Adductor Muscle Research Articles

Multi-tissue metabolomic profiling reveals the crucial metabolites and pathways associated with scallop growth.

Bivalves represent a vital economic resource in aquaculture for their high productivity and extensive market demand. Growth is one of the most important and desired aquaculture traits for bivalves, regulated by multiple levels, notably intricate metabolic processes. However, the understanding of the metabolic profiles that influence bivalve growth is limited, particularly from a multi-tissue perspective. In this study, metabolic profiles of multiple tissues of Chlamys farreri with different growth performance were systematically investigated by ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Through comparing the metabolic variation between fast-growing (FG) scallops and slow-growing (SG) scallops, 613, 509, 105, and 192 significantly different metabolites (SDMs) were identified in the mantle, gill, adductor muscle, and digestive gland, respectively. Growth-related metabolic pathways including sphingolipid metabolism, fatty acid biosynthesis, and ABC transporter pathway, along with 11 SDMs associated with growth traits were identified in all four tissues, implying they were involved in the growth of multiple tissues in scallops. Tissue-specific metabolic profiling indicated that sulfur-containing amino acid metabolism in the mantle potentially contributed to shell growth, while the gill synergistically participated with the mantle through various metabolic processes, such as tyrosine metabolism, glycine, serine, and threonine metabolism and melanogenesis; energy metabolism was crucial for adductor muscle growth; and nutrients digestion and absorption in the digestive gland were linked to scallop growth. Our results represent the first comprehensive analysis of the crucial pathways and metabolites associated with the growth of C. farreri, offering valuable insights for future bivalve aquaculture production.

Is hip adductor or abductor strength in healthy athletes associated with future groin pain? A systematic review and meta-analysis

ObjectiveTo systematically review the association between hip adduction and abduction strength, and adduction-to-abduction strength ratio in healthy athletes with the occurrence of future groin pain and time-loss groin injuries.DesignSystematic review...

Abstract 4135968: Radiomic features of skeletal muscle on prostate T1-Weighted MRI associated with MACE outcomes in prostate cancer patients undergoing hormonal therapy

Background: Patients with high-risk prostate cancer (PC) who undergo hormonal therapy(HT) frequently die of major adverse cardiovascular events (MACE). Skeletal muscle on abdominal T1-weighted MRI (T1W) has been shown to be associated with cardiovascular fitness. Aims: To quantify heterogeneity associated with skeletal muscle tissue composition on prostate MRI patients undergoing HT using computationally derived radiomic features and identify their association with MACE. Methods: Cohort of N=58 men diagnosed with PC who underwent a 3 Tesla pre-treatment multi-parametric MRI followed by HT and followed up for MACE events were identified. MACE is defined as a composite of cardiovascular death, atrial fibrillation, myocardial infarction, ischemic stroke, heart failure, coronary artery disease, and peripheral vascular disease. Regions of interest (ROI) of skeletal muscle, including the obturator externus, pectineus, and the adductor group of muscles, were delineated on axial T1W under the guidance of an experienced radiologist. A set of 120 radiomic features, including gray level statistics, co-occurrence, wavelet, and texture energy-based features, were extracted within the ROI which quantifies underlying subvisual texture-based heterogeneity. Radiomics associated with MACE events were identified using the Wilcoxon rank-sum test and univariate Cox-regression (p<0.05). Results: Of the N=58 patients included in this study, 18 experienced MACE. The most common MACE event was AF (8.6%). Median-time-to-MACE event was 7.3 years (6.2-8.2). 3 radiomic features (Table 1) quantifying the heterogeneity of skeletal muscle on prostate T1W were observed to be associated with MACE. Specifically, we observe that first order features have a lower response and wavelet features have a lower response in MACE patients which suggests a higher degree of local deformations and heterogeneity in skeletal tissue compared to non-MACE patients. Conclusions: Results from our study suggest that radiomics quantified texture characteristics of skeletal muscle tissue may indicate cardiovascular fitness, reflecting the likelihood of experiencing MACE following initiation of HT in PC men. Pre-treatment identification of PC patients at high risk of MACE may allow for alternative treatment options improving cardiovascular outcomes. Future studies will involve exploring larger, multi-site cohorts and machine learning modeling to determine cardiovascular risk.

