Determining the geometry and evolution of a basal detachment and its influence on orogenesis is a challenging, but important, aspect to understanding orogenic evolution. The basal detachment of the Himalayan orogen in far west Nepal is presently segmented by a documented tear fault. New pressure-temperature-time-deformation paths from the Himalayan metamorphic core along the Seti Khola river transect were integrated to compare the tectonometamorphic evolution on either side of the basal detachment tear fault to outline its history. Peak metamorphic conditions of 645−745 °C and 0.85−1.1 GPa were reached in the Seti Khola Himalayan metamorphic core rocks during the Oligocene to earliest Miocene, 10−14 m.y. prior to equivalent along-strike rocks in the adjacent Karnali valley, which indicates segmentation of the Himalayan metamorphic core across the tear fault. We interpret the segmentation of the orogen to have been caused by the development of the tear fault in the basal detachment of the Himalayan orogen and differing ramp-flat geometries on either side. The segmentation and change in basal detachment geometry is consistent with the reactivation of an underthrusted Indian plate inherited basement structure, the Great Boundary Fault, during the Oligocene to earliest Miocene. The comparison of tectonometamorphic histories along-strike in far west Nepal highlights the basal detachment geometry through time and the need to consider the pre-orogenic structural features of the plates involved in orogenesis. This study reinforces the importance of combining tectonometamorphic studies with geophysical and geomorphological data to fully understand the causes of along-strike segmentation of orogenic systems through time.