INTRODUCTION: E-cigarette/vaping product use-associated lung injury (EVALI) is a potentially life-threatening disease. Gastrointestinal manifestations have been noted in the past to shortly precede respiratory decline. A longer gastrointestinal prodrome may mean more EVALI patients will be referred to a gastroenterologist prior to respiratory decompensation making this an important consideration for providers. CASE DESCRIPTION/METHODS: A 32-year-old Caucasian male with a history of major depressive disorder and chronic low back pain presented to the emergency department (ED) with a one-month history of fever, weight-loss, anorexia, nausea, vomiting, ten-pound weight loss, and non-bloody diarrhea in the absence of abdominal pain. For these complaints, he had seen his primary care physician 3 weeks prior who had referred him to a gastroenterologist who the patient had not yet seen. The patient had no recent changes in diet, antibiotic usage or travel. Four days prior to presentation, he began having shortness of breath, pleuritic chest pain and watery diarrhea. He has been vaping “Dank Brand” THC via a cartridge nightly for the past six months. In the ED, he was tachycardic, diaphoretic, and had a new oxygen requirement. Initial WBC was 17,000 cells per microliter, AST 34 IU/L, ALT 22 IU/L, and AlkP 74 IU/L. He became increasingly hypoxic requiring transfer to the ICU and initiation of pulse dose steroids. CT chest with contrast showed scattered patchy ground-glass densities and consolidations bilaterally. KUB showed a normal gas pattern. Workup for Influenza A/B, blood cultures, rapid respiratory viral panel, sputum cultures, legionella, Pneumocystis jiroveci, and mycoplasma were negative. Multiplex Gastrointestinal PCR Panel was negative for infectious etiology. Bronchoalveolar lavage showed hemosiderin-laden macrophages. He had no serologic evidence of rheumatologic disease or occult neoplastic process. Patient had prone ventilation for four days, was treated with broad spectrum antibiotics and steroids. He improved by day seven, was extubated, and downgraded to the floor where is he was ultimately discharged on a slow taper of prednisone. At discharge, all gastrointestinal symptoms had resolved. DISCUSSION: It is important for clinicians to note that there is often a highly variable gastrointestinal prodrome in nature and duration proceeding EVALI. This case demonstrates the variable gastrointestinal manifestations of EVALI. The case was reported to the Hawai'i Department of Health and confirmed as EVALI.Image 1.: AP, Upright chest Radiograph on day of admission. Bilateral Infiltrates. Arrow points to patient's bone necklace.Image 2.: AP, Upright chest Radiograph on day 1 of the admission. With ground glass opacities.Image 3.: CT chest, abdomen and pelvis with contrast day 1 of admission.