The association between hip adductor and extensor strength, and hip-related patient-reported outcomes in patients with longstanding hip and groin pain: an exploratory cross-sectional study

ObjectiveThe objective of this study was to assess the association between hip muscle strength and hip-related patient-reported outcome measures (PROMs) in patients with longstanding hip and groin pain (LHGP). DesignCross-sectional design SettingOrthopedic care ParticipantsEighty-one patients with LHGP were consecutively recruited Main Outcome MeasuresHip muscle strength was measured in adduction and extension. Hip-related PROMs was measured with the Copenhagen Hip and Groin Outcome Score (HAGOS) which includes six subscales (Symptoms, Pain, Activity in Daily Living (ADL), Physical Function in Sports and Recreation (Sport/Rec), Participation in Physical Activities (PA), and Quality of Life (QoL). Linear regression examined the association between hip muscle strength and each HAGOS subscale. ResultsGreater isometric hip muscle strength in adduction was associated with better HAGOS score for Pain and ADL (p≤0.037), but not for Symptoms, Sport/Rec, PA, or QoL (p≥0.154). Greater isometric hip muscle strength in extension was associated with better HAGOS score for Symptoms, Pain, and ADL (p ≤0.034), but not for Sport/Rec, PA, or QoL (p ≥0.084). ConclusionsIn patients with LHGP, greater isometric hip muscle strength seems to be associated with less symptoms and pain, and better function in ADL. No association was found for Sport/Rec, PA, or QoL.

Preparation of gelatin/gelatin-dextran/gelatin-based three-layer films with cinnamaldehyde and α-tocopherol for scallop (Patinopecten yessoensis) adductor muscle preservation

Preparation of gelatin/gelatin-dextran/gelatin-based three-layer films with cinnamaldehyde and α-tocopherol for scallop (Patinopecten yessoensis) adductor muscle preservation

Effects of Supervised Exercise Therapy on Muscle Function During Walking in Patients with Peripheral Artery Disease

Background: Although supervised exercise therapy (SET) is a primary treatment for peripheral artery disease (PAD), the current literature is limited regarding the mechanisms contributing to increased walking distances, including how lower extremity muscle function is altered after SET. This study aimed to investigate the effects of SET on lower extremity muscle function during walking in patients with PAD. Methods: Twelve patients with PAD participated in a 6-month SET program consisting of three weekly exercise sessions (a total of 72 sessions) and adhered to the American College of Sports Medicine’s (ACSM) recommendations. Each session started with a 5 min warm-up of mild walking and static stretching of upper and lower body muscles, followed by 50 min of intermitted exercise on a treadmill, and then finished with 5 min of cool-down activities similar to the warm-up. Each patient walked across a 10 m pathway with reflective markers on their lower limbs twice: before (baseline) and after six months of participation in SET (post-exercise). Marker coordinates and ground reaction forces were recorded and imported to OpenSim software (version 4.0) for gait simulations. Muscle force, muscle power, and metabolic rate were estimated from OpenSim and compared between the baseline and post-exercise. Results: The mean plantar flexor force was not altered after SET. However, individuals’ plantar flexor muscles demonstrated improvements in force production (lateral gastrocnemius: 75–80% of stance, Cohen’s d = 0.20–0.43; medial gastrocnemius: 65–85% of stance, Cohen’s d = 0.20–0.71; soleus: 90–95% of stance, Cohen’s d = 0.20–0.26). Furthermore, plantar flexor power increased (80–95% of stance, Cohen’s d = 0.20–0.39) and this was attributed to increased power in the lateral gastrocnemius (80–85% of stance, Cohen’s d = 0.20–0.47), medial gastrocnemius (80–90% of stance, Cohen’s d = 0.22–0.60), and soleus muscles (85–95% of stance, Cohen’s d = 0.20–0.49). Similarly, other muscle groups (knee extensors, knee flexors, hip abductors, hip adductors, hip extensors, and hip flexors) also exhibited force and power increases after SET. Additionally, force and power variances were significantly decreased in several muscle groups (plantar flexors, knee extensors, hip abductors, hip external rotators, hip extensors, and hip flexors). Total metabolic rate also increased during the stance period where muscle force and power were elevated after SET (early stance: 5–25%, Cohen’s d = 0.20–0.82; mid stance: 35–45%, Cohen’s d = 0.20–0.47; late stance: 75–80%, Cohen’s d = 0.20–0.36). Conclusions: Our results suggest that from a biomechanics perspective, muscle functions during walking are improved in patients with PAD after SET; however, the improvements were generally small and were not reflected by all muscle groups.

