Historical Events Research Articles

Социально ответственная коммуникация бизнеса: генезис и эволюция

Introduction. In the modern world, socially responsible communication and the social policy of business in relation to the state and society play a key role on which the growth of the company’s intangible assets and its financial well-being depends. The purpose of the article is to analyze the prerequisites for the emergence of socially responsible business communication in Russia and abroad, consider the stages of their development and draw up a periodization. Methodology and methods. The theoretical and methodological basis of the study was a systematic approach that promotes ordering and systematization of many historical events and facts of social business initiatives into an integral unity. Research methods: analysis of literary sources, retrospective analysis, comparative analysis of Russian and Western practices of socially responsible communication and social business initiatives, synthesis, generalization. Results. Using a systematic approach, an analysis of Russian and global methodology for socially responsible behavior of companies and a historiographical review of communication activities in the context of social responsibility of business were made, and a periodization of the process of development of socially responsible communication of business in Russia and abroad was compiled. Scientific novelty lies in the systematization and periodization of the prerequisites and facts of the origin and development of socially responsible communication in Russia and abroad. Practical significance. The results of the study may be useful for improving socially responsible business communication.

Permanent areas and changes in forests, grasslands, and wetlands in the North European Plain since the eighteenth century—a case study of the Kościan Plain in Poland

This study investigates the intricate and enduring interplay of historical events, human activities, and natural processes shaping the landscape of North European Plain in western Poland over 230 years. Topographic maps serve as reliable historical data sources to quantify changes in forest, grassland, and wetland areas, scrutinizing their fragmentation and persistence. The primary objectives are to identify the permanent areas of the landscape and propose a universal cartographic visualization method for effectively mapping these changes. Using topographic maps and historical data, this research quantifies land cover changes, especially in forest, grassland, and wetland areas. With the help of retrogressive method we process raster historical data into vector-based information. Over time, wetlands experienced a substantial reduction, particularly in 1960–1982, attributed to both land reclamation and environmental factors. Grassland areas fluctuated, influenced by wetland and drier habitat dynamics. Fragmentation in grassland areas poses biodiversity and ecosystem health concerns, whereas forested areas showed limited fluctuations, with wetland forests nearly disappearing. These findings highlight wetland ecosystems’ sensitivity to human impacts and emphasize the need to balance conservation and sustainable development to preserve ecological integrity. This study advances landscape dynamics understanding, providing insights into historical, demographic, economic, and environmental transformations. It underscores the imperative for sustainable land management and conservation efforts to mitigate human impacts on ecosystems and biodiversity in the North European Plain.

Mining Real-World Big Data to Characterize Adverse Drug Reaction Quantitatively: Mixed Methods Study.

Adverse drug reactions (ADRs), which are the phenotypic manifestations of clinical drug toxicity in humans, are a major concern in precision clinical medicine. A comprehensive evaluation of ADRs is helpful for unbiased supervision of marketed drugs and for discovering new drugs with high success rates. In current practice, drug safety evaluation is often oversimplified to the occurrence or nonoccurrence of ADRs. Given the limitations of current qualitative methods, there is an urgent need for a quantitative evaluation model to improve pharmacovigilance and the accurate assessment of drug safety. In this study, we developed a mathematical model, namely the Adverse Drug Reaction Classification System (ADReCS) severity-grading model, for the quantitative characterization of ADR severity, a crucial feature for evaluating the impact of ADRs on human health. The model was constructed by mining millions of real-world historical adverse drug event reports. A new parameter called Severity_score was introduced to measure the severity of ADRs, and upper and lower score boundaries were determined for 5 severity grades. The ADReCS severity-grading model exhibited excellent consistency (99.22%) with the expert-grading system, the Common Terminology Criteria for Adverse Events. Hence, we graded the severity of 6277 standard ADRs for 129,407 drug-ADR pairs. Moreover, we calculated the occurrence rates of 6272 distinct ADRs for 127,763 drug-ADR pairs in large patient populations by mining real-world medication prescriptions. With the quantitative features, we demonstrated example applications in systematically elucidating ADR mechanisms and thereby discovered a list of drugs with improper dosages. In summary, this study represents the first comprehensive determination of both ADR severity grades and ADR frequencies. This endeavor establishes a strong foundation for future artificial intelligence applications in discovering new drugs with high efficacy and low toxicity. It also heralds a paradigm shift in clinical toxicity research, moving from qualitative description to quantitative evaluation.

