ), history of hormonal contraceptive use (p = 0.000 ), weight ( p = 0.003 ) withchanges in blood pressure. Conclusion : Ha Accepted and Ho was rejected

Relationship Between History of Hormonal Contraception with Hormonal Receptor’s Expression on Breast Cancer Patients in Mohammad Hoesin General Hospital Palembang

Background: Cancers with esterogen receptor negative (ER-) have a worse prognostic than estrogen receptor positive (ER +). Research by Cooper at al and Huiyan Ma et al have found strong association between history of hormonal contraceptive use and breast cancer with receptor negative estrogen (ER -). However, another study from Cotterchio et al found no difference.&#x0D; Methods: This study investigated breast cancer patients who went to dr. Moh Hoesin Palembang. This study involved 200 respondents with data obtained using patient immunohistochemical data and interviews using a questionnaire. This study uses a cross sectional analysis method. Data were obtained from the history of use of hormonal contraception, the type of hormonal contraception, and the status of hormonal receptors (Esterogen Receptors (ER) and Progesterone receptors (PR). 2x2 tables were used to obtain the Prevalence Ratio (PRR) and chi quare to obtain p values.&#x0D; Results: The results of the Chi square analysis showed that there was no significant relationship between the history of hormonal contraception and negative receptor expression with the prevalence ratio of hormonal contraceptives and ER (-) 1.48 times and PR (-) 1.43 times. There was no significant relationship between type of contraception and negative ER PR. The highest relative risk is in implant contraception with 1.54 times for ER (-) and 1.8 times for PR (-)&#x0D; Conclusion: There was no relationship between the history of hormonal contraception and negative hormonal receptors

Prevalence and frequency of menstrual cycle symptoms are associated with availability to train and compete: a study of 6812 exercising women recruited using the Strava exercise app

ObjectivesThe menstrual cycle can affect sports participation and exercise performance. There are very few data on specific menstrual cycle symptoms (symptoms during various phases of the cycle, not only during...

Prevalence and Determinants for Hypertension among Rural Women of Reproductive Age in Indonesia

This study aimed to investigate the prevalence and determinants of hypertension in rural women of reproductive age. The cross-sectional study was conducted in Cianjur district on August 2019. It involved 193 married rural women aged 20–49 years old. Independent variables investigated were socio-economic characteristics, anthropometry, fat distribution and nutrient intake. The prevalence of hypertension in the study population using the new American Guideline (ACC/AHA) was 58% in contrast to 23.8% using the European (ESC/ESH) cut offs. Socioeconomic characteristics and nutrient intake showed no significant association with hypertension (p>0.05) while, Body Mass Index (BMI) (p>0.012), Visceral Fat (VF) (p>0.013) and Waist Circumference (WC) (p>0.010) were significantly associated with hypertension. Hence, result of binary logistic regression showed waist circumference is the strongest factor to determine hypertension in our study (OR=2.2; 95% CI: 1.20–4.01). Overall, the use of the American guideline increases the sensitivity of hypertension screening. The use of simple anthropometry measurement of WC combined with BMI can be applied for risk screening of hypertension in the primary health care setting including in the integrated community health post to improve preventive measure. Due to several limitations in the current study, future study should consider larger sample size and addresses history of hormonal contraceptive use as well as physical activity

Determinan Kejadian Kanker Payudara Pada Wanita Di Rsud Arifin Achmad Provinsi Riau Tahun 2019

Breast cancer is among the most discussed cancers because of its malignancy which often ends in death. Based on the 2013 Basic Health Research Data (Riskesdas), the number of breast cancer patients reached 61,682 cases in Indonesia. As in Riau Province according to the medical records of Arifin Achmad Regional Hospital, breast cancer ranks first with 325 cases out of 580 cases in Irna Surgical Cendrawasih in 2016. Purpose of this study was to determine the determinants of breast cancer incidence in women in Arifin Achmad Regional Hospital in Riau Province in 2019. This research uses a quantitative research design with a case control approach. The research instrument used was a questionnaire. The sampling technique was Consecutive Sampling. This research was conducted in May to July 2019. Case samples in this study were women who were diagnosed positive for breast cancer and control samples were women who were diagnosed with negative breast cancer. Univariate and bivariate data analysis with chi square test and multivariate analysis using Simple Logistic Regression test. The results showed the most dominant variables related to cause and effect with the incidence of breast cancer were a history of abortion 3.7 times, a history of hormonal contraceptive use 5.4 times, the age of first child birth&gt; 35 years 3 times, and the number of nulliparous children 2.3 times. It is expected that health workers and related institutions will be able to provide health education regarding the positive and negative impacts of contraceptive use, the importance of planning the marriage age and promoting family planning programs that have been launched by the government.

Risk of meningioma associated with exposure of hormonal contraception. A case control study

Objective: To identify the effect of hormonal contraceptive exposure to the occurrence of meningioma.Materials and Methods: This study, conducted in 2016, was a case-control study by collecting a group of cases comprising all patients diagnosed histopathologically with meningioma in 2012-2013 and treated in dr. Soetomo Hospital, Surabaya, Indonesia. Medical record data were analyzed and compared to control group of patients diagnosed with non-meningioma who underwent contrast head ct scan and direct interviews. We obtained 101 cases and 101 controls. Data were analyzed using univariate logistic regression test.Results: Based on the history of hormonal contraceptive use, patients who had history of hormonal contraceptive use had 12.31 times higher risk (p=0.000). In this study, those who had contraceptive injections for one month and used contraceptive pills had a meningioma risk lower than those who used injectables 3 months. Patients who used hormonal contraception more than 10 years had an increased risk for meningioma as much as 18.216 times (p=0.000). Histopathologically, we found a non-significant association between history of hormonal contraceptive use and the distribution of histopathology, but based on descriptive data showed it was found that the most histopatological meningioma was of the transitional type in cases group.Conclusion: There is a significant association between hormonal contraceptive use, the type of injectable hormonal contraception for 3 months, the duration of hormonal contraceptive use &gt;10 years, and no significant association between meningioma grade and the history of hormonal contraception exposure.

Risk of meningioma associated with exposure of hormonal contraception. A case control study

Objective: To identify the effect of hormonal contraceptive exposure to the occurrence of meningioma.Materials and Methods: This study, conducted in 2016, was a case-control study by collecting a group of cases comprising all patients diagnosed histopathologically with meningioma in 2012-2013 and treated in dr. Soetomo Hospital, Surabaya, Indonesia. Medical record data were analyzed and compared to control group of patients diagnosed with non-meningioma who underwent contrast head ct scan and direct interviews. We obtained 101 cases and 101 controls. Data were analyzed using univariate logistic regression test.Results: Based on the history of hormonal contraceptive use, patients who had history of hormonal contraceptive use had 12.31 times higher risk (p=0.000). In this study, those who had contraceptive injections for one month and used contraceptive pills had a meningioma risk lower than those who used injectables 3 months. Patients who used hormonal contraception more than 10 years had an increased risk for meningioma as much as 18.216 times (p=0.000). Histopathologically, we found a non-significant association between history of hormonal contraceptive use and the distribution of histopathology, but based on descriptive data showed it was found that the most histopatological meningioma was of the transitional type in cases group.Conclusion: There is a significant association between hormonal contraceptive use, the type of injectable hormonal contraception for 3 months, the duration of hormonal contraceptive use &gt;10 years, and no significant association between meningioma grade and the history of hormonal contraception exposure.