Walking biomechanics in women with patellofemoral osteoarthritis differ compared to men with and women without patellofemoral osteoarthritis

BackgroundDifferences in walking biomechanics between women and men with patellofemoral joint (PF) osteoarthritis (OA) may contribute to the development or progression of persistent symptoms in people with PFJ OA. ObjectiveEvaluate how walking biomechanics of women with PF OA differ from: (i) men with PFJ OA; and (ii) women without PF OA. Second, explore the relationship between knee-related symptoms/function and walking biomechanics in individuals with PF OA, and whether these are modified by sex. MethodsSixty-seven individuals with PF OA (43 women) and 14 women without PF OA were included. Biomechanics data were recorded during walking. Patient-reported symptoms and function were obtained using the Knee injury and Osteoarthritis Outcome Score. Differences in continuous biomechanical data were assessed using statistical parametric mapping, with discrete data and relationships evaluated using linear models. ResultsWomen with PF OA walked with a greater hip adduction angle throughout stance (t > 2.757) and lower impulses for the hip flexion, knee flexion, and ankle dorsiflexion moments (adjusted mean differences [95 % CI]:3.3 × 10–2 [-4.9 × 10–2, -1.6 × 10–2], -2.9 × 10–2 [-5.3 × 10–2, -0.4 × 10–2], -5.1 × 10–2 [-8.2 × 10–2, -2.0 × 10–2] Nms/kg, respectively) compared to men with PF OA. Compared to their asymptomatic peers, women with PF OA displayed a 5° offset towards greater hip flexion. Higher knee adduction moment impulse correlated with worse KOOS-ADL scores in men, not women. ConclusionObserved biomechanical differences were small in nature with moderate to weak relationship observed with the KOOS. Findings were not limited to the knee, indicating that women with PF OA display unique biomechanical features across the kinetic-chain.

Strength effects of the Copenhagen adduction exercise vs an adductor squeeze exercise in male football players - A randomized controlled trial.

To examine the effect of assigning male football players to an 8-week Copenhagen Adduction (CA) and Adductor Squeeze (SQ) Pragmatic randomized controlled trial, 57 participants (16.7 ± 0.9 years, 175.9 ± 7.3height and 66 ± 8.4 weight) were individually randomized to an 8-week progressive dynamic training protocol with the CA or an isometric training protocol with the SQ twice per week. Maximal eccentric (EHAD) and isometric (IHAD) hip adductor torque was tested with a handheld dynamometer. Perceived exertion and delayed onset muscle soreness (DOMS) were recorded throughout the intervention period. In the intention-to-treat analysis, no significant between-group difference was observed for EHAD (p = 0.478-0.833) nor IHAD (p = 0.084-0.118). There was a significant difference in DOMS between groups in the third to sixteenth exercise session, with the CA group reporting higher values (median varying between 0-3 vs 0-1, p = 0.000-0.009). Perceived exertion was greater for the CA group only in the fifteenth exercise session of the protocol (median of 4 vs 3, p = 0.031). No other significant differences between the groups were observed for DOMS nor perceived exertion. An 8-week adductor training program with either the Copenhagen Adduction or Adductor Squeeze exercise performed with two sets twice a week and adjusted for total volume did not result in significant differences in eccentric nor isometric adduction torque between the groups.

Effects of space allowance on behaviour during lairage, stress physiology, skin lesion scores and meat quality of market pigs transported in an actively-ventilated vehicle in the winter

A total of 1,488 pigs were transported to slaughter using a mechanically-ventilated vehicle in the winter in Canada. On each of six journeys, a sub-sample of 78 pigs were randomly assigned to two space allowances (0.46 or 0.53 m2/pig), distributed across six compartments, in two positions (near-front and near-rear) and three deck levels (top, middle, and bottom). Compartment ambient conditions (e.g., T°C and RH%) were monitored during transport and pig behaviour was recorded during lairage. Blood lactate, hematocrit, creatine kinase (CK) concentrations and meat quality in the longissimus (LM), semimembranosus (SM), and adductor (AD) muscles were assessed on a total of 108 pigs. Pigs transported at 0.53 m2/pig had greater blood hematocrit levels (P = 0.05), but lower blood CK concentrations at slaughter (P = 0.01). The top deck was colder during all transport events (P < 0.001), and pigs transported in this location stood less in lairage compared to those transported on the bottom deck (P = 0.05). Pigs from the top deck showed lower L* values in the LM and SM muscle (P = 0.02 and P = 0.04, respectively). Overall, animal location had a greater impact than space allowance on animal welfare and meat quality of pigs.