Association between Glucose-lowering Treatments and Risk of Diabetic Retinopathy in People with Type 2 Diabetes: A Nationwide Cohort Study.

Glycaemic variability is possibly linked to the development of diabetic retinopathy, and newer second-line glucose-lowering treatments in type 2 diabetes might reduce glycaemic variability. This study aimed to investigate whether newer second-line glucose-lowering treatments are associated with an alternative risk of developing diabetic retinopathy in people with type 2 diabetes. A nationwide cohort of people with type 2 diabetes on second-line glucose-lowering treatment regimens in 2008-2018 was extracted from the Danish National Patient Registry. Adjusted time to diabetic retinopathy was estimated with a Cox Proportional Hazards model. The model was adjusted for age, sex, diabetes duration, alcohol abuse, treatment start year, education, income, history of late-diabetic complications, history of non-fatal major adverse cardiovascular events, history of chronic kidney disease, and history of hypoglycaemic episodes. Treatment regimens of metformin + basal insulin (HR: 3.15, 95% CI: 2.42-4.10) and metformin + glucagon-like peptide-1 receptor agonist (GLP-1-RA, HR: 1.46, 95% CI: 1.09-1.96) were associated with an increased risk of diabetic retinopathy compared with metformin + dipeptidyl peptidase-4 inhibitors (DPP-4i). Treatment with metformin + sodium-glucose cotransporter-2 inhibitor (SGLT2i, HR: 0.77, 95% CI: 0.28-2.11) was associated with the numerically lowest risk of diabetic retinopathy compared with all regimens investigated. Findings from this study indicate that basal insulin and GLP-1-RA are suboptimal second- line choices for people with type 2 diabetes at risk of developing diabetic retinopathy. However, many other considerations concerning the choice of second-line glucose-lowering treatment for type 2 diabetes patients should be taken into account.

The problems of the Anthropocene in the Geologic Time Scale, and beyond

The formalization of the Anthropocene in the Geologic Time Scale (GTS) is a matter of debate. An assessment of the two current options, one formalizing the Anthropocene as an Epoch and the other considering the Anthropocene as an informal event in the Earth's history that does not require formalization, are critically analyzed. The focus of the analysis is on the philosophical issues underlying these two options, which make them unsatisfactory for addressing the occurrence of humans on Earth and the evolution of the relationship between humans and nature. Essentially, the approach followed by these options is non-historical, and does not undertake a research on the structural socio-economic roots of the Anthropocene. As a result, the concept of the Anthropocene is unable to identify the particular and historical form of Anthropos underlying the ongoing environmental degradation. Some inconsistencies in the current configuration of the GTS and in the rules for formalizing units inherited from the historical tradition of the GTS are also highlighted. The current dualistic approach of the Earth system science community, including the two options analyzed for the Anthropocene, prevents a proper understanding of the relationship between humans and nature, which is fundamental to confront the Earth's habitability crisis of the Anthropocene.

