ABSTRACT The research aims to assess the interplay between climate dynamics and snow cover changes, informing water resource management. Utilizing the SWAT model with historical and future data, hydrological responses in the Marshyangdi River Basin are examined. The model's performance confirms its ability to simulate runoff components effectively. Projections indicate a concerning decrease in snow cover area for 2030, 2050, and 2090, with declines of 2.03, 4.03, and 14.20%, respectively, attributed to global warming and human activities. Isolating climate change reveals substantial increases in stream flow, notably pre-monsoon surges under different scenarios, with projected increments of 84 and 130% under SSP245 and SSP585, respectively. Analysis of snow cover impact shows a slight increase in annual stream flow, with a 3.54% anticipated decrease during the post-monsoon period, raising concerns for water availability in the dry season. Comparing both impacts reveals no significant differences in stream flow or precipitation. Annual stream flow increases under different scenarios, driven by precipitation, with varying impacts. Climate change emerges as the dominant driver, affecting surface runoff, groundwater, and evapotranspiration. This research unravels complex relationships between climate change, snow cover, and hydrological responses, providing valuable insights for water resource management in mountainous regions like the Hindu Kush Himalaya.