Monitoring hip adductor strength in professional women's football players over a season: A prospective study

ObjectivesTo describe the changes in hip adductor strength of professional women's football players over a season. DesignOne-season prospective study. SettingFacilities of a national first division club. ParticipantsProfessional women's football players. Main outcome measuresMaximum hip adductor isometric strength in the long-lever and short-lever positions at four timepoints: early preseason, early season, mid-season, and end-season. ResultsTwenty-two players completed the study. Hip adductor strength values in early preseason (134 ± 29 N in the long-lever position and 317 ± 68 N in the short-lever position) were significantly lower than in the early season (171 ± 29 N and 363 ± 54 N) and mid-season (163 ± 23 N and 369 ± 53 N). By the end of the season (150 ± 19 N and 345 ± 39 N), strength values had significantly declined from both early and mid-season levels. Visual inspection of individual athletes' strength evolution over time reveals heterogeneous responses, with some players showing trajectories opposite to the group at specific time points. ConclusionsHip adductor strength increased from the preseason to the start of the women's football national league, remained stable during the first half of the league, but slightly declined in the second half. The heterogeneous responses among athletes underscore the importance of individualized monitoring throughout the season.

Effectiveness of Injury Prevention Program Using a Global Systems Approach on High-Risk Movement Mechanics for Noncontact ACL Injury.

Injury prevention training using a global systems approach was designed to develop integrated trunk-lower extremity neuromuscular control using whole-body, rotational forces about the vertical Z-axis during simulated sports movements. Compared with traditional hip-focused exercises, injury prevention training using a global systems approach could improve kinetic and kinematic measures related to anterior cruciate ligament injury. Controlled laboratory study. Level 3. A total of 39 male and female athletes received 6 weeks of either global systems approach (n = 20), or hip-focused strengthening, balance, and plyometrics training (n = 19) exercises. Before and after the training program, participants performed a single-leg vertical drop jump task on their dominant leg. Peak vertical ground-reaction forces (GRFs), peak knee abduction, internal rotation moments, peak hip flexion, hip adduction, knee flexion, knee abduction, contralateral pelvic drop, and lateral trunk flexion angles were assessed. Biomechanical data were compared between the 2 groups using a random-intercept linear mixed-models analysis. A significant group × time interaction effect was found for vertical GRFs (P = 0.01; change difference relative to baseline: 4.5%), knee abduction moment (P = 0.01; 14.8%), hip adduction (P < 0.01; 16.7%), knee abduction (P < 0.01; 13.8%), contralateral pelvic drop (P < 0.01; change difference: 26.6%), and lateral trunk flexion (P = 0.04; 20.37%) angles, favoring the global systems approach group after 6 weeks of training. Participants who trained using the global systems approach had significantly decreased lateral trunk flexion, hip adduction, knee abduction and contralateral pelvic drop angles, peak vertical GRFs, and peak knee abduction moment during a single-leg vertical drop jump compared with participants who trained with hip-focused exercises. Incorporating additional external resistance at the proximal trunk results in improved biomechanics compared with conventional hip-focused exercises.

Exploring the acid-insoluble shell organic matrix of freshwater mussels (Unionoida) as a proxy for palaeodietary and paleoenvironmental studies

ABSTRACT The shells of freshwater mussels, commonly found at archaeological sites associated with the Kodjadermen-Gumelnița-Karanovo VI human groups (5th millennium BCE, Romania and Bulgaria), were a significant dietary component for this population. The organic matrix of these ancient shells is often well-preserved and can be analysed using stable isotopes. This study establishes the empirical relationship between the isotopic composition of the acid-insoluble shell organic matrix (AIM) and the soft tissues of modern Unio tumidus. A quality criterion for AIM (C:N ratio 3.6 (3.3–<3.8)) was defined, and isotopic offsets (Δ15NAIM-defatted body = +0.95‰, Δ13CAIM-defatted body = +0.93‰ for soft tissues; Δ15NAIM-muscle = +1.7‰, Δ13CAIM-muscle = +0.3‰ for the adductor muscle) were determined. Our data suggest that the Gumelnița mussels were omnivorous, with a similar trophic level to carp and pond turtles, sourced from diverse water bodies (rivers, lakes …) based on δ13C values.