The Use of Weighted Euclidean Distance to Provide Assistance in the Selection of Safety Risk Prevention and Control Strategies for Major Railway Projects

A major railway project is a complex, giant system with multi-party participation, one characterized by complex geological conditions, long construction periods and large scale, which leads to an increased likelihood of safety risk events during construction. In order to solve the problem of scientific selection and formulation of safety risk prevention and control strategies for major railway projects, an auxiliary selection method of safety risk prevention and control strategies for major railway projects based on weighted Euclidean distance (WED) is proposed. The relevant ontology is used to conceptualize and formalize the knowledge of safety risks of major railroad projects, and combine the characteristics of major railroad projects; it refers to the prevention and control measures of historical safety risk events associated with major railroad projects, and then constructs the knowledge structure and case base around safety risks of major railroad projects and the circumstances of the case. In determining the comprehensive weights, the G1 method is used to determine the subjective weights, the anti-entropy weight method is used to determine the objective weights and game theory combines the subjective and objective weights. In comparing the array of safety risk prevention and control cases associated with major railway projects, the weighted Euclidean distance is used to calculate the similarity between these cases and the target case, which in turn assists project managers in determining the safety risk prevention and control strategies appropriate for major railway projects. This study takes Landslide No. 1 in the Tunnel A inlet planning area as an example. It utilizes the WED method to assist in selecting safety risk prevention and control strategies for major railway projects, which verifies the method’s feasibility. The proposed method enriches the method of the assisted selection of safety risk prevention and control strategies for major railway projects, makes strategy formulation more scientific, has specific reference significance for the formulation of safety risk prevention and control strategies for major railway projects, and promotes the improvement of safety risk prevention and risk control for participating units.

The Impact of Geopolitical Risk, Institutional Governance and Green Finance on Attaining Net-Zero Carbon Emission

This research investigates the impact of geopolitical risk, institutional governance and green finance on environmental outcomes, specifically focusing on carbon emissions and ecological footprint. Utilizing the dynamic CS-ARDL method and aggregated mean group analysis on a panel dataset covering 21 nations from 2000 to 2021, our findings reveal that heightened geopolitical risk leads to both short and long run increases in carbon emissions and the ecological footprint. Our study finds both a direct as well as indirect connection between governance, green finance and environmental outcomes in both the short and long run, highlighting the nuanced impact of governance on the formulation of environmental policies and regulatory frameworks. The results emphasize the need for targeted strategies, including focused investments and incentives for sustainable finance, particularly in conflict-affected regions. Furthermore, our research underscores the enduring impact of historical events, such as wars, on contemporary environmental indicators, emphasizing the importance of proactive conflict prevention measures. Our research suggests that policymakers should adopt comprehensive strategies that prioritize emission reduction during short-run spikes in geopolitical risk while maintaining a steadfast commitment to long-run sustainability.

Quotidien et la guerre : adaptation et survie dans La vie d’un homme inconnu et Le testament français d’Andreï Makine

This article explores the representation of everyday life in contemporary writing as a survival mechanism in the face of traumatic historical events in the novels Le testament français (1995) and La vie d’un homme inconnu (2009) by Franco-Russian writer Andreï Makine.

The Thudong Bhikkhu Pilgrimage

Thousands of kilometres travelled by 32 thudong monks from Thailand to Indonesia was not only a spiritual moment for the participants but also a historical event in Indonesian interfaith relations. Given the abundance of enthusiasm, this article aims to explain the purity of interfaith harmony created by local communities and Thai monks, who also contributed to promoting interfaith dialogue discourse among grassroots communities. By delving into the internet, a netnography approach is used to get a deeper and broader understanding of the events by comparing one digital document with another. In the interfaith encounters along the pilgrimage highway, both parties exhibited reciprocal behaviours of shared feelings and kindness that encouraged them to complete the ritual mission together. They were able to dismantle the religious barriers that frequently impede harmonious interfaith relations as a result of warm acceptance, hospitable interactions, and engaging dialogue onsite and via social media.

Defining media speech effectiveness: A case of Ukrainian president Zelenskyy's addresses to national parliaments

The paper argues that effectiveness of media speeches, i.e., their ability to influence the addressees, largely rests on national prototypes, representing cultural entities and historic events. The national prototypes are clear and accessible, resonating with the addressees' values, attitudes, and beliefs. The article analyzes rhetorical effectiveness of Ukrainian president's addresses delivered at the beginning of the Russian-Ukrainian full-scale war to parliaments of seven states: Poland, USA, Canada, Germany, Italy, Japan and Greece. Volodymyr Zelenskyy appeals to the target audiences' national prototypes representing events or cultural entities correlating with Ukraine's current plight. It is found that with respect to the similarity to the national prototypes of other countries the arguments employed in Zelenskyy’s speeches fall into three types: direct, implicit, and gradual. The most effective is direct reference to prototypes at the global or national levels of the listeners' worldviews. Less effective are implicit arguments left for the addressee to be inferred like any other implicature. The least effective are gradual arguments based on presuppositions about some commonly shared information: they modify the existing national prototypes with reference to the present or future which is not always accepted by the audience.

THE USE OF CULTURAL AND ENVIRONMENTAL HERITAGE IN EDUCATIONAL CONTEXTS BETWEEN SPACES, IDENTITIES, ATTITUDES, AND COGNITIVE WELL-BEING

The paper explores some links between educational research, the use of cultural and environmental heritage and education, where it is possible to combine knowledge, disciplines, and skills to strengthen the cultural profile of the school population, but also to bring about important changes in attitudes and behavior. The world's cultural and environmental heritage, which collects the traces of extraordinary but also tragic events in human history, can act as a unifying force for peaceful coexistence for the whole of humanity, enabling future citizens to participate in democratic debate and make informed choices about the social challenges they face. It therefore contributes not only to the development of knowledge, but also to the ability of children, young people, and adults to understand contemporary problems by placing them in human, social, environmental, historical, and cultural contexts that help them to live. For cultural heritage to contribute to the recovery of knowledge, researchers, teachers, and operators must be able to share a solid research background that allows them to address the various issues relating to the quality of the experiences of use carried out in school contexts, with the aim of improving the learning processes of users. In fact, the cultural and environmental resources of the territory can only be a real methodological resource for improving cognitive well-being and the overall quality of education at all levels if they are seen as useful tools for different types of learning (cognitive, social, etc.) and not as general educational tools. The paper therefore questions the use of cultural and environmental heritage in education and its adequacy with respect to learning conditions, pausing to consider also the role played by attitudes to fruition, highlighting those elements and dimensions that can contribute to redefining the relationship between education, goods, and environment, in the idea of strengthening interpretative repertoires in educational contexts.

Leader and the Leadership of the Prophet Muhammad: Strategy and Innovation in the Battle of Trench

This article examines Prophet Muhammad's strategic and innovative leadership during the Battle of the Trench, a pivotal event in early Islamic history. Faced with a large confederate army, Muhammad adopted the unprecedented strategy of digging a trench around Medina, demonstrating his adaptability and inclusiveness by accepting a Persian companion's suggestion, Salman al-Farsi. This tactic effectively neutralized the enemy's advantage, highlighting Muhammad’s foresight and strategic acumen which can only be seen if we read the references in detail and feel the tense occurred on that day. The analysis of this article focuses on Muhammad's leadership qualities, including visionary strategy, resilience, ethical conduct, and inspirational influence. These attributes were crucial in uniting and motivating the Muslim community under extreme adversity. The successful defence of Medina not only solidified the Muslim community but also set new precedents in military tactics and ethical warfare, influencing Islamic governance and leadership principles. The Battle of the Trench serves as a significant historical case study of strategic and ethical leadership shown by Muhammad in facing a direct enemy from outside and a potential internal enemy that turns up in that despairing situation. The insights drawn from Muhammad’s leadership approach are relevant to modern leadership and contemporary challenges, transcending religious and cultural contexts. This article contributes to the discourse on leadership, strategy, and crisis management, underscoring the enduring relevance of Muhammad's leadership principles which have proven effective in saving the situation.

¡Raza Sí! ¡Guerra No!