Biomechanical Analysis of the “Cuban Motion”

Abstract Purpose “Cuban Motion” (CM) is a term often used to label a basic movement of many Latin-American dances, such as salsa and bachata. It is characterized by a cyclical and rhythmic flexion and rotation of the pelvis, accompanied by ample movements of the spine and lower limbs. Since Latin dances are considered both a recreational activity and a kind of healthy gymnastics for young and older subjects, a biomechanical analysis of the CM was performed to quantitatively assess the main features of this movement, from joint kinematics to muscle activations. Method The study combined experimental acquisitions with a Vicon Motion Capture system and musculoskeletal analyses in OpenSim. Only one subject was considered, an instructor of Latin dances, who was equipped with 55 retro-reflective markers, according to the Full Body CGM2.5 marker set. Data were processed in OpenSim, using the ThoracoLumbar model (111 DoFs and 620 musculo-tendon actuators). Results The cycle of the CM and its main events were defined. Results showed a wide RoM of many joints, with correlations between hip and knee flexion angles and among list, between hip adduction and shoulder flexion. The main role of the iliopsoas and the ileus costalis muscles was observed. Conclusions The current study quantified the CM as a physical exercise using a biomechanical approach similar to a gait analysis. The main kinematic and kinetic features were described, also providing an estimation of the muscle activations and joint reactions, derived from simulation activity in OpenSim. The main limitation of this study is the focus on a single subject, but this step was necessary to define a context and guidelines for future investigations, where we are going to compare èlite vs. novices and male vs. female dancers.

Non-destructive Analytical Study of Raman Spectra Variations and Mechanisms of Calcite and Aragonite in Modern and Fossilized Oysters.

Oyster fossils are some of the most common bivalve mollusk fossils found all over the world, they are different from other fossils because the oyster is still alive in the present day, and the body structure of modern oyster is almost the same as that of ancient one. Therefore, we designed a control experiment comparing the Raman spectra of minerals from both modern oysters and fossil oysters to explore the mechanism of oyster's fossilization process, which is considered to be helpful for investigating biological evolution or paleoenvironment. The oyster fossil sample was found in Nagi-Cho, Okayama Prefecture, Japan. We focused on the variations of band position and full width half-maximum of ν1 Raman band (symmetric stretching mode) of calcite (CaCO3) from modern and fossil oysters and the mineral conversion between calcite and aragonite (CaCO3) around the adductor muscle inside the oyster. Compared to modern oysters, the ν1 band at around 1086 cm-1 of calcite from oyster fossils shifted to a high wavenumber region, and the possible reason for this phenomenon is considered an elemental substitution between Ca2+ and Mg2+. As for aragonite around adductor muscle in fossil oysters, it has been found by Raman spectra that most of the aragonite has been converted into calcite because calcite has a relatively more stable structure.

Obturator Nerve Block Performed Blinded Versus by Ultrasound-guidence for Transurethral Resection of Bladder Tumors: A Randomized Controlled Trial.

The primary outcome of this study is to compare the success rates of ONB techniques performed either with ultrasound guidance or with the blind technique. The second outcome is to compare the incidences of perioperative bleeding and the presence of recurrent tumors in the control cystoscopy performed in the 3rd postoperative month in both groups. The study was conducted in the urology operating room of Mugla Sitki Kocman Training and Research Hospital between December 2019 and March 2023. A total of 122 patients were included in the study: 22 females with a mean age of 56.63 ± 12.99 years and 100 males with a mean age of 63.18 ± 8.00 years. In one group (group 1), ONB was performed under ultrasound guidance by the same anesthesiologist, and in another group (group 2), ONB was performed blindly based on anatomical signs by the same urologist. Adductor muscle contraction was not observed in 53 patients (91.4%) in group 1 and in 49 patients (76.6%) in group 2 (p = 0.027). The success rate of ONB was higher when using an ultrasound-guided technique than when using a blind technique.

Anesthetic sampling and the tissue regeneration potential of oysters: A study with Crassostrea hongkongensis

The use of an appropriate amount of anesthetic can prevent the sacrifice of oysters during experimental sampling or seedling rearing. In this study, we assessed the effects of air exposure and three concentrations of magnesium chloride (10, 40, and 70 g L–1) on the anesthetic efficiency for Crassostrea hongkongensis. We examined the recuperative capacity of the oysters post-tissue sampling. The results indicated that 36 h of air exposure could significantly enhance the anesthetic efficiency of C. hongkongensis while ensuring the oysters’ survival. A 40 g L–1 solution of magnesium chloride had the optimal anesthetic effect on C. hongkongensis across all oyster sizes. In addition, smaller oysters (119.10 g) had a higher relaxation rate than larger oysters (191.00 g). The oysters anesthetized with 40 g L–1 magnesium chloride also demonstrated the best recovery. No deaths were observed among the non-anesthetized oysters, anesthetized-recovered oysters, or non-recovered oysters during a seven-day post-farming period. In terms of live sampling, the control group (100 %), gonad group (100 %), mantle group (98.67 %), gill group (89.33 %), and adductor muscle group (97.33 %) all showed high survival rates after anesthesia. Observation of tissue growth post-sampling revealed the presence of focal green areas in tissues between days 7 and 14. By day 30, the adductor muscle and mantle tissues had fully healed, and the regrown tissue in the gills had approached its original length. A 40 g L–1 magnesium chloride solution had no significant effects on gametes in terms of fertilization rate, growth rate, and attachment rate. The present findings indicated that C. hongkongensis could be effectively anesthetized using a 40 g L–1 magnesium chloride solution following 36 h of aerial exposure. Post-anesthesia tissue and gamete sampling did not result in significant mortality, and the tissues had fully recovered within 30 days post-sampling. The anesthesia did not have any adverse effects on the progeny.

Role of the Kölliker-Fuse/parabrachial complex in the generation of postinspiratory vagal and sympathetic nerve activities and their recruitment by hypoxemic stimuli in the rat.

In the rat, the activity of laryngeal adductor muscles, the crural diaphragm, and sympathetic vasomotor neurons is entrained to the postinspiratory (post-I) phase of the respiratory cycle, a mechanism thought to enhance cardiorespiratory efficiency. The identity of the central neurons responsible for transmitting respiratory activity to these outputs remains unresolved. Here we explore the contribution of the Kölliker-Fuse/parabrachial nuclei (KF-PBN) in the generation of post-I activity in vagal and sympathetic outputs under steady-state conditions and during acute hypoxemia, a condition that potently recruits post-I activity. In artificially ventilated, vagotomized, and urethane-anesthetized rats, bilateral KF-PBN inhibition by microinjection of the GABAA receptor agonist isoguvacine evoked stereotypical responses on respiratory pattern, characterized by a reduction in phrenic nerve burst amplitude, a modest lengthening of inspiratory time, and an increase in breath-to-breath variability, while post-I vagal nerve activity was abolished and post-I sympathetic nerve activity diminished. During acute hypoxemia, KF-PBN inhibition attenuated tachypneic responses and completely abolished post-I vagal activity while preserving respiratory-sympathetic coupling. Furthermore, KF-PBN inhibition disrupted the decline in respiratory frequency that normally follows resumption of oxygenation. These findings suggest that the KF-PBN is a critical hub for the distribution of post-I activities to vagal and sympathetic outputs and is an important contributor to the dynamic adjustments to respiratory patterns that occur in response to acute hypoxia. Although KF-PBN appears essential for post-I vagal activity, it only partially contributes to post-I sympathetic nerve activity, suggesting the contribution of multiple neural pathways to respiratory-sympathetic coupling.NEW & NOTEWORTHY Inhibition of neurons in the pontine Kölliker-Fuse/parabrachial complex (KF-PBN) differentially inhibited postinspiratory (post-I) activity in vagal and sympathetic outputs. The strong recruitment of post-I vagal activity that occurs in response to hypoxemia is selectively abolished by KF-PBN inhibition. This suggests that 1) post-I activity in vagal and sympathetic outputs may be generated by partially independent mechanisms and 2) neurons in the KF-PBN are a preeminent source of drive for the generation of eupneic post-I activity.