On August 29, 1970, thousands of demonstrators took to the streets in Los Angeles to protest the Vietnam war as part of the National Chicano Moratorium. In response to highly disproportionate numbers of Chicano casualties listed among the wounded, protestors from all factions of the Chicano Movement marched to demand an end to the war. By the end of the day, the police had killed three protestors while dozens more were critically injured. The massacre at the Chicano Moratorium was a low point in the civil rights history of the United States, but it is also clear evidence of how numerous actors, institutions, and events unified the Chicano movement towards one goal during the Vietnam War. Its violent suppression by the Los Angeles Police Department also situates the event in a larger history of government supported violence against minorities and civil rights groups. This paper tracks the development of the Chicano identity, civil rights movement, and the development of anti-war sentiment from the early twentieth century up to the 1970 moratorium.

Discovery of two warm mini-Neptunes with contrasting densities orbiting the young K3V star TOI-815

We present the discovery and characterization of two warm mini-Neptunes transiting the K3V star TOI-815 in a K–M binary system. Analysis of its spectra and rotation period reveal the star to be young, with an age of 200−200+400 Myr. TOI-8l5b has a 11.2-day period and a radius of 2.94 ± 0.05 R⊕ with transits observed by TESS, CHEOPS, ASTEP, and LCOGT. The outer planet, TOI-8l5c, has a radius of 2.62 ± 0.10 R⊕, based on observations of three nonconsecutive transits with TESS; targeted CHEOPS photometry and radial velocity follow-up with ESPRESSO were required to confirm the 35-day period. ESPRESSO confirmed the planetary nature of both planets and measured masses of 7.6 ± 1.5 M⊕ (ρP = 1.64−0.31+0.33 g cm−3) and 23.5 ± 2.4 M⊕ (ρP = 7.2−1.0+1.1 g cm−3), respectively. Thus, the planets have very different masses, which is unusual for compact multi-planet systems. Moreover, our statistical analysis of mini-Neptunes orbiting FGK stars suggests that weakly irradiated planets tend to have higher bulk densities compared to those undergoing strong irradiation. This could be ascribed to their cooler atmospheres, which are more compressed and denser. Internal structure modeling of TOI-815b suggests it likely has a H-He atmosphere that constitutes a few percent of the total planet mass, or higher if the planet is assumed to have no water. In contrast, the measured mass and radius of TOI-815c can be explained without invoking any atmosphere, challenging planetary formation theories. Finally, we infer from our measurements that the star is viewed close to pole-on, which implies a spin-orbit misalignment at the 3σ level. This emphasizes the peculiarity of the system’s orbital architecture, and probably hints at an eventful dynamical history.

Storm‐Time Very‐Near‐Earth Magnetotail Reconnection: A Statistical Perspective

AbstractThe ring current, an equatorial near‐Earth current, fluctuates in response to solar wind plasma interactions with Earth's magnetosphere. Despite extensive research on storm‐time ring current energization, direct evidence of the energy transport into the inner‐magnetosphere that powers this current remains scarce. Recent observations revealing that very‐near‐Earth reconnection (VNERX, occurring at geocentric distance <14 RE) can occur during storms suggest that such reconnection could play an important role in ring current development. Here we address how common VNERX is. We use inner‐magnetosphere and plasma sheet observations from the Time History of Events and Macroscale Interactions during Substorms (THEMIS) satellites spanning 13 years. During this period, THEMIS observed 512 storms and 7 VNERX events. All VNERX events occurred during storm main‐phase at or near the pre‐midnight sector (None were observed during storm recovery‐phase.). The events occurred within 1 RE of the modeled neutral sheet, suggesting that VNERX events are elusive because they lie near the neutral sheet. Since THEMIS spent 5,253 hr within 1 RE of the modeled neutral sheet during storm main‐phase, the inferred observational VNERX occurrence rate is 1.3 per 1,000 hr of storm main‐phase. This rate is lower than published ion‐diffusion‐region occurrence rates seen in the near‐Earth plasma sheet during non‐storm times (likely substorms). These results suggest that while VNERX events might be significant for the storm‐time ring current's initial buildup (during storm main‐phase), other transport mechanisms, like enhanced global convection, may be responsible for maintaining the strength of the ring current during storm recovery‐phase.