Posterior Hip Pericapsular Block (PHPB) with pericapsular nerve group (PENG) block for hip fracture: a case series

BackgroundPain after total hip arthroplasty (THA) for femoral neck fracture (FNF) can be severe, potentially leading to serious complications. PENG block has become an optional local analgesic strategy in hip fracture surgery, but it cannot provide effective pain relief for the posterior capsule of the hip joint. Therefore, we modified the traditional sacral plexus nerve block and named it Posterior Hip Pericapsule Block (PHPB) to complement the blockade of the relevant nerves innervating the posterior hip capsule region. Thereby, we detail the analgesic effect of PHPB combined with PENG block on five hip fracture patients and the effect on their hip motor function.MethodsThis case series was conducted from December 2023 to February 2024. We performed ultrasound-guided PHPB combined with PENG block on five patients with hip fractures. Numerical Rating Scale (NRS) pain scores at rest and maximum NRS pain scores during limb movement of the five patients were recorded within 48 h after surgery. Their hip flexion, abduction, adduction, keen flexion and quadriceps muscle strength were also recorded. Serious postoperative complications, including wound infection, hematoma formation, or nerve injury, were recorded.ResultsThey experienced effective pain control within 48 h postoperatively, with NRS pain scores at rest decreasing from 3.0 (3.0, 4.5) to 0.0 (0.0, 1.0) and maximum NRS pain scores during limb movement from 8.0 (7.5, 8.5) to 1.0 (0.5, 2.0). They can autonomously perform hip flexion, abduction, adduction, and knee flexion within 48 h postoperatively without any signs of movement disorders or quadriceps muscle weakness. No severe postoperative complications, such as wound infections, hematoma formation or nerve damage, were observed in any of the patients.ConclusionsUltrasound-guided PENG block combined with PHPB provided effective analgesia for hip fracture patients in the perioperative period. It maintained hip joint motor function and quadriceps muscle strength within 24 h after THA.

Magnetic resonance imaging verification of anterior capsular impingement in the hip joint: A three-dimensional analysis

BackgroundThis study aimed to clarify whether the anterior hip capsular ligament is impinged between the acetabulum and femur during hip flexion or adduction and to determine the difference in the distance between the femur and capsular ligament in healthy adults and those with hip pain. MethodsMagnetic resonance imaging of the hip joint was conducted at the following hip positions: 0° of flexion, 60° of flexion, maximal flexion, and maximal flexion with adduction. A three-dimensional model of the capsular ligament and femur was constructed. The minimal distance between the femur and capsular ligament, termed the capsule-femur distance, was computed. Because a capsule-femur distance of 0 mm indicates contact between the femur and the capsular ligament, that is, capsular impingement, the distance in each position was compared for each group using a one-sample t-test. The capsule-femur distance in the various groups and for different positions was compared using a split-plot analysis of variance. FindingsFifteen healthy individuals and sixteen individuals experiencing hip pain were enrolled. The capsule-femur distance was significantly greater than 0 mm in all positions in both groups, and none of the groups had a capsule-femur distance of 0 mm. The capsule-femur distance was significantly longer in the other positions than in the 0° flexion position, and significantly longer in the hip pain group than in the healthy group. InterpretationCapsular impingement did not occur in either group, even during hip flexion or adduction. Furthermore, the capsule-femur distance was longer in the hip flexion and hip pain groups.

Symbiodiniaceae‐Derived Fatty Acids Are Stored Differentially Across Giant Clam Species and Organs

ABSTRACTGiant clams are invertebrates that form mutualistic associations with Symbiodiniaceae dinoflagellates. Despite their ecological significance, gaps persist regarding our understanding of their trophic ecology. Specifically, it is unknown whether Symbiodiniaceae‐derived photosynthates are metabolized differently according to species and organ. Therefore, we maintained Tridacna derasa and T. noae for 3 months in a well‐lit recirculated system without food supply. Samples were taken from eight organs and underwent lipid extraction and fatty acid esterification before analysis of three symbiont‐derived fatty acids (stearidonic acid, docosapentaenoic acid, and docosahexaenoic acid—SDA, DPA, and DHA, respectively) using gas chromatography. Results show considerable variation in fatty acids concentration among species and organs. SDA was found in higher concentrations in T. noae, especially in the adductor muscle. DPA was detected in low concentrations across T. noae organs and absent for T. derasa. DHA did not vary significantly among species and organs. Our findings indicate that Symbiodiniaceae supply clams with fatty acids, which are stored differentially according to species and organs. This demonstrates that these compounds are translocated to multiple organs throughout the complex giant clam anatomical system, in contrast to simpler hosts like corals. These results advance our understanding of the physiological dynamics of the mollusk‐algae association.