Haematococcus lacustris Carotenogensis: A Historical Event of Primary to Secondary Adaptations to Earth’s Oxygenation

(1) Background: Oxygen has exerted a great effect in shaping the environment and driving biological diversity in Earth’s history. Green lineage has evolved primary and secondary carotenoid biosynthetic systems to adapt to Earth’s oxygenation, e.g., Haematococcus lacustris, which accumulates the highest amount of secondary astaxanthin under stresses. The two systems are controlled by lycopene ε-cyclase (LCYE) and β-cyclase (LCYB), which leave an important trace in Earth’s oxygenation. (2) Objectives: This work intends to disclose the underlying molecular evolutionary mechanism of Earth’s oxygenation in shaping green algal carotenogensis with a special focus on lycopene cyclases. (3) Methods: The two kinds of cyclases were analyzed by site-directed mutagenesis, phylogeny, divergence time and functional divergence. (4) Results: Green lineage LCYEs appeared at ~1.5 Ga after the first significant appearance and accumulation of atmospheric oxygen, the so-called Great Oxygenation Event (GOE), from which LCYBs diverged by gene duplication. Bacterial β-bicyclases evolved from β-monocyclase. Enhanced catalytic activity accompanied evolutionary transformation from ε-/β-monocyclase to β-bicyclase. Strong positive selection occurred in green lineage LCYEs after the GOE and in algal LCYBs during the second oxidation, the Neoproterozoic Oxygenation Event (NOE). Positively selected sites in the catalytic cavities of the enzymes controlled the mono-/bicyclase activity, respectively. Carotenoid profiling revealed that oxidative adaptation has been wildly preserved in evolution. (5) Conclusions: the functionalization of the two enzymes is a result of primary to secondary adaptations to Earth’s oxygenation.

Dynamic shifts in the southern Benguela upwelling system since the latest Miocene

This study reconstructs the upwelling history of the Southern Benguela Upwelling System (SBUS), examining its sensitivity to both regional and global climatic influences. We analyze planktic foraminiferal relative abundance and stable isotope data from ODP Site 1087 to investigate the history of SBUS since ∼ 6.1 Ma. During the latest Miocene-earliest Pliocene, the SBUS experienced increased productivity, fueled by wind-driven upwelling and an enriched global nutrient reservoir associated with the late Miocene biogenic bloom. The early Pliocene witnessed an apparent weakening of the SBUS due to the deepening of the global thermocline and weak trade winds. Significantly, our proxy records indicate strengthening of the SBUS beginning before the onset of intense northern hemisphere glaciation (iNHG) between 3.5 and 3 Ma. Despite contraction of upwelling cells after ∼ 3 Ma, our study challenges the notion of water column stability during the Matuyama Diatom Maximum event (3 to 2 Ma); we alternatively propose the existence of water column instability and probable presence of upwelling during this time. Post 2 Ma, the main upwelling cells shifted northward in response to the strengthening and equatorward migration of the Hadley cell, marked by long-term marginal upwelling. The SBUS achieved its modern state by ∼ 1 Ma with complete isolation from the coastal upwelling zone. Our observations indicate a strong correlation between the history of SBUS and global climatic events, with a strong correlation between them prior to the initiation of iNHG. Subsequently, local climatic influences have become more predominant, overshadowing the signals from global climatic events. The data also suggest linkages between shifts in the SBUS strengths and southwest African climate.

Prevalence of Cardiovascular and Cancer Risk Factors Among Rheumatoid Arthritis Patients Prescribed JAKi and TNFi: A MarketScan by Merative Cross-Sectional Study.

To determine the prevalence of baseline risk factors for cardiovascular outcomes and cancer among commercially insured rheumatoid arthritis (RA) patients during their first dispensed treatment for either TNFi or JAKi. Patients with RA from 8/16/2019-3/31/2022 were identified in the Merative MarketScan® Commercial and Medicare databases. The first dispensed TNFi or JAKi was the index date and baseline risk factors were assessed among patients continuously eligible for 12-months pre-index. Patients were stratified into "elevated" risk categories: age≥65 years, smoking, and/or a history of Major Adverse Cardiovascular Event (MACE), Venous Thromboembolism (VTE), or cancer. The prevalence of modifiable risk factors was also reported: hypertension, hyperlipidemia, obesity, and diabetes. The crude prevalence and prevalence difference (PD) were reported. A total of 12,673 patients [TNFi (n=7,748; 61%) and JAKi (n=4,925; 39%)] met inclusion criteria. The prevalence of "elevated" risk was the same for all TNFi (n=2,051; 26%) and JAKi (n=1,262; 26%) patients. Compared to patients at low risk, patients with an elevated risk also had a higher prevalence of at least one primary modifiable risk factor for both JAKi [79% vs. 58%; PD: 21% (95%CI: 18%-24%)] and TNFi [81% vs. 60%; PD: 21% (95%CI: 19%-23%)] patients. In recent years, JAKi and TNFi were used in similar proportions to treat RA among commercially insured patients at elevated cardiovascular and cancer risk. Because uncontrolled disease, modifiable comorbidities, and treatment with JAKi are associated with these adverse events, future studies evaluating how practice patterns may be affected by the emergence of safety data will be of value.

Increasing tree cover and high-albedo surfaces reduces heat-related ER visits in Los Angeles, CA.

There is an urgent need for strategies to reduce the negative impacts of a warming climate on human health. Cooling urban neighborhoods by planting trees and vegetation and increasing albedo of roofs, pavements, and walls can mitigate urban heat. We used synoptic climatology to examine how different tree cover and albedo scenarios would affect heat-related morbidity in Los Angeles, CA, USA, as measured by emergency room (ER) visits. We classified daily meteorological data for historical summer heat events into discrete air mass types. We analyzed those classifications against historical ER visit data to determine both heat-related and excess morbidity. We used the Weather Research and Forecasting model to examine the impacts of varied tree cover and albedo scenarios on meteorological outcomes and used these results with standardized morbidity data algorithms to estimate potential reductions in ER visits. We tested three urban modification scenarios of low, medium, and high increases of tree cover and albedo and compared these against baseline conditions. We found that avoiding 25% to 50% of ER visits during heat events would be a common outcome if the urban environment had more tree cover and higher albedo, with the greatest benefits occurring under heat events that are moderate and those that are particularly hot and dry. We conducted these analyses at the county level and compared results to a heat-vulnerable, working-class Los Angeles community with a high concentration of people of color, and found that reductions in the rate of ER visits would be even greater at the community level compared to the county.

Comparative efficacy of prophylactic protocols in reducing perioperative nausea and vomiting during video-assisted thoracoscopic radical resection of lung cancer

Lung cancer, a global mortality leader, often necessitates Video-Assisted Thoracoscopic (VATS) surgery. However, post-operative nausea and vomiting (PONV) is common, highlighting a need for effective management and prevention strategies in this context. A retrospective case–control study at Fujian Medical University Union Hospital evaluated patients undergoing VATS radical resection of lung cancer between May and September 2022. Patients were categorized based on PONV prevention methods, and data encompassing demographics, surgical history, and postoperative adverse events s were analyzed to assess the association between prophylactic protocols and PONV incidence. The Netupitant and Palonosetron Hydrochloride (NEPA) group showed a significant reduction in PONV occurrences post-surgery compared to Ondansetron (ONDA) and Control groups, emphasizing NEPA’s efficacy in alleviating PONV symptoms (P < 0.05). Furthermore, following VATS radical resection of lung cancer, NEPA markedly reduced the intensity of PONV symptoms in patients. Both univariate and multivariate logistic analyses corroborated that NEPA independently reduces PONV risk, with its protective effect also apparent in susceptible populations like females and non-smokers. NEPA utilization markedly reduced both the incidence and severity of PONV in patients undergoing VATS radical resection of lung cancer, serving as an independent protective factor in mitigating PONV risk post-surgery.